Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Ocular surface manifestation of COVID-19 and tear film analysis

    Authors: Alessandro Meduri; Giovanni William Oliverio; Giuseppe Mancuso; Angela Giuffrida; Claudio Guarneri; Emmanuele Venanzi Rullo; Giuseppe Nunnari; Pasquale Aragona

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    Purpose: To evaluate the ocular manifestation in patients hospitalized with coronavirus disease MESHD 2019 (COVID-19) and to search for the presence of severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) in tears.Methods: This study was conducted in 29 hospitalized patients who were admitted to the COVID center at the Policlinic Hospital of the University of Messina, Italy.All patients underwent an ophthalmologic assessment comprising a Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire, anterior segment, and the ocular surface examination of both eyes using a portable slit lamp.The Schirmer I test was performed, and the filter paper strip was used to search for the presence of SARS-CoV-2 on the ocular surface by real-time quantitative polymerase chain reaction (RT-qPCR).Results: A total of 10 patients reported ocular symptoms; in particular, four reported eye burning MESHD, three reported foreign body MESHD sensation, and three reported tearing. Moreover, seven patients presented conjunctival hyperemia HP hyperemia MESHD and/or chemosis HP, eleven patients presented blepharitis MESHD blepharitis HP signs such as lid margin hyperemia MESHD and/or telangiectasia HP, crusted eyelashes, and meibomian orifices alterations. Tear analysis did not reveal the presence of SARS-CoV-2.Conclusion: Ocular symptoms are common in patients with COVID-19; although, tear analysis did not reveal the presence of SARS-CoV-2.

    Triage assessment of cardiorespiratory risk status based on measurement of the anaerobic threshold, and estimation by patient-reported activity limitation

    Authors: Saranya Thurairatnam; Filip Gawecki; Timothy Strangeways; Joseph Perks; Vatshalan Santhirapala; Jonathan Myers; Hannah C Tighe; Luke SGE Howard; Claire L Shovlin

    doi:10.1101/2020.03.27.20045203 Date: 2020-03-30 Source: medRxiv

    BACKGROUND: Rapid triaging, as in the current COVID-19 pandemic, focuses on age TRANS and pre-existing medical conditions. In contrast, preoperative assessments use cardiopulmonary exercise testing (CPET) to categorise patients to higher and lower risk independent of diagnostic labels. Since CPET is not feasible in population-based settings, our aims included evaluation of a triage/screening tool for cardiorespiratory risk. METHODS: CPET-derived anaerobic thresholds were evaluated retrospectively in 26 patients with pulmonary arteriovenous malformations HP arteriovenous malformations MESHD (AVMs) who represent a challenging group to risk-categorise. Pulmonary AVM-induced hypoxaemia secondary to intrapulmonary right-to-left shunts HP right-to-left shunts HP, anaemia from underlying hereditary haemorrhagic telangiectasia HP and metabolic equivalents derived from the 13-point Veterans Specific Activity Questionnaire (VSAQ) were evaluated as part of routine clinical care. Pre-planned analyses evaluated associations and modelling of the anaerobic threshold and patient-specific variables. RESULTS: In the 26 patients ( aged TRANS 21-77, median 57 years), anaerobic threshold ranged from 7.6-24.5 (median 12.35) ml.min-1kg-1 and placed more than half of the patients (15, 57.7%) in the >11 ml.min-1kg-1 category suggested as lower-risk for intra-abdominal surgeries. Neither age TRANS nor baseline SpO2 predicted anaerobic threshold, or lower/higher risk categories, either alone or in multivariate analyses, despite baseline oxygen saturation (SpO2) ranging from 79 to 99 (median 92)%, haemoglobin from 108 to 183 (median 156)g.L-1. However, lower haemoglobin, and particularly, arterial oxygen content and oxygen pulse were associated with increased cardiorespiratory risk: Modelling a haemoglobin increase of 25g.L-1 placed a further 7/26 (26.9%) patients in a lower risk category. For patients completing the VSAQ, derived metabolic equivalents were strongly associated with anaerobic threshold enabling risk evaluations through a simple questionnaire. CONCLUSIONS: Baseline exercise tolerance may override age TRANS and diagnostic labels in triage settings. These data support approaches to risk reduction by aerobic conditioning and attention to anaemia. The VSAQ is suggested as a rapid screening tool for cardiorespiratory risk assessment to implement during triage/screening.

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MeSH Disease
Human Phenotype

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