SARS-CoV-2 causing COVID-19 disease MESHD has moved rapidly around the globe, infecting millions and killing hundreds of thousands. The basic reproduction number TRANS, which has been widely used and misused to characterize the transmissibility TRANS of the virus, hides the fact that transmission TRANS is stochastic, is dominated by a small number of individuals, and is driven by super-spreading events (SSEs). The distinct transmission TRANS features, such as high stochasticity under low prevalence SERO, and the central role played by SSEs on transmission TRANS dynamics, should not be overlooked. Many explosive SSEs have occurred in indoor settings stoking the pandemic and shaping its spread, such as long-term care facilities, prisons, meat-packing plants, fish factories, cruise ships, family gatherings, parties and night clubs HP. These SSEs demonstrate the urgent need to understand routes of transmission TRANS, while posing an opportunity that outbreak can be effectively contained with targeted interventions to eliminate SSEs. Here, we describe the potential types of SSEs, how they influence transmission TRANS, and give recommendations for control of SARS-CoV-2.