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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Influence of influenza A virus in COVID-19 patients: A retrospective cohort study

    Authors: Yuan Cheng; Jing Ma; He Wang; Xi Wang; Zhanwei Hu; Haichao Li; Hong Zhang; Xinmin Liu

    doi:10.21203/rs.3.rs-39932/v1 Date: 2020-07-02 Source: ResearchSquare

    Background and objective: Coronavirus disease MESHD (COVID-19) is currently an urgent global issue, but we cannot ignore the impact of influenza A since there is an overlap of infection MESHD time and region and similar clinical manifestations and chest computed tomography (CT) images for influenza A and COVID-19 infections MESHD. We compared patients who had a COVID-19 infection MESHD and co- infection MESHD with the influenza A virus.Methods: We retrospectively reviewed patients who met the inclusion criteria for this study.Results: There were 213 patients included in this study, of whom 106 were females TRANS and 107 were males TRANS, with a median age TRANS of 63 years. All patients were diagnosed with COVID-19 and were subsequently divided into influenza positive (n = 97) and influenza negative (n = 116) groups according to the serum SERO test results for the influenza A IgM antibody SERO. The two groups had similar symptoms, outcomes, CT manifestation and CT scores, except for lymphadenopathy MESHD lymphadenopathy HP (6.2% in the influenza positive group vs. 14.7% in the negative group, P = 0.047). However, in the subgroup analysis, male TRANS or younger patients ( age TRANS <= 60 years) in the influenza negative group had higher CT scores than patients in the influenza positive group (P < 0.05).Conclusions: COVID-19 patients who had co- infection MESHD with the influenza A virus showed similar symptoms, outcomes, CT manifestation and CT scores to influenza negative patients. However, male TRANS patients and younger patients had higher CT scores in the influenza negative group.

    Symptomatology of Coronavirus Disease MESHD 2019 (COVID-19) - Lessons from A Meta-Analysis Across 13 Countries

    Authors: Champika Saman Kumara Gamakaranage; Dineshani Hettiarachchi; Dileepa Ediriweera; Saroj Jayasinghe

    doi:10.21203/rs.3.rs-39412/v1 Date: 2020-07-01 Source: ResearchSquare

    Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians.Objective: The objective of the study was to identify symptoms and their frequencies of coronavirus disease MESHD 2019 with a meta-analysis of studies from several countries. Data sources: A systematic review using PubMed and Google Scholar data sources and reference tracing TRANS were used to identify 7176 relevant articles. Eligibility criteria: Suitable articles were selected manually with selection criteria and 14 original articles included for meta-analysis. Data abstraction analysis: PRISMA guideline was used for abstracting data. Then a table was generated by feeding it with numbers and proportions of each symptom described in original studies. A meta-analysis was carried out using random effect models on each symptom separately across the studies and their prevalence SERO rates and 95% confident intervals calculated.Results: We identified 14 relevant scientific papers, either cross-sectional or cohort studies and analyzed. There were 2,660 cases of COVID-19. he majority were from China (n=2,439, 91.7%) and remainder from the Netherlands, Italy, Korea and India and one article from Europe. There was a total of 32 symptoms (i.e. present in >50% of patients): fever (79.56%, 95% CI: 72.17-86.09%), malaise (63.3%, 95% CI: 53.1 – 73.0%), cough MESHD cough HP (56.7. %, 95% CI: 48.6 - 64.6 %) and cold (55.6%, 95% CI: 45.2 – 65.7%). Symptoms of intermediate incidence (5-49%) were; anosmia HP, sneezing MESHD sneezing HP, ocular pain HP pain MESHD, fatigue MESHD fatigue HP, sputum production, arthralgia MESHD arthralgia HP, tachypnea MESHD tachypnea HP, palpitation HP, headache MESHD headache HP, chest tightness HP, shortness of breath, chills MESHD chills HP, myalgia MESHD myalgia HP, sore throat, anorexia MESHD anorexia HP, weakness, diarrhea MESHD diarrhea HP, rhinorrhea HP, dizziness MESHD, nausea MESHD nausea HP, altered level of consciousness, vomiting MESHD vomiting HP and abdominal pain MESHD abdominal pain HP. Rare symptoms (<5% of patients) were: tonsil swelling, haemoptysis, conjunctival injection, lymphadenopathy MESHD lymphadenopathy HP and rash were uncommon symptoms of coronavirus disease MESHD (<5%).Conclusion and implications of key findings: We found (25/32) symptoms to be present in =>5% of cases which could be considered as “typical” symptoms of COVID-19. The list of symptoms we identified are different from those documents released by the WHO, CDC, NHS, Chinese CDC, Institute Pasteur and Mayo Clinic. The compiled list would be useful for future researchers to document a comprehensive picture of the illness.

    Comparison of initial thin-section CT features in coronavirus disease MESHD 2019 pneumonia MESHD pneumonia HP and other community-acquired pneumonia MESHD pneumonia HP

    Authors: Qiao Zhu; Cui Ren; Xiao Hua Wang

    doi:10.21203/rs.3.rs-29838/v1 Date: 2020-05-19 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP caused similar symptoms to other community-acquired pneumonia MESHD pneumonia HP (CAP). It is important to early quarantine suspected patients with COVID-19 pneumonia MESHD pneumonia HP from patients with other CAP to reduce cross infection MESHD. The purpose of the study is to review and compare initial thin-section computed tomography (CT) features in patients with coronavirus disease MESHD 2019 (COVID-19) pneumonia MESHD pneumonia HP and other community-acquired pneumonia MESHD pneumonia HP (CAP). Methods 24 cases of COVID-19 pneumonia MESHD pneumonia HP (14 males TRANS and 10 females TRANS; age TRANS range, 14-87 years; mean age TRANS, 48.0 years) and 28 cases of CAP caused by other pathogens (13 males TRANS and 15 females TRANS; age TRANS range, 24-85 years; mean age TRANS, 49.5 years) were included. Thin-section CT features of the lungs for all patients were retrospectively reviewed by two independent radiologists. Results There were no significant differences for the shape of main lesions, pure ground glass attenuation (GGA), mixed GGA with consolidation, air bronchogram, linear opacities, halo sign/reversed halo sign, cavitation and lymphadenopathy MESHD lymphadenopathy HP between the group of COVID-19 pneumonia MESHD pneumonia HP and the group of other CAP. However, the frequency of crazy-paving appearance, vessel dilatation HP, bilaterally involvement and peripherally distribution were significantly higher in patients with COVID-19 compared with other CAP ( p =0.031, p =0.000, p =0.029 and p =0.009, respectively). Conversely, the frequencies of pure consolidation, tree-in-bud sign and pleural effusion MESHD pleural effusion HP were significantly higher in patients with CAP than in patients with COVID-19 pneumonia MESHD pneumonia HP ( p =0.002, p =0.000 and p =0.048, respectively). Conclusion There are considerable overlaps in thin-section CT features between COVID-19 pneumonia MESHD pneumonia HP and other CAP. However, the presence of crazy paving pattern, vessel dilation, bilateral involvement and peripheral distribution contributes to the diagnosis of COVID-19 pneumonia MESHD pneumonia HP. While the presence of pure consolidation tree-in-bud sign, pleural effusion MESHD pleural effusion HP can be assisting in exclusive the diagnosis of COVID-19 pneumonia MESHD pneumonia HP.

    High Resolution Computed Tomography Finding in 552 Patients with Symptomatic COVID-19: First Report from North of Iran

    Authors: Hadi Majidi; Elham-Sadat Bani-Mostafavi; Zahra Mardanshahi; Farnaz Godazandeh; Roya Gasemian; Keyvan Heydari; Reza Alizadeh-Navaei

    doi:10.21203/rs.3.rs-25817/v1 Date: 2020-04-27 Source: ResearchSquare

    Purpose: Due to the emergence of the new Coronavirus-2019 and the lack of sufficient information about infected patients, this study was conducted to investigate the Chest High Resolution Computed Tomography (HRCT) findings of patients infected with the new Coronavirus 2019.Methods: This cross-sectional study was performed on COVID-19 patients referred to Medical Imaging Centers of Sari, Mazandaran, Iran, on March 2020 for Computed Tomography Scan (CT-Scan). Symptomatic patients were referred to the Medical Imaging Center for diagnosis confirmation through CT-scan. In addition to age TRANS and sex, HRCT findings were collected from the picture archiving and communication system (PACS) for further evaluations.Results: Out of 552 patients with mean age TRANS of 14.8 ± 51.2 years, the male TRANS/ female TRANS ratio was 1.38 to 1. The most common expressive findings in patients were ground-glass opacity (GGO) (87.3%), peripheral distribution (82.4%) and posterior distribution (81.5%). The most conflicting findings in patients were pleural effusion MESHD pleural effusion HP (7.6%), peribronchovascular distribution (7.6%), and lymphadenopathy MESHD lymphadenopathy HP (5.1%). The peripheral distribution (p = 0.034), round opacities (p = 0.02), single lobe (p = 0.003) and pleural effusion MESHD pleural effusion HP (p = 0.037) were significantly in people under and over 50 years of age TRANS.Conclusion: In summary, the present study indicated that in addition to GGO, peripheral distribution findings could be a vital diagnostic choice in COVID-19 patients.

    Coronavirus Disease MESHD 2019 (COVID-19) in Children TRANS: A Systematic Review of Imaging Findings

    Authors: Susan C Shelmerdine; Jovan Lovrenski; Pablo Caro-Domínguez; Seema Toso; Collaborators of the European Society of Paediatric Radiology cardiothoracic imaging taskforce

    doi:10.21203/rs.3.rs-22081/v1 Date: 2020-04-08 Source: ResearchSquare

    Background:Covid-19, a novel coronavirus infection MESHD which can cause a severe respiratory illness, has been declared a pandemic by the World Health Organisation (WHO). As children TRANS appear less severely affected than adults TRANS, their imaging appearances are not extensively reported.Objectives:To systematically review available literature regarding imaging findings in paediatric cases of Covid-19.Materials and Methods:Four databases (Medline, Embase, Cochrane, Google Scholar) were searched for articles describing imaging findings in children TRANS with Covid-19. All modalities, age <18 years and foreign language articles were included. Descriptive statistics were used to identify pattern, location of imaging findings and association with outcomes.Results:Twenty two articles were included, reporting chest imaging findings in 382 children TRANS, of which 372 (97.4%) underwent CT. Criteria for imaging was lacking. At diagnosis, 120/372 (32.3%) had a normal CT. Abnormalities were more common in the lower lobes and predominantly unilateral. The most common imaging pattern was ground glass opacification (136/246, 55.3%). None of the studies described lymphadenopathy MESHD lymphadenopathy HP, while pleural effusions MESHD pleural effusions HP (2/246, 0.8%) were rare. Improvement at follow-up CT imaging, (3 – 15 days later) was seen in 27/91 (29.7%), remained normal in 23/91 (25.3%) and progressed in 11/91 (12.1%).Conclusions:CT chest findings in children TRANS with Covid-19 are frequently normal or mild. Lower lobes are predominantly affected by patchy ground glass opacification. Appearances at follow-up remain normal or improve in the majority of children TRANS. Chest CT imaging adds little to the further management of the patient and should be reserved for severe cases or identifying alternative diagnoses.This study was registered in PROSPERO, an international prospective register of systematic reviews (Registration ID: CRD42020175945

    Clinical and Imaging features in COVID-19 Patients: Analysis of Data from Patients in Non-pandemic areas

    Authors: Shengkun Peng; Lingai Pan; Shaojin Zhang; Yalong Liu; Hua Zhang; Liming Tan; Yang Guo; Xiaobo Huang; Jie Zeng; Hong Pu

    doi:10.21203/rs.3.rs-21373/v1 Date: 2020-04-04 Source: ResearchSquare

    Purpose To describe the imaging characteristics in COVID-19 Patients from non-pandemic regions to improve understanding of the disease MESHD. Methods We reviewed chest CT scans of 30 COVID-19 patients from three hospitals in Sichuan province, China. Results Typical CT manifestations include the involvement of multiple lobes, mostly in the peripheral zone of the lungs, and subpleural distribution. GGO, crazy paving or mixed GGO and consolidation is the most common signs. Few patients can present small amount of pleural effusion MESHD pleural effusion HP. It is worth noting that none of the lung cavities, tree buds, and lymphadenopathy MESHD lymphadenopathy HP appeared. The follow-up imaging findings of some patients showed progress when the initial CT score reached 7. Conclusion The CT scan still play an important role in screening the COVID-19, most of the images present positive signs, mainly subpleural, multiple GGO. CT might can predict the severity or whether the patient will progress to severe illness. A small number of patients may be missed if they are based on CT findings alone, which should be closely combined with the patient's epidemiological history and nucleic acid test.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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