Corpus overview


Overview

MeSH Disease

Disease (1)

Hypertension (1)

Fever (1)


Human Phenotype

Transmission

Seroprevalence
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    COVID-19 Outcomes in 4712 consecutively confirmed SARS-CoV2 cases in the city of Madrid.

    Authors: Sarah Heili-Frades; Pablo Minguez; Ignacio Mahillo-Fernandez; Tomas Prieto-Rumeau; Antonio Herrero Gonzalez; Lorena de la Fuente; Maria Jesus Rodriguez Nieto; German Peces-Barba Romero; Mario Peces-Barba; Maria del Pilar Carballosa de Miguel; Itziar Fernandez Ormaechea; Alba Naya Prieto; Farah Ezzine de Blas; Luis Jimenez Hiscock; Cesar Perez Calvo; Arnoldo Santos; Luis Enrique Munoz Alameda; Fredeswinda Romero Bueno; Miguel Gorgolas Hernandez-Mora; Alfonso Cabello Ubeda; Beatriz Alvarez Alvarez; Elizabet Petkova; Nerea Carrasco; Dolores Martin Rios; Nicolas Gonzalez Mangado; Olga Sanchez Pernaute

    doi:10.1101/2020.05.22.20109850 Date: 2020-05-25 Source: medRxiv

    There is limited information describing features and outcomes of patients requiring hospitalization for COVID19 disease MESHD and still no treatments have clearly demonstrated efficacy. Demographics and clinical variables on admission, as well as laboratory markers and therapeutic interventions were extracted from electronic Clinical Records (eCR) in 4712 SARS-CoV2 infected patients attending 4 public Hospitals in Madrid. Patients were stratified according to age TRANS and stage of severity. Using multivariate logistic regression analysis, cut-off points that best discriminated mortality were obtained for each of the studied variables. Principal components analysis and a neural network (NN) algorithm were applied. A high mortality incidence associated to age TRANS >70, comorbidities ( hypertension MESHD hypertension HP, neurological disorders and diabetes), altered vitals such as fever MESHD fever HP, heart rhythm disturbances or elevated systolic blood pressure HP blood SERO pressure, and alterations in several laboratory tests. Remarkably, analysis of therapeutic options either taken individually or in combination drew a universal relationship between the use of Cyclosporine A and better outcomes as also a benefit of tocilizumab and/or corticosteroids in critically ill patients. We present a large Spanish population-based study addressing factors influencing survival in current SARS CoV2 pandemic, with particular emphasis on the effectivity of treatments. In addition, we have generated an NN capable of identifying severity predictors of SARS CoV2. A rapid extraction and management of data protocol from eCR and artificial intelligence in-house implementations allowed us to perform almost real time monitoring of the outbreak evolution.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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