Corpus overview


MeSH Disease

Human Phenotype


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    Authors: Michele Gaeta; Giuseppe Cicero; Maria Adele Marino; Tommaso D'Angelo; Enrico Maria Mormina; Silvio Mazziotti; Alfredo Blandino; Giulio Siracusano; Aurelio La Corte; Massimo Chiappini; Giovanni Finocchio

    doi:10.1101/2020.04.16.20061044 Date: 2020-04-17 Source: medRxiv

    Background CT is a very sensitive technique to detect pneumonia HP pneumonia MESHD in COVID-19 patients. However, it is impaired by high costs, logistic issues and high risk of exposure. Chest x-ray (CXR) is a low-cost, low-risk, not time consuming technique and is emerging as the recommended imaging modality to use in COVID-19 pandemic. This technique, although less sensitive than CT-scan, can provide useful information about pulmonary involvement. Purpose To describe chest x-ray features of COVID-19 pneumonia HP pneumonia MESHD and to evaluate the sensitivity SERO of this technique in detecting pneumonia HP pneumonia MESHD. A further scope is to assess the effectiveness of a post-processing algorithm in improving lung lesions detectability MESHD. Materials and Methods 72 patients with laboratory-confirmed COVID-19 underwent bedside chest X-ray. Two radiologists were asked to express their opinion about: (i) presence of pneumonia HP pneumonia MESHD (negative or positive); (ii) localization (unilateral or bilateral); (iii) topography (according to pulmonary fields); (iv) density (non consolidative ground-glass or inhomogeneous opacities; consolidative nodulartype or triangular; mixed consolidative e non-consolidative); and (v) presence of pleural effusion HP pleural effusion MESHD. The point (i) was evaluated separately, while the other points in consensus. A quality assessment of post-processed x-ray images was performed by two different readers. Results The agreement about presence of pneumonia HP pneumonia MESHD was almost perfect with K value of 0.933 and p < 0.001. Sensitivity SERO was 69%. The following findings were seen: unilateral lung involvement in 50%; lower lung lesions MESHD in 54%; peripheral distribution in 48%; and non-consolidative pattern in 44%. Post-processed images improved the detection of lesions in 7 out 72 patients ({cong}10%) Conclusion CXR owns a good sensitivity SERO in detecting COVID-19 lung involvement. Use of post-processing algorithm can improve detection of lesions. Our data support recommendations of the Radiological Society of North America (RSNA) to consider chest x-ray as first step imaging examination in Covid-19 patients.

    Coronavirus Disease MESHD 2019 (COVID-19) in Children TRANS: A Systematic Review of Imaging Findings

    Authors: Susan C Shelmerdine; Jovan Lovrenski; Pablo Caro-Domínguez; Seema Toso; Collaborators of the European Society of Paediatric Radiology cardiothoracic imaging taskforce

    doi:10.21203/ Date: 2020-04-08 Source: ResearchSquare

    Background:Covid-19, a novel coronavirus infection MESHD which can cause a severe respiratory illness MESHD, has been declared a pandemic by the World Health Organisation (WHO). As children TRANS appear less severely affected than adults TRANS, their imaging appearances are not extensively reported.Objectives:To systematically review available literature regarding imaging findings in paediatric cases of Covid-19.Materials and Methods:Four databases (Medline, Embase, Cochrane, Google Scholar) were searched for articles describing imaging findings in children TRANS with Covid-19. All modalities, age <18 years and foreign language articles were included. Descriptive statistics were used to identify pattern, location of imaging findings and association with outcomes.Results:Twenty two articles were included, reporting chest imaging findings in 382 children TRANS, of which 372 (97.4%) underwent CT. Criteria for imaging was lacking. At diagnosis, 120/372 (32.3%) had a normal CT. Abnormalities MESHD were more common in the lower lobes and predominantly unilateral. The most common imaging pattern was ground glass opacification (136/246, 55.3%). None of the studies described lymphadenopathy HP lymphadenopathy MESHD, while pleural effusions HP pleural effusions MESHD (2/246, 0.8%) were rare. Improvement at follow-up CT imaging, (3 – 15 days later) was seen in 27/91 (29.7%), remained normal in 23/91 (25.3%) and progressed in 11/91 (12.1%).Conclusions:CT chest findings in children TRANS with Covid-19 are frequently normal or mild. Lower lobes are predominantly affected by patchy ground glass opacification. Appearances at follow-up remain normal or improve in the majority of children TRANS. Chest CT imaging adds little to the further management of the patient and should be reserved for severe cases or identifying alternative diagnoses.This study was registered in PROSPERO, an international prospective register of systematic reviews (Registration ID: CRD42020175945

    Chest CT imaging characteristics of COVID-19 pneumonia HP pneumonia MESHD in preschool children TRANS: a retrospective study

    Authors: Yang Li; Jianghui Cao; Xiaolong Zhang; Guangzhi Liu; Xiaxia Wu; Baolin Wu

    doi:10.21203/ Date: 2020-04-07 Source: ResearchSquare

    Background: Recently, the World Health Organization has declared the coronavirus disease MESHD 2019 (COVID-19) outbreak a public health emergency of international concern. So far, however, limited data are available for children TRANS. Therefore, we aimed to investigate the clinical and chest CT imaging characteristics of COVID-19 in preschool children TRANS.Methods: From January 26, 2020 to February 20, 2020, the clinical and initial chest CT imaging data of eight preschool children TRANS with laboratory-confirmed COVID-19 from two hospitals were retrospectively collected. The chest CT imaging characteristics, including the distribution, shape, and density of lesions, and the pleural effusion HP pleural effusion MESHD, pleural changes, and enlarged lymph nodes were evaluated. Results: Two cases (25%) were classified as mild type, and they showed no obvious abnormal CT findings or minimal pleural thickening HP pleural thickening MESHD on the right side. Five cases (62.5%) were classified as moderate type. Among these patients, one case showed consolidation located in the subpleural region of the right upper lobe, with thickening in the adjacent pleura; one case showed multiple consolidation and ground-glass opacities with blurry margins; one case displayed bronchial pneumonia HP pneumonia MESHD-like changes in the left upper lobe; and two cases displayed asthmatic bronchitis HP bronchitis MESHD-like changes. One case (12.5%) was classified as critical type and showed bronchial pneumonia MESHD pneumonia HP-like changes in the bilateral lungs, presenting blurred and messy bilateral lung markings MESHD and multiple patchy shadows scattered along the lung markings with blurry margins.Conclusions: The chest CT findings of COVID-19 in preschool children TRANS are atypical and various. Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data. 

    A Systematic Meta-Analysis of CT Features of COVID-19: Lessons from Radiology

    Authors: Vasantha Kumar Venugopal; Vidur Mahajan; Sriram Rajan; Vikash Kumar Agarwal; Ruchika Rajan; Salsabeel Syed; Harsh Mahajan

    doi:10.1101/2020.04.04.20052241 Date: 2020-04-07 Source: medRxiv

    Several studies have been published in the past few months describing the CT features of Coronavirus Disease MESHD 2019 (COVID-19). There is a great degree of heterogeneity in the study designs, lesion descriptors used and conclusions derived. In our systematic analysis and meta-review, we have attempted to homogenize the reported features and provide a comprehensive view of the disease pattern and progression in different clinical stages. After an extensive literature search, we short-listed and reviewed 49 studies including over 4145 patients with 3615 RT-PCR positive cases of COVID-19 disease. We have found that there is a good agreement among these studies that diffuse bilateral ground-glass opacities (GGOs) is the most common finding at all stages of the disease followed by consolidations and mixed density lesions. 78% of patients with RT-PCR confirmed COVID-19 infections had either ground-glass opacities, consolidation or both. Inter-lobular septal thickening was also found to be a common feature in many patients in advanced stages. The progression of these initial patchy ground-glass opacities and consolidations to diffuse lesions with septal thickening, air bronchograms in the advanced stages, to either diffuse white-out lungs needing ICU admissions or finally resolving completely without or with residual fibrotic strips was also found to be congruent among multiple studies. Prominent juxta-lesional pulmonary vessels, pleural effusion HP pleural effusion MESHD and lymphadenopathy HP lymphadenopathy MESHD in RT-PCR proven cases were found to have poor clinical prognosis. Additionally, we noted wide variation in terminology used to describe lesions across studies and suggest the use of standardized lexicons to describe findings related to diseases of vital importance.

    A Mini Review on Current Clinical and Research Findings for Children TRANS Suffering from COVID-19

    Authors: Xiao Li; Kun Qian; Ling-ling Xie; Xiu-juan Li; Min Cheng; Li Jiang; Bjoern W. Schuller

    doi:10.1101/2020.03.30.20044545 Date: 2020-04-04 Source: medRxiv

    Background: As the novel coronavirus triggering COVID-19 has broken out in Wuhan, China and spread rapidly worldwide, it threatens the lives of thousands of people and poses a global threat on the economies of the entire world. However, infection MESHD with COVID-19 is currently rare in children TRANS. Objective To discuss the latest findings and research focus on the basis of characteristics of children TRANS confirmed with COVID-19, and provide an insight into the future treatment and research direction. Methods: We searched the terms "COVID-19 OR coronavirus OR SARS-CoV-2" MESHD AND "Pediatric OR children TRANS" on PubMed, Embase, Cochrane library, NIH, CDC, and CNKI. The authors also reviewed the guidelines published on Chinese CDC and Chinese NHC. Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. Conclusion: The numbers of children TRANS with COVID-19 pneumonia HP pneumonia MESHD infection are small, and most of them come from family aggregation. Symptoms are mainly mild or even asymptomatic TRANS, which allow children TRANS to be a risk factor for transmission TRANS. Thus, strict epidemiological history screening is needed for early diagnosis and segregation. This holds especially for infants, who are more susceptible to infection MESHD than other age groups TRANS in pediatric age TRANS, but have most likely subtle and unspecific symptoms. They need to be paid more attention to. CT examination is a necessity for screening the suspected cases, because most of the pediatric patients are mild cases, and plain chest X-ray do not usually show the lesions or the detailed features. Therefore, early chest CT examination combined with pathogenic detection is a recommended clinical diagnosis scheme in children TRANS. The risk factors which may suggest severe or critical progress for children TRANS are: Fast respiratory rate and/or; lethargy HP and drowsiness HP mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion HP pleural effusion MESHD or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. For those critical pediatric patients with positive SARS-CoV-2 diagnosis, polypnea may be the most common symptom. For treatment, the elevated PCT seen in children TRANS in contrast to adults TRANS suggests that the underlying coinfection/ secondary infection MESHD may be more common in pediatric patients and appropriate antibacterial treatment should be considered. Once cytokine storm is found in these patients, anti-autoimmune or blood SERO-purifying therapy should be given in time. Furthermore, effective isolation measures and appropriate psychological comfort need to be provided timely.

    Clinical and Imaging features in COVID-19 Patients: Analysis of Data from Patients in Non-pandemic areas

    Authors: Shengkun Peng; Lingai Pan; Shaojin Zhang; Yalong Liu; Hua Zhang; Liming Tan; Yang Guo; Xiaobo Huang; Jie Zeng; Hong Pu

    doi:10.21203/ Date: 2020-04-04 Source: ResearchSquare

    Purpose To describe the imaging characteristics in COVID-19 Patients from non-pandemic regions to improve understanding of the disease. Methods We reviewed chest CT scans of 30 COVID-19 patients from three hospitals in Sichuan province, China. Results Typical CT manifestations include the involvement of multiple lobes, mostly in the peripheral zone of the lungs, and subpleural distribution. GGO, crazy paving or mixed GGO and consolidation is the most common signs. Few patients can present small amount of pleural effusion HP pleural effusion MESHD. It is worth noting that none of the lung cavities, tree buds, and lymphadenopathy HP lymphadenopathy MESHD appeared. The follow-up imaging findings of some patients showed progress when the initial CT score reached 7. Conclusion The CT scan still play an important role in screening the COVID-19, most of the images present positive signs, mainly subpleural, multiple GGO. CT might can predict the severity or whether the patient will progress to severe illness. A small number of patients may be missed if they are based on CT findings alone, which should be closely combined with the patient's epidemiological history and nucleic acid test.

    In-flight Transmission TRANS Cluster of COVID-19: A Retrospective Case Series

    Authors: Naibin Yang; Yuefei Shen; Chunwei Shi; Ada Hoi Yan Ma; Xie Zhang; Xiaomin Jian; Liping Wang; Jiejun Shi; Chunyang Wu; Guoxiang Li; Yuan Fu; Keyin Wang; Mingqin Lu; Guoqing Qian

    doi:10.1101/2020.03.28.20040097 Date: 2020-03-30 Source: medRxiv

    Objectives: No data were available about in-flight transmission TRANS of SARS-CoV-2. Here, we report an in-flight transmission TRANS cluster of COVID-19 and describe the clinical characteristics of these patients. Methods: After a flight, laboratory-confirmed COVID-19 was reported in 12 patients. Ten patients were admitted to the designated hospital. Data were collected from 25th January to 28th February 2020. Clinical information was retrospectively collected. Results: All patients are passengers without flight attendants. The median age TRANS was 33 years, and 70% were females TRANS. None was admitted to intensive care unit, and no patients succumbed through 28th February. The median incubation period TRANS was 3.0 days and from illness onset to hospital admission was 2 days. The most common symptom was fever HP fever MESHD. Two patients were asymptomatic TRANS and negative for chest CT scan throughout the disease course. On admission, initial RT-PCR were positive in 9 patients, however initial chest CT were positive in only half patients. The median lung total severity score of chest CT was 6. Notably, Crazy-Paving pattern, pleural effusion HP pleural effusion MESHD, and ground-glass nodules were also seen. Conclusion: It is potential for COVID-19 transmission TRANS by airplane, but the symptoms are mild. Passengers and attendants must be protected during the flight.

    Early CT manifestations and short-term evolution of coronavirus disease-2019

    Authors: Wei Wei; Wen Xiao Hu; Fu Wei Lv

    doi:10.21203/ Date: 2020-03-24 Source: ResearchSquare

    Objectives: This study explored the features of coronavirus disease-2019 (COVID-19) with the aim of improving clinical diagnosis.Methods: We retrospectively analyzed the clinical and CT data of 85 patients with COVID-19 who were diagnosed between January 20, 2020 and February 20, 2020. The imaging findings, clinical and laboratory data were evaluated.Results: Of the 85 patients, five had mild symptoms, 60 had moderate symptoms, and 20 had severe symptoms. Sixty-nine patients had direct or indirect contact history, while 16 patients (19%) had no obvious epidemiological history. Eighty-five patients had prominent respiratory symptoms, while 70 patients (82%) had moderate to low fever MESHD fever HP. There were no obvious lung abnormalities MESHD in CT images of patients with mild symptoms. Common chest CT manifestations in patients with moderate or severe symptoms were ground glass opacity (GGO) (16%); GGO combined with grid (39%) or consolidation (32%); and air bronchogram sign (13%). In these patients, lesions were mostly distributed in the lower lobes of the lungs, and most were located in the periphery; pleural effusion HP pleural effusion MESHD was rare. Within 3 days after onset, GGO (23%) and GGO combined with grid (45%) were the most common manifestations in CT images; GGO combined with grid (35%) and/or consolidation (41%) were the main manifestations in CT images at 5–10 days after onset.Conclusions: Common CT manifestations of COVID-19 were GGO alone and GGO combined with grid and/or consolidation. Short-term increases in ranges of lesions or consolidation areas may indicate disease aggravation.

    Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection MESHD during late pregnancy: A Report of 18 patients from Wuhan, China

    Authors: Lu Zhang; Lan Dong; Lei Ming; Min Wei; Jun Li; Ruheng Hu; Jing Yang

    doi:10.21203/ Date: 2020-03-20 Source: ResearchSquare

    Background: Compared with Severe Acute Respiratory Syndrome MESHD(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease MESHD 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hoped to provide some references for obstetric treatment and management.Methods: A total of 18 patients with COVID-19 treated in Renmin Hospital of Wuhan University were collected. The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis.Results: 1. 18 cases of late pregnancy infected with SARS-CoV-2 pneumonia MESHD pneumonia HP were delivered at 35 + 5 weeks to 41 weeks. According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. 2. According to Imaging examinations: 15 (83%) cases showed unilateral or bilateral pneumonia HP pneumonia MESHD, 2 (11%) cases had pulmonary infection MESHD with pleural effusion HP pleural effusion MESHD, and 1 (6%) case had no abnormal imaging changes. 8 (44%) cases were positive and 10 (56%) cases were negative for nasopharyngeal-swab tests of SARS-CoV-2. 3. Among the 18 newborns, there were 3 (17%) premature infants, 1 (6%) case of mild asphyxia MESHD, 5 (28%) cases of bacterial pneumonia MESHD pneumonia HP, 1 (6%) case of gastrointestinal bleeding MESHD, 1 (6%) case of necrotizing enteritis MESHD, 2 (11%) cases of hyperbilirubinemia HP hyperbilirubinemia MESHD and 1 (6%) case of diarrhea HP diarrhea MESHD. All the newborns were negative for the first throat swab test of SARS-CoV-2 after birth. 4. Follow-up to Mar 7, 2020, no maternal and neonatal deaths MESHD occurred.Conclusions: The majority of patients in late term pregnancy with COVID-19 were of ordinary type, and they less likely developed into critical pneumonia HP pneumonia MESHD after early isolation and antiviral treatment. Vertical transmission TRANS of SARS-CoV-2 was not detected, but the proportion of neonatal bacterial pneumonia MESHD pneumonia HP was higher than other neonatal diseases in newborns.

    The added value of chest high-resolution CT findings of Corona Virus Disease MESHD 2019 in predicting severity of disease

    Authors: Jie Zhou; Jie Cao; Ziyun Xiang; Hanshou Cai; Yuhui Zhu; Heng Zhang; Xu Huang; Wanling Ma

    doi:10.21203/ Date: 2020-03-16 Source: ResearchSquare

    The aim of this study was to retrospectively analyze chest thin-section high-resolution CT (HRCT) findings for 32 patients with Corona Virus Disease MESHD 2019 (COVID-19) and clarify the correlation between CT data and laboratory results. 30 patients presented with abnormal initial CT scans. Of 30 patients, COVID-19 showed the involvement of bilateral lungs in 24 (80%), involvement of more than two lobes in 24 (80%), ground-glass opacities without consolidation in 27 (90%), ground-glass opacities with consolidation in 23 (76.7%), opacities with irregular intralobular lines in 26 (86.7%), opacities with round morphology in 25 (83.3%), and peripheral distribution in 30 (100%). Pleural effusion HP Pleural effusion MESHD or mediastinal lymphadenopathy MESHD was relatively rare manifestations. Rapidly progression of the disease demonstrated by increasing number and range of ground glass opacities and appearance of consolidations at follow-up CT images in two patients. The CT lung severity score and No. of lobes involved were negatively correlated with lymphocyte count(r=-0.363, P=0.041; r=-0.367, P=0.039, respectively). Chest HRCT of COVID-19 predominantly manifests multiple, round, ground glass opacities with irregular intralobular lines, and peripheral distribution of bilateral lungs. HRCT is a potential tool for early screening, assessing progress, and predicting disease severity of COVID-19.Authors Jie Zhou and Jie Cao contributed equally to this work and are co-first authors.

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MeSH Disease
Human Phenotype

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