Background: Neurological manifestations of COVID-19 have only recently been described, with a paucity of literature reporting the potential relationship between COVID-19 and acute symptomatic seizures HP seizures MESHD. Two prior studies found no clinical or electrographic seizures MESHD seizures HP in their cohorts of COVID-19 patients with altered mental status (AMS) and clinical seizure MESHD seizure HP-like events (SLEs). Methods: In this retrospective cohort study, 22 critically-ill COVID-19 patients above the age TRANS of 18 years who underwent EEG (electroencephalography) monitoring between April 20th, 2020 and May 20th, 2020 were studied. 19 patients underwent continuous EEG (cEEG) for at least 24 hours, and 3 patients underwent routine EEGs (<1 hour). Demographics including age TRANS, gender TRANS, comorbid medical, and neurological conditions were collected. Clinical variables included EEG findings, anti- seizure MESHD seizure HP medications, discharge disposition, and survival. Findings: 17 patients underwent EEG monitoring for unexplained altered mental status changes and 5 patients underwent monitoring for a seizure MESHD seizure HP-like event. 5 patients had epileptiform abnormalities on EEG HP (4 patients on cEEG, 1 on routine EEG); and only 2 of 5 epileptic EEG patients had a prior history of epilepsy MESHD. 2 patients in our cohort had electrographic seizures MESHD seizures in the absence HP in the absence of prior epilepsy MESHD history. No patients with epileptiform abnormalities or electrographic seizures MESHD seizures HP had acutely abnormal neuroimaging on CT or MRI. Interpretation: Encephalopathic COVID-19 positive patients had a range of EEG abnormalities HP, and a higher proportion of patients in this series had electrographic seizures MESHD seizures HP than previous literature suggests. This may be influenced by the duration of monitoring with cEEG and the use of a 21 channel electrode system. cEEG findings may help to guide antiseizure medical therapy, as well as the workup of altered mental status in the setting of unremarkable neuroimaging. Funding: No funding was used for this study.