Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Investigating the Effects of COVID-19 Quarantine on Migraine HP: Data from the Italian National Headache MESHD Headache HP Registry (RICe)

    Authors: Marianna Delussi; Eleonora Gentile; Gianluca Coppola; Addolorata Maria Pia Prudenzano; Innocenzo Rainero; Grazia Sances; Chiara Abagnale; Valeria Caponnetto; Francesco De Cesaris; Chiara Lupi; Ilaria Frattale; Elena Guaschino; Andrea Marcinnò; Raffaele Ornello; Francesca Pistoia; Alessia Putortì; Maria Elena Roca; Fausto Roveta; Maria Trojano; Francesco Pierelli; Pierangelo Geppetti; Simona Sacco; Marina De Tommaso

    doi:10.21203/rs.3.rs-39228/v1 Date: 2020-06-30 Source: ResearchSquare

    BACKGROUND Previous studies during the SARS and Ebola pandemics have shown that quarantine is associated with several negative psychological effects. Although it is possible that quarantine for the current COVID-19 pandemic affects migraine HP burden, no information is currently available on this i AIM:  In this study, we aimed: a)  to explore the effect of quarantine on migraine HP frequency, severity and days with acute medication intake, and  b) to evaluate whether migraine HP, changes in lifestyle, and emotions. were affected in a different manner in three geographic Italian areas with diverse COVID-19 diffusion,   METHODS We interviewed patients included in the observational Italian registry of headache MESHD headache HP (Registro Italiano Cefalee, RICe), retrospectively collecting information on main headache MESHD headache HP features, lifestyles factors, emotions, individual infection MESHD status, and perception for COVID-19 for the two months before quarantine and during quarantine. Inclusion criteria were:  age TRANS > 18; diagnosis of migraine without aura MESHD migraine without aura MESHD migraine without aura HP migraine without aura HP, migraine with aura MESHD migraine with aura MESHD migraine with aura HP migraine with aura HP, and chronic migraine HP; last in-person visit in the  3 months before the beginning of the quarantine. RESULTS A total of 433 migraine HP subjects agreed to be interviewed. We found an overall reduction in headache MESHD headache HP frequency and days with acute medication intake during the quarantine as compared to pre-quarantine. Reduction in headache MESHD headache HP frequency prevailed in patients reported more days of effective staying at home. Improvement was not evident in northern Italy. Disgust against viral infection MESHD corresponded to a reduced improvement in migraine HP parameters. CONCLUSIONS. Migraine HP patients showed a resilient behavior toward the pandemic distress. Disgust against the contagious disease MESHD, could increase migraine HP frequency. ssue.

    Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro) Identified from the Library of FDA Approved Drugs Using Molecular Docking Studies

    Authors: Dipesh Verma; Srajan Kapoor; Satyajeet Das; Krishan Thakur

    id:10.20944/preprints202004.0149.v1 Date: 2020-04-09 Source: Preprints.org

    Corona Virus Infectious Disease MESHD-2019 (COVID-19) outbreak originated recently at Wuhan, China in December 2019. It has already spread rapidly to more than 200 countries and has been declared a pandemic by WHO. It is caused by a beta-coronavirus named as SARS-CoV-2. There is no definitive cure, either drug or vaccine, to treat or prevent this viral disease MESHD. Recently, the crystal structure of the main protease Mpro has been determined. Mpro is responsible for the proteolytic maturation of the polyprotein essential for the viral replication and transcription, which makes it an important drug target. The discovery of new drug molecules may take years before getting to the clinics. So, considering urgency we performed molecular docking studies using FDA approved drugs to identify molecules that could potentially bind to the substrate-binding site and inhibit SARS-CoV-2 main protease (Mpro). We used the Glide module in Schrodinger software suite to perform molecular docking studies followed by MM-GBSA based energy calculations to score the hit molecules. Molecular docking and manual analysis suggest that several drugs may bind and potentially inhibit Mpro. We also performed molecular simulations studies for selected compounds to evaluate protein-drug interactions. Interestingly, we observed only one antiviral compound, Adefovir, in the top50 list of compounds. Considering bioavailability, lesser toxicity, route of administration some of the top-ranked drugs including lumefantrine (antimalarial), dipyridamole (coronary vasodilator), dihydroergotamine (used for treating migraine HP), hexoprenaline (anti- asthmatic), riboflavin (vitamin B2) and pantethine (vitamin B5) may be taken forward for further in vitro and in vivo experiments to investigate their therapeutic potential.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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