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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Cutaneous manifestations associated with COVID-19 in children TRANS: A Systematic Review

    Authors: Seema Shah; Kiran Akhade; Satyaki Ganguly; Rachita Nanda; Eli Mohapatra; Anil Kumar Goel

    doi:10.21203/rs.3.rs-45314/v1 Date: 2020-07-18 Source: ResearchSquare

    Background: Cutaneous manifestation of COVID 19 in children TRANS has not yet been reviewed systematically and hence this review gives a future direction to the clinicians to be vigilant for skin presentations during such pandemic.Methodology: The review was done as per the guidelines of PRISMA and literature search was done on PubMed database using keywords as COVID-19, children TRANS and skin in different combinations. Articles published in English with cases of age TRANS 1 month to 18 years were eligible. The outcome included varied aspects of cutaneous and COVID-19 infection MESHD. The review protocol was not registered.Results: Of 51 publications identified, 13 studies containing 149 children TRANS met the eligibility criteria. Acrally located erythematous maculopapular lesion was the most common finding in 138 children TRANS. Erythema multiforme MESHD Erythema HP, varicella like exanthem and Kawasaki disease MESHD like presentations were reported in the rest of the cases. The duration of the skin lesion was 1-2 weeks in 43%. Skin biopsy done in 18 cases revealed superficial & deep perivascular and peri-eccrine lymphocytic infiltrate & lymphocytic vasculitis MESHD vasculitis HP. RT-PCR was positive in 13.8% cases. Serological markers for HSV, parvovirus B19 analyzed across various studies, were found negative, except for mycoplasma pneumoniae MESHD pneumoniae HP in 2 of 20 cases tested.Discussion: Clinicopathologic analysis established chilblains MESHD chilblains HP like lesion in 43% cases with no confirmed TRANS etiology like cold exposure, autoimmune dysfunction, drug reaction, or viral infection MESHD. The usual cephalo-caudal spread of a viral exanthem was also missing. However, a low number of discussed cases was a limitation of the study.Conclusion: In the absence of any confirmed etiology for such cutaneous manifestations, the possibility of COVID-19 should be explored and evaluated thoroughly during such pandemic.

    The impact of COVID-19 pandemic on pediatric rheumatology patients under immunosuppressive therapy: A single-center experience

    Authors: Oya Koker; Fatma Gul Demirkan; Gulsah Kayaalp; Figen Cakmak; Ayse Tanatar; Serife Gul Karadag; Emine Sonmez; Rukiye Omeroglu; Nuray Aktay Ayaz

    doi:10.21203/rs.3.rs-36583/v1 Date: 2020-06-19 Source: ResearchSquare

    Objective: The aim of the research was to further broaden current knowledge of whether severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) disease MESHD 2019 (COVID-19) entails a risk for children TRANS with rheumatic diseases MESHD regarding immunosuppressive treatment.Methods: Telephone-survey was administered by conducting interviews with the parents TRANS. A message containing a link to the actual questionnaire was sent to their phones simultaneously. The medical records of the patients were reviewed for gathering information about demographic data, clinical follow-up, and treatments.Results: Patients who were followed up with immunosuppressive treatment (n=439) were attempted to be contacted between 1 May 2020 and 15 May 2020. The diagnostic distribution of patients who were accessible and eligible for the study was as follows; juvenile idiopathic arthritis MESHD arthritis HP (JIA) (n=243, 58.7%), autoinflammatory diseases MESHD (n=109, 26.3%), autoimmune connective tissue diseases MESHD (n=51, 12.3%) and vasculitis MESHD vasculitis HP (n=11, 2.7%). In the entire cohort, the mean age TRANS was 12 ± 4.7 years, and 54.1% (n=224) of the patients were female TRANS. One patient with seronegative polyarticular JIA, previously prescribed methotrexate and receiving leflunomide during pandemic has been identified to be diagnosed with COVID-19. None of the patients, including the patient diagnosed with COVID-19, had any severe symptoms. More than half of the patients with household contacts TRANS required hospitalization as they were asymptomatic TRANS.Conclusion: Although circumstances such as compliance in social distancing policy, transmission TRANS patterns, attitude following contact may influence the results, immunosuppressive treatment does not seem to pose additional risk in terms of COVID-19.

    COVID-19: Neutrophils “Unfriendly Fire” Imbalance Proteolytic Cascades Triggering Clinical Worsening and Viral Sepsis MESHD Sepsis HP. Potential Role Explanation for Convalescent Plasma SERO as “Fire Hose”

    Authors: Pier Maria Fornasari

    id:10.20944/preprints202005.0373.v1 Date: 2020-05-23 Source: Preprints.org

    Based on Chinese CDCP report on COVID-19, 14% of patients presented severe disease MESHD and 5% critical conditions. The average case-fatality rate was 2.3%, but mortality was as high as 49% in patients with critical illness MESHD. Serious life threatening thromboembolic complications have been found in 71·4% of non-survivors and micro/macro angiopathic coagulopathy has been found, also at autopsy, with highly increased neutrophil number, fibrinogen, concentrations of D-dimer and FDPs and NETs, ATIII decrease and normal number of platelets. A cytokine storm and interaction between inflammation MESHD and coagulation has been advocated as explanation of hypercoagulability HP. In this paper, it’s hypothesised that SARS-CoV-2 infection MESHD of alveolar cells induces recruitment of innate responder neutrophils, which release proteases and NETs inducing endothelial damage/endotheliopathy and imbalance of the four major proteolytic cascades (coagulation, complement, fibrinolysis and kallikrein) with prevalence SERO of activators over inhibitors and consequent thrombotic complications. Platelets adhesion to damaged endothelium and the presence of ULVWF multimers, due to decreased ADAMTS13, contributes to the state of hypercoagulability HP. Neutrophil innate “unfriendly fire” response can be identified as the trigger of a “proteolytic storm”, responsible for subsequent well known prothrombotic condition and “cytokine storm”. The hypothesis explains also the pathology of recently described systemic “Kawasaki Disease MESHD like” vasculitis MESHD vasculitis HP cases in Covid-19 young ill patients.

    Vasculitis MESHD Vasculitis HP-Associated Auto- antibodies SERO and Complement Levels in patients with COVID-19 Infection MESHD

    Authors: Maryam Mobini; Roya Ghasemian; Laleh Vahedi Larijani; Maeede Mataji; Iradj Maleki

    doi:10.21203/rs.3.rs-30488/v1 Date: 2020-05-21 Source: ResearchSquare

    Introduction / objectives: The cause of coronavirus disease MESHD 2019 (COVID-19) is severe acute respiratory syndrome MESHD 2 (SARS-CoV-2). There are evidences of involvement of immune system in pathogenesis of this disease MESHD. We investigated the presence of various vasculitis MESHD vasculitis HP-associated auto- antibodies SERO and complement levels in a series of patients with COVID-19 infection MESHD admitted to our hospital.Methods: Forty patients with severe or critical type of COVID 19 were evaluated for symptoms, signs MESHD and laboratory tests of vasculitis MESHD vasculitis HP syndromes MESHD including rheumatoid factor (RF), anti-nuclear antibody SERO (ANA), anti dsDNA, c and p anti-neutrophilic cytoplasmic antibody SERO (c ANCA and p ANCA) and complement levels. Descriptive statistics methods were used to describe the clinical / laboratory findings.Results: Forty patients with severe to critical illness MESHD were enrolled in the study. The mean age TRANS of the patients was 48.5 ± 9.8 years. All patients had pulmonary involvement in lung CT scan. Lymphopenia MESHD Lymphopenia HP in 19 (47.5%), raised creatinine in 8(20%) and hyperbilirubinemia MESHD hyperbilirubinemia HP in 19(47.5%) of patients were seen. Vasculitis MESHD Vasculitis HP laboratory test results included: RF in 2 patients, ANA in 3 patients and ANCA in one patient. 17(42.5%) of patients had hypocomplementemia in one or more complement tests. Of the four patients who were expired, three had a decrease in complement.Conclusion: In 17 of patients (42.5%) we detected low complement levels. A decrease in complement levels may predict a critical state of the disease MESHD. Therefore, measuring its levels may be helpful in making earlier decisions to initiate disease MESHD-suppressing treatments, including corticosteroids and IVIG.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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