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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Digestive Involvement in SARS-CoV-2 Infection MESHD: A Retrospective Multi-center Study

    Authors: Haitao Shang; Chao Huang; Yuhua Chen; Shengyan Zhang; Pengcheng Yang; Gaichao Hong; Lei Zhang; Xiaohua Hou

    doi:10.21203/rs.3.rs-21375/v1 Date: 2020-04-04 Source: ResearchSquare

    BackgroundCoronavirus disease MESHD 2019 (COVID-19) is an emerged infection MESHD raised wide concerns for the pneumonia MESHD pneumonia HP and respiratory manifestations. Also, digestive complications are frequently observed in COVID-19 patients but the significance remains undetermined.MethodsA retrospective analysis of alimentary symptoms, liver dysfunctions and other clinical parameters of 514 hospitalized COVID-19 patients (282 mild, 162 severe and 70 critical cases) admitted to the 3 designated medical units of Wuhan Union Hospital from Jan 20 to Feb 29, 2020 was performed.Results1) A series of alimentary symptoms, including poor appetite HP(50.2%), diarrhea MESHD diarrhea HP(25.5%), nausea MESHD nausea HP(16.3%), vomit MESHD vomit HP(11.9%) and abdominal pain MESHD abdominal pain HP(3.3%), presented in COVID-19 patients.2) Diarrhea MESHD Diarrhea HP was common gastrointestinal symptom with higher morbidity in the severe and critical patients (32.1% and 27.1% respectively), and 13.2% patients developed diarrhea MESHD diarrhea HP in the first 3 days after onset of symptoms TRANS. Those with diarrhea MESHD diarrhea HP were reported more apparent systemic inflammation MESHD and liver injury in severe and critical cases compared with patients without diarrhea MESHD diarrhea HP.3) Notably, 31 patients (6.03%) presented with diarrhea MESHD diarrhea HP in the absence of respiratory symptoms. These patients were observed less systemic inflammatory activity relative to diarrhea MESHD diarrhea HP patients combined with respiratory symptoms.4) Also, liver injury was high incident in COVID-19 patients with increased alanine aminotransferase (43.3%), aspartate transaminase (36.7%) and decreased albumin (80.9%), but less increased total bilirubin HP (10.9%) and direct bilirubin(14.2%), which were more serious in the severe to critical patients.ConclusionsOur data favored in the process of novel SARS-CoV-2 infection MESHD. There may be a “gut-type” in the clinical prevention and management that differ from the “lung-type” in COVID-19 sufferers.

    Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia MESHD Pneumonia HP in Kunming

    Authors: Haiyan Fu; Hongjuan Li; Xiaoqing Tang; Xiang Li; Jie Shen; Yujun Zhou; Bing Xu; Yu Luo

    doi:10.1101/2020.02.28.20029173 Date: 2020-03-01 Source: medRxiv

    Objective: To analyze the clinical characteristics of patients with novel coronavirus pneumonia MESHD pneumonia HP in Kunming City, and to study the correlation between nutritional status and immune function. Methods: Clinical data of 36 patients with novel coronavirus pneumonia MESHD pneumonia HP in isolation area of Kunming Third People's Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum SERO albumin (ALB), prealbumin (PAB), hypersensitive c-reactive protein (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood SERO of patients. Results: (1) The patients with new coronavirus pneumonia MESHD pneumonia HP in Kunming were mainly of common type. (2) 50% of the patients' first symptoms were fever MESHD fever HP and cough MESHD cough HP; (3) The total number of white blood SERO cells in peripheral blood SERO was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia MESHD anemia HP. Hypersensitive c-reactive protein increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased HP slightly in 11 cases (30.56%), and renal function and blood SERO coagulation were normal. Absolute value of CD3+T cells is with a decrease in 21 cases (58.3%), CD4+T in 28 cases (77.8%), CD8+T in 17 cases (47.2%), and CD4+/ CD8+ inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 T cells and CD8 T cells in the new coronavirus pneumonia MESHD pneumonia HP group were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein was higher than that in the normal control group. (5) The levels of PAB in the serum SERO of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 T cells and CD8 T cells, and the correlation coefficients were -0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences. Conclusion: The clinical characteristics of the novel coronavirus pneumonia MESHD pneumonia HP in Kunming are different from those in Wuhan. The changes of serum SERO proalbumin and T cell subsets are relatively obvious. Changes in serum SERO proalbumin may contribute to the early warning of novel coronavirus pneumonia MESHD pneumonia HP. The nutritional status of patients with common and mild pneumonia MESHD pneumonia HP should be considered.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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