Corpus overview


Overview

MeSH Disease

Human Phenotype

Diarrhea (125)

Fever (78)

Cough (75)

Fatigue (38)

Pneumonia (31)


Transmission

Seroprevalence
    displaying 91 - 100 records in total 125
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    A case of SARS-CoV-2 carrier TRANS for 32 days with several times false negative nucleic acid tests

    Authors: Lingjie Song; Guibao Xiao; Xianqin Zhang; Zhan Gao; Shixia Sun; Lin Zhang; Youjun Feng; Guangxin Luan; Sheng Lin; Miao He; Xu Jia

    doi:10.1101/2020.03.31.20045401 Date: 2020-04-06 Source: medRxiv

    In 2019, a novel coronavirus (SARS-CoV-2) was first discovered in Wuhan, Hubei, China, causing severe respiratory disease MESHD in humans, and has been identified as a public health emergency of international concern. With the spread of the virus, there are more and more false negative cases of RT-PCR nucleic acid detection in the early stage of potential infection MESHD. In this paper, we collected the epidemiological history, clinical manifestations, outcomes, laboratory results and images of a SARS-CoV-2 carrier TRANS with no significant past medical history. The patient was quarantined because of her colleague had been diagnosed. After the onset of clinical symptoms, chest CT results showed patchy ground-glass opacity (GGO) in her lungs, but it took a total of nine nucleic acid tests to confirm the diagnosis, among which the first eight RT-PCR results were negative or single-target positive. In addition to coughing HP up phlegm during her stay in the hospital, she did not develop chills HP, fever HP fever MESHD, abdominal pain HP abdominal pain MESHD, diarrhea HP diarrhea MESHD and other clinical symptoms. Since initial antiviral treatment, the lung lesions were absorbed. But the sputum nucleic acid test was still positive. In combination with antiviral and immune therapy, the patient tested negative for the virus. Notably, SARS-CoV-2 was detected only in the lower respiratory tract samples (sputum) throughout the diagnosis and treatment period. This is a confirmed case TRANS of SARS-CoV-2 infection MESHD with common symptoms, and her diagnosis has undergone multiple false negatives ,suggesting that it is difficult to identify certain carriers TRANS of the virus and that such patients may also increase the spread of the SARS-CoV-2.

    Comparison of clinical characteristics and risk factors in hospitalized patients with SARS-CoV-2, MERS-CoV, and SARS-CoV infection MESHD

    Authors: Zhengtu Li; Xidong Wang; Guansheng Su; Shaoqiang Li; Yuwei Ye; Qiuxue Deng; Jinchuang Li; Xiaoyu Xiong; Xinguang Wei; Zeqiang Lin; Zichen Jie; Feng Ye

    doi:10.21203/rs.3.rs-21414/v1 Date: 2020-04-05 Source: ResearchSquare

    Herein, we compared the risk factors, clinical presentation of patients hospitalized with  SARS-CoV-2, SARS-CoV MESHD, or MERS-CoV infection MESHD. The proportion of male TRANS patients with COVID-19 was higher than who with SARS but lower than who with MERS (p<0.001). More patients with COVID-19 had coexisting chronic medical conditions than those with SARS (p<0.001) but fewer than those with MERS (p<0.001), and the prevalence SERO of hypertension HP hypertension MESHD (17%) and smoking history (14%) was higher than in patients with SARS (p<0.001). Furthermore,the symptom of fever HP fever MESHD (53%), hemoptysis HP (1%), diarrhea HP diarrhea MESHD (4%) and vomiting HP vomiting MESHD (3%) of COVID-19 were significantly lower than that in patients with SARS or MERS. The level of ALT and AST in COVID-19 was significantly lower (p<0.001), however, thrombocytopenia HP thrombocytopenia MESHD, high LDH were common. Summary, male TRANS, smoking history and hypertension HP hypertension MESHD were the most common risk factors for hospitalization with COVID-19; and the clinical feature was less severe in COVID-19.

    Digestive Involvement in SARS-CoV-2 Infection MESHD: A Retrospective Multi-center Study

    Authors: Haitao Shang; Chao Huang; Yuhua Chen; Shengyan Zhang; Pengcheng Yang; Gaichao Hong; Lei Zhang; Xiaohua Hou

    doi:10.21203/rs.3.rs-21375/v1 Date: 2020-04-04 Source: ResearchSquare

    BackgroundCoronavirus disease 2019 (COVID-19) is an emerged infection MESHD raised wide concerns for the pneumonia HP pneumonia MESHD and respiratory manifestations. Also, digestive complications are frequently observed in COVID-19 patients but the significance remains undetermined.MethodsA retrospective analysis of alimentary symptoms, liver dysfunctions MESHD and other clinical parameters of 514 hospitalized COVID-19 patients (282 mild, 162 severe and 70 critical cases) admitted to the 3 designated medical units of Wuhan Union Hospital from Jan 20 to Feb 29, 2020 was performed.Results1) A series of alimentary symptoms, including poor appetite HP(50.2%), diarrhea HP diarrhea MESHD(25.5%), nausea HP nausea MESHD(16.3%), vomit HP vomit MESHD(11.9%) and abdominal pain HP abdominal pain MESHD(3.3%), presented in COVID-19 patients.2) Diarrhea HP Diarrhea MESHD was common gastrointestinal symptom with higher morbidity in the severe and critical patients (32.1% and 27.1% respectively), and 13.2% patients developed diarrhea HP diarrhea MESHD in the first 3 days after onset of symptoms TRANS. Those with diarrhea HP diarrhea MESHD were reported more apparent systemic inflammation MESHD and liver injury MESHD in severe and critical cases compared with patients without diarrhea HP diarrhea MESHD.3) Notably, 31 patients (6.03%) presented with diarrhea HP diarrhea MESHD in the absence of respiratory symptoms. These patients were observed less systemic inflammatory activity relative to diarrhea HP diarrhea MESHD patients combined with respiratory symptoms.4) Also, liver injury MESHD was high incident in COVID-19 patients with increased alanine aminotransferase (43.3%), aspartate transaminase (36.7%) and decreased albumin (80.9%), but less increased total bilirubin HP (10.9%) and direct bilirubin(14.2%), which were more serious in the severe to critical patients.ConclusionsOur data favored in the process of novel SARS-CoV-2 infection MESHD. There may be a “gut-type” in the clinical prevention and management that differ from the “lung-type” in COVID-19 sufferers.

    Analysis on Diagnosis of Family Clustering Infection of SARS-CoV-2

    Authors: Rong Qiu; Ming-wei Liu; Chuan Zhao; Wei-min Li

    doi:10.21203/rs.3.rs-21188/v1 Date: 2020-04-03 Source: ResearchSquare

    Background: Novel coronavirus (nCoV, SARS-CoV-2) infection MESHD has complicated and diversified symptoms, but no special treatment. In this study, diagnosis and treatment of family clustering nCoV infection MESHD were analyzed. Methods: The Sichuan Suining Central Hospital received 11 patients with confirmed nCoV virus infection MESHD from 4 families during January 23rd, 2020 to February 20th, 2020. Their clinical symptoms, treatment conditions and changes of disease state were reviewed in the present study. Results: In all 4 families, there were 1-2 members in each family TRANS who had contact with epidemic disease MESHD. Clinical manifestations were: 3 cases had debilitation only, 1 case had cough HP only, 1 case had diarrhea HP diarrhea MESHD, 5 cases had fever HP fever MESHD and cough HP cough MESHD, and 1 case had blood SERO-stained sputum. According to image changes, no image change was observed in 1 child TRANS patient. Multiple focal ground-glass opacities were detected from 2 patients and multiple patchy shadows were observed from 8 patients, especially in lung periphery. Complications: there were hypertension HP hypertension MESHD in 3 cases, diabetes MESHD in 2 cases, depression MESHD in 1 cases and hypertension HP hypertension MESHD and diabetes MESHD in 1 case. Moreover, there’s one patient who had rheumatic heart disease MESHD and received mitral and aortic valve replacement 2 years ago. All 11 cases divided into mild type (1 child TRANS patient), moderate type (8 patients), severe type (1 patient) and critical type (1 patient). Treatment: 11 patients were treated with intravenous drip of ribavirin injection ( adult TRANS 0.5g/time; child15mg/kg.time,twice per day) and lopinavir/ritonavior ( adult TRANS: 2 tablets/ time; child TRANS: 1/2 tablets/times, twice per day) for 6-12 days, accompanied with appropriate amount of intravenous drip of antibiotics. Discharge: After treatment, 11 patients met the discharge criteria and were allowed to discharge. Adverse reactions: 4 patients had loose stools and abdominal discomfort, and another 2 cases had diarrhea HP diarrhea MESHD. Conclusions: SARS-CoV-2 infection MESHD have complicated and diversified symptoms, which shall be identified according to epidemic history and novel coronavirus nucleic acid test. In particular, the whole family in which there’s a patient with confirmed SARS-CoV-2 shall be isolated for screening in addition to the patient. The lopinavir/ritonavior administration combined with ribavirin or recombinant Human Interferon (RHI) α2b is effective, accompanied with mild adverse reaction.

    Clinical Manifestations of Children TRANS with COVID-19: a Systematic Review

    Authors: Tiago Henrique de Souza; Jose Antonio Nadal; Roberto Jose Negrao Nogueira; Ricardo Mendes Pereira; Marcelo Barciela Brandao

    doi:10.1101/2020.04.01.20049833 Date: 2020-04-03 Source: medRxiv

    Context: The coronavirus disease MESHD 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children TRANS with COVID-19 remain unclear. Objective: To describe the clinical, laboratorial and radiological characteristics of children TRANS with COVID-19. Data Sources: The Medline database was searched between December 1st 2019 and March 30th 2020. Study Selection: Inclusion criteria were: (1) studied patients younger than 18 years old; (2) presented original data from cases of COVID-19 confirmed by reverse-transcription polymerase chain reaction; and (3) contained descriptions of clinical manifestations, laboratory tests or radiological examinations. Data Extraction: Number of cases, gender TRANS, age TRANS, clinical manifestations, laboratory tests, radiological examinations and outcomes. Results: A total of 34 studies (1,118 cases) were included. From all the cases, 1,111 had their severity classified: 14.3% were asymptomatic TRANS, 36.4% were mild, 46.0% were moderate, 2.2% were severe and 1.2% were critical. The most prevalent symptom was fever HP fever MESHD (16.3%), followed by cough HP (14.4%), nasal symptoms (3.6%), diarrhea HP diarrhea MESHD (2.7%) and nausea/vomiting HP nausea/vomiting MESHD (2.5%). One hundred forty-five (12.9%) children TRANS were diagnosed with pneumonia HP pneumonia MESHD and 43 (3.8%) upper airway infections MESHD were reported. Reduced lymphocyte count were reported in 13.1% of cases. Abnormalities on computed tomography was reported in 62.7% of cases. The most prevalent abnormalities reported were ground glass opacities, patchy shadows and consolidations. Only one death was reported. Conclusions: Clinical manifestations of children TRANS with COVID-19 differ widely from adults TRANS cases. Fever HP Fever MESHD and respiratory symptoms should not be considered a hallmark of COVID-19 in children TRANS.

    The clinical data from 19 critically ill MESHD patients with Corona Virus Disease MESHD 2019: a single-centered, retrospective, observational study

    Authors: Jinping Zhang

    doi:10.21203/rs.3.rs-20800/v1 Date: 2020-04-02 Source: ResearchSquare

    Background To analyze the clinical features of Corona Virus Disease MESHD 2019 (COVID-19) and evaluate the diagnosis and treatment.Methods Making retrospective analysis of the clinical manifestation and auxiliary examination of the 19 patients of COVID-19 which from the Liyuan Hospital ICU between January 16, 2020 and February 20, 2020.Results There were 11 male TRANS and 8 female TRANS cases among the patients. The median (range) age TRANS was 73 (38-91) years. There are 8(42.1%)patients had died , and the median duration from ICU to death was 2 (IQR: 1–10.75) days in non-survivors. Seven patients have the basic diseases which in the dead patients. Auxiliary examination: fever HP (68.4%), dry cough MESHD cough HP (15.8%), dyspnea HP dyspnea MESHD (10.5%), diarrhea HP diarrhea MESHD (5.3%). 19 cases (100%) showed ground-glass changes on Chest computed tomography. Serum SERO Hypersensitive C-Reactive Protein (hs-CRP) and Serum SERO Amylase A (SAA) were increased obviously of 19 cases (100%); there are 16(84.2%)cases which the total number of lymphocytes decreased; 12 cases (63%) liver function; 11 cases (58%) were deviant in fibrinogen (FIB) and D-dimer, in particular, the D-dimer was significantly higher compared with the non-survivors and survivors.Conclusion More men than women in critically ill MESHD patients. All the cases showed ground-glass changes on chest CT, and the vast majority of patients will appear fever HP fever MESHD and dry cough MESHD cough HP. Clinical lab index changes obviously, especially the D-dimer in Non-survivors. 

    Clinical characteristics of 208 patients with COVID-19 in a surrounding city of Wuhan, China

    Authors: Xin Chen; Peng Chen; Dodji Kossi Djakpo; Yan Lin; Rong Zhang; Zhiquan Wang

    doi:10.21203/rs.3.rs-20783/v1 Date: 2020-04-01 Source: ResearchSquare

    Background: Since December 2019, a severe novel coronavirus ( SARS-CoV-2) infection (Coronavirus Disease MESHD 2019,COVID-19) has occurred in Wuhan, China, and has rapidly spread to the country and around the world. This study intends to investigate the epidemiological and clinical characteristics of patients with COVID-19 in a surrounding city of Wuhan.Methods: A retrospective study was conducted on 208 cases of COVID -19 patients from February 11, 2020 to February 29, 2020 in Xiaogan dongnan Hospital, collected basic information, history of exposure, medical history, clinical symptoms, laboratory indicators and pulmonary imaging Data, and analyzed the epidemiological and clinical characteristics of all patients. According to the clinical classification criteria, 208 patients were divided into light group and ordinary group, and the epidemiological and clinical characteristics of the two groups were compared.Results: Among 208 patients in this study, with a median age TRANS of 50.5 years (IQR,36-64.7,range,10-91 years), among which 107 (51.4%) were males TRANS and 101 (48.6%) were females TRANS. 51 (24.5%) had a clear exposure to COVID-19 infection within 2 weeks before admission, and 40 (19.2%) had a history of residence or exposure in Wuhan within 2 weeks before admission. Among all the patients, there were 16 (7.7%) with pulmonary diseases MESHD, 41 (19.7%) with hypertension HP hypertension MESHD, 11 (5.3%) with coronary heart disease MESHD, 13 (6.3%) with diabetes MESHD, 12(5.8%) with a history of alcohol consumption, and 12(5.8%) with a history of smoking. Among all clinical symptoms, 146 cases (70.2%) of fever HP fever MESHD, the highest temperature range was 37.3℃-41℃ before admission, 115 (55.3%) cases of cough HP, and 57 (27.4%) cases of chest tightness HP chest tightness MESHD, 47 (22.6%) cases of fatigue HP fatigue MESHD, 28 (13.5%) cases of inappetence, 9 (4.3%) cases of diarrhea HP diarrhea MESHD, 7 (3.4%) cases of nasal congestion or runny nose , and 5 ( 2.4%) cases of pharyngalgia. Analysis of the laboratory results of 208 patients showed that 42 (20.2%) cases had decreased white blood SERO cell count, and 61 (29.3%) cases had decreased lymphocyte count. There were 154 (74%) cases with elevated CRP, 50 (24%) cases with elevated fasting blood SERO glucose, and 23 (11.1%) cases with elevated LDH (>245U/L). The comparison of clinical characteristics between the light group and the common group showed that the median age TRANS of the light group was 44.8 years (IQR 30-58), the median age TRANS of the common group was 53.1 years (IQR 38.8-67) (P<0.01). The symptoms of fever HP fever MESHD [53(80.3%) vs 93(65.5%),P<0.05], fatigue HP fatigue MESHD [53(80.3%) vs 93(65.5%),P<0.05] and inappetence [4(6.1%) vs 24(16.9%),P<0.05] in the light group were less than those in the common group. The white blood SERO cell count (5.48 vs 6.37, P<0.05), lymphocyte count (1.40 vs 1.61, P<0.05) and HDL-C (1.5 vs 1.3, P<0.05) of the common group were lower than that of the light group, while CRP (26.5 vs 22.1, P<0.01), AST (22.9 vs 18.5, P<0.05), fasting blood SERO glucose (5.8 vs 5.6, P<0.05), LDH (196.8 vs 157.9, P<0.001) of the common group were higher than that of the light group.Conclusion: COVID-19 infection is mainly in middle- aged TRANS and elderly TRANS patients, patients with other diseases MESHD are more susceptible to infection. The main symptoms of COVID-19 infection MESHD were fever HP fever MESHD, cough HP cough MESHD, chest tightness HP chest tightness MESHD, fatigue HP fatigue MESHD, and inappetence. Decreased lymphocyte count, increased CRP concentration, increased LDH concentration and decreased HDL-C concentration were the laboratory features of COVID-19 infection MESHD, and were important indicators to assess the severity of COVID-19 disease.

    Viral Kinetics and Antibody SERO Responses in Patients with COVID-19

    Authors: Wenting Tan; Yanqiu Lu; Juan Zhang; Jing Wang; Yunjie Dan; Zhaoxia Tan; Xiaoqing He; Chunfang Qian; Qiangzhong Sun; Qingli Hu; Honglan Liu; Sikuan Ye; Xiaomei Xiang; Yi Zhou; Wei Zhang; Yanzhi Guo; Xiu-Hua Wang; Weiwei He; Xing Wan; Fengming Sun; Quanfang Wei; Cong Chen; Guangqiang Pan; Jie Xia; Qing Mao; Yaokai Chen; Guohong Deng

    doi:10.1101/2020.03.24.20042382 Date: 2020-03-26 Source: medRxiv

    Background A pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading over the world. However, the viral dynamics, host serologic responses, and their associations with clinical manifestations, have not been well described in prospective cohort. Methods We conducted a prospective cohort and enrolled 67 COVID-19 patients admitting between Jan 26 and Feb 5, 2020. Clinical specimens including nasopharyngeal swab, sputum, blood SERO, urine and stool were tested periodically according to standardized case report form with final follow-up on February 27. The routes and duration of viral shedding, antibody SERO response, and their associations with disease severity and clinical manifestations were systematically evaluated. Coronaviral particles in clinical specimens were observed by transmission TRANS electron microscopy (TEM). Results The median duration of SARS-CoV-2 RNA shedding were 12 (3-38), 19 (5-37), and 18 (7-26) days in nasopharyngeal swabs, sputum and stools, respectively. Only 13 urines (5.6%) and 12 plasmas SERO (5.7%) were viral positive. Prolonged viral shedding was observed in severe patients than that of non-severe patients. Cough HP but not fever HP, aligned with viral shedding in clinical respiratory specimens, meanwhile the positive stool-RNA appeared to align with the proportion who concurrently had cough HP and sputum production, but not diarrhea HP. Typical coronaviral particles could be found directly in sputum by TEM. The anti-nucleocapsid-protein IgM started on day 7 and positive rate peaked on day 28, while that of IgG was on day 10 and day 49 after illness onset. IgM and IgG appear earlier, and their titers are significantly higher in severe patients than non-severe patients (p<0.05). The weak responders for IgG had a significantly higher viral clearance rate than that of strong responders (p= 0.011). Conclusions Nasopharyngeal, sputum and stools rather than blood SERO and urine, were the major shedding routes for SARS-CoV-2, and meanwhile sputum had a prolonged viral shedding. Symptom cough HP seems to be aligned with viral shedding in clinical respiratory and fecal specimens. Stronger antibody SERO response was associated with delayed viral clearance and disease severity.

    Rigorous Measures are Vital for Preventing and Controlling Coronavirus Disease MESHD 2019 (COVID-19): A Cross-sectional Study

    Authors: Lushi Yu; Yi Wang; Haihua He; Yuxin Chu; Hongyan Feng; Yuehua Wei; Jin Zhou; Qibin Song; Hongyun Gong

    doi:10.21203/rs.3.rs-19186/v1 Date: 2020-03-24 Source: ResearchSquare

    Background Since December 2019, a novel corona virus disease named COVID-19 outbreak in Wuhan, China and spread worldwide then. Active prevention and control measures have been carried out in China, such as vigorous publicity, active screening and rapid isolation. As the major epidemic area, the passages in and out of Wuhan were temporarily closed since January 23. We aimed to demonstrate the effectiveness of rigorous measures by comparing the characteristics of patients hospitalized before and after implementation of vital measures. Methods Clinical data of patients admitted to hospital with COVID-19 during January 17-23 (Phase I) and February 3-9 (Phase II) were collected and compared. The cut-off date for follow-up was March 13, 2020. Results Of 176 patients with COVID-19, 97 were admitted in Phase I (43 [44.3%] male TRANS; mean age TRANS: 47.7), and 79 were in Phase II (33 [41.8%] male TRANS; mean age TRANS: 50.1). The proportions of severe cases were 21.6% and 10.1% respectively. Fewer patients had comorbidities (13 [16.5%] vs. 7 [7.2%]) and more asymptomatic TRANS patients were in Phase II (27.8% vs. 13.9%). Patients in Phase II had less fever HP fever MESHD (53.2% vs. 70.1%), cough HP (34.2% vs. 52.6%) and myalgia HP myalgia MESHD (11.4% vs.28.9%), while more diarrhea HP diarrhea MESHD (11.4% vs. 2.1%). Lymphopenia HP Lymphopenia MESHD and elevated CRP, as well as eosinopenia and elevated SAA were common in two groups, but all of that were significantly better in Phase II. More patients in Phase II preformed normal CT image on admission (10 [12.7%] vs. 7 [7.2%]). And lower CT scores (3 [2-4] vs. 2 [1-3]) were observed in Phase II. Up to cut-off date, average response time on CT image were 11.2 and 8.1 days in Phase I and II respectively. Shorter average hospitalized days were in Phase II (18.9 vs. 23.3 days). Four patients (4.1%) in Phase I and two (2.5%) in Phase II died. Conclusions Various actions (including vigorous publicity, active screening and rapid isolation) prompted more early patients with COVID-19 found, diagnosed and remedied, leading to good prognosis. Call for pretty attention to the epidemics of COVID-19 and timely measures around the world.

    Clinical characteristics of 57 patients infected with COVID-19 in Baodi area of Tianjin, China

    Authors: Yingchao Zhang; Zhentao Lin; Lijing Wang; Shuxiang Shan

    doi:10.21203/rs.3.rs-19003/v1 Date: 2020-03-24 Source: ResearchSquare

    BackgroundCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has been spreading worldwide.ObjectiveTo study the clinical characteristics of COVID-19, we included 57 real-time RT-PCR confirmed patients in Baodi area of Tianjin, China, admitted to hospital from 31 January 2020 and 22 February 2020.MethodsEpidemiological, demographic, clinical, and radiological features and laboratory data were analyzed. Patients were confirmed by real-time RT-PCR with pharyngeal swab and/or sputum samples. Some patients that presented positive results with sputum samples yielded negative results with multiple swab tests, suggesting sputum samples RT-PCR tests may be a more reliable means of positively diagnosing infected individuals.ResultsOf the 57 patients studied, three were mild and 54 were moderate in severity. None of the patients infected traveled TRANS to Wuhan indicating all studied cases were infected by human to human transmission TRANS. The most common symptoms at onset TRANS of illness were included fever HP fever MESHD (86%), cough HP (29.8%), myalgia HP myalgia MESHD or fatigue HP fatigue MESHD (14%), chest tightness HP chest tightness MESHD (5.3%), sore throat (5.3%), and diarrhea HP diarrhea MESHD (5.3%).ConclusionCompared with patients of COVID-19 in Wuhan, the symptoms of patients in Baodi area of Tianjin province are relatively mild.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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