Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence

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    Lung Mechanics in Type L CoVID-19 Pneumonia MESHD Pneumonia HP: A Pseudo-Normal ARDS.

    Authors: Lorenzo Viola; Emanuele Russo; Marco Benni; Emiliano Gamberini; Alessandro Circelli; Luca Bissoni; Domenico Pietro Santonastaso; Giovanni Scognamiglio; Giuliano Bolondi; Luca Mezzatesta; Vanni Agnoletti

    doi:10.21203/rs.3.rs-37028/v1 Date: 2020-06-19 Source: ResearchSquare

    Since its outbreak, in January, 2020, it has been clear that CoVID-19 pneumonia MESHD pneumonia HP is atypical. Despite a full concordance to Berlin criteria for Acute Respiratory Distress HP Syndrome MESHD (ARDS), respiratory system mechanics is preserved [1]. Mechanical ventilation and muscular paralysis MESHD paralysis HP are recommended in worsening respiratory insufficiency MESHD respiratory insufficiency HP [2]; in a substantial number of cases, prone positioning significantly improves oxygenation.

    B Cells Over-Activation by Viral Proteins <70 kDa Causes Th2 Immune Suppression in COVID-19 Sepsis MESHD Sepsis HP

    Authors: Javier Martín

    id:10.20944/preprints202005.0244.v1 Date: 2020-05-14 Source: Preprints.org

    COVID-19 sepsis MESHD sepsis HP immune response remains unclear. Here we propose a new perspective in host response against pathogenic proteins that may lead to a vaccine design by polymerization of antigens of <70 kDa. In COVID-19, initial Th1 response kills infected cells releasing viral proteins. SARS-CoV-2 viral structural proteins are Spike (140 kDa), Nucleocapsid (50 kDa), Membrane (25 kDa) and Envelope (10 kDa). B cell receptor cannot capture antigens >70 kDa. The Spike protein (140 kDa) cannot be captured by B cells and triggers inflammatory Th1 response via the macrophages. Only proteins with a size <70 kDa can activate B cell receptor and trigger Th2 adaptative humoral response. Moreover, M-25 kDa and E-12 kDa glycoproteins can activate IgM-BCR like oligovalent or monovalent antigens. The sustained infected cells lysis overfeeds high levels of viral proteins <70 kDa, increases B cells activation and, in the shift from Th1 to Th2 immune response, triggers the cytokine storm. The continuous BCR activation increases IL-10 releasing and may lead to immune paralysis MESHD paralysis HP.

    Early Guillain-Barré syndrome MESHD in COronaVIrus Disease MESHD 2019 (COVID-19): a case report from an Italian COVID-Hospital

    Authors: Donatella Ottaviani; Federica Boso; Enzo Tranquillini; Ilaria Gapeni; Giovanni Pedrotti; Susanna Cozzio; Giovanni M. Guarrera; Bruno Giometto

    doi:10.21203/rs.3.rs-24886/v1 Date: 2020-04-24 Source: ResearchSquare

    Guillain Barré syndrome MESHD (GBS) is an acute polyradiculoneuropathy MESHD associated with dysimmune processes, often related to a previous infectious exposure. During Italian Severe Acute Respiratory Syndrome MESHD Coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis MESHD paralysis HP with unilateral facial neuropathy after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS, along with consistent neurophysiological data. Despite immunoglobulin infusions and intensive supportive care, her clinical picture worsened simultaneously both from respiratory and neurological point of view, as if reflecting different aspects of the same systemic inflammatory response. Similar early complications have already been observed in patients with para-infectious GBS related to Zika virus, but pathological mechanisms have yet to be established.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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