Corpus overview


Overview

MeSH Disease

Human Phenotype

Diarrhea (128)

Fever (80)

Cough (78)

Fatigue (39)

Pneumonia (32)


Transmission

Seroprevalence
    displaying 101 - 110 records in total 128
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    Viral Kinetics and Antibody SERO Responses in Patients with COVID-19

    Authors: Wenting Tan; Yanqiu Lu; Juan Zhang; Jing Wang; Yunjie Dan; Zhaoxia Tan; Xiaoqing He; Chunfang Qian; Qiangzhong Sun; Qingli Hu; Honglan Liu; Sikuan Ye; Xiaomei Xiang; Yi Zhou; Wei Zhang; Yanzhi Guo; Xiu-Hua Wang; Weiwei He; Xing Wan; Fengming Sun; Quanfang Wei; Cong Chen; Guangqiang Pan; Jie Xia; Qing Mao; Yaokai Chen; Guohong Deng

    doi:10.1101/2020.03.24.20042382 Date: 2020-03-26 Source: medRxiv

    Background A pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading over the world. However, the viral dynamics, host serologic responses, and their associations with clinical manifestations, have not been well described in prospective cohort. Methods We conducted a prospective cohort and enrolled 67 COVID-19 patients admitting between Jan 26 and Feb 5, 2020. Clinical specimens including nasopharyngeal swab, sputum, blood SERO, urine and stool were tested periodically according to standardized case report form with final follow-up on February 27. The routes and duration of viral shedding, antibody SERO response, and their associations with disease severity and clinical manifestations were systematically evaluated. Coronaviral particles in clinical specimens were observed by transmission TRANS electron microscopy (TEM). Results The median duration of SARS-CoV-2 RNA shedding were 12 (3-38), 19 (5-37), and 18 (7-26) days in nasopharyngeal swabs, sputum and stools, respectively. Only 13 urines (5.6%) and 12 plasmas SERO (5.7%) were viral positive. Prolonged viral shedding was observed in severe patients than that of non-severe patients. Cough HP but not fever HP, aligned with viral shedding in clinical respiratory specimens, meanwhile the positive stool-RNA appeared to align with the proportion who concurrently had cough HP and sputum production, but not diarrhea HP. Typical coronaviral particles could be found directly in sputum by TEM. The anti-nucleocapsid-protein IgM started on day 7 and positive rate peaked on day 28, while that of IgG was on day 10 and day 49 after illness onset. IgM and IgG appear earlier, and their titers are significantly higher in severe patients than non-severe patients (p<0.05). The weak responders for IgG had a significantly higher viral clearance rate than that of strong responders (p= 0.011). Conclusions Nasopharyngeal, sputum and stools rather than blood SERO and urine, were the major shedding routes for SARS-CoV-2, and meanwhile sputum had a prolonged viral shedding. Symptom cough HP seems to be aligned with viral shedding in clinical respiratory and fecal specimens. Stronger antibody SERO response was associated with delayed viral clearance and disease severity.

    Rigorous Measures are Vital for Preventing and Controlling Coronavirus Disease MESHD 2019 (COVID-19): A Cross-sectional Study

    Authors: Lushi Yu; Yi Wang; Haihua He; Yuxin Chu; Hongyan Feng; Yuehua Wei; Jin Zhou; Qibin Song; Hongyun Gong

    doi:10.21203/rs.3.rs-19186/v1 Date: 2020-03-24 Source: ResearchSquare

    Background Since December 2019, a novel corona virus disease named COVID-19 outbreak in Wuhan, China and spread worldwide then. Active prevention and control measures have been carried out in China, such as vigorous publicity, active screening and rapid isolation. As the major epidemic area, the passages in and out of Wuhan were temporarily closed since January 23. We aimed to demonstrate the effectiveness of rigorous measures by comparing the characteristics of patients hospitalized before and after implementation of vital measures. Methods Clinical data of patients admitted to hospital with COVID-19 during January 17-23 (Phase I) and February 3-9 (Phase II) were collected and compared. The cut-off date for follow-up was March 13, 2020. Results Of 176 patients with COVID-19, 97 were admitted in Phase I (43 [44.3%] male TRANS; mean age TRANS: 47.7), and 79 were in Phase II (33 [41.8%] male TRANS; mean age TRANS: 50.1). The proportions of severe cases were 21.6% and 10.1% respectively. Fewer patients had comorbidities (13 [16.5%] vs. 7 [7.2%]) and more asymptomatic TRANS patients were in Phase II (27.8% vs. 13.9%). Patients in Phase II had less fever HP fever MESHD (53.2% vs. 70.1%), cough HP (34.2% vs. 52.6%) and myalgia HP myalgia MESHD (11.4% vs.28.9%), while more diarrhea HP diarrhea MESHD (11.4% vs. 2.1%). Lymphopenia HP Lymphopenia MESHD and elevated CRP, as well as eosinopenia and elevated SAA were common in two groups, but all of that were significantly better in Phase II. More patients in Phase II preformed normal CT image on admission (10 [12.7%] vs. 7 [7.2%]). And lower CT scores (3 [2-4] vs. 2 [1-3]) were observed in Phase II. Up to cut-off date, average response time on CT image were 11.2 and 8.1 days in Phase I and II respectively. Shorter average hospitalized days were in Phase II (18.9 vs. 23.3 days). Four patients (4.1%) in Phase I and two (2.5%) in Phase II died. Conclusions Various actions (including vigorous publicity, active screening and rapid isolation) prompted more early patients with COVID-19 found, diagnosed and remedied, leading to good prognosis. Call for pretty attention to the epidemics of COVID-19 and timely measures around the world.

    Clinical characteristics of 57 patients infected with COVID-19 in Baodi area of Tianjin, China

    Authors: Yingchao Zhang; Zhentao Lin; Lijing Wang; Shuxiang Shan

    doi:10.21203/rs.3.rs-19003/v1 Date: 2020-03-24 Source: ResearchSquare

    BackgroundCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has been spreading worldwide.ObjectiveTo study the clinical characteristics of COVID-19, we included 57 real-time RT-PCR confirmed patients in Baodi area of Tianjin, China, admitted to hospital from 31 January 2020 and 22 February 2020.MethodsEpidemiological, demographic, clinical, and radiological features and laboratory data were analyzed. Patients were confirmed by real-time RT-PCR with pharyngeal swab and/or sputum samples. Some patients that presented positive results with sputum samples yielded negative results with multiple swab tests, suggesting sputum samples RT-PCR tests may be a more reliable means of positively diagnosing infected individuals.ResultsOf the 57 patients studied, three were mild and 54 were moderate in severity. None of the patients infected traveled TRANS to Wuhan indicating all studied cases were infected by human to human transmission TRANS. The most common symptoms at onset TRANS of illness were included fever HP fever MESHD (86%), cough HP (29.8%), myalgia HP myalgia MESHD or fatigue HP fatigue MESHD (14%), chest tightness HP chest tightness MESHD (5.3%), sore throat (5.3%), and diarrhea HP diarrhea MESHD (5.3%).ConclusionCompared with patients of COVID-19 in Wuhan, the symptoms of patients in Baodi area of Tianjin province are relatively mild.

    Epidemiological and clinical characteristics of COVID-19 in Shenzhen, the largest migrant city of China

    Authors: Ying Wen; Lan Wei; Yuan Li; Xiujuan Tang; Shuo Feng; Kathy Leung; Xiaoliang Wu; Xiong-Fei Pan; Cong Chen; Junjie Xia; Xuan Zou; Tiejian Feng; Shujiang Mei

    doi:10.1101/2020.03.22.20035246 Date: 2020-03-23 Source: medRxiv

    We conducted a retrospective study among 417 confirmed COVID-19 cases from Jan 1 to Feb 28, 2020 in Shenzhen, the largest migrant city of China, to identify the epidemiological and clinical features in settings of high population mobility. We estimated the median incubation time to be 5.0 days. 342 (82.0%) cases were imported, 161 (38.6%) cases were identified by surveillance, and 247 (59.2%) cases were reported from cluster events. The main symptoms on admission were fever HP fever MESHD and dry cough MESHD cough HP. Most patients (91.4%) had mild or moderate illnesses. Age TRANS of 50 years or older, breathing problems, diarrhea HP diarrhea MESHD, and longer time between the first medical visit and admission were associated with higher level of clinical severity. Surveillance-identified cases were much less likely to progress to severe illness. Although the COVID-19 epidemic has been contained in Shenzhen, close monitoring and risk assessments are imperative for prevention and control of COVID-19 in future.

    Clinical characteristics and reasons of different duration from onset to release from quarantine for patients with COVID-19 Outside Hubei province, China.

    Authors: Suochen Tian; Zhenqin Chang; Yunxia Wang; Min Wu; Wenming Zhang; Guijie Zhou; Xiuli Zou; Hui Tian; Tingfang Xiao; Junmin Xing; Juan Chen; Jian Han; Kang Ning; Tiejun Wu

    doi:10.1101/2020.03.21.20038778 Date: 2020-03-23 Source: medRxiv

    Objective: To find out more characteristics and rules of COVID-19 by analyzing the clinical course of COVID-19 patients in a region outside Hubei province. Methods: 37 cases diagnosed adult TRANS COVID-19 cases of general characteristics, history of epidemiology, chronic underlying diseases,clinical symptoms and complications, chest CT, biochemical monitoring, severity assessment, treatment and outcome were retrospectively analyzed, and according to the duration from onset to release from quarantine were divided into 20-day group and > 20-day group, compare the similarities and differences between the two groups. Results: Among the 37 patients, 5 were mild, 30 were moderate, 1 was severe and 1 was critical. All the patients were released from quarantine without death MESHD. The average duration from onset to release from quarantine was 20.2{+/-}6.6 days, The average length of stay from onset to hospitalization was 4.1{+/-}3.7 days, and hospitalization duration average 16.1{+/-} 6.2 days. The average age TRANS was 44.3{+/-}1.67 years. 78.4% of cases were caused by exposure to a confirmed patient or the workplace of a confirmed patient. The main symptoms were cough HP (67.6%), fever HP fever MESHD( 62.2%), shortness of breath MESHD (32.4%), fatigue HP fatigue MESHD (24.3%), sore throat (21.6%,) vomiting HP vomiting MESHD or diarrhea HP diarrhea MESHD (21.6%). The white blood SERO cell count was decreased in 27.0% of the patients, and the lymphocyte count was decreased in 62.2% of the patients, of which 43.5% patients were <0.6 x 109/L. On admission, 86.5% of patients with chest CT showed pneumonia HP pneumonia MESHD, including some asymptomatic TRANS patients. 68.8% of patients showed bilateral infiltration. In the > 20-day group, the average age TRANS was 49.9{+/-}1.38 years old, and the duration from onset to hospitalization was 5.5{+/-}3.9 days. Compared with the [≤]20-day group, the age was older TRANS and and duration was longer, P < 0.05. All the 7 asymptomatic TRANS patients were [≤]20-day group. When 37 patients were released from quarantine, the white blood SERO cell count of 16.2% patients was <4.0 x 109/L, and the lymphocyte count of 59.5% patients was <1.1x109/L, and the absolute count of white blood SERO cells and lymphocytes was 5.02 {+/-} 1.34x109/L and 1.03{+/-} 0.34x109/L respectively , compared with those on admission, P >0.05. Conclusion: The majority of COVID-19 cases in the study area were mild and moderate, with good clinical outcomes. There were some special characteristics in the clinical process. The reasons of duration from onset to release from quarantine were complex. There was no significant change in the number of granulocytes at the time of release from quarantine compared to the time of admission.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18696/v1 Date: 2020-03-20 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia MESHD” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis. Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020. Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever HP fever MESHD (46/64), dry cough MESHD cough HP (38/64), fatigue HP fatigue MESHD or myalgia HP myalgia MESHD (23/64), sore throat (10/64), diarrhea HP diarrhea MESHD (3/64) along with late- onset symptoms TRANS like chest pains HP chest pains MESHD (2/64) and headaches HP headaches MESHD (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia HP leukopenia MESHD. Only two patients (3.1 %) presented with leukocytosis HP leukocytosis MESHD. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death so far. Conclusions: Early intervention in COVID-19 disease improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection MESHD during late pregnancy: A Report of 18 patients from Wuhan, China

    Authors: Lu Zhang; Lan Dong; Lei Ming; Min Wei; Jun Li; Ruheng Hu; Jing Yang

    doi:10.21203/rs.3.rs-18247/v3 Date: 2020-03-20 Source: ResearchSquare

    Background: Compared with Severe Acute Respiratory Syndrome MESHD(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease MESHD 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hoped to provide some references for obstetric treatment and management.Methods: A total of 18 patients with COVID-19 treated in Renmin Hospital of Wuhan University were collected. The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis.Results: 1. 18 cases of late pregnancy infected with SARS-CoV-2 pneumonia MESHD pneumonia HP were delivered at 35 + 5 weeks to 41 weeks. According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. 2. According to Imaging examinations: 15 (83%) cases showed unilateral or bilateral pneumonia HP pneumonia MESHD, 2 (11%) cases had pulmonary infection MESHD with pleural effusion HP pleural effusion MESHD, and 1 (6%) case had no abnormal imaging changes. 8 (44%) cases were positive and 10 (56%) cases were negative for nasopharyngeal-swab tests of SARS-CoV-2. 3. Among the 18 newborns, there were 3 (17%) premature infants, 1 (6%) case of mild asphyxia MESHD, 5 (28%) cases of bacterial pneumonia MESHD pneumonia HP, 1 (6%) case of gastrointestinal bleeding MESHD, 1 (6%) case of necrotizing enteritis MESHD, 2 (11%) cases of hyperbilirubinemia HP hyperbilirubinemia MESHD and 1 (6%) case of diarrhea HP diarrhea MESHD. All the newborns were negative for the first throat swab test of SARS-CoV-2 after birth. 4. Follow-up to Mar 7, 2020, no maternal and neonatal deaths MESHD occurred.Conclusions: The majority of patients in late term pregnancy with COVID-19 were of ordinary type, and they less likely developed into critical pneumonia HP pneumonia MESHD after early isolation and antiviral treatment. Vertical transmission TRANS of SARS-CoV-2 was not detected, but the proportion of neonatal bacterial pneumonia MESHD pneumonia HP was higher than other neonatal diseases in newborns.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18096/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia MESHD” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis.Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020.Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever HP fever MESHD (46/64), dry cough MESHD cough HP (38/64), fatigue HP fatigue MESHD or myalgia HP myalgia MESHD (23/64), sore throat (10/64), diarrhea HP diarrhea MESHD (3/64) along with late- onset symptoms TRANS like chest pains HP chest pains MESHD (2/64) and headaches HP headaches MESHD (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia HP leukopenia MESHD. Only two patients (3.1 %) presented with leukocytosis HP leukocytosis MESHD. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death so far. Conclusions: Early intervention in COVID-19 disease improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Analysis on Diagnosis of Family Clustering Infection of SARS-CoV-2

    Authors: Rong Qiu; Ming-wei Liu; Chuan Zhao; Wei-min Li

    doi:10.21203/rs.3.rs-18076/v1 Date: 2020-03-18 Source: ResearchSquare

    Objective: Novel coronavirus (nCoV, SARS-CoV-2) infection MESHD becomes a world-wide epidemic which has complicated and diversified symptoms, but no special treatment. In this study, diagnosis and treatment of family clustering nCoV infection MESHD were analyzed.Methods: The Sichuan Suining Central Hospital received 11 patients with confirmed nCoV virus infection MESHD from 4 families during January 23rd, 2020 to February 20th, 2020. Their clinical symptoms, treatment conditions and changes of disease state were reviewed in the present study.Results: In all 4 families, there were 1-2 members in each family TRANS who had contact with epidemic disease MESHD. Clinical manifestations were: 3 cases had debilitation only, 1 case had cough HP only, 1 case had diarrhea HP diarrhea MESHD (a child TRANS patient of four years old), 5 cases had fever HP fever MESHD and cough HP cough MESHD, and 1 case had blood SERO-stained sputum. According to image changes, no image change was observed in 1 child TRANS patient. Multiple focal ground-glass opacities were detected from 2 patients and multiple patchy shadows were observed from 8 patients, especially in lung periphery. Complications with basic diseases: there were hypertension HP hypertension MESHD in 3 cases, diabetes MESHD in 2 cases, and hypertension HP hypertension MESHD and diabetes MESHD in 1 case. Moreover, there’s one patient who had rheumatic heart disease MESHD and received mitral and aortic valve replacement 2 years ago. There’s another one who had depression MESHD and suicidal tendency. All 11 cases divided into mild type (1 child TRANS patient), moderate type (8 patients), severe type (1 patient) and critical type (1 patient). Treatment: the mild child TRANS patient (4 years old) was administrated with 2.75ml lopinavir / ritonavir oral liquid (twice per day) and intravenous drip of 0.17g ribavirin injection (1ml: 0.1g*10pcs/box) every 12h for one week. Meanwhile, the child TRANS was asked to take azithromycin orally. 7 moderate patients were treated with intravenous drip of 0.5g ribavirin injection (1ml: 0.1g*10pcs/box) every 12h (twice per day) and two pieces of lopinavir/ritonavior (twice per day) for 7-10 days. In the same time, patients were given with reasonable amount of antibiotics by oral or intravenous drip. 1 severe patient and 1 critical patent were treated with 5,000,000 U recombinant human interferon α2b injection (3,000,000 U/pc) and aerosol inhalation of 2ml sterile water for injection (5ml*50 pcs/ box), twice per day. Besides, they took 2 pieces of lopinavir/ritonavior, twice per day. The whole treatment program lasted for 6-12 days, accompanied with appropriate amount of intravenous drip of antibiotics. The critical patient was also provided with mechanical ventilation. During the treatment, severe and critical patients were treated by resochin for 4-5 days for evident respiratory symptoms. One moderate patient was treated with 2 pieces of lopinavir/ritonavior, twice per day. In the same time, it was administrated by intravenous drip of antibiotics. However, resochin treatment was applied for positive novel coronavirus nucleic acid of respiratory sputum specimen after 11 days of treatment. Discharge: After treatment, patients with body temperatures of all patients recovered to normal level, and respiratory symptoms and digestive tract symptoms relieved significantly, significant coefficient of exudative lesion at lung according to chest CT and negative novel coronavirus nucleic acid of continuous two respiratory sputum specimens (sampling interval was at least 1 day) were allowed to be discharged. Adverse reactions: 4 patients had loose stools and abdominal discomfort, and another 2 cases had diarrhea HP diarrhea MESHD.Conclusions: SARS-CoV-2 infection MESHD have complicated and diversified symptoms, which shall be identified according to epidemic history and novel coronavirus nucleic acid test. In particular, the whole family in which there’s a patient with confirmed SARS-CoV-2 shall be isolated for screening in addition to the patient. The lopinavir/ritonavior administration combined with ribavirin or recombinant Human Interferon (RHI) α2b is effective, accompanied with mild adverse reaction. If lopinavir/ritonavior administration and / or combined with ribavirin and RHI α2b is invalid, adding resochin might be effective.

    Comparative Analysis of Clinical Characteristics in Children TRANS and Adults TRANS with 2019 Novel Coronavirus Infection: A Descriptive Study

    Authors: Ya-nan Han; Zhan-wei Feng; Li-na Sun; Xiao-xia Ren; Hua Wang; Yong-ming Xue; Yi Wang; Ying Fang

    doi:10.21203/rs.3.rs-17872/v1 Date: 2020-03-17 Source: ResearchSquare

    Background: Since December 2019, acute respiratory disease MESHD ( ARD MESHD) caused by 2019 novel coronavirus (2019-nCoV) rapidly spread throughout China. Children TRANS and adults TRANS seemed to differ in the clinical course of the disease. The purpose of the current study is to comparatively analyze the clinical characteristics of children TRANS and adult TRANS patients with 2019-nCoV infection MESHD and to explore the possible causes for the discrepant aspects.Methods: In this retrospective study, the medical records of 32 cases confirmed TRANS with 2019-nCoV ARD MESHD from Xi'an eighth hospital (Shaanxi, China) from January 31 to February 16, 2020 were reviewed.Results: In all 32 patients contained 7 children TRANS and 25 adults TRANS. All children TRANS were family cluster. For adult TRANS patients, local residents of Wuhan, recently travelled TRANS to Wuhan, patient contacted with people from Wuhan were 14 (56%), 10 (40%), 1 (4%), respectively. The median incubation period TRANS of children TRANS and adult TRANS was 5 days (range, 3 to 12) and 4 days (range, 2 to 12), respectively. Altogether 10 (40%) adult TRANS patients had underlying conditions significantly, but no children TRANS had. Fever HP Fever MESHD ( Children TRANS 71.4% vs. Adult TRANS 96%) and cough HP ( Children TRANS 71.4% vs. Adult TRANS 76%) were the most common symptoms in both groups. The third symptom observed in children TRANS was diarrhea HP diarrhea MESHD and/or vomiting HP vomiting MESHD (57.1%), for adult TRANS it was myalgia HP myalgia MESHD or fatigue HP fatigue MESHD (52%). On admission, 5 (71.4%) children TRANS patients showed pneumonia HP pneumonia MESHD roughly the same as adult TRANS patients (20, 80%), and that the two group shared a multitude of common imaging characteristics. 20% of adult TRANS with leucopoenia, but leukocytosis HP leukocytosis MESHD was significantly more frequently in children TRANS (28.6%, P=0.014). More children TRANS had elevated creatine kinase isoenzyme (57.1% vs. 4%, P=0.004). All patients were discharged after symptomatic treatment, including oxygen therapy, antiviral treatment, antibiotic treatment. Only one infant was intravenously injected low-dose glucocorticoids.Conclusions: Our results multi-dimensionally demonstrate that children TRANS with 2019-nCoV infection MESHD present a clinical picture which is often distinct from that of adults TRANS. Knowledge of these differences will be helpful for the clinical diagnosis of 2019 novel coronavirus diseases MESHD (COVID-19) and for a future discussion on age TRANS specific infection MESHD case definitions.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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