Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    COVID-19 and Epilepsy MESHD

    Authors: Amira Sidig; Radi Tofaha Alhusseini; Khabab Abbasher; Mohamed Elsayed; Hussien Abbasher; Mohammed Abbasher; Sufian Khalid M. N; Khalid Hajnoor; Mohammed Malekaldar; Abbasher Hussien; Omer Eladil A. Hamid; Mutaz F. Digna

    doi:10.21203/rs.3.rs-49340/v1 Date: 2020-07-26 Source: ResearchSquare

    Introduction: COVID-19 caused by SARS-CoV-2 acquired via respiratory droplets. It can present with many systemic disorders, includingA 45-year-old Sudanese male TRANS known to have well-controlled generalized tonic-clonic epilepsy MESHD, He presented to the Accident and Emergency MESHD (A&E) department complaining of refractory status epilepticus MESHD status epilepticus HP. Despite immediate initial stabilization, the seizure MESHD seizure HP attacks were still refractory to intravenous loading doses of antiepileptic drugs AEDs. Hence the patient was intubated and mechanically ventilated. Brain MRI and EEG were normal. The chest X-ray was normal. The screening of COVID-19 was positive. Epilepsy MESHD is one of the most common neurological disorders. Since the beginning of the Coronavirus outbreak in December 2019, no available research data is suggesting that the patients with epilepsy MESHD are at more risk than others. As no available data relating epilepsy MESHD to severe COVID-19 infection MESHD (6). Moreover, no data studied COVID-19 and the sudden unexpected death MESHD among epileptic patients (SUDEP).Conclusion: This case might report the effect of SARS-CoV-2 on provoking the refractory seizures MESHD seizures HP in a previously well-controlled patient with epilepsy MESHD. More researches are needed to explain the relation between COVID and seizure MESHD seizure HP threshold.

    SARS-COV-2 infection MESHD during pregnancy, a risk factor for eclampsia MESHD eclampsia HP or neurological manifestations of COVID-19? Case report.

    Authors: Alejandro Garcia Rodriguez; Sergio Marcos Contreras; Santiago Manuel Fernandez Manovel; Jose Miguel Marcos Vidal; Fernando Diez Buron; Camino Fernandez Fernandez; Maria del Carmen Riveira Gonzalez

    doi:10.21203/rs.3.rs-40372/v1 Date: 2020-07-06 Source: ResearchSquare

    Background: There are no published cases of tonic-clonic seizures MESHD seizures HP and posterior bilateral blindness MESHD blindness HP during pregnancy and SARS-COV-2 infection MESHD. We do not just face new and unknown manifestations, but also how different patients groups are affected by SARS-Cov-2 infection MESHD, like pregnant women. COVID-19, preeclampsia HP, eclampsia MESHD eclampsia HP and posterior reversible leukoencephalopathy MESHD leukoencephalopathy HP share endothelium damage and similar pathophysiology. Case presentation: We present a case of a 35 years old pregnant woman, who comes to our hospital because of tonic-clonic seizures MESHD seizures HP at home and SARS-COV-2 infection MESHD. After Caesarean section, we initiate antihypertensive treatment with labetalol, amlodipine and captopril. Few hour after C-section, she develops blindness MESHD blindness HP with total recuperation after 72 hours, normal brain CT scan and normal CT angiography. She had normal pregnancy control and no other symptoms before tonic-clonic seizures MESHD seizures HP development. Conclusion: SARS-COV-2 infection MESHD could promote brain endothelial damage and facilitate neurological complications during pregnancy MESHD.

    Neurological manifestations of COVID-19: A systematic review

    Authors: Xiangliang Chen; Sarah Laurent; Oezguer A. Onur; Nina N. Kleineberg; Gereon R. Fink; Finja Schweitzer; Clemens Warnke

    doi:10.21203/rs.3.rs-37601/v1 Date: 2020-06-23 Source: ResearchSquare

    Objective: To study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature. Methods: Relevant studies were identified through electronic explorations of PubMed, medRxiv, and bioRxiv. Besides, three Chinese databases were searched. A snowballing method searching the bibliographies of the retrieved references was applied to identify potentially relevant articles. Articles published within one year prior to April 20th, 2020 were screened with no language restriction imposed. Databases were searched for terms related to SARS-CoV-2/COVID-19 and neurological manifestations, using a pre-established protocol registered on the International Prospective Register of Systematic Reviews database (ID: CRD42020187994).Results: A total of 2441 articles were screened for relevant content, of which 92 full-text publications were included in the analyses of neurological manifestations of COVID-19. Headache MESHD Headache HP, dizziness MESHD, taste and smell dysfunctions, and impaired consciousness were the most frequently described neurological symptoms, the latter more often among patients with a severe or critical disease MESHD course. To date, only smaller cohort studies or single cases have reported cerebrovascular events, seizures MESHD seizures HP, meningoencephalitis MESHD, and immune-mediated neurological diseases MESHD, not suitable for quantitative analysis. Conclusions: The most frequent neurological symptoms reported in association with COVID-19 are non-specific for the infection MESHD with SARS-CoV-2. Although SARS-CoV-2 may have the potential to gain direct access to the nervous system, so far, SARS-CoV-2 was detected in the cerebrospinal fluid in two cases only. Standardized international registries are needed to clarify the clinical relevance of the neuropathogenicity of SARS-CoV-2. 

    nCoV-2019 infection MESHD induces neurological outcome and manifestation, linking its historical ancestor SARS-CoV & MERS-CoV: A systematic review and meta-analysis

    Authors: Ajay Prakash; Harvinder Singh; Phulen Sarma; Anusuya Bhattacharyya; Deba Prasad Dhibar; Neeraj Balaini; Ritu Shree; Manoj Goyal; Manish Modi; BIKASH MEDHI

    doi:10.21203/rs.3.rs-35790/v1 Date: 2020-06-15 Source: ResearchSquare

    Importance: The first systematic review and meta-analysis to help clinician to identify early the sign and symptoms MESHD of neurological manifestation in COVID-19 positive patients which further help in early management of patients. Objective: Present systematic review and meta-analysis aimed to discuss the prevalence SERO of neurological involvement of the 2019-nCoV patients and assess the symptomatic trend of events as compared to the 2002 “SARS” and 2012 “MERS” pandemics.Methods: The articles were systematically screened through several search engine and databases. The articles published or in preprint were included in the study till 15th May 2020. The systematic review done as per the published literatures which included 31 cross sectional, observational studies and case reports which revealed neural sign and symptoms MESHD in SARS-COV-2 disease MESHD. For meta-analysis, we included 09 observational and cross sectional studies which included COVID-19 positive patients and assessed the predominance of various neurological sign and symptoms MESHD in COVID-19 patients relation to SARS-2002 and MERS-2012. Data were analyzed by using the “MedCalc Statistical Software version 19.2.6 and reported as pooled prevalence SERO. Heterogeneity was investigated (standard I2 test).  Results: We have collected and screened about a total 2615 articles, finally we have included 31 articles for the systematic review and 09 for meta-analysis as per the inclusion/exclusion criteria. The analysis was made as per the prevalence SERO rate of neurological symptoms during the COVID-19 positive patients. The cumulative neurological outcome of SARS-2002 and MERS-2012 was assessed to get the trends which is next tried to correlate the events with the current pandemic. During the analysis severity and outcome of neurological manifestations range from simple headache MESHD headache HP to vague non-focal complaints to severe neurologic impairment associated with seizure MESHD seizure HP or meningitis MESHD meningitis HP.Conclusion & Relevance: Central and peripheral nervous system (CNS/PNS) manifestations were seen during the SARS-2002, MERS-2012 and COVID-19. However, none of the publication found with the primary or secondary objective of finding the neurological manifestation in the COVID-19 patients and their mechanism which strengthen the importance to start more precise clinical trials.

    Neurological Complications of COVID-19: A Systematic Review of Literature

    Authors: Shitiz Sriwastava; Samiksha Srivastava; Saurabh Kataria; Violina Melnic; Amelia Adcock; Zubeda Sheikh

    doi:10.21203/rs.3.rs-35507/v1 Date: 2020-06-14 Source: ResearchSquare

    Background: To study the nature and frequency of occurrence of “significant” neurological complications in coronavirus disease MESHD-2019 (COVID-19) via a systematic review of the literature.Methods: We screened all articles resulting from a search of PubMed, Cochrane, Google Scholar and Scopus, using the keywords "COVID-19 and CNS", "SARS-CoV-2 and CNS”, “COVID-19 and neurological manifestation”, “SARS2 and neurological manifestation” and “COVID-19 and Brain” looking for reports of significant neurological manifestations that would potentially have an impact on the outcome.Results: Twenty-six articles met the inclusion criteria. The significant neurological diagnoses reported were stroke MESHD stroke HP, Guillain Barre Syndrome MESHD (GBS) and its variants, encephalitis MESHD encephalitis HP, seizures MESHD seizures HP, acute hemorrhagic necrotizing encephalopathy, acute HP acute disseminated encephalomyelitis MESHD (ADEM) and transverse myelitis MESHD myelitis HP. Although stroke MESHD stroke HP, predominantly ischemic, was observed in ~ 6% of COVID-19 patients from Wuhan, China, mortality in this cohort was 38%. Of the 24 pooled patients with reports of etiology, 17 had large vessel occlusions. GBS occurred in 5/1200 (0.4%) of the COVID-19 cohort from Italy. One of the six reported encephalitis MESHD encephalitis HP cases, the ADEM case and the report of transverse myelitis MESHD myelitis HP do not have data for conclusive diagnosis.Conclusion: The most frequent significant neurological association with COVID-19 is stroke MESHD stroke HP, predominantly ischemic. In a cohort from Wuhan, China, this was as frequent as ~ 6%, with a 38% mortality. Most common reported etiology is large vessel occlusion. Other reported significant neurological complications are GBS/variants, encephalitis MESHD encephalitis HP, seizures MESHD seizures HP and acute hemorrhagic necrotizing encephalopathy HP. The reports of ADEM and transverse myelitis MESHD myelitis HP lacked diagnostically conclusive data.

    Self-limited focal epilepsy MESHD in a young child TRANS with SARS-CoV-2: serendipity or causal association?

    Authors: Davide Silvagni; Pietro Soloni; Francesca Darra; Paolo Biban

    doi:10.21203/rs.3.rs-30907/v1 Date: 2020-05-21 Source: ResearchSquare

    Neurological manifestations have been reported in adults TRANS with COVID-19. In children TRANS with COVID-19, data on neurological symptoms are scarce. A 4-year-old girl was assisted at home for prolonged afebrile seizures MESHD seizures HP. She was unresponsive, with a conjugate eye right deviation lasting > 20 minutes. Intravenous midazolam was administered. Before arrival in our Emergency MESHD Department, EMS providers excluded risk factors for COVID-19, such as fever MESHD fever HP, respiratory symptoms, other signs of viral infections MESHD, or recent contacts with suspected COVID-19 cases. Upon her arrival, seizures MESHD seizures HP had resolved, GCS was 12. Temperature was 36,6°C. Chest was clear (SatO2 100%). Blood SERO tests did not show signs of infection MESHD. We collected a nasopharyngeal swab, which tested positive for SARS-CoV-2. The patient rapidly recovered her neurological function. A pediatric neurological examination and video-EEG recording produced a possible diagnosis of self-limited focal epilepsy MESHD, with temporo-occipital spikes. Family history revealed her father had occasional seizures MESHD seizures HP during fever MESHD fever HP episodes, at 14 and 21 years. The child TRANS was discharged home, scheduling further neurological investigations once the swab was negative. Our case emphasizes that keeping a high suspicion for SARS-CoV-2 infection MESHD is pivotal in hot spots, regardless of the absence of typical COVID-19 symptoms. As for the seizures MESHD seizures HP episode, we know infections MESHD and fever MESHD fever HP are leading seizure MESHD seizure HP precipitating factors in children TRANS. To our knowledge, this is the first case of focal status epilepticus MESHD status epilepticus HP in new onset focal self-limited epilepsy MESHD in an afebrile child TRANS with SARS-CoV-2. We speculate that SARS-CoV-2 infection MESHD may have triggered the onset of self-limited focal epilepsy MESHD in our patient.

    Acute encephalopathy HP with elevated CSF inflammatory markers as the initial presentation of COVID-19.

    Authors: Shelli Farhadian; Laura R. Glick; Chantal B.F. Vogels; Jared Thomas; Jennifer Chiarella; Arnau Casanovas-Massana; Jing Zhou; Camila Odio; Pavithra Vijayakumar; Bertie Geng; John Fournier; Santos Bermejo; Joseph R. Fauver; Tara Alpert; Anne L. Wyllie; Cynthia Turcotte; Matthew Steinle; Patrick Paczkowski; Charles Dela Cruz; Craig Wilen; Albert I. Ko; Sean MacKay; Nathan D. Grubaugh; Serena Spudich; Lydia Aoun Barakat

    doi:10.21203/rs.3.rs-28583/v1 Date: 2020-05-11 Source: ResearchSquare

    Background: COVID-19 is caused by the severe acute respiratory syndrome MESHD virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Case presentation: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure MESHD seizure HP-like activity at home. She was found to have SARS-CoV-2 infection MESHD and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection MESHD and find a unique pattern of inflammation MESHD in CSF, but no evidence of viral neuroinvasion. Conclusion: Our findings suggest that neurologic symptoms such as encephalopathy HP and seizures MESHD seizures HP may be the initial presentation of COVID-19.  Central nervous system inflammation MESHD may associate with neurologic manifestations MESHD of disease MESHD.

    Cerebrovascular complications in patients with SARS-CoV-2 infection MESHD: Case series

    Authors: Mauro Morassi; Daniele Bagatto; Milena Cobelli; Serena D’Agostini; Gian Luigi Gigli; Claudio Bnà; Alberto Vogrig

    doi:10.21203/rs.3.rs-23137/v1 Date: 2020-04-15 Source: ResearchSquare

    Background: Italy is one of the most affected countries by the Coronavirus disease MESHD 2019 (COVID-19). The responsible pathogen is named Severe Acute Respiratory Syndrome MESHD Coronavirus (SARS-CoV-2). The clinical spectrum ranges from asymptomatic infection MESHD asymptomatic TRANS infection to severe HP pneumonia MESHD pneumonia HP leading to intensive care unit admission. Evidence of cerebrovascular complications associated with SARS-CoV-2 is limited. We herein report 6 patients who developed acute stroke MESHD stroke HP during COVID-19 infection MESHD. Methods: Retrospective case series of patients diagnosed with COVID-19 using reverse-transcriptase–polymerase-chain-reaction (RT-PCR) on nasopharyngeal swabs, who developed clinical and neuroimaging evidence of acute stroke MESHD stroke HP during SARS-CoV-2 infection MESHD.Results: Six patients were identified (5 men); median age TRANS was 69 years (range: 57-82). Stroke MESHD Stroke HP subtypes were ischemic (4, 67%) and hemorrhagic (2, 33%). All patients but 1 had pre-existing vascular risk factors. One patient developed encephalopathy HP prior to stroke MESHD stroke HP, characterized by focal seizures MESHD seizures HP and behavioral abnormalities HP. COVID-19-related pneumonia MESHD pneumonia HP was severe (i.e. requiring critical care support) in 5/6 cases (83%). Liver enzyme alteration and lactate dehydrogenase (LDH) elevation was registered in all cases. Four patients (67%) manifested acute kidney failure prior to stroke MESHD stroke HP. Four patients (67%) had abnormal coagulation tests. Outcome was poor in the majority of the patients: 4 died (67%), 1 is still in coma MESHD coma HP (20%) and the remaining 1 remains severely neurologically affected (mRS: 4).Conclusions: Acute stroke MESHD stroke HP can complicate the course of COVI-19 infection MESHD. In our series, stroke MESHD stroke HP developed mostly in patients with severe pneumonia MESHD pneumonia HP and multi organ failure, liver MESHD enzymes and LDH were markedly increased in all cases, and the outcome was poor.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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