Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Complex Immuno-metabolic Profiling Reveals Activation of Cellular Immunity and Biliary Lesion in Patients with Severe COVID-19

    Authors: Adam Klocperk; Marketa Bloomfield; Zuzana Parackova; Irena Zentsova; Petra Vrabcova; Jan Balko; Grigorij Meseznikov; Luis Fernando Casas Mendez; Alzbeta Grandcourtova; Jan Sipek; Martin Tulach; Josef Zamecnik; Tomas Vymazal; Anna Sediva

    id:10.20944/preprints202007.0596.v1 Date: 2020-07-24 Source: Preprints.org

    The aim of this study was to assess the key laboratory features displayed by coronavirus disease MESHD 2019 (COVID-19) inpatients which associated with mild, moderate, severe and fatal course of the disease MESHD and, through longitudinal follow-up, to understand the dynamics of COVID-19 pathophysiology. All SARS-CoV-2 positive patients admitted to the University Hospital in Motol between March and June 2020 were included in this study. Severe course of COVID-19 was associated with elevation of proinflammatory markers, efflux of immature granulocytes into peripheral blood SERO, activation of CD8 T cells, which infiltrate lungs, and transient liver disease MESHD. In particular, the elevation of serum SERO gamma-glutamyl transferase (GGT) and histological signs of cholestasis MESHD cholestasis HP were highly specific for patients with severe disease MESHD. In contrast, patients with fatal course of COVID-19 failed to upregulate markers of inflammation MESHD, showed dyscoordination of immune response and progressed towards acute kidney failure. COVID-19 is a disease MESHD with multi-organ affinity characterized by activation of innate and cellular adaptive immunity. Biliary lesion with elevation of GGT and organ-infiltration of IL-6 producing cells are defining characteristic for patients with fulminant disease MESHD.

    Maternal and fetal effects of covid-19 virus on a complicated triplet pregnancy. A case-report

    Authors: Maryam Rabiei; Tahereh Soori; Amene Abiri; Arshia Shizarpour; Zohreh Farsi; Reihaneh Pirjani

    doi:10.21203/rs.3.rs-25864/v1 Date: 2020-04-28 Source: ResearchSquare

    Background:  COVID-19 virus it is going to be pandemic all around the world. There is still limited scientific evidence on the manifestations and potential impact of this virus on pregnancy.Case presentation She was a 38 year-old triplet pregnant with a history of primary infertility MESHD infertility HP and had become pregnant by induction ovulation and a history of hypothyroidism MESHD hypothyroidism HP and also a history of gestational diabetes MESHD. She was hospitalized at 29 weeks and 2 days gestational age TRANS due to elevated liver enzymes and finally based on a probable diagnosis of gestational cholestasis MESHD cholestasis HP, she was treated with ursodeoxycholic acid. On the first day after hospitalization, a sonography was performed in which biophysical scores and amniotic fluid were found normal in all three fetuses with normal Doppler findings in two fetuses and increased umbilical artery resistance (PI>95%) in one fetus. Four days after hospitalization, she developed fever MESHD fever HP, cough MESHD cough HP and myalgia MESHD myalgia HP and her covid-19 test was positive. After maternal infection MESHD with the virus, exacerbated placental insufficiency MESHD occurred in two of the fetuses so that absent umbilical artery end diastolic flow occurred rapidly in two fetuses and finally, six days later, she underwent cesarean section due to rapid exacerbated placental insufficiency MESHD and declined biophysical score in two of fetuses. Covid-19 test of nasopharyngeal swabs was negative for first and third babies and positive for second baby .The first and third babies died 3 and 13 days after birth respectively duo to collapsed white lung and sepsis MESHD sepsis HP. The second baby was discharged with a good general condition. The mother was discharged three days after cesarean section. She had no fever MESHD fever HP at discharge time and also she was in good general condition.Conclusions: It was a complicated triplet pregnancy, in which, after maternal infection MESHD with the Covid-19 virus, exacerbated placental insufficiency MESHD occurred in two of the fetuses, and another fetus had positive covid-19 virus test after birth. It sounds wise that in pregnancy infected by corona virus, in addition to managing the mother, special attention should also be given to the possibility of acute placental insufficiently and subsequent fetal hypoxia MESHD and also probability of vertical transmission TRANS.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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