COVID-19 breakout in Italy has caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection MESHD very few information are available about liver involvement in COVID-19 infection MESHD, that could possibly evocate a systemic disease MESHD targeting a lot of organs. Since now there are no reports of large series of histological evaluation of liver morphology in this setting. Knowledge of histological liver findings connected to clinical data is crucial in management of this disease MESHD. Post-mortem wedge liver biopsies from 48 patients died for COVID-19 infection MESHD were available from two main hospitals located in northern Italy, Lombardy; all sample were obtained during autopsies. No patient has a significant clinical complain of liver disease MESHD or signs of liver failure MESHD before and during hospitalization; for each of them laboratory data focused on liver were available. All liver samples showed minimal inflammation MESHD features; on the other side, many histological pictures compatible with vascular alterations were observed, characterized by portal vein braches number increase associated with lumen massive dilatation HP, partial or complete recent luminal thrombosis MESHD of portal and sinusoidal vessels, fibrosis MESHD fibrosis of portal HP of portal tract, focally severely enlarged and fibrotic. Our preliminary results concerning histological liver involvement in COVID-19 infection MESHD infection confirm TRANS confirm the clinical impression that liver failure MESHD is not a main concern and this organ is not the target of significant inflammatory damage; histopatological findings are highly suggestive for marked alteration of intrahepatic blood SERO vessel network secondary to systemic alterations induced by virus that could target, besides lung parenchyma, cardiovascular system, coagulation cascade or endothelial layer of blood SERO vessels.