Corpus overview


MeSH Disease

Human Phenotype


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    Effect of COVID-19 on Liver Abnormalities HP: A Systematic review and Meta‐analysis

    Authors: Khalid Bzeizi; Maheeba Abdulla; Nafeesa Mohammed; Jehad Alqamish; Negar Jamshidi; Dieter Broering

    doi:10.21203/ Date: 2020-07-20 Source: ResearchSquare

    Emerging evidence suggest association of severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD with development of many liver abnormalities HP. The overarching aim of this study was therefore to assess the available evidence on the clinical effects of SARS-CoV-2 on liver function laboratory tests and coagulation profile in affected individuals. We considered all study designs including epidemiological and observational that reported liver function test abnormalities in patients diagnosed with SARS-CoV-2 infection MESHD. Medline, Embase databases and Google Scholar as well as relevant reviews were searched to identify appropriate studies from inception to April 30th, 2020. We calculated pooled mean with 95% confidence intervals (95%CI) through a random-effect model meta-analysis. A total of 29 studies with 9991 participants were considered for the review from which 20 studies with sufficient quantitative data were included for the meta-analysis. The pooled mean for liver enzymes and coagulation parameters did not significantly change in patients affected by COVID-19 and remained within normal range. Our systematic review and meta-analysis findings of the available evidence suggest that COVID-19 did not have a significant impact on the liver enzymes or coagulation profile of patients with SARS-CoV-2 infection MESHD. Future studies need to adequately report all the liver function parameters with event rates.

    Coronavirus Disease MESHD (COVID-19) and the Liver: A comprehensive systematic review and meta-analysis

    Authors: Praveen Kumar-M; Shubhra Mishra; Daya Krishna Jha; Jayendra Shukla; Arup Choudhury; Ritin Mohindra; Harshal S Mandavdhare; Usha Dutta; Vishal Sharma

    doi:10.21203/ Date: 2020-06-24 Source: ResearchSquare

    Background: Liver function derangements have been reported in coronavirus disease MESHD (COVID-19) but reported rates are variable. Methods: We searched Pubmed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence SERO, stratified prevalence SERO based on severity, estimated risk ratio (RR) and estimated standardized mean difference (SMD) of liver function parameters in severe as compared to nonsevere COVID. Random effect method utilizing inverse variance approach was used for pooling the data. Results: In all, 128 studies were included. The most frequent abnormalities were hypoalbuminemia MESHD hypoalbuminemia HP [61.27% (48.24 - 72.87)], elevations of gamma-glutamyl transferase (GGT) [27.94%(18.22 -40.27)], alanine aminotransferase (ALT) [23.28%(19.92 - 27.01)] and aspartate aminotransferase (AST) [23.41%(18.84 - 28.70)]. Further the relative risk of these abnormalities was higher in the patients with severe COVID-19 when compared to non-severe disease MESHD [ Hypoalbuminemia MESHD Hypoalbuminemia HP - 2.65(1.38 - 5.07); GGT - 2.31(1.6 - 3.33); ALT - 1.76(1.44 - 2.15); AST 2.30(1.82 - 2.90)]. The SMD of hypoalbuminemia MESHD hypoalbuminemia HP, GGT, ALT and AST elevation in severe as compared to nonsevere were -1.05(-1.27 - -0.83), 0.76(0.40 - 1.12), 0.42(0.27 - 0.56) and 0.69 (0.52 - 0.86) respectively. The pooled prevalence SERO and RR of chronic liver disease MESHD as a comorbidity was 2.64% (1.73- 4) and 1.69(1.05-2.73) respectively. Conclusion: The most frequent abnormality in liver HP functions was hypoalbuminemia MESHD hypoalbuminemia HP followed by derangements in gamma-glutamyl transferase and aminotransferases and these abnormalities were more frequent in severe disease MESHD.  The systematic review was, however, limited by heterogeneity in definitions of severity and liver function derangements.  

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MeSH Disease
Human Phenotype

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