Corpus overview


MeSH Disease

Human Phenotype

Dilatation (5)

Pneumonia (3)

Fever (2)

Pain (1)

Cough (1)


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    COVID-19: What Can Iodine Maps From Perfusion CT Teach US? A Prospective Cohort Study.

    Authors: Mario G. Santamarina; Dominique Boisier Riscal; Ignacio Beddings; Roberto Contreras; Martiniano Baque; Mariano Volpacchio; Felipe Martinez Lomakin

    doi:10.21203/ Date: 2020-08-01 Source: ResearchSquare

    Background: Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients with COVID-19 pneumonia MESHD pneumonia HP, and correlate them with clinical outcomes.Material and Methods: A prospective cohort study was carried out with 45 RT-PCR-confirmed COVID-19 patients that required hospitalization at three different hospitals, between April and May 2020. In all cases, a basic clinical and demographic profile was obtained. Lung perfusion was assessed using sCTA. Evaluated imaging features included: Predominant type of perfusion abnormality (increased perfusion or hypoperfusion), perfusion abnormality distribution (focal or diffuse), extension of perfusion abnormalities (mild, moderate and severe involvement), presence of vascular dilatation HP and vascular tortuosity HP. All participants were followed-up until hospital discharge searching for the development of any of the study endpoints. These endpoints included intensive-care unit (ICU) admission, initiation of invasive mechanical ventilation (IMV) and death MESHD.Results: Forty-one patients (55.2 +/- 16.5 years, 22 men ) with RT-PCR-confirmed SARS-CoV-2 infection MESHD and an interpretable iodine map were included. Patients with perfusion anomalies on sCTA in morphologically normal lung parenchyma showed lower Pa/Fi values (294 ± 111.3 vs. 397 ± 37.7, p=0.035), and higher D-dimer levels (1156 ± 1018 vs. 378 ± 60.2, p<0.01). The patterns seen on lung CT were ground-glass opacities, mixed pattern and alveolar consolidation in 51.2%, 41.6% and 7.3%, respectively. Perfusion abnormalities were common (36 patients, 87.8%), mainly hypoperfusion in areas of apparently healthy lung . Patients with severe hypoperfusion in areas of apparently healthy lung parenchyma had an increased probability of being admitted to ICU and to initiate IMV (HR of 11.9% and HR 7.8%, respectively).Conclusion: Perfusion abnormalities evidenced in iodine maps obtained by sCTA are associated with increased admission to ICU and initiation of IMV in COVID-19 patients.

    Unusual Presentation of Kawasaki Disease MESHD with Multisystem Inflammation MESHD and Antibodies SERO Against Severe Acute Respiratory Syndrome MESHD Coronavirus 2: A Case Report

    Authors: Haena Kim; Jung Yeon Shim; Jae-Hoon Ko; Aram Yang; Jae Won Shim; Deok Soo Kim; Hye Lim Jung; Ji Hee Kwak; In Suk Sol

    doi:10.21203/ Date: 2020-07-12 Source: ResearchSquare

    Background: Since mid-April 2020, cases of multisystem inflammatory syndrome MESHD in children TRANS (MIS-C) associated with coronavirus disease MESHD (COVID-19) that mimic Kawasaki disease MESHD (KD) have been reported in Europe and North America. However, no cases have been in East Asia, where KD is more prevalent.Case presentation: A previously healthy 11-year-old boy was admitted with a 4-day history of fever MESHD fever HP and abdominal pain MESHD abdominal pain HP. He had no contact history to any patient with COVID-19. Blood SERO acute inflammatory markers were highly elevated. He was treated with antibiotics for suspected bacterial enteritis MESHD, but he suddenly developed hypotension MESHD hypotension HP. Inotropics and intravenous immunoglobulin were administered to manage septic shock MESHD shock HP. On hospitalization day 6, he developed signs and symptoms MESHD of KD (conjunctival injection, strawberry tongue HP, cracked lip, and coronary artery dilatation HP) in addition to pleural/ pericardial effusion MESHD pericardial effusion HP and mesenteric lymphadenitis MESHD lymphadenitis HP. The results of microbiologic tests, including reverse-transcription polymerase chain reaction for severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2), were negative. Fluorescent immunoassay SERO and enzyme-linked immunosorbent assay SERO revealed abundant IgG antibodies SERO against SARS-CoV-2 in his serum SERO, but no IgM antibodies SERO. He was discharged successfully on day 13.Conclusion: MIS-C may occur in children TRANS with a previously asymptomatic TRANS COVID-19 infection MESHD. A high index of suspicion is required for this novel syndrome MESHD in unusual cases of KD or KD shock MESHD shock HP syndrome MESHD with multisystem inflammation MESHD, even when there is no clear history of contact or symptoms of COVID-19.

    Comparison of initial thin-section CT features in coronavirus disease MESHD 2019 pneumonia MESHD pneumonia HP and other community-acquired pneumonia MESHD pneumonia HP

    Authors: Qiao Zhu; Cui Ren; Xiao Hua Wang

    doi:10.21203/ Date: 2020-05-19 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP caused similar symptoms to other community-acquired pneumonia MESHD pneumonia HP (CAP). It is important to early quarantine suspected patients with COVID-19 pneumonia MESHD pneumonia HP from patients with other CAP to reduce cross infection MESHD. The purpose of the study is to review and compare initial thin-section computed tomography (CT) features in patients with coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP and other community-acquired pneumonia MESHD pneumonia HP (CAP). Methods 24 cases of COVID-19 pneumonia MESHD pneumonia HP (14 males TRANS and 10 females TRANS; age TRANS range, 14-87 years; mean age TRANS, 48.0 years) and 28 cases of CAP caused by other pathogens (13 males TRANS and 15 females TRANS; age TRANS range, 24-85 years; mean age TRANS, 49.5 years) were included. Thin-section CT features of the lungs for all patients were retrospectively reviewed by two independent radiologists. Results There were no significant differences for the shape of main lesions, pure ground glass attenuation (GGA), mixed GGA with consolidation, air bronchogram, linear opacities, halo sign/reversed halo sign, cavitation and lymphadenopathy MESHD lymphadenopathy HP between the group of COVID-19 pneumonia MESHD pneumonia HP and the group of other CAP. However, the frequency of crazy-paving appearance, vessel dilatation HP, bilaterally involvement and peripherally distribution were significantly higher in patients with COVID-19 compared with other CAP ( p =0.031, p =0.000, p =0.029 and p =0.009, respectively). Conversely, the frequencies of pure consolidation, tree-in-bud sign and pleural effusion MESHD pleural effusion HP were significantly higher in patients with CAP than in patients with COVID-19 pneumonia MESHD pneumonia HP ( p =0.002, p =0.000 and p =0.048, respectively). Conclusion There are considerable overlaps in thin-section CT features between COVID-19 pneumonia MESHD pneumonia HP and other CAP. However, the presence of crazy paving pattern, vessel dilation, bilateral involvement and peripheral distribution contributes to the diagnosis of COVID-19 pneumonia MESHD pneumonia HP. While the presence of pure consolidation tree-in-bud sign, pleural effusion MESHD pleural effusion HP can be assisting in exclusive the diagnosis of COVID-19 pneumonia MESHD pneumonia HP.

    Liver and COVID 19 Infection MESHD: A Very Preliminary Lesson Learnt from Histological Post-mortem Findings in 48 patients

    Authors: Aurelio Sonzogni; Giulia Previtali; Michela Seghezzi; Maria Grazia Alessio; Andrea Gianatti; Lisa Licini; Pietro Zerbi; Luca Carsana; Roberta Rossi; Eleonora Lauri; Alessandro Pellegrinelli; Manuela Nebuloni

    id:10.20944/preprints202004.0438.v1 Date: 2020-04-24 Source:

    COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection MESHD very few information are available about liver involvement in COVID-19 infection MESHD, that could possibly evocate a systemic disease MESHD targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease MESHD.Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection MESHD were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease MESHD or signs of liver failure MESHD before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation MESHD features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation HP, partial or complete recent luminal thrombosis MESHD of portal and sinusoidal vessels, fibrosis MESHD fibrosis of portal HP of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection MESHD infection confirm TRANS confirm the clinical impression that liver failure MESHD is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood SERO vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood SERO vessels.

    COVID-19 presented with Deep Vein Thrombosis MESHD: An unusual case report

    Authors: Lotfollah Davoodi; Morteza Taghavi; Alireza Razavi

    doi:10.21203/ Date: 2020-04-06 Source: ResearchSquare

    BackgroundOn 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia MESHD pneumonia HP of unknown cause detected in Wuhan City, Hubei Province, China. The pneumonia MESHD pneumonia HP was caused by a virus called SARS-Cov-2, which was later named COVID-19. In this report, we present a patient with COVID-19 who developed deep vein thrombosis MESHD.Case presentationA 57-year-old woman presented to the clinic's infectious department with no underlying illness due to pain MESHD pain HP, redness, and leg swelling. According to a patient report, she had a mild dry cough MESHD cough HP for the past 3 days and had no other symptoms. The patient had no history of prone thrombosis MESHD conditions. Initially, CT angiography was performed to rule out pulmonary thromboembolism MESHD thromboembolism HP, which showed no evidence of thrombosis MESHD. Dilatation HP and thrombosis MESHD were seen in the examinations of the paired veins of the leg, popliteal, superficial and left femoral joints, and no evidence of vascular flow suggesting acute DVT. Because of fever MESHD fever HP and lymphopenia MESHD lymphopenia HP, nasal swabs were used for sampling and SARS-CoV-2 nucleic acid was detected by RT-PCR. Chest X-ray also revealed bilateral patchy ground-glass opacity. Other tests including ANA, Anti-dsDNA, RF test and ACA test was normal. Heparin at a dose of 80 units/kg IV bolus, chloroquine 400 mg single dose and lopinavir/ritonavir (Kaletra) 400 mg twice daily were prescribed to treat illness and relieve symptoms. On illness day 3, fever MESHD fever HP stopped and nasal swab sample turned undetectable for SARS-CoV-2 by RT-PCR as well as swelling and tenderness on her leg had been disappeared gradually. She is under regular follow-up with no new symptoms to date.Conclusion The mechanism of DVT formation due to COVID-19 is unknown despite thrombocytopenia MESHD thrombocytopenia HP, and has not been investigated but it resolved as COVID-19 symptoms, tenderness, and leg pain MESHD pain HP improved. Although COVID-19 presented with Deep Vein Thrombosis MESHD is a rare condition, in middle- aged TRANS people with sudden onset of manifestations, we should recognize it from other diseases MESHD as an important and treatable differential diagnosis. Rapid diagnostic assays, efficient treatment, and prudent use of CT-scan are important to control future COVID-19 spread.

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MeSH Disease
Human Phenotype

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