Corpus overview


MeSH Disease

Human Phenotype


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    Clinical Features of Pregnant Women and Neonates with COVID-19 in Wuhan: a paired comparison study

    Authors: Qin Xie; Quan Gan; Jing Hu; Dong Zhou; Shuhan Cai; Lianjiu Su; Yunxiang Li; Yiming Li; Zhiyong Peng

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background Our study aimed to find symptoms unique in pregnancy and to help the early diagnosis in pregnant women and to evaluate the impact of COVID-19 in postpartum women and their newborns.Methods Clinical data were reviewed and collected for 11 pregnant women with laboratory-confirmed COVID-19 who were consecutively admitted to Zhongnan Hospital of Wuhan University and Women and Children’s Hospital of Hubei Province, from Jan 26 to Feb 26, 2020.Results All the confirmed women didn’t have any exposure history and their early symptoms were mildly elevated temperate and fatigue MESHD fatigue HP. The chest CT scans of confirmed women can be atypical manifestations, such as bilateral pleural effusions MESHD pleural effusions HP and slightly increased densities. Eight of eleven confirmed women did not feel anything unusual until abnormalities were found on chest CT scans on admission screening test. All three groups had elevated white blood SERO cell count, neutrophil count and lactate dehydrogenase, and reduced total protein.The infection MESHD did not increase the risk for premature delivery, premature rupture of membrane HP rupture MESHD of membrane, or comorbidities in pregnancy.Conclusions Pregnant women were often asymptomatic TRANS and accidentally detected abnormalities on chest CT scan on admission which emphasize the importance of CT scan in prevalent areas of the COVID-19. Even after the laboratory confirmation, the manifestation of the CT scan could be atypical, which alerted the necessity of protection for healthcare workers. The COVID-19 did not increase the risk of complications in pregnant women and their neonates.Trial registration: This case series was approved by the institutional ethics board of Zhongnan Hospital of Wuhan University (No. 2020020) and Women and Children’s Hospital of Hubei Province(NO. LW035).

    Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors to Drive Pathogenesis of SARS-CoV-2

    Authors: Nancy Ashray; Anshul Bhide; Priyanka Chakarborty; Stacy Colaco; Anuradha Mishra; Karisma Chhabria; Mohit Kumar Jolly; Deepak Modi

    id:10.20944/preprints202005.0195.v1 Date: 2020-05-11 Source:

    Infection MESHD Infection by the Severe HP by the Severe Acute Respiratory Syndrome MESHD-Coronavirus-2 (SARS-CoV-2) results in the novel coronavirus disease MESHD COVID-19, which has posed a serious threat globally. Infection MESHD of SARS-CoV-2 during pregnancy is associated with complications like preterm labor and premature rupture of membranes HP rupture MESHD of membranes; a proportion of neonates born to the infected mothers are also positive for the virus. During pregnancy, the placental barrier protects the fetus from pathogens and ensures healthy development. However, whether or not SARS-CoV-2 can infect the placenta is unknown. Herein, utilizing single-cell RNA-seq data, we report that the SARS-CoV-2 binding receptor ACE2 and the S protein priming protease TMPRSS2 are co-expressed by a subset of syncytiotrophoblasts (STB) in the first trimester and extra villous trophoblasts (EVT) in the second trimester human placenta. The ACE2- and TMPRSS2-positive (ACE2+TMPRSS2+) placental subsets express mRNA for proteins involved in viral budding and replication. These cells also express mRNA for proteins that interact with SARS-CoV-2 structural and non-structural proteins in the host cells. We also discovered unique signatures of genes in ACE2+TMPRSS2+ STBs and EVTs. The ACE2+TMPRSS2+ STBs are highly differentiated cells and express genes involved mitochondrial metabolism and glucose transport. The second trimester ACE2+TMPRSS2+ EVTs are enriched for markers of endovascular trophoblasts. Further, both these subtypes abundantly expressed genes in Toll like receptor pathway, the second trimester EVTs (but not first trimester STBs) are also enriched for component of the JAK-STAT pathway that drive inflammation MESHD. To conclude, herein we uncovered the cellular targets for SARS-CoV-2 entry and show that these cells can potentially drive viremia MESHD viremia HP in the developing human placenta. Our results provide a basic framework towards understanding the paraphernalia involved in SARS-CoV-2 infections MESHD in pregnancy.

    Pregnancy outcomes, Newborn complications and Maternal-Fetal Transmission TRANS of SARS-CoV-2 in women with COVID-19: A systematic review

    Authors: Rahul Gajbhiye; Deepak Modi; Smita Mahale

    doi:10.1101/2020.04.11.20062356 Date: 2020-04-15 Source: medRxiv

    Abstract Objective: The aim of this systematic review was to examine published and preprint reports for maternal and fetal outcomes in pregnant women with COVID-19 and also assess the incidence of maternal-fetal transmission TRANS of SARS CO-V-2 infection MESHD. Design : Systematic review Data sources:We searched PUMBED. Medline, Embase, MedRxiv and bioRxiv databases upto 31st March 2020 utilizing combinations of word variants for " coronavirus " or " COVID-19 " or " severe acute respiratory syndrome MESHD " or " SARS-COV-2 " and " pregnancy " . We also included data from preprint articles. Study selection : Original case reports and case series on pregnant women with a confirmed diagnosis of SARS-CoV-2 infection MESHD. Data extraction : We included 23 studies [China (20), USA (01), Republic of Korea (01) and Honduras, Central America (01) reporting the information on 172 pregnant women and 162 neonates. The primary outcome measures were maternal health characteristics and adverse pregnancy outcomes, neonatal outcomes and SARS-CoV-2 infection MESHD in neonates was extracted. Treatments given to pregnant women with COVID-19 were also recorded. Results: Out of 172 women affected by COVID-19 in pregnancy, 160 women had delivered 162 newborns (2 set of twins, 12 ongoing pregnancies). In pregnant women with COVID-19, the most common symptoms were fever MESHD fever HP (54%), cough MESHD cough HP (35%), myalgia MESHD myalgia HP (17%), dyspnea MESHD dyspnea HP (12%) and diarrhea MESHD diarrhea HP (4%). Pneumonia MESHD Pneumonia HP was diagnosed by CT scan imaging in 100 % of COVID-19 pregnant women. Pregnancy complications MESHD included delivery by cesarean section (89%), preterm labor (21%), fetal distress MESHD fetal distress HP (9%) and premature rupture of membranes HP rupture MESHD of membranes (8%). The most common co-morbidities associated with pregnant women with COVID-19 were diabetes (11%), hypertensive disorders (9%), placental disorders (5%), co- infections MESHD (6%), scarred HP uterus (5%), hypothyroidism MESHD hypothyroidism HP (5%) and anemia MESHD anemia HP (4%). Amongst the neonates of COVID-19 mothers, preterm birth (23%), respiratory distress HP syndrome MESHD (14%), pneumonia MESHD pneumonia HP (14%) low birth weight MESHD (11%), small for gestational age HP age TRANS (3%) were reported. There was one still birth and one neonatal death MESHD reported. Vertical transmission TRANS rate of SARS-CoV-2 is estimated to be 11%. Conclusion In pregnant women with COVID-19, diabetes and hypertensive disorders are common co-morbidities and there is a risk of preterm delivery. Amongst the neonates born to mothers with COVID-19, respiratory distress HP syndrome MESHD and pneumonia MESHD pneumonia HP are common occurrence. There is an evidence of vertical transmission TRANS of SARS-CoV-2 infection MESHD in women with COVID-19.

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MeSH Disease
Human Phenotype

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