Patients with COVID-19 may experience multiple conditions (e.g., fever MESHD fever HP, hyperventilation MESHD hyperventilation HP, anorexia MESHD anorexia HP, gastroenteritis MESHD, acid-base disorder) that may cause electrolyte imbalances. Hypokalemia MESHD Hypokalemia HP is a concerning electrolyte disorder that may increase the susceptibility to various kinds of arrhythmia HP. This study aimed to estimate prevalence SERO, risk factors and outcome of hypokalemia MESHD hypokalemia HP in a cohort of non-critically ill patients. A retrospective analysis was conducted on 290 hospitalized patients with confirmed COVID-19 infection MESHD at the tertiary teaching hospital of Modena, Italy. Hypokalemia MESHD Hypokalemia HP (<3.5 mEq/L) was detected in 119 patients (41%). The decrease of serum SERO potassium level was of mild entity (3-3.4 mEq/L) and occurred in association with hypocalcemia MESHD hypocalcemia HP (P=0.001) and lower level of serum SERO magnesium (P=0.028) compared to normokaliemic patients. Urine K: creatinine ratio, measured in a small subset of patients (n=45; 36.1%), showed an increase of urinary potassium HP excretion in the majority of the cases (95.5%). Causes of kaliuria were diuretic therapy (53.4%) and corticosteroids (23.3%). In the remaining patients, urinary potassium loss was associated with normal serum SERO magnesium, low sodium excretion (FENa< 1%) and metabolic alkalosis HP alkalosis MESHD. Risk factors for hypokalemia MESHD hypokalemia HP were female TRANS gender TRANS (P=0.002; HR 0.41, 95%CI 0.23-0.73) and diuretic therapy (P=0.027; HR 1.94, 95%CI 1.08-3.48). Hypokalemia MESHD Hypokalemia HP, adjusted for sex, age TRANS and SOFA score, resulted not associated with ICU admission (P=0.131, 95% CI 0.228-1.212) and in-hospital mortality (P=0.474; 95% CI 0,170-1,324) in our cohort of patients. Hypokalemia MESHD Hypokalemia HP is a frequent disorder in COVID-19 patients and urinary potassium loss may be the main cause of hypokalemia MESHD hypokalemia HP. The disorder was mild in the majority of the patients and was unrelated to poor outcomes. Nevertheless, hypokalemic patients required potassium supplements to dampen the risk of arrhythmias HP.