Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    A nomogram for predicting the severity of COVID-19 using laboratory examination and CT findings 

    Authors: Yani Kuang; Susu He; Shuangxiang Lin; Rui Zhu; Rongzhen Zhou; Jian Wang; Renzhan Li; Haiyong Lin; Zhibang Zhang; Peipei Pang; Wenbin Ji

    doi:10.21203/rs.3.rs-46841/v1 Date: 2020-07-21 Source: ResearchSquare

    Background: The outbreak of COVID-19 has a significant impact on the health of people around the world. In the clinical condition of COVID-19, the condition of critical cases changes rapidly with a high mortality rate. Therefore, early prediction of disease MESHD severity and active intervention play an important role in the prognosis of severe patients.Methods: All the patients with COVID-19 in Taizhou city were retrospectively included and segregated into the non-severe and severe group according to the severity of the disease MESHD. The clinical manifestations, laboratory examination results, and imaging findings of the 2 groups were analysed for comparing the differences between the 2 groups. Univariate and multivariate logistic regression were used for screening the factors that could predict the disease MESHD, and the nomogram was constructed.Results: A total of 143 laboratory- confirmed cases TRANS were included in the study, including 110 non-severe patients and 33 severe patients. The median age TRANS of patients was 47 years (range, 4–86 years). Fever MESHD Fever HP (73.4%) and cough MESHD cough HP (63.6%) were the most common initial clinical symptoms. By using the method of multivariate logistic regression, the variables to construct nomogram include age TRANS (OR: 1.052, 95% CI: 1.020–1.086, P = 0.001), body temperature (OR: 2.252, 95% CI: 1.139–4.450, P = 0.020), lymphocyte count (OR: 1.128, 95% CI: 1.000–1.272, P = 0.049), ADA (OR: 1.163, 95% CI: 1.023–1.323, P = 0.021), PaO2 (OR: 0.972, 95% CI: 0.953–0.992, P = 0.007), IL-10 (OR: 1.184, 95% CI: 1.037–1.351, P = 0.012), and bronchiectasis MESHD bronchiectasis HP (OR: 3.818, 95% CI: 1.694–8.605, P = 0.001). The AUC of the established nomogram was 0.877.Conclusions: This study established a stable nomogram for predicting the severity of COVID-19, and the clinicians can use the established nomogram for predicting the severity of newly diagnosed COVID-19 patients and to conduct active intervention for minimising the mortality rate and improving the prognosis of severe patients.

    COVID-19 related concerns of people with long-term respiratory conditions: A qualitative study

    Authors: Keir Elmslie James Philip; Bradley Lonergan; Andrew Cumella; Joe Farrington-Douglas; Michael Laffan; Nicholas S Hopkinson

    doi:10.1101/2020.06.19.20128207 Date: 2020-06-26 Source: medRxiv

    BACKGROUND The COVID-19 pandemic is having profound psychological impacts on populations globally, with increasing levels of stress, anxiety HP, and depression being reported, especially in people with pre-existing medical conditions who appear to be particularly vulnerable. There are limited data on the specific concerns people have about COVID-19 and what these are based on. METHODS The aim of this study was to identify and explore the concerns of people with long-term respiratory conditions in the UK regarding the impact of the COVID-19 pandemic and how these concerns were affecting them. We conducted a thematic analysis of free text responses to the question 'What are your main concerns about getting coronavirus?', which was included in the British Lung Foundation/ Asthma MESHD Asthma HP UK (BLF-AUK) partnership COVID-19 survey, conducted between the 1st and 8th of April. This was during the 3rd week of the UK's initial social distancing measures. RESULTS 7,039 responses were analysed, with respondents from a wide range of ages TRANS, gender TRANS, and all UK nations. Respondents reported having asthma MESHD asthma HP (85%), COPD (9%), bronchiectasis MESHD bronchiectasis HP (4%), interstitial lung disease MESHD (2%), or 'other' lung diseases MESHD (e.g. lung cancer) (1%). Four main themes were identified: 1) vulnerability to COVID-19; 2) anticipated experience of contracting COVID-19; 3) wide-reaching uncertainty; and 4) inadequate national response. CONCLUSIONS The COVID-19 pandemic is having profound psychological impacts. The concerns we identified largely reflect objective, as well as subjective, aspects of the current situation. Hence, key approaches to reducing these concerns require changes to the reality of their situation, and are likely to include i) helping people optimise their health, limit risk of infection TRANS risk of infection TRANS infection MESHD, and access necessities; ii) minimising the negative experience of disease MESHD where possible, iii) providing up-to-date, accurate and consistent information, iv) improving the government and healthcare response.

    Impact of the COVID-19 epidemic on outpatient visits of common respiratory diseases MESHD

    Authors: Weiyi Wang; Yulu Zheng; Libin Jiang

    doi:10.21203/rs.3.rs-34656/v1 Date: 2020-06-11 Source: ResearchSquare

    Background/Purpose The outbreak of corona virus disease MESHD 2019 (COVID-19) has become a worldwide threat to public health. The purpose of this study is to analyze the impact of COVID-19 epidemic on outpatient visits of common respiratory diseases MESHD. Methods Through statistics and comparing the data with the same period last year,we present the changes of outpatient visits of 14 common respiratory diseases MESHD in an upper first-class hospital in China from January to May,2020. Results From January to May,2020, the number of outpatient visits of most common respiratory diseases MESHD fell HP below the previous year,and total number of outpatient visits of 14 common respiratory diseases MESHD decreased by 58.07% year-on-year. Bronchitis MESHD Bronchitis HP, pneumonia MESHD pneumonia HP, cough MESHD cough HP, acute upper respiratory infection MESHD and bronchiectasis MESHD bronchiectasis HP infection MESHD are in our top 5 drop list,decreased by 76.79%,71.03%,66.51%56.87% and 56.31% respectively. Conclusion COVID-19 epidemic had a strong influence on the outpatient visits of common respiratory diseases MESHD, particularly for infectious diseases MESHD.

    CT features of COVID-19 patients with two consecutive negative RT-PCR tests after treatment

    Authors: Zhao Fu; Ningning Tang; Yanqing Chen; Longbai Ma; Youyong Wei; Yumin Lu; Kun Ye; Hang Liu; Fen Tang; Guangyi Huang; Yingxia Yang; Fan Xu

    doi:10.21203/rs.3.rs-33163/v1 Date: 2020-06-02 Source: ResearchSquare

    Purpose: The objective of this study is to expound the CT features of COVID-19 patients whose nucleic acid tests converted to negative after treatment.Materials and Methods: We retrospectively reviewed 46 COVID-19 patients with two consecutive negative RT-PCR tests after treatment. The cases were divided into moderate group and severe/critical group according to disease MESHD severity. Clinical and CT scanning data were collected. CT signs of pulmonary lesions and the score of long involvement were expounded.Results: 39 moderate cases and 7 severe/critical cases were included. All moderate patients showed peripheral lesions while severe/critical cases exhibited both central and peripheral lesions with all lobes involvement. Ground glass opacity (GGO) and mixed GGO were observed. Aberrant pulmonary interstitium manifested as reticular and thin linear pattern. Thickened blood SERO vessels and pleural thickening HP were found. Pulmonary fibrosis MESHD Pulmonary fibrosis HP, annular thickening of the bronchial wall, bronchiectasis MESHD bronchiectasis HP, air bronchogram and small amount of bilateral pleural effusion MESHD pleural effusion HP were observed in severe/critical patients. The severe/critical group showed higher CT score of involvement.Conclusions: Pulmonary lesions persisted even after twice consecutive nucleic acid tests converted to negative. We strongly recommended regular follow-up of CT scans after nucleic acid tests conversion. Evaluation of complete remission should base on chest CT.

    Clinical Characteristics and CT Manifestations of 143 Patients With 2019 Novel Coronavirus Disease MESHD (COVID-19) in Taizhou City, Zhejiang, China

    Authors: Yani Kuang; Susu He; Shuangxiang Lin; Rui Zhu; Rongzhen Zhou; Shuying Ying; Renzhan Li; Haiyong Lin; Zhibang Zhang; Peipei Pang; Wenbin Ji

    doi:10.21203/rs.3.rs-32895/v1 Date: 2020-06-01 Source: ResearchSquare

    Background: In December 2019, the first case of pneumonia MESHD pneumonia HP associated with the SARS-CoV-2 was found in Wuhan and rapidly spread throughout China, so data are needed on the affected patients. The purpose of our study was to find the clinical manifestations and CT features of COVID-19.Methods: All patients with COVID-19 in Taizhou city were retrospectively included and divided into non-severe group and severe group according to the severity of the disease MESHD. The clinical manifestations, laboratory examinations and imaging features of COVID-19 patients were analyzed, and the differences between the two groups were compared.Results: A total of 143 laboratory- confirmed cases TRANS were included in the study, including 110 non-severe patients and 33 severe patients. The median age TRANS of patients was 47 (range 4–86 years). Fever MESHD Fever HP (73.4%) and cough MESHD cough HP (63.6%) were the most common initial clinical symptoms. Between two groups of cases, the results of aspartate transaminase, creatine kinase and lactate dehydrogenase, serum SERO albumin, CR, glomerular filtration rate, amyloid protein A, fibrinogen, calcitonin level and oxygen partial pressure, IL – 10, absolute value of CD3, CD4, CD8 were different, and the difference was statistically significant (P < 0.05). Therefore, these quantitative indicators can be used to help assess the severity. On admission, the CT showed that the lesions were mostly distributed in the periphery of the lung or subpleural (135 cases (98%)), and most of lesions presented as patchy (81%), mixed density (63%) shadow. Consolidation (68% vs 41%), bronchial inflation signs (59% vs 41%), and bronchiectasis MESHD bronchiectasis HP (71% vs 39%) were more common in the severe group.Conclusions: Most of the cases of COVID-19 in Taizhou have mild symptoms and no death MESHD. In addition to clinical symptoms, some laboratory tests (such as absolute values of CD4 and CD8) and CT findings can be used to assess the severity of the disease MESHD.

    Early fibroproliferative changes on high-resolution CT predict mortality in COVID-19 pneumonia MESHD pneumonia HP patients with ARDS

    Authors: Zhilin Zeng; Min Xiang; Hanxiong Guan; Yiwen liu; huilan Zhang; Liming Xia; Zhan Juan; Qiongjie Hu

    doi:10.21203/rs.3.rs-32245/v1 Date: 2020-05-28 Source: ResearchSquare

    Objectives: To investigate the chest high-resolution CT (HRCT) findings in coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP patients with acute respiratory distress HP syndrome MESHD (ARDS) and to evaluate its relationship with clinical outcome.Materials and Methods In this retrospective study, seventy-nine COVID-19 patients with ARDS were recruited. Clinical data were extracted from electronic medical records and analyzed. HRCT scans, obtained within 3 days before clinical ARDS onset, were evaluated by three independent observers and graded into six findings according to the extent of fibroproliferation. Multivariable Cox proportional hazard regression analysis was used to assess the independent predictive value of the CT score and radiologically fibroproliferation. Patient survival was determined by Kaplan-Meier analysis.Results: Compared with survivors, non-survivors showed higher of lung fibroproliferation, whereas there no significant differences in the area of increased attenuation without traction bronchiolectasis HP or bronchiectasis MESHD bronchiectasis HP. A HRCT score <230 enabled prediction of survival with 73.5% sensitivity SERO and 93.3% specificity (AUC= 0.9; 95% CI 0.831 to 0.968). Multivariate Cox proportional hazards model showed that the HRCT score is a significant independent risk factor for mortality (HR 13.007; 95% CI 3.935 to 43.001). Kaplan-Meier analysis revealed HRCT score≥230 was associated with higher fatality rate. Organ injury occurred less frequently in patients with HRCT score<230 compared to those with HRCT score≥230.Conclusion: Early pulmonary fibroproliferative changes in HRCT predicts increased mortality and susceptibility to organ injury in COVID-19 pneumonia MESHD pneumonia HP patients with early ARDS.

    Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism MESHD Pulmonary Embolism HP

    Authors: Ting Li; Gregory Kicska; Paul E Kinahan; Chengcheng Zhu; Murat Alp Oztek; Wei Wu

    doi:10.1101/2020.04.20.20064105 Date: 2020-04-24 Source: medRxiv

    Objective: To describe clinical, and imaging findings including the evolution pattern in COVID-19 pneumonia MESHD pneumonia HP complicated by pulmonary embolism MESHD pulmonary embolism HP (PE). Methods: Eleven of 1453 patients with a probable diagnosis of COVID-19 pneumonia MESHD pneumonia HP were retrospectively selected for the presence of PE. Clinical and laboratory data were recorded. All cross-sectional CT imaging was qualitatively scored for the first 28 days after onset of symptoms TRANS. Results: Of 24 patients underwent CTA-PE, 11 were confirmed with PE. All 11 patients developed acute respiratory distress HP syndrome MESHD (ARDS). We observed an evolution pattern of predominant findings with ground-glass opacities (GGO) to GGO with crazy paving in 3 patients, then to consolidation with linear densities, or to reticulation in 9 patients. Lung cysts MESHD or traction bronchiectasis MESHD bronchiectasis HP could be seen from day 5 to 9 after symptoms and reticulation, subpleural curvilinear lines were more common from day 20. The pulmonary opacities HP were predominantly peripheral in distribution with relative sparing of nondependent lungs. The severity of lung involvement was high with an average score of 9.7 in the first phase, 18 in the second phase plateauing in the next two phases, with a slight decrease to 16.9 in the late phase. The pulmonary emboli were most common in segmental and subsegmental pulmonary arteries. Conclusion: The incidence of PE among suspected patients in COVID-19 was high. Our study suggests PE may occur with increased frequency in the ARDS subgroup. The evolution of radiographic abnormalities showed a general pattern, but are also unique with more extensive lung injury MESHD and specific imaging features.

    Clinical Characteristics and CT Manifestations of 143 Patients With 2019 Novel Coronavirus Disease MESHD (COVID-19) in Taizhou City, Zhejiang, China

    Authors: Yani Kuang; Susu He; Shuangxiang Lin; Rui Zhu; Rongzhen Zhou; Shuying Ying; Renzhan Li; Haiyong Lin; Zhibang Zhang; Peipei Pang; Wenbin Ji

    doi:10.21203/rs.3.rs-23614/v1 Date: 2020-04-17 Source: ResearchSquare

    Background In December 2019, the first case of pneumonia MESHD pneumonia HP associated with the SARS-CoV-2 was found in Wuhan and rapidly spread throughout China, so data are needed on the affected patients. The purpose of our study was to find the clinical manifestations and CT features of COVID-19.Methods All patients with COVID-19 in Taizhou city were retrospectively included and divided into non-severe group and severe group according to the severity of the disease MESHD. The clinical manifestations, laboratory examinations and imaging features of COVID-19 patients were analyzed, and the differences between the two groups were compared.Results A total of 143 laboratory- confirmed cases TRANS were included in the study, including 110 non-severe patients and 33 severe patients. The median age TRANS of patients was 47 (range 4–86 years). Fever MESHD Fever HP (73.4%) and cough MESHD cough HP (63.6%) were the most common initial clinical symptoms. Between two groups of cases, the results of aspartate transaminase, creatine kinase and lactate dehydrogenase, serum SERO albumin, CPR, glomerular filtration rate, amyloid protein A, fibrinogen, calcitonin level and oxygen partial pressure, red protein, IL – 10, absolute value of CD3, CD4, CD8 were different, and the difference was statistically significant (P < 0.05). On admission, the CT showed that the lesions were mostly distributed in the external lung or under the pleura (135 cases (98%)), and most of lesions presented as patchy (81%), heterogeneous (73%) and mixed density (63%) shadow. Consolidation (68% vs 41%), bronchial inflation signs (59% vs 41%), and bronchiectasis MESHD bronchiectasis HP (71% vs 39%) were more common in the severe group.Conclusions Most of the cases of COVID-19 in Taizhou have mild symptoms and no death MESHD. In addition to clinical symptoms, some laboratory tests (such as absolute values of CD4 and CD8) and CT findings can be used to assess the severity of the disease MESHD.

    Computed Tomography Findings and Short-term follow-up with Novel Coronavirus Pneumonia MESHD Pneumonia HP

    Authors: Shi Qi; Hui Guo; Hua Shao; Siqin Lan; Yuanlin He; Maijudan Tiheiran; Hongjun Li

    doi:10.1101/2020.04.02.20042614 Date: 2020-04-04 Source: medRxiv

    Objective: To assess the characteristics of computed tomography (CT) features and changes in CT monitoring in patients with novel coronavirus pneumonia MESHD pneumonia HP (NCP) . Methods: In this retrospective, two-center study, we reviewed the medical records of 57 patients with NCP in CT from January 21 to February 12, 2020. Cases were confirmed TRANS by the results of nucleic acid test positive, and were analyzed for demographic, clinical, and CT features. Results: Of the 57 patients, 31cases were male TRANS, and 45.6% were female TRANS. The average age TRANS was 46.5 years. Patients had fever MESHD fever HP (84.2%), cough MESHD cough HP (49.1%), weak (31.6%), muscle ache (17.5%), shortness of breath (12.3%). The distribution of abnormality was a subpleural lesions in 51 cases, with 96.5% ground-glass opacity (GGO) and 68.4% consolidation. Another observation reveals 45.6% fibrosis MESHD, 33.3% lymph node enlargement, 21.1% pleural thickening HP, 17.5% small nodule, 7.0% white lung, 5.3% emphysema MESHD emphysema HP, and 3.5% bronchiectasis MESHD bronchiectasis HP. Importantly, the group of men had more septal thickening and air trapping than the female TRANS group (p < 0.05); Compared with the younger, the elderly TRANS had higher of subpleural lesion, interlobular septal thickening and pleural HP thickening (p < 0.05). In the first monitoring, there were 37.3% improvement, 60.8% progress. In the second monitoring, there were 55% improvement, 35% progress. The improvement rate during the third follow-up visit was 100%. Conclusions: CT features and CT dynamic observation play a vital role in the diagnosis and treatment with NCP. It is conducive to early diagnosis, deepen the knowledge of NCP and accumulate experience.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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