Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Analysis of the Primary Presenting Symptoms and Hematological Findings of COVID-19 Patients in Bangladesh

    Authors: Abu Taiub Mohammed Mohiuddin Chowdhury; Md Rezaul Karim; H.M. Hamidullah Mehedi; Mohammad Shahbaz; Md Wazed Chowdhury; Guo Dan; Shuixiang He

    id:10.20944/preprints202006.0275.v1 Date: 2020-06-21 Source: Preprints.org

    Objective: SARS-Cov-2 infection MESHD or COVID-19 is a global pandemic. From the time of identification to till, multiple clinical symptoms and parameters have been identified by the researchers of various countries and regions regarding the diagnosis and presentations of COVID-19 disease MESHD. In this manuscript, we investigated the primary symptoms and basic hematological presentations of SARS-CoV-2 infection MESHD among the Bangladeshi patients. Methodology: We have collected the disease MESHD history of mild to moderate degree of COVID-19 patients; hematological and biochemical on admission reports of moderate degree COVID-19 patients. All of them were tested positive for SARS-CoV-2 by RT-PCR in different institutes in Bangladesh. Results: According to this study though COVID-19 patients in Bangladesh commonly presented with fever MESHD fever HP, cough MESHD cough HP, fatigue MESHD fatigue HP, shortness of breath, and sore throat, but symptoms like myalgia MESHD myalgia HP, diarrhea MESHD diarrhea HP, skin rash HP, headache MESHD headache HP, Abdominal pain MESHD Abdominal pain HP/cramp, nausea MESHD nausea, vomiting HP, vomiting MESHD, restlessness HP, and a higher temperature of >1000F have a greater presentation rate and more frequent than other published studies. CRP and Prothrombin time was found to increase in all the patients. Serum SERO ferritin, ESR, SGPT, and D-Dimer were found increased among 53.85%, 80.43, 44%, and 25% patients respectively. 17.39% of the patients had leukocytosis MESHD leukocytosis HP and neutrophilia HP. 28.26% of patients presented with lymphocytopenia. 62.52% of patients had mild erythrocytopenia. Conclusion: Despite some similarities, our study has evaluated a different expression in presenting symptoms in the case of COVID-19 patients in Bangladesh. CRP, Prothrombin time, serum SERO ferritin, ESR, SGPT, D-Dimer, erythrocytopenia, and lymphocytopenia can be initial diagnostic hematological findings and assessment for prognosis COVID-19 disease MESHD. Also, gender TRANS variations have a different scenario of clinical and laboratory appearance in this region.

    Risk factors for the critical illness MESHD in SARS-CoV-2 infection MESHD: a multicenter retrospective cohort study

    Authors: Sijing Cheng; Dingfeng Wu; Jie Li; Yifeng Zou; Yunle Wan; Lihan Shen; Lixin Zhu; Mang Shi; Linlin Hou; Tao Xu; Na Jiao; Yichen Li; Yibo Huang; Zhipeng Tang; Mingwei Xu; Shusong Jiang; Maokun Li; Guangjun Yan; Ping Lan; Ruixin Zhu

    doi:10.21203/rs.3.rs-35957/v2 Date: 2020-06-16 Source: ResearchSquare

    Background: Prior studies reported that 5~32% COVID-19 patients were critically ill, a situation that poses great challenge for the management of the patients and ICU resources. We aim to identify independent risk factors to serve as prediction markers for critical illness MESHD of SARS-CoV-2 infection MESHD. Methods : Fifty-two critical and 200 non-critical SARS-CoV-2 nucleic acid positive patients hospitalized in 15 hospitals outside Wuhan from January 19 to March 6, 2020 were enrolled in this study. Multivariable logistic regression and LASSO logistic regression were performed to identify independent risk factors for critical illness MESHD.Results: Age TRANS older than 60 years, dyspnea MESHD dyspnea HP, respiratory rate > 24 breaths per min, leukocytosis MESHD leukocytosis HP >9.5 X109/L, neutrophilia HP >6.3 X109/L, lymphopenia MESHD lymphopenia HP <1.1 X109/L, neutrophil-to-lymphocyte ratio >3.53, fibrinogen >4g/L, d-dimer >0.55 µg/mL, blood SERO urea nitrogen >7.1 mM, elevated aspartate transaminase, elevated alanine aminotransferase, total bilirubin >21 µM, and Sequential Organ Failure Assessment (SOFA) score ≥2 were identified as risk factors for critical illness MESHD. LASSO logistic regression identified the best combination of risk factors as SOFA score, age TRANS, dyspnea MESHD dyspnea HP, and leukocytosis MESHD leukocytosis HP. The Area Under the Receiver-Operator Curve values for the risk factors in predicting critical illness MESHD were 0.921 for SOFA score, 0.776 for age TRANS, 0.764 for dyspnea MESHD dyspnea HP, 0.658 for leukocytosis MESHD leukocytosis HP, and 0.960 for the combination of the four risk factors.Conclusions: Our findings advocate the use of risk factors SOFA score ≥2, age TRANS >60, dyspnea MESHD dyspnea HP and leukocytosis MESHD leukocytosis HP >9.5 X109/L on admission, alone or in combination, to determine the optimal management of the patients and health care resources.

    Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza

    Authors: Yang Mei; Samuel E Weinberg; Lihui Zhao; Chao Qi; Adam Frink; Amir Behdad; Peng Ji

    doi:10.1101/2020.05.18.20101709 Date: 2020-05-22 Source: medRxiv

    Background The outbreak of coronavirus disease MESHD 2019 (COVID-19) in December 2019 overlaps with the flu season. Methods We compared clinical and laboratory results from 719 influenza and 973 COVID-19 patients from January to April 2020. We compiled laboratory results from the first 14 days of the hospitalized patients using parameters that are most significantly different between COVID-19 and influenza and hierarchically clustered COVID-19 patients based on these data. The clinical outcomes were compared among different clusters. Results Temporal analyses of laboratory results revealed that compared to influenza, patients with COVID-19 exhibited a continued increase in the white blood SERO cell count, rapid decline of hemoglobin, more rapid increase in blood urea nitrogen HP blood SERO urea nitrogen (BUN) and D-dimer, and higher level of alanine transaminase, C-reactive protein, ferritin, and fibrinogen. Using these results, we sub-classified the COVID-19 patients into 5 clusters through a hierarchical clustering analysis. We then reviewed the medical record of these patients and risk stratified them based on the clinical outcomes. The cluster with the highest risk showed 27.8% fatality, 94% ICU admission, 94% intubation, and 28% discharge rates compared to 0%, 38%, 22%, and 88% in the lowest risk cluster, respectively. Patients in the highest risk cluster had leukocytosis MESHD leukocytosis HP including neutrophilia HP and monocytosis HP, severe anemia MESHD anemia HP, higher BUN, creatinine, D-dimer, alkaline phosphatase, bilirubin, and troponin. Conclusions There are significant differences in the clinical and laboratory courses between COVID-19 and influenza. Risk stratification in hospitalized COVID-19 patients using laboratory data could be useful to predict clinical outcomes and pathophysiology of these patients.

    Laboratory Findings of COVID-19 Infection MESHD are Conflicting in Different Age Groups TRANS and Pregnant Women: A Literature Review

    Authors: Sina Vakili; Amir Savardashtaki; Sheida jamalnia; Reza Tabrizi; Mohammad Hadi Nematollahi; Morteza Jafarinia; Hamed Akbari

    doi:10.1101/2020.04.24.20078568 Date: 2020-04-29 Source: medRxiv

    Coronavirus disease MESHD 2019 (COVID-19), a new type and rapidly spread viral pneumonia MESHD pneumonia HP, is now producing an outbreak of pandemic proportions. The clinical features and laboratory results of different age groups TRANS are different due to the general susceptibility of the disease MESHD. The laboratory findings of COVID-19 in pregnant women are also conflicting. Para-clinical investigations including laboratory tests and radiologic findings play an important role in early diagnosis and treatment monitoring of severe acute respiratory syndrome MESHD and coronavirus-2 (SARS-CoV-2). The majority of previous reports on the SARS-CoV-2 laboratory results were based on data from the general population and limited information is available based on age TRANS difference and pregnancy status. This review aimed to describe the COVID-19 laboratory findings in neonates, children TRANS, adults TRANS, elderly TRANS and pregnant women altogether for the first time. The most attracting and reliable markers of COVID-19 in patients were: normal C-reactive protein (CRP) and very different and conflicting laboratory results regardless of clinical symptoms in neonates, normal or temporary elevated CRP, conflicting WBC count results and procalcitonin elevation in children TRANS, lymphopenia MESHD lymphopenia HP and elevated lactate dehydrogenase (LDH) in adult TRANS patients, lymphopenia MESHD lymphopenia HP and elevated CRP and LDH in the elderly TRANS people and high CRP, leukocytosis MESHD leukocytosis HP and elevated neutrophil ratio in pregnant women.

    Computerized tomography scan findings of a patient with severe enterocolitis MESHD enterocolitis HP associated with the coronavirus disease MESHD 2019: a case report

    Authors: Katsunari Takifuji; Hiroshi Terasawa; Masami Oka; Masaki Sahara; Tomoko Hara; Hidekazu Itoh

    doi:10.21203/rs.3.rs-21006/v1 Date: 2020-04-03 Source: ResearchSquare

    Background: Currently, there is no available study about the occurrence of enterocolitis MESHD enterocolitis HP associated with the coronavirus disease MESHD 2019 (COVID-19) among adults TRANS. Case presentation: A 56-year-old man had lower abdominal pain MESHD abdominal pain HP, distension, diarrhea MESHD diarrhea, and bloody HP, and bloody stool. Moreover, the patient presented with fever MESHD fever HP and general fatigue MESHD fatigue HP. Laboratory examination did not reveal leukocytosis MESHD leukocytosis HP nor neutrophilia HP. However, the patient’s C-reactive protein level increased to 4.9 (normal range: 0.0–0.3) mg/dL. Both sputum and stool cultures had normal results. However, abdominal computed tomography (CT) scan revealed wall thickness mainly in the submucosal layer of the left part of the large intestine. Thus, real-time polymerase chain reaction test of throat swabs was performed for the diagnosis of COVID-19, and positive results were obtained. Conclusions: We report the first case of enterocolitis MESHD enterocolitis HP correlated to COVID-19, and the patient had positive abdominal CT scan findings. This imaging modality could be effective for the diagnosis of enterocolitis MESHD enterocolitis HP associated with COVID-19.

    Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan, China

    Authors: Ling Hu; Shaoqiu Chen; Yuanyuan Fu; Zitong Gao; Hui Long; Hong-wei Ren; Yi Zuo; Huan Li; Jie Wang; Qing-bang Xv; Wen-xiong Yu; Jia Liu; Chen Shao; Jun-jie Hao; Chuan-zhen Wang; Yao Ma; Zhanwei Wang; Richard Yanagihara; Jian-ming Wang; Youping Deng

    doi:10.1101/2020.03.25.20037721 Date: 2020-03-26 Source: medRxiv

    Background With evidence of sustained transmission TRANS in more than 190 countries, coronavirus disease MESHD 2019 (COVID-19) has been declared a global pandemic. As such, data are urgently needed about risk factors associated with clinical outcomes. Methods A retrospective chart review of 323 hospitalized patients with COVID-19 in Wuhan was conducted. Patients were classified into three disease MESHD severity groups (non-severe, severe, and critical), based on their initial clinical presentation. Clinical outcomes were designated as favorable and unfavorable, based on disease progression MESHD and response to treatments. Logistic regression models were performed to identify factors associated with clinical outcomes, and logrank test was conducted for the association with clinical progression. Results Current standard treatments did not show significant improvement on patient outcomes in the study. By univariate logistic regression model, 27 risk factors were significantly associated with clinical outcomes. Further, multivariate regression indicated that age TRANS over 65 years, smoking, critical disease MESHD status, diabetes, high hypersensitive troponin I (>0.04 pg/mL), leukocytosis MESHD leukocytosis HP (>10 x 109/L) and neutrophilia HP (>75 x 109/L) predicted unfavorable clinical outcomes. By contrast, the use of hypnotics was significantly associated with favorable outcomes. Survival analysis also confirmed that patients receiving hypnotics had significantly better survival. Conclusions To our knowledge, this is the first indication that hypnotics could be an effective ancillary treatment for COVID-19. We also found that novel risk factors, such as higher hypersensitive troponin I, predicted poor clinical outcomes. Overall, our study provides useful data to guide early clinical decision making to reduce mortality and improve clinical outcomes of COVID-19.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18696/v1 Date: 2020-03-20 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease MESHD quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis. Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020. Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever MESHD fever HP (46/64), dry cough MESHD cough HP (38/64), fatigue MESHD fatigue HP or myalgia MESHD myalgia HP (23/64), sore throat (10/64), diarrhea MESHD diarrhea HP (3/64) along with late- onset symptoms TRANS like chest pains MESHD chest pains HP (2/64) and headaches MESHD headaches HP (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia MESHD leukopenia HP. Only two patients (3.1 %) presented with leukocytosis MESHD leukocytosis HP. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death MESHD so far. Conclusions: Early intervention in COVID-19 disease MESHD improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18096/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease MESHD quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis.Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020.Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever MESHD fever HP (46/64), dry cough MESHD cough HP (38/64), fatigue MESHD fatigue HP or myalgia MESHD myalgia HP (23/64), sore throat (10/64), diarrhea MESHD diarrhea HP (3/64) along with late- onset symptoms TRANS like chest pains MESHD chest pains HP (2/64) and headaches MESHD headaches HP (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia MESHD leukopenia HP. Only two patients (3.1 %) presented with leukocytosis MESHD leukocytosis HP. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death MESHD so far. Conclusions: Early intervention in COVID-19 disease MESHD improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Comparative Analysis of Clinical Characteristics in Children TRANS and Adults TRANS with 2019 Novel Coronavirus Infection MESHD: A Descriptive Study

    Authors: Ya-nan Han; Zhan-wei Feng; Li-na Sun; Xiao-xia Ren; Hua Wang; Yong-ming Xue; Yi Wang; Ying Fang

    doi:10.21203/rs.3.rs-17872/v1 Date: 2020-03-17 Source: ResearchSquare

    Background: Since December 2019, acute respiratory disease MESHD (ARD) caused by 2019 novel coronavirus (2019-nCoV) rapidly spread throughout China. Children TRANS and adults TRANS seemed to differ in the clinical course of the disease MESHD. The purpose of the current study is to comparatively analyze the clinical characteristics of children TRANS and adult TRANS patients with 2019-nCoV infection MESHD and to explore the possible causes for the discrepant aspects.Methods: In this retrospective study, the medical records of 32 cases confirmed TRANS with 2019-nCoV ARD from Xi'an eighth hospital (Shaanxi, China) from January 31 to February 16, 2020 were reviewed.Results: In all 32 patients contained 7 children TRANS and 25 adults TRANS. All children TRANS were family cluster. For adult TRANS patients, local residents of Wuhan, recently travelled TRANS to Wuhan, patient contacted with people from Wuhan were 14 (56%), 10 (40%), 1 (4%), respectively. The median incubation period TRANS of children TRANS and adult TRANS was 5 days (range, 3 to 12) and 4 days (range, 2 to 12), respectively. Altogether 10 (40%) adult TRANS patients had underlying conditions significantly, but no children TRANS had. Fever MESHD Fever HP ( Children TRANS 71.4% vs. Adult TRANS 96%) and cough MESHD cough HP ( Children TRANS 71.4% vs. Adult TRANS 76%) were the most common symptoms in both groups. The third symptom observed in children TRANS was diarrhea MESHD diarrhea HP and/or vomiting MESHD vomiting HP (57.1%), for adult TRANS it was myalgia MESHD myalgia HP or fatigue MESHD fatigue HP (52%). On admission, 5 (71.4%) children TRANS patients showed pneumonia MESHD pneumonia HP roughly the same as adult TRANS patients (20, 80%), and that the two group shared a multitude of common imaging characteristics. 20% of adult TRANS with leucopoenia, but leukocytosis MESHD leukocytosis HP was significantly more frequently in children TRANS (28.6%, P=0.014). More children TRANS had elevated creatine kinase isoenzyme (57.1% vs. 4%, P=0.004). All patients were discharged after symptomatic treatment, including oxygen therapy, antiviral treatment, antibiotic treatment. Only one infant was intravenously injected low-dose glucocorticoids.Conclusions: Our results multi-dimensionally demonstrate that children TRANS with 2019-nCoV infection MESHD present a clinical picture which is often distinct from that of adults TRANS. Knowledge of these differences will be helpful for the clinical diagnosis of 2019 novel coronavirus diseases MESHD (COVID-19) and for a future discussion on age TRANS specific infection MESHD case definitions.

    Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China.

    Authors: Dawei Wang; Yimei Yin; Chang Hu; Xing Liu; Xingguo Zhang; Shuliang Zhou; Mingzhi Jian; Haibo Xu; John Prowle; Bo Hu; Yirong Li; Zhi-Yong Peng

    doi:10.21203/rs.3.rs-16485/v2 Date: 2020-03-04 Source: ResearchSquare

    Background In December 2019, Coronavirus Disease MESHD 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. Methods Retrospective case series of COVID-19 patients from Zhongnan Hospital of Wuhan University in Wuhan, and Xi-shui Hospital, Hubei Province, China, up to February 10, 2020. Epidemiological, demographic and clinical data were collected. Clinical course of survivors and non-survivors were compared. Risk factors for death MESHD were analyzed. Results A total of 107 discharged patients with COVID-19 were enrolled. The clinical course of COVID-19 presented as a tri-phasic pattern. Week 1 after illness onset was characterized by fever MESHD fever HP, cough MESHD cough HP, dyspnea MESHD dyspnea HP, lymphopenia MESHD lymphopenia HP and radiological multilobar pulmonary infiltrates HP. In severe cases, thrombocytopenia MESHD thrombocytopenia HP, acute kidney injury MESHD acute kidney injury HP, acute myocardial injury or adult respiratory distress syndrome MESHD adult TRANS respiratory distress HP syndrome were observed. During week 2, in mild cases, fever MESHD fever HP, cough MESHD cough HP and systemic symptoms began to resolve and platelet count rose to normal range, but lymphopenia MESHD lymphopenia HP persisted. In severe cases, leukocytosis MESHD leukocytosis HP, neutrophilia HP and deteriorating multi-organ dysfunction were dominant. By week 3, mild cases had clinically resolved except for lymphopenia MESHD lymphopenia HP. However, severe cases showed persistent lymphopenia MESHD lymphopenia HP, severe acute respiratory dyspnea MESHD dyspnea HP syndrome MESHD , refractory shock MESHD shock HP, anuric acute kidney injury MESHD acute kidney injury HP, coagulopathy, thrombocytopenia MESHD thrombocytopenia HP and death MESHD. Older age TRANS and male TRANS sex were independent risk factors for poor outcome of the illness. Conclusions A period of 7–13 days after illness onset is the critical stage in COVID-19 course. Age TRANS and male TRANS gender TRANS were independent risk factors for death MESHD of COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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