Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Characteristics, outcome and predictors of in-hospital mortality in an elderly TRANS population from a SARS-CoV-2 outbreak in a long-term care facility.

    Authors: ENRICO MARIA TRECARICHI; MARIA MAZZITELLI; FRANCESCA SERAPIDE; MARIA CHIARA PELLE; BRUNO TASSONE; EUGENIO ARRIGHI; GRAZIELLA PERRI; PAOLO FUSCO; VINCENZO SCAGLIONE; CHIARA DAVOLI; ROSARIA LIONELLO; VALENTINA LA GAMBA; GIUSEPPINA MARRAZZO; MARIA TERESA BUSCETI; AMERIGO GIUDICE; MARCO RICCHIO; ANNA CANCELLIERE; ELENA LIO; GIADA PROCOPIO; FRANCESCO SAVERIO COSTANZO; DANIELA FOTI; GIOVANNI MATERA; CARLO TORTI

    doi:10.1101/2020.06.30.20143701 Date: 2020-07-02 Source: medRxiv

    Since December 2019, coronavirus disease MESHD 2019 (COVID-19) pandemic has spread from China all over the world, many COVID-19 outbreaks have been reported in long-term care facilities (LCTF). However, data on clinical characteristics and prognostic factors in such settings are scarce. We conducted a retrospective, observational cohort study to assess clinical characteristics and baseline predictors of mortality of COVID-19 patients hospitalized after an outbreak of SARS-CoV-2 infection MESHD in a LTCF. A total of 50 patients were included. Mean age TRANS was 80 years (SD, 12 years), and 24/50 (57.1%) patients were males TRANS. A total of 42/50 (84%) patients experienced symptoms of SARS-CoV-2 infection MESHD. The overall in-hospital mortality rate was 32%. In Cox regression, significant predictors of in-hospital mortality were: hypernatremia MESHD hypernatremia HP (HR 9.12), lymphocyte count <1000 cells/L (HR 7.45), cardiovascular diseases MESHD other than hypertension MESHD hypertension HP (HR 6.41), and higher levels of serum SERO interleukin-6 (IL-6, pg/mL) (HR 1.005). Our study shows a high in-hospital mortality rate in a cohort of elderly TRANS patients with COVID-19 and hypernatremia MESHD hypernatremia HP, lymphopenia MESHD lymphopenia HP, CVD other than hypertension MESHD hypertension HP, and higher IL-6 serum SERO levels were identified as independent predictors of in-hospital mortality. Further studies are necessary to better understand and confirm our findings in the setting of a LTCF outbreak of COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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