Corpus overview


MeSH Disease

Human Phenotype


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    Prevalence SERO of malnutrition MESHD malnutrition HP in COVID-19 inpatients: the Nutricov study

    Authors: Antoine Rouget; Fanny Vardon-Bounes; Pierre Lorber; Adrien Vavasseur; Olivier Marion; Bertrand Marcheix; Olivier Lairez; Laurent Balardy; Olivier Fourcade; Jean-Marie Conil; Vincent Minville

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: Recent ESPEN guidelines highlighted the interest of prevention, diagnosis and treatment of malnutrition MESHD malnutrition HP in the management of coronavirus disease MESHD 19 (COVID-19) patients. The aim of our study was to evaluate the prevalence SERO of malnutrition MESHD malnutrition HP in patients hospitalized for COVID-19. Methods: Prospective observational cohort study on COVID-19 inpatients admitted to a tertiary hospital. Malnutrition MESHD Malnutrition HP was diagnosed according to the Global Leadership Initiative on Malnutrition MESHD Malnutrition HP two-step approach. Patients were divided in two groups according to the diagnosis of malnutrition MESHD malnutrition HP. Covariate selection for the multivariate analysis was based on P value <0.2 in univariate analysis, with a logistic regression model and a backward elimination procedure. A partitioning of the population was represented using a Classification and Regression Tree analysis.Results: 80 patients were prospectively enrolled in the study. Thirty patients (37.5%) had criteria for malnutrition MESHD malnutrition HP. The need for ICU admission (n=46, 57.5%) was similar in the two groups. Three patients who died (3.75%) were malnourished. Multivariate analysis exhibited that low BMI (OR=0.83, 95% CI [0.73-0.96], p=0.0083), dyslipidemia (OR=29.45, 95% CI [3.12-277.73], p=0.0031), oral intakes reduction <50% (OR=3.169, 95% CI [1.04-9.64], p=0.0422) and GFR (CKD-EPI) at admission (OR=0.979, 95% CI [0.96-0.998], p=0.0297) were associated with the occurrence of malnutrition MESHD malnutrition HP in COVID-19 inpatients.Conclusions: We demonstrate the existence of a high prevalence SERO of malnutrition MESHD malnutrition HP (37.5%) in a general cohort of COVID-19 inpatients according to GLIM criteria. Considering this high prevalence SERO, nutritional support in COVID-19 care seems an essential element. Trial registration: Ethical Committee No 2020-A01237-32)(RC31/20/0165 NUTRI-COV

    Clinical Features of Hemodialysis (HD) patients confirmed with Coronavirus Disease MESHD 2019 (COVID-19): a Retrospective Case-Control Study

    Authors: Xiaohui Wang; Huan Zhou; Xiaofen Xiao; Xianhua Tan; Xin Zhang; Yong He; Jing Li; Guosheng Yang; Mingmei Li; Duan Liu; Shanshan Han; Haibo Kuang

    doi:10.1101/2020.07.06.20147827 Date: 2020-07-10 Source: medRxiv

    Background: Since December 2019, Coronavirus Disease MESHD 2019(COVID-19) occurred in wuhan, China, and outbreaked rapidly into a global pandemic. This current poses great challenges to hemodialysis (HD) patients. Objective: To make a comprehensive evaluation and comparison between HD patients confirmed with COVID-19 and the general HD patients. Methods: HD patients confirmed with COVID-19 in Wuhan No.5 Hospital were admitted as confirmed group from Jan 10 to Mar 15, 2020. And HD patients not infected in our dialysis center were chosen as control group. General characteristics, laboratory indicators were retrospectively collected, analyzed and compared. Results: A total of 142 cases were admitted, including 43 cases in confirmed TRANS group and 99 in control group. Body mass index (BMI) was slightly lower in confirmed group than that in control group (P=0.011). The proportion of one or less underlying disease MESHD in confirmed group(51.16%) was higher than that in control group(14.14%)(P< 0.001), and the proportion of three or more underlying diseases MESHD in confirmed group(11.63%) was lower than that in control group(52.53%)(P< 0.001). Patients in confirmed group exhibited significantly lower hemoglobin, lymphocyte count, and lymphocyte percentage, but higher neutrophil percentage, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein, aspartate transaminase, and alkaline phosphatase. There was no significant difference in age TRANS, gender TRANS, dialysis age TRANS, primary disease MESHD, the using of ACEI/ARB, platelet-to-lymphocyte ratio (PLR) , and other indicators between the two groups. Conclusions: Faced with Severe Acute Respiratory Syndrome MESHD-CoV-2 (SARS-CoV-2), HD patients with lower BMI and hemoglobin were more susceptible to be infected, which might be related to malnutrition MESHD malnutrition HP. Once confirmed with COVID-19, HD patients expressed obviously disregulated in inflammation MESHD and immune.

    The COVID-19 mortality effects of underlying health conditions in India: a modelling study

    Authors: Paul Novosad; Radhika Jain; Alison Campion; Sam Asher

    doi:10.1101/2020.07.05.20140343 Date: 2020-07-08 Source: medRxiv

    Objective: To model how known COVID-19 comorbidities will affect mortality rates and the age TRANS distribution of mortality in a large lower middle income country (India), as compared with a high income country (England), and to identify which health conditions drive any differences. Design: Modelling study. Setting: England and India. Participants: 1,375,548 respondents aged TRANS 18 to 99 to the District Level Household Survey-4 and Annual Health Survey in India. Additional information on health condition prevalence SERO on individuals aged TRANS 18 to 99 was obtained from the Health Survey for England and the Global Burden of Diseases MESHD, Risk Factors, and Injuries Studies (GBD). Main outcome measures: The primary outcome was the proportional increase in age TRANS-specific mortality in each country due to the prevalence SERO of each COVID-19 mortality risk factor (diabetes, hypertension MESHD hypertension HP, obesity MESHD obesity HP, chronic heart disease MESHD, respiratory illness, kidney disease MESHD, liver disease MESHD, and cancer, among others). The combined change in overall mortality and the share of deaths MESHD under 60 from the combination of risk factors was estimated in each country. Results: Relative to England, Indians have higher rates of diabetes (10.6% vs. 8.5%), chronic respiratory disease MESHD (4.8% vs. 2.5%), and kidney disease MESHD (9.7% vs. 5.6%), and lower rates of obesity MESHD obesity HP (4.4% vs. 27.9%), chronic heart disease MESHD (4.4% vs. 5.9%), and cancer (0.3% vs. 2.8%). Population COVID-19 mortality in India relative to England is most increased by diabetes (+5.4%) and chronic respiratory disease MESHD (+2.3%), and most reduced by obesity MESHD obesity HP (-9.7%), cancer (-3.2%), and chronic heart disease MESHD (-1.9%). Overall, comorbidities lower mortality in India relative to England by 9.7%. Accounting for demographics and population health explains a third of the difference in share of deaths MESHD under age TRANS 60 between the two countries. Conclusions: Known COVID-19 health risk factors are not expected to have a large effect on aggregate mortality or its age TRANS distribution in India relative to England. The high share of COVID-19 deaths MESHD from people under 60 in low- and middle-income countries (LMICs) remains unexplained. Understanding mortality risk associated with health conditions prevalent in LMICs, such as malnutrition MESHD malnutrition HP and HIV/AIDS, is essential for understanding differential mortality. Keywords: COVID-19, India, low- and middle-income countries, comorbidity

    Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19

    Authors: Yan Liu; Guoshi Luo; Xin Qian; Chenglin Wu; Yijun Tang; kun lu; Biyu Chen; Elaine Lai-Han Leung; Meifang Wang

    doi:10.21203/ Date: 2020-06-08 Source: ResearchSquare

    Object: To report the successful diagnosis and treatment of a patient with critical condition of novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) and to summarize its clinical features and airway management experience in successful treatment.Methods: Retrospectively analyzed the successful management of one case of COVID-19 with critical condition combined respiratory failure HP and discussed the clinical characteristics and airway management of the patient in conjunction with a review of the latest literature.Results: A patient with an anastomotic fistula MESHD after radical treatment of esophageal cancer and right-side encapsulated pyopneumothorax was admitted with cough MESHD cough HP and dyspnea MESHD dyspnea HP and was diagnosed with novel coronavirus pneumonia MESHD pneumonia HP and malnutrition MESHD malnutrition HP by pharyngeal swab nucleic acid test in combination with chest CT. The patient was treated with antibiotics, antiviral and antibacterial medications, respiratory support, expectorant nebulization, and nutritional support, expressed progressive deterioration. Endotracheal intubation and mechanical ventilation were performed since the onset of the type Ⅱ respiratory failure HP on the 13th day of admission. The patient had persistent refractory hypercapnia MESHD hypercapnia HP after mechanical ventilation. Based on the treatment mentioned above, combined with repeated bronchoalveolar lavage by using N-acetylcysteine ​​(NAC) inhalation solution, the patient's refractory hypercapnia MESHD hypercapnia HP was gradually improved. It was cured and discharged after being given the mechanical ventilation for 26 days as well as 46 days of hospitalization, currently is surviving well.Conclusion: Patients with severe conditions of novel coronavirus pneumonia MESHD pneumonia HP often encounter bacterial infection MESHD in their later illness-stages. They may suffer respiratory failure HP and refractory hypercapnia MESHD hypercapnia HP that is difficult to improve due to excessive mucus secretion leading to small airway obstruction MESHD. In addition to the use of reasonable antibiotics and symptomatic respiratory support and other treatment, timely artificial airway and repeated bronchoalveolar NAC inhalation solution lavage, expectorant and other airway management are essential for such patients.

    Risks to Children TRANS under-five in India from COVID-19

    Authors: Isabel Frost; Katie Tseng; Stephanie Hauck; Geetanjali Kappor; Aditi Sriram; Arindam Nandi; Ramanan Laxminarayan

    doi:10.1101/2020.05.18.20105239 Date: 2020-05-22 Source: medRxiv

    Objective: The novel coronavirus, COVID-19, has rapidly emerged to become a global pandemic and is known to cause a high risk to patients over the age TRANS of 70 and those with co-morbidities, such as hypertension MESHD hypertension HP and diabetes. Though children TRANS are at comparatively lower risk compared to adults TRANS, the Indian population has a large young demographic that is likely to be at higher risk due to exposure to pollution, malnutrition MESHD malnutrition HP and poor access to medical care. We aimed to quantify the potential impact of COVID-19 on Indias child TRANS population. Methods: We combined district family household survey data with data from the COVID-19 outbreak in China to analyze the potential impact of COVID-19 on children TRANS under the age TRANS of 5, under three different scenarios; each of which assumed the prevalence SERO of infection MESHD to be 0.5%, 1%, or 5%. Results: We find that in the lowest prevalence SERO scenario, across the most populous 18 Indian states, asymptomatic TRANS, non-hospitalized symptomatic and hospitalized symptomatic cases could reach 87,200, 412,900 and 31,900, respectively. In a moderate prevalence SERO scenario, these figures reach 174,500, 825,800, and 63,800, and in the worst case, high prevalence SERO scenario these cases could climb as high as 872,200, 4,128,900 and 319,700. Conclusion: These estimates show COVID-19 has the potential to pose a substantial threat to Indias large population of children TRANS, particularly those suffering from malnutrition MESHD malnutrition HP and exposure to indoor air pollution, who may have limited access to health services.

    The Early Food Insecurity Impacts of COVID-19

    Authors: Meredith T. Niles; Farryl Bertmann; Emily H. Belarmino; Thomas Wentworth; Erin Biehl; Roni A. Neff

    doi:10.1101/2020.05.09.20096412 Date: 2020-05-13 Source: medRxiv

    Background COVID-19 has disrupted food access and impacted food insecurity, which is associated with numerous adverse individual and public health outcomes. Methods We conducted a statewide population-level survey in Vermont from March 29-April 12, 2020, during the beginning of a statewide stay-at-home order. We utilized the USDA six-item validated food security module to measure food insecurity before COVID-19 and since COVID-19. We assessed food insecurity prevalence SERO and reported food access challenges, coping strategies, and perceived helpful interventions among food secure, consistently food insecure (pre-and post COVID-19), and newly food insecure (post COVID-19) respondents. Results Among 3,219 respondents, there was a 33% increase in household food insecurity since COVID-19 (p<0.001), with 35.6% of food insecure households classified as newly food insecure. Respondents experiencing a job loss were more likely to experience food insecurity (OR 3.43; 95% CI, 2.45-4.80). Multiple physical and economic barriers, as well as concerns related to food access during COVID-19, are reported, with respondents experiencing household food insecurity more likely to face access challenges (p<0.001). Significant differences in coping strategies were documented between respondents in newly food insecure vs. consistently insecure households. Conclusions Since the declaration of the COVID-19 pandemic, there has been a significant increase in food insecurity in Vermont, accompanied by major food access barriers. These findings have important potential impacts on individual health, including mental health and malnutrition MESHD malnutrition HP, as well as on future healthcare costs. We suggest proactive strategies to address food insecurity during this crisis.

    COVID-19 in Elderly TRANS Patient: A Case Report

    Authors: Zheng Qin; Xingjian Wang; Wei Wang

    doi:10.21203/ Date: 2020-05-06 Source: ResearchSquare

    Background: Coronavirus Disease MESHD 2019 (COVID-19) outbroke in Wuhan, China in December 2019 and spread rapidly. Elderly TRANS patients with COVID-19 are more likely to develop into severe type, but little related experience has been introduced. Case presentation: An 82-year-old female TRANS patient living in Wuhan, China was referred because of fever MESHD fever HP, dry cough MESHD cough HP and chest distress for a week. Clinical diagnosis of COVID-19 was considered, confirmed by viral nucleic acid detection. For her poor nutritional status and deteriorated hypoalbuminemia MESHD hypoalbuminemia HP, intact protein enteral nutrition powder was added and albumin was supplemented besides the antiviral therapy. Her fever MESHD fever HP gradually subsided with the alleviation of related symptoms. During her hospitalization, D-dimer level elevated with ultrasonographically detected thromboembolism MESHD thromboembolism HP in bilateral gastrocnemius veins, and low molecular weight heparin was thereby administrated for the prevention of pulmonary embolism MESHD pulmonary embolism HP. Conclusions: The experience of this case suggested that the timely screening and intervention of malnutrition MESHD malnutrition HP and venous thromboembolism MESHD thromboembolism HP are crucial issues to be concerned when treating elderly TRANS patients with severe COVID-19 besides the routine antiviral therapy. 

    Comparison of the Clinical Implications among Two Different Nutritional Indices in Hospitalized Patients with COVID-19

    Authors: ling chen; Xuebei Du; Yuwei Liu; Jing Chen; Li Peng; Zhenshun Cheng; Harry H.X. Wang; Mingqi Luo; Yalei Jin; Yan Zhao

    doi:10.1101/2020.04.28.20082644 Date: 2020-05-01 Source: medRxiv

    Background: Coronavirus disease MESHD 2019 (COVID 19) is an emerging infectious disease MESHD.It was first reported in Wuhan, China, and then broke out on a large scale around the world.This study aimed to assess the clinical significance of two different nutritional indices in 245 patients with COVID 19. Methods: In this retrospective single center study, we finally included 245 consecutive patients who confirmed COVID 19 in Wuhan University Zhongnan Hospital from January 1 to February 29. Cases were classified as either discharged or dead. Demographic, clinical and laboratory datas were registered, two different nutritional indices were calculated: (i)the Controlling nutritional status (CONUT) score; (ii) prognostic nutritional index (PNI). We used univariate and multivariate logistic regression analysis to explore the relationship between nutritional indices and hospital death MESHD . Results: 212 of them were discharged and 33 of them died. In hospital mortality was signifcantly higher in the severe group of PNI than in the moderate and normal groups. It was also significantly worse in the severe CONUT group than in the moderate, mild , and normal CONUT groups. Multivariate logistic regression analysis showed the CONUT score (odds ratio3.371,95%CI (1.124 10.106), p = 0.030) and PNI(odds ratio 0.721,95% CI(0.581 0.896),P=0.003) were independent predictors of all cause death MESHD at an early stage; Multivariate logistic regression analysis also showed that the severe group of PNI was the independent risk predictor of in hospital death MESHD(odds ratio 24.225, 95% CI(2.147 273.327), p=0.010).The CONUT score cutoff value was 5.5 (56.00 and 80.81%; AUC 0.753; 95% CI(0.644 0.862);respectively).The PNI cutoff value was 40.58 (81.80 and 66.20%; AUC 0.778; 95% CI(0.686 0.809); respectively).We use PNI and the COUNT score to assess malnutrition MESHD malnutrition HP, which can have a prognosis effect of COVID 19 patients. Conclusion:The CONUT score and PNI could be a reliable prognostic marker of all cause death MESHD in patients with COVID 19. Keywords: Coronavirus disease MESHD 2019; nutrition; indicies; prognosis

    A multi-centered, retrospective, descriptive study on 107 dead patients with COVID-19

    Authors: chong zhang; Minhao Wu; Xiaobin Zhu; meng wu; yufan zhu; kun li; zhouming deng; yuanlong xie; lin cai

    doi:10.21203/ Date: 2020-04-02 Source: ResearchSquare

    Since the emergence of Corona Virus Disease MESHD 2019 (COVID-19) in Wuhan city, Hubei Province, China, it has caused thousands of deaths MESHD. As the ongoing outbreak of COVID-19 around the world, the number of deaths MESHD will definitely continue to increase. We aimed to further describe the clinical characteristics of dead cases with COVID-19 through a large sample and multi-centered study and to find some clinical predictors for the deterioration of COVID-19 during the process.   Methods One hundred and seven patients (16 patients from Lei Shen-Shan Hospital, 54 patients from Seventh Hospital of Wuhan and 37 patients from Zhongnan Hospital of Wuhan University) with COVID-19 were enrolled in our research from Jan 22 to Feb 29, 2020. The demographic, clinical, radiological, laboratory and treatment data of all cases were analysed.   Results Of the 107 dead patients with COVID-19, 71 (66.4%) were male TRANS and 36 (33.6%) were female TRANS. The mean age TRANS of the patients was 71.2 ± 12.1 years. 82 (76.6%) of patients had chronic diseases MESHD. The mean duration from admission to death MESHD was 9 (IQR,5-14) days. Respiratory functional damage was the most common one followed by heart and kidney. Hematuria MESHD Hematuria HP was found in 36(33.6%) patients. 89(83.2%) patients’ albumin levels were decreased. 68(63.6%) patients had anemia MESHD anemia HP. concerning laboratory results, 55 (69.6%) and 56 (70.1%) patients have the elevated white blood SERO cells and elevated Neutrophils during the process; only 43 (54.4%) have the decreased Lymphocytes; The values of platelets and haemoglobin decreased in 64(81.0%) and 58 (73.4%) patients. Alanine aminotransferase and aspartate aminotransferase elevated in near half of patients, while almost 80% of patients have the decreased albumin. The elevated blood SERO urea nitrogen and cystatin C were manifested in about 70% of patients. Procalcitonin was elevated in 38 (71.7%) patients.   Conclusions In conclusion, the older men with chronic diseases MESHD are more likely to die from COVID-19. Apart from that, more attention should be pay on timely treatment, coinfections MESHD, malnutrition MESHD malnutrition HP, and dysfunction of kidney and coagulation. The rising values (white blood SERO cell, blood SERO urea nitrogen, cystatin C, PCT and PT) and the decreased values (PLT, Hb and albumin) maybe meaningful for predict the poor prognosis.

    Clinical characteristics of 25 death MESHD cases infected with COVID-19 pneumonia MESHD pneumonia HP: a retrospective review of medical records in a single medical center, Wuhan, China

    Authors: Xun Li; Luwen Wang; Shaonan Yan; Fan Yang; Longkui Xiang; Jiling Zhu; Bo Shen; Zuojiong Gong

    doi:10.1101/2020.02.19.20025239 Date: 2020-02-25 Source: medRxiv

    Summary Background The pneumonia MESHD pneumonia HP caused by the 2019 novel coronavirus (SARS-CoV-2) is a highly infectious disease MESHD, which was occurred in Wuhan, Hubei Province, China in December 2019. As of February 13, 2020, a total of 59883 cases of COVID-19 in China have been confirmed and 1368 patients have died from the disease MESHD. However, the clinical characteristics of the dyed patients were still not clearly clarified. This study aims to summarize the clinical characteristics of death MESHD cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. Methods The clinical records, laboratory findings and radiologic assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. Findings The mean age TRANS of the dead was 71.48 years, the average course of the disease MESHD was 10.56 days, all patients eventually died of respiratory failure HP. All of those who died had underlying diseases MESHD, the most common of which was hypertension MESHD hypertension HP (16/25, 64%), followed by diabetes (10/25, 40%), heart diseases MESHD (8/25, 32%), kidney diseases MESHD (5/25, 20%), cerebral infarction MESHD (4/25, 16%), chronic obstructive pulmonary disease MESHD chronic obstructive pulmonary disease HP (COPD, 2/25, 8%), malignant tumors (2/25, 8%) and acute pancreatitis HP pancreatitis MESHD (1/25, 4%). The most common organ damage outside the lungs was the heart, followed by kidney and liver. In the patients' last examination before death MESHD, white blood SERO cell and neutrophil counts were elevated in 17 patients (17/25, 68%) and 18 patients (18/25, 72%), lymphocyte counts were decreased in 22 patients (22/25, 88%). Most patients' PCT, CRP and SAA levels were elevated, the percentages were 90.5% (19/21), 85% (19/20) and 100% (21/21) respectively. The levels of the last test of neutrophils (15/16, 93.8%), PCT (11/11, 100%), CRP (11/13, 84.6%), cTnI (8/9, 88.9%), D-Dimer (11/12, 91.6%) and LDH (9/9, 100%) were increased as compared to the first test, while the levels of lymphocytes were decreased (14/16, 87.5%). Interpretation The age TRANS and underlying diseases MESHD ( hypertension MESHD hypertension HP, diabetes, etc.) were the most important risk factors for death MESHD of COVID-19 pneumonia MESHD pneumonia HP. Bacterial infections MESHD may play an important role in promoting the death MESHD of patients. Malnutrition MESHD Malnutrition HP was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT, CRP, cTnI, D-Dimer and LDH levels can be used as indicators of disease progression MESHD, as well as the decline of lymphocytes counts.

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MeSH Disease
Human Phenotype

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