Corpus overview


MeSH Disease

Human Phenotype


    displaying 11 - 20 records in total 43
    records per page

    Clinical Characteristics of COVID-19 and the Value of Mulbsta Scoring System in Prognosis Evaluation

    Authors: Chao Wang; Zhixiu Luo; Junyi Wu; Jie Zhou; Yahang Lin; Guilin Yan; Manman Yan; Xi Wang; Hanhua Yu; Xiaoyun Zeng

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    BackgroundCOVID-19, a worldwideinfectious disease MESHD, has killed more than 420000 people, whichis extremely harmful.MethodsIn this single-center retrospective study, we included the novel coronavirus pneumonia MESHD pneumonia HP confirmed in our hospital. This study collected the basic information andclinical examination features.ResultsThe enrolled 704 patients were affirmed infected with 2019-nCoV by the test of throat swabs. There are 334 men and 369 women, and gender TRANS, age TRANS, combined with basic diseasesare distinct in diverse disease classification (p<0.05). From the symptom analysis, the proportion of fever HP fever MESHD over 38 degrees, dyspnea HP dyspnea MESHD, fatigue HP fatigue MESHD, poor appetite HP and other symptoms is diverse in different types of diseases (p<0.05). As the severity of the disease increases, the median lymphocyte count decreases, C-reactive protein increase, erythrocyte sedimentation rateincrease, albumin decrease, pleural effusion HP pleural effusion MESHD increase, D-Dimer and NT-proBNP increase significantly (p<0.05).As the disease severity increases, the average value of MuLBSTA score obviously ascend (p<0.05), MuLBSTA scoring system predicts novel coronavirus pneumonia MESHD pneumonia HP patients' prognosis is still insufficient, and may require additional indicators including anorexia HP anorexia MESHD, fatigue HP fatigue MESHD, C reactive protein, etc (p<0.05).ConclusionThe MuLBSTA evaluation system has certain value for the evaluation of the disease, but it needs to be improved.

    The Chest CT Features of Coronavirus Disease MESHD 2019 (COVID-19) in China: A Meta-analysis of 19 Trials

    Authors: Haitao Yang; lan yuzhu; Xiujuan Yao; Sheng Lin; Baosong Xie

    doi:10.1101/2020.05.31.20118059 Date: 2020-06-03 Source: medRxiv

    Objective: This study aimed to summarize the characteristics of chest CT imaging in Chinese patients with Coronavirus Disease MESHD 2019 (COVID-19) to provide reliable evidence for further guiding clinical routine. Methods: PubMed, Embase and Web of Science databases were thoroughly searched to identified relevant articles involving the features of chest CT imaging in Chinese patients with COVID-19. All data were analyzed utilizing R software version i386 4.0.0. Random-effects models were employed to calculate pooled mean differences. Results: 19 trials incorporating 1332 cases were included in the study. The results demonstrated that the incidence of ground-glass opacities (GGO) was 0.79, consolidation was 0.34; mixed GGO and consolidation was 0.46; air bronchogram sign was 0.41; crazy paving pattern was 0.32; interlobular septal thickening was 0.55; reticulation was 0.30; bronchial wall thickening was 0.24; vascular enlargement was 0.74. subpleural linear opacity was 0.28; intrathoracic lymph node enlargement was 0.03; pleural effusions HP pleural effusions MESHD was 0.03. The distribution in lung: the incidence of central was 0.05; peripheral was 0.74; peripheral involving central was 0.38; diffuse was 0.19; unifocal involvement was 0.09; multifocal involvement was 0.57; unilateral was 0.16; bilateral was 0.83; The incidence of lobes involved (>2) was 0.70; lobes involved ([less double equals]2) was 0.35. Conclusion: GGO, vascular enlargement MESHD, interlobular septal thickening more frequently occurred in patients with COVID-19. Peripheral, bilateral, involved lobes >2 might be the features of COVID-19 in the distribution aspect. Therefore, based on the aboved features of COVID-19 in chest CT imaging, it might be a promising means for identifying COVID-19.

    Pulmonary Thromboembolic Disease MESHD in Patients with COVID-19 Undergoing Computed Tomography Pulmonary Angiography (CTPA): Incidence and Relationship with Pulmonary Parenchymal Abnormalities MESHD

    Authors: Cheng Fang; Giorgio Garzillo; Bhavna Batohi; James T Teo; Marko Berovic; Paul Sidhu; Hasti Robbie

    doi:10.1101/2020.06.01.20118505 Date: 2020-06-02 Source: medRxiv

    Purpose This study aims to report the incidence, severity and extent of pulmonary thromboembolic disease MESHD ( PTD MESHD) in patients with confirmed COVID-19 who have undergone CT pulmonary angiography (CTPA) in a tertiary centre. Materials and Methods This is a retrospective analysis of all patients undergoing CTPA between 23rd March 2020 and 19th April 2020 in a tertiary centre. The presence of PTD MESHD, location and involved pulmonary lobes MESHD were documented. The pattern and extent of pulmonary parenchymal abnormalities MESHD including the presence of fibrosis MESHD, lymph node enlargement MESHD and pleural effusion HP pleural effusion MESHD were evaluated by two experienced observers independently and consensus was achieved for the most disparate results. Inter-observer agreement was assessed using Kappa statistics. Student t-test, Chi square and Mann-Whitney U tests were used to compare imaging features between PTD MESHD and non- PTD MESHD sub-groups. Results During the study period, 2157 patients were confirmed with COVID-19, 297/2157 (13.8%) had CT imaging, 100/2157 (4.6%) were CTPA studies, 93 studies were analysed, excluding sub-optimal studies. Overall incidence of PTD MESHD was 41/93 (44%) with a third of patients showing segmental and subsegmental PTD MESHD (n=28/93, 30%,). D-dimer was elevated in 90/93 (96.8%) of cases. High Wells score did not differentiate between PE and non-PE groups (p=0.801). The inter-observer agreement was fair (Kappa=0.659) for parenchymal pattern and excellent (Kappa = 0.816) for severity. Lymph node enlargement was found in 34/93 of cases (36.6%) with 29/34 (85.3%) showing no additional source of infection MESHD. Fibrosis MESHD was seen in 16/93 (17.2%) of cases, mainly demonstrating fibrotic organising pneumonia HP pneumonia MESHD. Conclusion There is a high incidence of PTD MESHD in COVID -19 patients undergoing CTPA, complicated by lack of a valid risk stratification tool. Our data indicates a much higher suspicion of PTD MESHD is needed in severe COVID-19 patients. The concomitant presence of fibrotic features on CT indicates the need for follow-up for evaluation of chronic pulmonary complications MESHD.

    Radiologic evaluation of discharge quality in patients with COVID-19

    Authors: Jingwen Li; Xi Long; Fang Fang; Xuefei Lv; Dandan Zhang; Yu Sun; Na Li; Qing Zhang; Xi Fang; Shaoping Hu; Zhicheng Lin; Nian Xiong

    doi:10.21203/ Date: 2020-06-02 Source: ResearchSquare

    Background   Worldwide spread of the novel coronavirus disease MESHD 2019 (COVID-19) has made hundreds of thousands people sick and fortunately many of them have been treated and discharged. However, it remains unclear how well the discharged patients were recovering. Chest CT scan, with demonstrated high sensitivity SERO to COVID-19, was used here to examine clinical manifestations in patients at discharge.Methods This study registered retrospectively single-center case series of 180 discharged patients, all confirmed with COVID-19 at Wuhan Red Cross Hospital in Wuhan, China. Epidemiological, demographic, clinical, laboratory and treatment data were collected. CT imaging features of absorption vs progressive stage were compared and analyzed.Results Five pulmonary lobes were affected in 54 (30%) of the 180 patients at the absorption stage, comparing to 66% of them at the progressive stage (P=1.45×10-11). Forty five (25%) patients had pleural effusion HP pleural effusion MESHD on admission and 13 of them still carried hydrothorax when discharged as per standard discharge criteria(P=4.48×10-6). Besides, compared with those at progressive stage, 97 (54%) discharged patients had interlobular thickening (P=6.95×10-3) and 43% of them still presented adjacent pleura thickening (P=5.58×10-5). The median total CT score of discharged patients at absorption stage was lower than progressive stage (3 vs 12.5 ). The median total CT score recovery rate was 67% (range, 0-100%) and 139 (77%) patients showed less than 90% improvement at discharge.Conclusions A majority (77%) of the discharged patients had not recovered completely. The current discharge criteria may need to include 90% or higher CT score-based recovery rate.Authors Jingwen Li, Xi Long, Fang Fang, and Xuefei Lv contributed equally to this work.Authors Zhicheng Lin and Nian Xiong are joint last coauthors.

    CT features of COVID-19 patients with two consecutive negative RT-PCR tests after treatment

    Authors: Zhao Fu; Ningning Tang; Yanqing Chen; Longbai Ma; Youyong Wei; Yumin Lu; Kun Ye; Hang Liu; Fen Tang; Guangyi Huang; Yingxia Yang; Fan Xu

    doi:10.21203/ Date: 2020-06-02 Source: ResearchSquare

    Purpose: The objective of this study is to expound the CT features of COVID-19 patients whose nucleic acid tests converted to negative after treatment.Materials and Methods: We retrospectively reviewed 46 COVID-19 patients with two consecutive negative RT-PCR tests after treatment. The cases were divided into moderate group and severe/critical group according to disease severity. Clinical and CT scanning data were collected. CT signs of pulmonary lesions MESHD and the score of long involvement were expounded.Results: 39 moderate cases and 7 severe/critical cases were included. All moderate patients showed peripheral lesions while severe/critical cases exhibited both central and peripheral lesions with all lobes involvement. Ground glass opacity (GGO) and mixed GGO were observed. Aberrant pulmonary interstitium manifested as reticular and thin linear pattern. Thickened blood SERO vessels and pleural thickening HP pleural thickening MESHD were found. Pulmonary fibrosis HP Pulmonary fibrosis MESHD, annular thickening of the bronchial wall, bronchiectasis HP, air bronchogram and small amount of bilateral pleural effusion MESHD pleural effusion HP were observed in severe/critical patients. The severe/critical group showed higher CT score of involvement.Conclusions: Pulmonary lesions persisted even after twice consecutive nucleic acid tests converted to negative. We strongly recommended regular follow-up of CT scans after nucleic acid tests conversion. Evaluation of complete remission should base on chest CT.

    Comparing Lung CT in COVID-19 Pneumonia HP and Acute Heart Failure MESHD: An Imaging Conundrum

    Authors: Leonardo Paskah Suciadi; Yonathan William; Patricia Jorizal; Vera Nevyta Tarigan; Andreas Hartanto Santoso; Joshua Henrina; Firman Tedjasukmana; Nathania Marliani Kristanti

    id:10.20944/preprints202005.0483.v1 Date: 2020-05-31 Source:

    Background: Lung CT provides an effective modality to evaluate patients with suspected COVID-19. However, overlapping imaging findings with cardiogenic pulmonary oedema MESHD have been reported. Reports comparing lung CT features of these diseases have not been elaborated. Thus, we aimed to investigate these gaps in the knowledge regarding low-dose lung CT features of patients with COVID-19 pneumonia HP pneumonia MESHD with those with acute heart failure MESHD ( HF MESHD). Methods: This retrospective analysis enrolled hospitalized patients with COVID-19 (n=10) and acute heart failure MESHD (n=9) that exclusively underwent low-dose lung CT scans within 24-hours of admission. Clinical and lung CT characteristics were collected and analysed. Results: Ground-glass-opacities (GGO) appearance has been recorded in all subjects in HF MESHD and COVID-19 group. There was no significant statistical difference between the two groups for rounded morphology, consolidation, crazy paving pattern, lesion distribution, parenchymal band (P> 0.05). However, diffuse lesions were more frequent in HF MESHD cases (55.6% vs. 0%) than in COVID-19 pneumonia HP pneumonia MESHD, which had predominantly multifocal pattern. Notably, CT images in HF MESHD patients were more likely to have signs of interstitial tissue thickening such as the interlobular septums, fissures and peribronchovascular interstitium (55.6% vs 0%, 88.9% vs 20% and 44.4% vs 0%,respectively), as well as cardiomegaly HP cardiomegaly MESHD (77.8% vs 0%), increased artery to bronchus ratio (55.6% vs 0%), and pleural effusions HP pleural effusions MESHD (77.8% vs 0%). Conclusions: Major overlaps of lung CT imaging features existed between COVID-19 pneumonia HP pneumonia MESHD and acute HF MESHD cases. However, signs of fluid redistribution are clues that favour HF over COVID-19 pneumonia HP pneumonia MESHD.

    Single-Cell Analysis Reveals Macrophage-Driven T Cell Dysfunction MESHD in Severe COVID-19 Patients

    Authors: Xiaoqing Liu; Airu Zhu; Jiangping He; Zhao Chen; Longqi Liu; Yuanda Xu; Feng Ye; Huijian Feng; Lin Luo; Baomei Cai; Yuanbang Mai; Lihui Lin; Zhekun Zhang; Sibei Chen; Junjie Shi; Lilan Wen; Yuanjie Wei; Jianfen Zhuo; Yingying Zhao; Fang Li; Xiaoyu Wei; Dingbin Chen; Xinmei Zhang; Na Zhong; Yaling Huang; He Liu; Jinyong Wang; Xun Xu; Jie Wang; Ruchong Chen; Xinwen Chen; Nanshan Zhong; Jinxian Zhao; Yimin Li; Jincun Zhao; Jiekai Chen

    doi:10.1101/2020.05.23.20100024 Date: 2020-05-26 Source: medRxiv

    The vastly spreading COVID-19 pneumonia HP pneumonia MESHD is caused by SARS-CoV-2. Lymphopenia HP Lymphopenia MESHD and cytokine levels are tightly associated with disease severity. However, virus-induced immune dysregulation HP at cellular and molecular levels remains largely undefined. Here, the leukocytes in the pleural effusion HP pleural effusion MESHD, sputum, and peripheral blood SERO biopsies from severe and mild patients were analyzed at single-cell resolution. Drastic T cell hyperactivation accompanying elevated T MESHD cell exhaustion was observed, predominantly in pleural effusion HP pleural effusion MESHD. The mechanistic investigation identified a group of CD14+ monocytes and macrophages highly expressing CD163 and MRC1 in the biopsies from severe patients, suggesting M2 macrophage polarization. These M2-like cells exhibited up-regulated IL10, CCL18, APOE, CSF1 (M-CSF), and CCL2 signaling pathways. Further, SARS-CoV-2-specific T cells were observed in pleural effusion HP pleural effusion MESHD earlier than in peripheral blood SERO. Together, our results suggest that severe SARS-CoV-2 infection MESHD causes immune dysregulation HP dysregulation MESHD by inducing M2 polarization and subsequent T cell exhaustion. This study improves our understanding of COVID-19 pathogenesis.

    Clinical Features of Pregnant Women and Neonates with COVID-19 in Wuhan: a paired comparison study

    Authors: Qin Xie; Quan Gan; Jing Hu; Dong Zhou; Shuhan Cai; Lianjiu Su; Yunxiang Li; Yiming Li; Zhiyong Peng

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background Our study aimed to find symptoms unique in pregnancy and to help the early diagnosis in pregnant women and to evaluate the impact of COVID-19 in postpartum women and their newborns.Methods Clinical data were reviewed and collected for 11 pregnant women with laboratory-confirmed COVID-19 who were consecutively admitted to Zhongnan Hospital of Wuhan University and Women and Children’s Hospital of Hubei Province, from Jan 26 to Feb 26, 2020.Results All the confirmed women didn’t have any exposure history and their early symptoms were mildly elevated temperate and fatigue HP fatigue MESHD. The chest CT scans of confirmed women can be atypical manifestations, such as bilateral pleural effusions MESHD pleural effusions HP and slightly increased densities. Eight of eleven confirmed women did not feel anything unusual until abnormalities were found on chest CT scans on admission screening test. All three groups had elevated white blood SERO cell count, neutrophil count and lactate dehydrogenase, and reduced total protein.The infection did not increase the risk for premature delivery, premature rupture of membrane HP, or comorbidities in pregnancy.Conclusions Pregnant women were often asymptomatic TRANS and accidentally detected abnormalities MESHD on chest CT scan on admission which emphasize the importance of CT scan in prevalent areas of the COVID-19. Even after the laboratory confirmation, the manifestation of the CT scan could be atypical, which alerted the necessity of protection for healthcare workers. The COVID-19 did not increase the risk of complications in pregnant women and their neonates.Trial registration: This case series was approved by the institutional ethics board of Zhongnan Hospital of Wuhan University (No. 2020020) and Women and Children’s Hospital of Hubei Province(NO. LW035).

    Lung ultrasound findings in patients with novel SARS-CoV2

    Authors: Mark Evert Haaksma; Micah L.A. Heldeweg; Jorge E. Lopez Matta; Jasper Martijn Smit; Jessica D. van Trigt; Jip Suzanne Nooitgedacht; Carlos V. Elzo Kraemer; Armand R.J. Girbes; Leo M.A. Heunks; David J. van Westerloo; Pieter R. Tuinman

    doi:10.1101/2020.05.18.20105775 Date: 2020-05-21 Source: medRxiv

    Background: Over 2 million people worldwide have been infected with Severe Acute Respiratory Distress Syndrome Corona Virus 2 MESHD Respiratory Distress HP Syndrome Corona Virus 2 ( SARS CoV2 MESHD). Lung ultrasound has been proposed to diagnose and it. However, little is known about ultrasound findings in these patients. Our aim is to present an overview of lung ultrasound characteristics in critically ill patients with SARS CoV2 pneumonia HP pneumonia MESHD overall and in relation to the duration of symptoms and clinical parameters. Methods: On the Intensive Care Unit of two academic hospitals, adult TRANS patients who tested positive for SARS-CoV2 were included. Images were analyzed for pleural MESHD line characteristics, number and appearance of B-lines, BLUE-profiles (Bedside Lung Ultrasound in Emergency), pathology in the PLAPS (Postero Lateral Alveolar MESHD and Pleural Syndrome MESHD) point and a LUS-score (lung ultrasound). The primary outcomes were frequencies, percentages and differences in lung ultrasound findings overall and between short ([≤]14 days) and long (>14 days) duration of symptoms and their correlation with clinical parameters. Results: In this pilot observational study, 61 patients were included with 75 examinations for analysis. The most prevalent ultrasound findings were decreased lung sliding (36%), thickening of the pleural HP pleural MESHD line (42%) and a C-profile per view (37%). Patients with ''long'' duration of symptoms presented more frequently with a thickened and irregular pleural MESHD line (21% (32) vs 9% (11), p=.01), C-profile per patient (47% (18) vs. 25% (8),p=.01) and pleural effusion HP pleural effusion MESHD (19% (14) vs 5% (3),p=.02) compared to patients with short duration of symptoms. Lung ultrasound findings did not correlate with P/F ratio, fluid balance or dynamic compliance, with the exception of the LUS-score and dynamic compliance (R2=0.27, p=.02). Conclusion: SARS CoV2 results in significant ultrasound changes, with decreased lung sliding, thickening of the pleural HP pleural MESHD line and a C-profile being the most observed. With time, a thickened and irregular pleural MESHD line, C-profile and pleural effusion HP pleural effusion MESHD become more common findings.

    Comparison of initial thin-section CT features in coronavirus disease MESHD 2019 pneumonia HP pneumonia MESHD and other community-acquired pneumonia HP pneumonia MESHD

    Authors: Qiao Zhu; Cui Ren; Xiao Hua Wang

    doi:10.21203/ Date: 2020-05-19 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) pneumonia HP pneumonia MESHD caused similar symptoms to other community-acquired pneumonia HP pneumonia MESHD (CAP). It is important to early quarantine suspected patients with COVID-19 pneumonia HP pneumonia MESHD from patients with other CAP to reduce cross infection MESHD. The purpose of the study is to review and compare initial thin-section computed tomography (CT) features in patients with coronavirus disease MESHD 2019 (COVID-19) pneumonia HP pneumonia MESHD and other community-acquired pneumonia HP pneumonia MESHD (CAP). Methods 24 cases of COVID-19 pneumonia HP pneumonia MESHD (14 males TRANS and 10 females TRANS; age TRANS range, 14-87 years; mean age TRANS, 48.0 years) and 28 cases of CAP caused by other pathogens (13 males TRANS and 15 females TRANS; age TRANS range, 24-85 years; mean age TRANS, 49.5 years) were included. Thin-section CT features of the lungs for all patients were retrospectively reviewed by two independent radiologists. Results There were no significant differences for the shape of main lesions, pure ground glass attenuation (GGA), mixed GGA with consolidation, air bronchogram, linear opacities, halo sign/reversed halo sign, cavitation and lymphadenopathy HP lymphadenopathy MESHD between the group of COVID-19 pneumonia HP pneumonia MESHD and the group of other CAP. However, the frequency of crazy-paving appearance, vessel dilatation HP, bilaterally involvement and peripherally distribution were significantly higher in patients with COVID-19 compared with other CAP ( p =0.031, p =0.000, p =0.029 and p =0.009, respectively). Conversely, the frequencies of pure consolidation, tree-in-bud sign and pleural effusion HP pleural effusion MESHD were significantly higher in patients with CAP than in patients with COVID-19 pneumonia HP pneumonia MESHD ( p =0.002, p =0.000 and p =0.048, respectively). Conclusion There are considerable overlaps in thin-section CT features between COVID-19 pneumonia HP pneumonia MESHD and other CAP. However, the presence of crazy paving pattern, vessel dilation, bilateral involvement and peripheral distribution contributes to the diagnosis of COVID-19 pneumonia HP pneumonia MESHD. While the presence of pure consolidation tree-in-bud sign, pleural effusion HP pleural effusion MESHD can be assisting in exclusive the diagnosis of COVID-19 pneumonia HP pneumonia MESHD.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.



MeSH Disease
Human Phenotype

Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.