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Overview

MeSH Disease

Human Phenotype

Transmission

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Seroprevalence
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    Steroid-responsive severe encephalopathy HP in SARS-CoV-2 infection MESHD

    Authors: Andrea Pilotto; SIlvia Odolini; Stefano Masciocchi; Agnese Comelli; Irene Volonghi; Stefano Gazzina; Sara Nocivelli; Alessandro Pezzini; Emanuele Focà; Arnaldo Caruso; Matilde Leonardi; Maria Pia Pasolini; Roberto Gasparotti; Francesco Castelli; Nicholas J Ashton; Kaj Blennow; Henrik Zetterberg; Alessandro Padovani

    doi:10.1101/2020.04.12.20062646 Date: 2020-04-17 Source: medRxiv

    SARS-CoV-2 infection MESHD has the potential for targeting central nervous system and several neurological symptoms have been described in patients with severe respiratory distress HP. Here we described the case of an otherwise healthy 60-year old subject with SARS-CoV-2 infection MESHD but only mild respiratory abnormalities who developed severe progressive encephalopathy HP associated with mild pleocytosis and hyperproteinorrachia. MRI was negative whereas EEG showed theta waves on the anterior brain regions. Serum SERO and CSF analyses excluded other known infectious or autoimmune disorders. The patient dramatically improved after high-doses steroid treatment suggesting an inflammatory-mediated brain involvement related to SARS-CoV-2 infection MESHD

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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