Corpus overview


MeSH Disease

Headache (53)

Cough (35)

Fever (33)

Disease (29)

Infections (27)

Human Phenotype

Headache (53)

Cough (35)

Fever (33)

Fatigue (23)

Myalgia (15)


    displaying 1 - 10 records in total 53
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    Blood SERO biomarkers for assessing headaches MESHD headaches HP in healthcare workers after wearing biological personal protective equipment in a COVID-19 field-hospital

    Authors: Francisco Martín-Rodríguez; Raquel M. Portillo Rubiales; Laura N. Fadrique Millán; Virginia Carbajosa Rodríguez; Ancor Sanz-García; Gabino Mozo Herrera; Guillermo J. Ortega; Esther Durá Ballester; Miguel Ángel Castro Villamor; Raúl López Izquierdo

    doi:10.21203/ Date: 2020-08-07 Source: ResearchSquare

    The consequences of wearing biosafety equipment by healthcare professionals during their work and the prediction of such consequences need to be assessed. To analyze the role played by different blood SERO biomarkers in predicting the appearance of headaches MESHD headaches HP in healthcare workers wearing personal protective equipment (PPE) in a COVID-19 treatment unit, a Prospective cohort study of 38 healthcare workers from a convalescence MESHD unit of patients with COVID-19 in a field hospital was performed during April 2020. Blood SERO analysis was carried out before the start of the 4 hours shift of the volunteers equipped with PPE. After decontamination, there were asked if they had suffered from headache MESHD headache HP, obtaining the binary outcome. This study included 38 participants with a median age TRANS of 29 years (25th-75th percentile: 26-44 years old), 73.7% female TRANS (28 cases). 44.7% (17 cases) had a headache MESHD headache HP after wearing PPE for 4 hours. The baseline creatinine value reflected a specific odds ratio in the regression model of 241.36 (95% CI: 2.50-23,295.43; p=0.019), and an AUC of 0.737 (95%CI: 0.57-0.90; p<0.01). Blood SERO creatinine is a good candidate for predicting the appearance of a de novo headache MESHD headache HP in healthcare workers after wearing PPE for 4 hours in a COVID – 19 unit.

    Associations between personal protective equipment and nursing staff stress during the COVID-19 pandemic

    Authors: Manuela Hoedl; Doris Eglseer; Silvia Bauer

    doi:10.1101/2020.08.06.20164129 Date: 2020-08-07 Source: medRxiv

    Background: The results of several projects on the effects of personal protective equipment (PPE) have been published since the outbreak of COVID-19. It is known that wearing PPE, and specifically face masks, has physcial consequences like headache MESHD headache HP and pain MESHD pain HP, which can increase stress among nursing staff. However, none of these studies placed a focus on PPE and nursing staff, although nurses are the only members of the health care profession who are at the patients bedsides 24/7, and PPE is the only way to protect them from a COVID-19 infection MESHD. Therefore, this study was carried out to investigate the association between the use of PPE and stress among nursing staff during the COVID-19 pandemic. Methods An online, cross-sectional survey was conducted, which we distributed using snowball sampling techniques. The questionnaire was developed on the basis of (inter-)national recommendations as well as the international literature. We used the perceived level of stress scale to measure the nursing staff members stress levels. Results We included data collected from 2600 nurses in this analysis. Nearly all nursing staff wore face masks. We showed that more than two-thirds of the nurses had moderate to high levels of stress. No statistically significant association between the use of PPE and stress was detected. However, we show a statistically significant association between the duration of mask usage and stress. Discussion and conclusions Nearly all participating nurses wore face masks or FFP masks to protect themselves from COVID-19 infection MESHD. This observation might indicate that Austrian nurses display a high level of compliance with national and international regulations and play a key role in such pandemics. Our results also show that increased mask-wearing time led to increased stress levels. These results suggest that (inter-)national regulations on how and when to use PPE should include a maximum duration of time for wearing each type of mask. Such regulations could help to prevent work-related stress, particularly in the case of future epidemics, and avoid burnout among nursing staff or even nurses leaving their jobs. The consequences of both of these negative outcomes should be considered in light of the predicted expected future shortage of health care workers.

    Ontology-based annotation and analysis of COVID-19 phenotypes

    Authors: Yang Wang; Fengwei Zhang; Hong Yu; Xianwei Ye; Yongqun He

    id:2008.02241v1 Date: 2020-08-05 Source: arXiv

    The epidemic of COVID-19 has caused an unpredictable and devastated disaster to the public health in different territories around the world. Common phenotypes include fever MESHD fever HP, cough MESHD cough HP, shortness of breath, and chills MESHD chills HP. With more cases investigated, other clinical phenotypes are gradually recognized, for example, loss of smell, and loss of tastes. Compared with discharged or cured patients, severe or died patients often have one or more comorbidities, such as hypertension MESHD hypertension HP, diabetes, and cardiovascular disease MESHD. In this study, we systematically collected and analyzed COVID-19-related clinical phenotypes from 70 articles. The commonly occurring 17 phenotypes were classified into different groups based on the Human Phenotype Ontology (HPO). Based on the HP classification, we systematically analyze three nervous phenotypes (loss of smell, loss of taste, and headache MESHD headache HP) and four abdominal phenotypes ( nausea MESHD nausea, vomiting HP, vomiting MESHD, abdominal pain MESHD abdominal pain HP, and diarrhea MESHD diarrhea HP) identified in patients, and found that patients from Europe and USA turned to have higher nervous phenotypes and abdominal phenotypes than patients from Asia. A total of 23 comorbidities were found to commonly exist among COVID-19 patients. Patients with these comorbidities such as diabetes and kidney failure had worse outcomes compared with those without these comorbidities.

    Diplopia MESHD Diplopia HP from abducens nerve paresis MESHD as a presenting symptom of COVID-19: a case report and review of literature

    Authors: Geulah Sarah Ben-David; Orly Halachmi-Eyal; Hana Shyriaiev; Shay Brikman; Guy Dori; Daniel Briscoe

    doi:10.21203/ Date: 2020-08-04 Source: ResearchSquare

    Neurological manifestations of COVID-19 are not well understood. We report a case of a 44-year-old man who presented with fever MESHD fever HP, double vision, and headache MESHD headache HP and was subsequently diagnosed with COVID-19 and transient abducens nerve paresis MESHD. He did not present with any respiratory symptoms or additional specific neurological findings. We suggest that as the number of cases rises worldwide, physicians should have a greater index of suspicion for COVID-19 in patients with cranial neuropathies even in mild cases without typical respiratory symptoms.

    Massive cerebral venous thrombosis HP venous thrombosis MESHD related to oligosymptomatic COVID-19 infection MESHD: a case report

    Authors: Simone Beretta; Fulvio Da Re; Valentina Francioni; Paolo Remida; Benedetta Storti; Lorenzo Fumagalli; Maria Luisa Piatti; Patrizia Santoro; Diletta Cereda; Claudia Cutellè; Fiammetta Pirro; Danilo Antonio Montisano; Francesca Beretta; Francesco Pasini; Annalisa Cavallero; Ildebrando Appollonio; Carlo Ferrarese

    doi:10.21203/ Date: 2020-07-27 Source: ResearchSquare

    Background: The development of thrombotic coagulopathy is frequent in COVID-19 patients, but the timing after infection MESHD, cerebral venous system involvement, treatment and outcome are uncertain.Case Presentation: We report a case of massive cerebral venous thrombosis HP venous thrombosis MESHD occurring in the late phase of COVID-19 infection MESHD. Mild respiratory symptoms, without fever MESHD fever HP, started three weeks before headache MESHD headache HP and acute neurological deficits. She had no dyspnea MESHD dyspnea HP, although she was hypoxic and with typical COVID-19 associated interstitial pneumonia MESHD pneumonia HP. Brain CT scan showed a left parietal hypodense lesion with associated sulcal subarachnoid haemorrhage. CT angiography showed a massive cerebral vein thrombosis MESHD. An asymptomatic TRANS concomitant right internal iliac vein thrombosis MESHD was found. Both cerebral venous thrombosis HP venous thrombosis MESHD and deep venous thrombosis HP venous thrombosis MESHD were effectively treated with unfractionated heparin started on the day of admission, then shifted to low molecular weight heparin, with a favorable clinical course. Nasopharyngel swab, repeated twice, tested negative for SARS-CoV-2. Serological tests SERO confirmed SARS-CoV-2 infection MESHD. Conclusions: Our case supports active surveillance and prevention of thrombotic complications associated with COVID-19, which may affect both peripheral and cerebral venous system. Early initiation of unfractionated heparin may lead to good neurological outcome.

    Aneurysmal Subarachnoid Haemorrhage After COVID-19 Infection MESHD

    Authors: Sajjad Muhammad; Soheil Naderi; Mostafa Ahmadi; Askar Ghorbani; Daniel Hänggi

    doi:10.21203/ Date: 2020-07-24 Source: ResearchSquare

    BackgroundSARS-CoV-2 virus infection MESHD leads to a severe and dysbalanced inflammatory response with hypercytokinemia and immunodepression. Systemic inflammation MESHD due to viral infections MESHD can potentially cause vascular damage including disruption of blood SERO-brain barrier (BBB) and alterations in coagulation system that may also lead to cardiovascular and neurovascular events. Here, we report the first case of COVID-19 infection MESHD leading to aneurysmal subarachnoid haemorrhage (aSAH). Case DescriptionA 61-year-old woman presented with dyspnea MESHD dyspnea HP, cough MESHD cough HP and fever MESHD fever HP. She was over weight with Body MESHD mass-index of 34 and history of hypertension MESHD hypertension HP. No history of subarachnoid hemorrhage MESHD subarachnoid hemorrhage HP in the family. She was admitted in ICU due to low oxygen saturation (89%). A chest CT showed typical picture of COVID-19 pneumonia MESHD pneumonia HP. Oropharyngeal swab with a PCR-based testing was COVID-19 positive. She was prescribed with favipiravir and hydroxychloroquine in Addition to oxygen support. On second day she experienced sudden headache MESHD headache HP and losst conciousness. A computer tomography (CT) with CT-angiography revealed subarachnoid haemorrhage in basal cisterns from a ruptured MESHD anterior communicating artery aneurysm MESHD. The aneurysm MESHD was clipped microsurgically through a standard pterional approach and the patient was admitted again to intensive care unit for further intensive medical treatment. Post-operative the patient showed slight motor dysphasia HP. No other neurological deficits.ConclusionAneurysmal subarachnoid haemorrhage secondary to COVID-19 infection MESHD might be triggered by systemic inflammation MESHD. COVID-19 infection MESHD could be one of the risk factors leading to instability and rupture MESHD of intracranial aneurysm MESHD.

    Clinical Characteristics of 2019 Novel Coronavirus Pneumonia MESHD Pneumonia HP in China: A Systematic Review and Meta-analysis

    Authors: Kai Qian; Guo-Ping Wang; Hao Peng; Jun Peng; Hong-Zhong Cheng; Yi Deng; Jun Liu

    doi:10.21203/ Date: 2020-07-17 Source: ResearchSquare

    Background Although novel pneumonia MESHD pneumonia HP associated with the Corona Virus Disease MESHD 2019 (COVID-19) suddenly broke out in China, China has controlled this epidemic effectively. Therefore, evidence-based descriptions of medical and clinical characteristics in China are necessary.Methods Literatures have been systematically performed a search on PubMed, Embase, Web of Science, GreyNet International, and The Cochrane Library from inception up to March 15, 2020. Quality of evidence was evaluated according to the STROBE checklist, and publication bias was analyzed by Egger’s test. In the single-arm meta-analysis, A random-effects model was used to obtain a pooled incidence rate. We conducted subgroup analysis according to geographic region and research scale.Results A total of 30 Chinese studies and 1969 patients were included in this meta-analysis. The valid pooled incidence rates of symptoms were as follows: rhinorrhea HP 5.1% (95% CI: 3.7–6.8, I2 = 31.90), diarrhea MESHD diarrhea HP 11.0% (95% CI: 9.3–12.9, I2 = 16.58), pharyngalgia 9.4% (95% CI: 7.5–11.7, I2 = 36.40), headache MESHD headache HP 9.5% (95% CI: 8.5–11.1, I2 = 5.7), and lymphocytopenia 36.7% (95% CI: 33.8–39.8 I2 = 28.73). Meanwhile, 4.3% (95% CI: 3.5–5.4, I2 = 0.00) of patients were found without any symptoms, although they were diagnosed by RT-PCR. In terms of lung CT imaging, most of the patients showed bilateral mottling or ground-glass opacity, and 7.7% (95% CI: 4.4–12.9, I2 = 35.64) of patients had a crazy-paving pattern. In subgroup analysis, the pooled incidence rate of normal CT presentations in the Wuhan area and outside Wuhan area was 2.3% (95% CI: 1.4–3.6, I2 = 24.78) and 5.8% (95% CI: 4.4–7.7, I2 = 32.76) respectively (P = 0.001).Conclusions The findings suggest that although most of the COVID-19 patients have symptoms or abnormal CT imaging presentations, a few of them accompany with no symptoms or abnormal CT imaging results should also be noticed. The digestive symptoms and lymphocytopenia may be the potential clinical characteristics, especially for patients with a history of contact with COVID-19. Additionally, the incidence rate of ARDS in the Wuhan area and outside Wuhan area was different; however, the reasons for this phenomenon are unclear.

    The Incidence of SARS-COV-2 Manifestations in the Central Nervous System: A Rapid Review and Meta-Analysis

    Authors: Verena Mayr; Glechner Anna; Gerald Gartlehner; Irma Klerings; Peter Lackner

    doi:10.21203/ Date: 2020-07-17 Source: ResearchSquare

    Background: Coronavirus disease MESHD 2019 (COVID-19) is caused by SARS-CoV-2 and presents itself mainly as a respiratory tract infection MESHD respiratory tract infection HP. However, reports of associated central nervous system (CNS) manifestations are increasing.Methods: We conducted this rapid review to determine the frequency of CNS manifestations of COVID-19 (CNS symptoms, acute cerebrovascular disease MESHD, and infectious/inflammatory CNS diseases MESHD) and to summarize the current evidence for direct invasion of the CNS by SARS-CoV-2. An information specialist searched Ovid MEDLINE, the CDC: COVID-19 Research Articles Downloadable and WHO COVID-19 Databases, CENTRAL, and on May 13, 2020. Two reviewers screened abstracts and potentially relevant full-text publications independently. The data extraction, assessment of risk of bias,and certainty of evidence using GRADE was done by one reviewer and double-checked by another. If possible and reasonable, a meta-analysis was carried out.Results: We identified 13 relevant studies (four cohort studies, nine case studies) with a total of 866 COVID-19 patients.In a Chinese cohort, dizziness MESHD (16.8%; 36 of 214) and headache MESHD headache HP (13.1%; 28 of 214) were the most common CNS symptoms reported. A meta-analysis of four cohort studies including 851 COVID-19 patients showed an incidence of 3.3% (95% CI: 2.2–4.9) for ischemic stroke HP stroke MESHD (follow-up: one to five weeks). In 13 of 15 encephalitis MESHD encephalitis HP case studies, PCR testing of the cerebrospinal fluid did not detect any virus components.Conclusion: CNS manifestations occur frequently in patients with COVID-19. It is important to integrate neurologists into the multiprofessional COVID-19 treatment team to detect neurological complications early and to treat them correctly. 

    Clinical and Epidemiological Characteristics and Outcome of Patients With Covid-19 in Sri Lanka; An Observational Study

    Authors: Meththananda Herath; Jayasekera Madduma Mudiyanselage Priyamali thusharika; Pathirage Loku pathirage Manoji Muditha Kumari; Thushan Amila Wijesinghe Wedikkula Acharige; karthick Gunananthan; Bernard Pingamagae Don June; Nirosha Madhuwanthi Hettiarachchi; Thushari Dilrukshi Kaluthantrige Dona; Piyarathne Lasantha Roshan Samarakoon Pathirana Mudiyanselage; Nuwan Bhathiya Senevirathne; Sivajini Bhishman; Asanka Gunaseela Jayawardana Kankanamage Aruna Jayawardhana; Harsha Priya Sanjeewa Weerasinghe arachchige; Priyantha Balasooriya; Prasath Thushanthy; Ganaka Senarathna; Krishantha Jayasekera; Sutharshan Ponnuthurai; Suranga Ravinda Manilgama; Inoka Kumudini Jayasinghe; Thilak Widana Arachchilage Ananda Jayalath; Pirasath Selladurai

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background Clinical manifestations of coronavirus disease MESHD 2019 (COVID19) can vary from asymptomatic TRANS to profusely symptomatic due to many factors. Having data on the clinical characteristics of the affected patients is important for the screening and diagnosis of COVID-19. Main objective of this study is to evaluate the clinical and epidemiological characteristics and outcomes of patients with COVID-19 admitted to six treatment centres in Sri Lanka.Methods For the specific epidemic situation of COVID-19, we chose to conduct a descriptive retrospective study from six treatment centres in the country between March 10, 2020 and May 30, 2020.Results The study included 431 laboratory confirmed patients with COVID-19. Of them, 335 (78.2%) were males TRANS and their mean age TRANS was 37 years. Most patients (373: 86.5%) had had close contact TRANS with COVID-19 positive patients. The majority were asymptomatic TRANS (243: 56.3%) and of the symptomatic patients, the most common symptom was sore throat (81, 19%), followed by cough MESHD cough HP (72, 17%), headache MESHD headache HP (72, 17%), fever MESHD fever HP (50, 12%), and nasal discharge (36, 8%). Eight patients required either high dependency care or intensive unit care two of them succumbed to the illness (0.5%). Hydroxychloroquine (HCQ) was used as a treatment in 248 patients and they had a significantly longer (17.6 days) duration of hospital stays compared those who were not treated (13.6 days) with HCQ. When the HCQ was not used as a treatment, asymptomatic TRANS individuals had significantly shorter durations of hospital (11.1 days) stays compared to symptomatic individuals (14.3 days).Conclusions The majority of patients remained asymptomatic TRANS during the course of illness. The most common symptom was sore throat, seen in one fifth of patients, followed by cough MESHD cough HP, and headache MESHD headache HP. Our study also indicated the possibility of reduced viral clearance and hence longer duration of hospital stays with HCQ.

    COVID-19 Pandemic and Dental Hygienists in Italy: A Questionnaire Survey.

    Authors: Giuliana Bontà; Guglielmo Giuseppe Campus; Maria Grazia Cagetti

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Backgroud: This survey assesses the signs/symptoms MESHD, the protective measures taken and the awareness and risk perception regarding COVID-19 among Italian dental hygienists. All Italian dental hygienists were invited to participate. The online ad hoc questionnaire was divided into four domains: personal data, protective measures (-before patient arrival; -in the waiting room; -in the operating room) and PPE, awareness and risk perception. Results: Two-thousand-seven-hundred-ninety-eight subjects participated. Only 0.25% of the sample was positive to the virus. Sense of fatigue MESHD fatigue HP (8.19%), headache MESHD headache HP (7.81%) and sore throat (7.32%) were the most common symptoms. A statistically significant trend across the areas with a different prevalence SERO of COVID-19 was observed related to the number of signs/symptoms MESHD (areas z=6.38 p<0.01). Overall, 90.55% of the sample used protective glasses or visor, 90.10% disposable gloves and 82.80% surgical mask. Regarding the confidence to avoid the infection MESHD, a statistically significant difference was found among dental hygienists belong to the three years-professional-experiences groups who worked in the high COVID-19 prevalence SERO area. The findings of this survey show that Italian dental hygienists have modified their working habits according to the professional risk related to the current pandemic and they seem correctly prepared to face the SARS-CoV-2 infection MESHD.

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MeSH Disease
Human Phenotype

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