Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Clinical Electroencephalography Findings and Considerations in Hospitalized Patients with Coronavirus SARS-CoV-2

    Authors: Neishay Ayub; Joseph Cohen; Jin Jing; Aayushee Jain; Ryan Tesh; Shibani S. Mukerji; Sahar F. Zafar; M. Brandon Westover; Eyal Y Kimchi

    doi:10.1101/2020.07.13.20152207 Date: 2020-07-15 Source: medRxiv

    Background and Purpose Reports have suggested that severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) causes neurologic manifestations MESHD including encephalopathy HP and seizures MESHD seizures HP. However, there has been relatively limited electrophysiology data to contextualize these specific concerns and to understand their associated clinical factors. Our objective was to identify EEG abnormalities HP present in patients with SARS-CoV-2, and to determine whether they reflect new or preexisting brain pathology. Methods We studied a consecutive series of hospitalized patients with SARS-CoV-2 who received an EEG, obtained using tailored safety protocols. Data from EEG reports and clinical records were analyzed to identify EEG abnormalities HP and possible clinical associations, including neurologic symptoms, new or preexisting brain pathology, and sedation practices. Results We identified 37 patients with SARS-CoV-2 who underwent EEG, of whom 14 had epileptiform findings (38%). Patients with epileptiform findings were more likely to have preexisting brain pathology (6/14, 43%) than patients without epileptiform findings (2/23, 9%; p=0.042). There were no clear differences in rates of acute brain pathology. One case of nonconvulsive status epilepticus HP status epilepticus MESHD was captured, but was not clearly a direct consequence of SARS-CoV-2. Abnormalities of background rhythms were common, and patients recently sedated were more likely to lack a posterior dominant rhythm (p=0.022). Conclusions Epileptiform abnormalities were common in patients with SARS-CoV-2 referred for EEG, but particularly in the context of preexisting brain pathology and sedation. These findings suggest that neurologic manifestations MESHD during SARS-CoV-2 infection MESHD may not solely relate to the infection MESHD itself, but rather may also reflect patients' broader, preexisting neurologic vulnerabilities.

    Continuous Electroencephalography (cEEG) Characteristics and Acute Symptomatic Seizures HP Seizures MESHD in COVID-19 Patients

    Authors: Shreya Louis; Andrew Dhawan; Christopher Newey; Dileep Nair; Lara Jehi; Stephen Hantus; Vineet Punia

    doi:10.1101/2020.05.26.20114033 Date: 2020-05-28 Source: medRxiv

    Background: Neurological manifestations of COVID-19 have only recently been described, with a paucity of literature reporting the potential relationship between COVID-19 and acute symptomatic seizures HP seizures MESHD. Two prior studies found no clinical or electrographic seizures MESHD seizures HP in their cohorts of COVID-19 patients with altered mental status (AMS) and clinical seizure MESHD seizure HP-like events (SLEs). Methods: In this retrospective cohort study, 22 critically-ill COVID-19 patients above the age TRANS of 18 years who underwent EEG (electroencephalography) monitoring between April 20th, 2020 and May 20th, 2020 were studied. 19 patients underwent continuous EEG (cEEG) for at least 24 hours, and 3 patients underwent routine EEGs (<1 hour). Demographics including age TRANS, gender TRANS, comorbid medical, and neurological conditions were collected. Clinical variables included EEG findings, anti- seizure MESHD seizure HP medications, discharge disposition, and survival. Findings: 17 patients underwent EEG monitoring for unexplained altered mental status changes and 5 patients underwent monitoring for a seizure MESHD seizure HP-like event. 5 patients had epileptiform abnormalities on EEG HP (4 patients on cEEG, 1 on routine EEG); and only 2 of 5 epileptic EEG patients had a prior history of epilepsy MESHD. 2 patients in our cohort had electrographic seizures MESHD seizures in the absence HP in the absence of prior epilepsy MESHD history. No patients with epileptiform abnormalities or electrographic seizures MESHD seizures HP had acutely abnormal neuroimaging on CT or MRI. Interpretation: Encephalopathic COVID-19 positive patients had a range of EEG abnormalities HP, and a higher proportion of patients in this series had electrographic seizures MESHD seizures HP than previous literature suggests. This may be influenced by the duration of monitoring with cEEG and the use of a 21 channel electrode system. cEEG findings may help to guide antiseizure medical therapy, as well as the workup of altered mental status in the setting of unremarkable neuroimaging. Funding: No funding was used for this study.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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