Background: The coronavirus disease MESHD 2019 (COVID-19) is spreading worldwide with 16,558 deaths MESHD till date. Serum SERO albumin, high-density lipoprotein (HDL-C), and C-reactive protein have been known to be associated with the severity and mortality of community-acquired pneumonia MESHD pneumonia HP. However, the characteristics and role of metabolic and inflammatory indicators in COVID-19 is unclear. Methods: We included 97 hospitalized patients with laboratory-confirmed COVID-19. Epidemiological, clinical, and laboratory indices; radiological features; and treatment were analysed. The differences in the clinical and laboratory parameters between mild and severe COVID-19 patients and the role of these indicators in severity prediction of COVID-19 were investigated. Results: All were Wuhan residents with contact with confirmed COVID-19 cases. The median age TRANS was 39 years (IQR: 30-59). The most common presenting symptoms were fever MESHD fever HP (58.8%), cough MESHD cough HP (55.7%), and fatigue MESHD fatigue HP (33%). Other features were lymphopenia MESHD lymphopenia HP, impaired fasting glucose, hypoproteinaemia, hypoalbuminemia MESHD hypoalbuminemia HP, low high-density lipoproteinemia. Decrease in lymphocyte count, serum SERO total protein, serum SERO albumin, high-density lipoprotein cholesterol (HDL-C), ApoA1, CD3+T%, and CD8+T% were found to be valuable in predicting the transition of COVID-19 from mild to severe illness. Chest computed tomography (CT) images showed that the absorption of bilateral lung lesions synchronized with the recovery of metabolic and inflammatory indicators. Conclusions: Hypoproteinaemia, hypoalbuminemia MESHD hypoalbuminemia HP, low high-density lipoproteinemia, and decreased ApoA1, CD3+T%, and CD8+T% could predict severity of COVID-19. Lymphocyte count, total serum SERO protein, and HDL-C may be potentially useful for the evaluation of COVID-19.