The current pandemic caused by SARS-CoV-2 has posed an important threat to the human health, healthcare systems, economy, and structure of societies. In Colombia, the first case was diagnosed on March 6, 2020 , with exponential progressive growth, and there were >200,000 confirmed cases TRANS as of July 20, 2020, in this cross-sectional, analytical, and observational study, we focused on the demographic, epidemiologic, and clinical characteristics of patients with confirmed SARS-CoV-2 infection MESHD at a highly complex institution in Latinamerica, with special emphasis on gastrointestinal symptoms. Methods: Demographic and clinical data were collected, results related to the outcomes such as hospitalization time, admission to ICU, need for orotracheal intubation, and death MESHD were also included. Statistical analyses were conducted using Stata software V.15. Results: We included 72 patients RT-PCR positive for SARS-CoV-2 (34 women and 38 men) with age TRANS 47.5 17.7 years; 17 (23.6%) presented at least one of the gastrointestinal symptoms ( nausea MESHD nausea/vomiting HP/ vomiting MESHD, abdominal pain MESHD abdominal pain HP, and/or diarrhea MESHD diarrhea HP). 13 (76.47%) presented with diarrhea MESHD diarrhea HP, 29.41% with nausea MESHD nausea/vomiting HP/ vomiting MESHD, and five (29.41%) with abdominal pain MESHD abdominal pain HP. Diarrhea MESHD Diarrhea HP in 18.06% of all those infected with SARS-CoV-2 at the time of consultation, which was the most common digestive symptom. No significant differences were observed in requirement for endotracheal intubation, hospitalization, ICU admission, and fatal outcome between the NGIS and GIS groups (p:0.671, 0.483, 1,000, and 1,000). Conclusion: In our study, patients with gastrointestinal symptoms had no significant differences in disease MESHD severity, admission to ICU or death MESHD compared to those who did not have such symptoms.