Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    COVID-19 Mortality Risk Assessment: An International Multi-Center Study

    Authors: Dimitris Bertsimas; Galit Lukin; Luca Mingardi; Omid Nohadani; Agni Orfanoudaki; Bartolomeo Stellato; Holly Wiberg; Sara Gonzalez-Garcia; Carlos Luis Parra-Calderon; - The Hellenic COVID-19 Study Group; Kenneth Robinson; Michelle Schneider; Barry Stein; Alberto Estirado; Lia a Beccara; Rosario Canino; Martina Dal Bello; Federica Pezzetti; Angelo Pan

    doi:10.1101/2020.07.07.20148304 Date: 2020-07-08 Source: medRxiv

    Background: Timely identification of COVID-19 patients at high risk of mortality can significantly improve patient management and resource allocation within hospitals. This study seeks to develop and validate a data-driven personalized mortality risk calculator for hospitalized COVID-19 patients. Methods: De-identified data was obtained for 3,927 COVID-19 positive patients from six independent centers, comprising 33 different hospitals. Demographic, clinical, and laboratory variables were collected at hospital admission. The COVID-19 Mortality Risk (CMR) tool was developed using the XGBoost algorithm to predict mortality. Its discrimination performance SERO was subsequently evaluated on three validation cohorts. Findings: The derivation cohort of 3,062 patients has an observed mortality rate of 26.84%. Increased age TRANS, decreased oxygen saturation ([≤] 93%), elevated levels of C-reactive protein HP ([≥] 130 mg/L), blood SERO urea nitrogen ([≥] 18 mg/dL), and blood SERO creatinine ([≥] 1.2 mg/dL) were identified as primary risk factors, validating clinical findings. The model obtains out-of-sample AUCs of 0.90 (95% CI, 0.87-0.94) on the derivation cohort. In the validation cohorts, the model obtains AUCs of 0.92 (95% CI, 0.88-0.95) on Seville patients, 0.87 (95% CI, 0.84-0.91) on Hellenic COVID-19 Study Group patients, and 0.81 (95% CI, 0.76-0.85) on Hartford Hospital patients. The CMR tool is available as an online application at covidanalytics.io/mortality_calculator and is currently in clinical use. Interpretation: The CMR model leverages machine learning to generate accurate mortality predictions using commonly available clinical features. This is the first risk score trained and validated on a cohort of COVID-19 patients from Europe and the United States.

    Anaemia is Associated with Severe Illness in COVID-19: A Retrospective Cohort Study

    Authors: Zheying Tao; Mingyu Liu; Jingyi Wu; Jing Xu; Wei Chen; Zhitao Yang; Xiaoman Xu; Ling Liu; Ruwu Chen; Jingyuan Xie; Huiming Wang; Jialin Liu

    doi:10.21203/rs.3.rs-39184/v1 Date: 2020-06-30 Source: ResearchSquare

    Background and objective:Anaemia commonly aggravates the severity of respiratory diseases MESHD, whereas thus far, no study has elucidated the impact of anaemiaonCorona Virus Disease MESHD 2019(COVID-19). The aim of this study was to evaluate the clinical characteristics of patients with anaemia, and to further explore the relationship between anaemiaand the severity of COVID-19.METHODS:In this single-center, retrospective, observational study, a total of 222 patients were recruited, including 79 patients with anaemia and 143 patients without anaemia. Clinical characteristics, laboratory findings, disease progression MESHD and prognosis were collected and analyzed. Risk factors associated with the severe illness in COVID-19were established by univariable and multivariable logistic regression models.Result:In our cohort, compared to patients without anaemia, patients with anaemia were more likely to experience one or more comorbidities and severe COVID-19 illness, as well as higher mortality. More patients demonstrated elevated levels of C-reactive protein HP (CRP), procalcitonin(PCT) and creatinine in anaemia group. Levels of erythrocyte sedimentation rate(ESR), D-dimer, myoglobin, T-pro brain natriuretic peptide(T-pro-BNP) and urea nitrogen(BUN)in patients with anaemia were significantly higher than those without. In addition,the proportion of patients with dyspnoea,elevated CRP and PCT was positively associated with the severity of anaemia. The Odd Ratio (OR) of anaemia related to the severe condition of COVID-19 was 5.07 (95% CI:1.82-14.18, P=0.002) and 3.47 (95% CI:1.02-11.75, P=0.046) after adjustment for baseline date and laboratory indices, respectively.Conclusion:Anaemia is an independent risk factor associated with the severe illness of COVID-19, and healthcare professionals should be more sensitive to the haemoglobin levels of COVID-19 patients on admission. To avoid rapid deterioration, more intensive care should be given to patients with anaemia.Trial registration: Ethics committee of Wuhan University People's Hospital (wdry2020-k064)

    The Characteristics of Overseas Imported COVID-19 Cases and the Effectiveness of Screening Strategy in Beijing, China

    Authors: Li Li; Cheng-Jie Ma; Yu-Fei Chang; Si-Yuan Yang; Yun-Xia Tang; Linghang Wang

    doi:10.21203/rs.3.rs-37207/v1 Date: 2020-06-20 Source: ResearchSquare

    Background: In March 2020, the WHO declared the novel coronavirus (COVID-19) outbreak a global pandemic. While great success in the coronavirus disease MESHD 2019 (COVID-19) control has been achieved in China, imported cases have become a major challenge. This study aimed to describe the epidemiological and clinical characteristics of imported COVID-19 cases and to assess the effectiveness of screening strategy in Beijing, China.Methods: This retrospective study included all imported COVID-19 cases from Beijing Ditan Hospital from 29 February to 20 March 2020, who were screened by both chest computed tomography (CT) and reverse-transcriptase-polymerase chain reaction (RT-PCR) at initial presentation. Demographic, clinical and laboratory data, in addition to chest CT imaging were collected and analyzed. Results: A total of 71 imported cases were finally diagnosed with laboratory-confirmed COVID-19. The cases were mainly acquired from Europe (63cases, 88.73%). The main clinical manifestations were fever MESHD fever HP and cough MESHD cough HP, which accounted for 30 cases (42.25%) and 35 cases (49.30%), respectively. Only 4 cases (5.63%) had lymphocytopenia and 13 (18.31%) cases demonstrated elevated levels of C-reactive protein HP (CRP). All cases had normal serum SERO levels of procalcitonin(PCT). 35 cases (49.30%) had abnormal CT findings at initial presentation, whereas 36 cases (50.70%) had a normal CT. Using RT-PCR, 59 cases (83.10%) were tested positive at initial presentation.Conclusions: The combination of screening tools, particularly CT and RT-PCR, could be considered to improve the diagnosis in imported COVID-19 cases. Our findings provide the important information and clinical evidence for infection MESHD control of imported COVID-19 cases.

    The characteristics of overseas imported COVID-19 cases and the effectiveness of screening strategy in Beijing, China

    Authors: Li Li; Cheng-Jie Ma; Yu-Fei Chang; Si-Yuan Yang; Yun-Xia Tang; Rong-Meng Jiang

    doi:10.21203/rs.3.rs-30515/v1 Date: 2020-05-21 Source: ResearchSquare

    Background While great success in the coronavirus disease MESHD 2019 (COVID-19) control has been achieved in China, imported cases have become a major challenge. This study aimed to describe the epidemiological and clinical characteristics of imported COVID-19 cases and to assess the effectiveness of screening strategy in Beijing, China.Methods This retrospective study included all imported COVID-19 cases from Beijing Ditan Hospital from 29 February to 20 March 2020, who were screened by both chest computed tomography (CT) and reverse-transcriptase-polymerase chain reaction (RT-PCR) at initial presentation. Demographic, clinical and laboratory data, in addition to chest CT imaging were were collected and analyzed.Results A total of 71 imported cases were finally diagnosed with laboratory-confirmed COVID-19. The cases were mainly acquired from Europe (63 cases, 88.73%). The main clinical manifestations were fever MESHD fever HP and cough MESHD cough HP, which accounted for 30 cases (42.25%) and 35 cases (49.30%), respectively. Only 4 cases (5.63%) had lymphocytopenia and 13 (18.31%) cases demonstrated elevated levels of C-reactive protein HP (CRP). All cases had normal serum SERO levels of procalcitonin (PCT). 35 cases (49.30%) had abnormal CT findings at initial presentation, whereas 36 cases (50.70%) had a normal CT. Using RT-PCR, 59 cases (83.10%) were tested positive at initial presentation.Conclusions The number of overseas imported COVID-19 cases continues to rise in China. The combination of screening tools, particularly CT and RT-PCR, can detect imported COVID-19 cases efficiently.

    A comparative multi-centre study on the clinical and imaging features of comfirmed and uncomfirmed patients with COVID-19

    Authors: Congliang Miao; Jinqiang Zhuang; Mengdi Jin; Huanwen Xiong; Peng Huang; Qi Zhao; Li Miao; Jiang Du; Xinying Yang; Peijie Huang; Jiang Hong

    doi:10.1101/2020.03.22.20040782 Date: 2020-03-24 Source: medRxiv

    Background Previous studies had described the differences in clinical characteristics between ICU and non-ICU patients. However, seldom study focused on confirmed and unconfirmed groups. Our aim was to compare clinical and imaging characteristics of COVID-19 patients outside Hubei province between confirmed and unconfirmed group. Methods We retrospectively enrolled 163 consecutive adult TRANS patients with suspected COVID-19 from three tertiary hospitals in two provinces outside Hubei province from January 12, 2020 to February 13, 2020 and the differences in epidemiological, clinical, laboratory and imaging characteristics between the two groups were compared. Results This study enrolled 163 patients with 62 confirmed cases TRANS and 101 unconfirmed cases. Most confirmed patients were clustered (31, 50.0%) and with definite epidemiological exposure. Symptoms of COVID-19 were nonspecific, largely fever MESHD fever HP and dry cough MESHD cough HP. Laboratory findings in confirmed group were characterized by normal or reduced white blood SERO cell count, reduced the absolute value of lymphocytes, and elevated levels of C-reactive protein HP (CRP) and accelerated Erythrocyte sedimentation rate (ESR). The typical chest CT imaging features of patients with confirmed COVID-19 were peripherally distributed multifocal GGO with predominance in the lower lung lobe. Compared with unconfirmed patients, confirmed patients had significantly higher proportion of dry cough MESHD cough HP, leucopenia, lymphopenia MESHD lymphopenia HP and accelerated ESR (P<0.05); but not with alanine aminotransferase, aspartate aminotransferase, D-dimer, lactic dehydrogenase, and myoglobin (P>0.05). Proportion of peripheral, bilateral or lower lung distribution and multi-lobe involvement, GGO, crazy-paving pattern, air bronchogram and pleural thickening HP in the confirmed group were also higher (P<0.05). Conclusions Symptoms of COVID-19 were nonspecific. Leukopenia MESHD Leukopenia HP, lymphopenia MESHD lymphopenia HP and ESR, as well as chest CT could be used as a clue for clinical diagnosis of COVID-19.

    Clinical features and laboratory inspection of novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) in Xiangyang, Hubei 

    Authors: Weiliang Cao; Li Shi; Lin Chen; Xuemei Xu; Zirong Wu

    doi:10.21203/rs.3.rs-15925/v1 Date: 2020-02-28 Source: ResearchSquare

    Background: Since December 2019, a novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) rapidly spread in China, reached multiple continents currently.We aimed to reveal the infectious characteristics of COVID-19 that provide more information for the research of novel coronavirus. Methods: We performed a retrospective study on the clinical characteristics of 128 COVID-19 cases with laboratory-confirmed from Xiangyang No.1 People’s Hospital during January 2020 to 16 February 2020.Results: Female TRANS patients account for 53.1%. The aged TRANS below 20 years that accounts for 1.6% of overall patients. The aged TRANS in 21~50, 51~65, over 66 years were accounts for 44.5%, 35.1%,18.8%, respectively. In the difference age TRANS spectrum, all severe groups compared with non-severe groups were difference significantly ( P < 0.01 ). Fever MESHD Fever HP ( 89.8% ) and Cough MESHD Cough HP ( 67.2% ) were common clinical symptoms. The rate of patients with sore throats (14.1%) was rare. The rate of chest computed tomography scan showing ground glass opacity in overall, non-severe, severe groups were 63.3%, 60.7%, 76.2%, respectively. White blood SERO cell counts in the normal range of overall patients, but severe group patients were increased significantly ( P < 0.01). Lymphocytes of overall patients were decreased. Alanine transaminase (ALT) and aspartate transaminase (AST) in the normal range of overall patients, but its were elevated in the severe group. Creatinine (CR) and blood SERO urea nitrogen (BUN) of overall patients in the normal range. C-reactive protein (CRP) level of all patients were increased markedly, but it in the severe group was significantly higher than that in the non-severe group ( P < 0.01 ).Conclusions: Our data provide more information that advanced age TRANS, lower lymphocytes levels at the diagnosed COVID-19 patients may be a risk factor for unfavourable prognosis. The white blood SERO cells and C-reactive protein level elevated HP in severe COVID-19 patients may be accompanying bacterial infection MESHD. 2019-nCov may be carries a risk factor of impaired liver and kidney function.

    Clinical features and laboratory inspection of novelcoronavirus pneumonia MESHD pneumonia HP (COVID-19) in Xiangyang, Hubei

    Authors: Weiliang Cao

    doi:10.1101/2020.02.23.20026963 Date: 2020-02-25 Source: medRxiv

    Background: Since December 2019, a novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) rapidly spread in China, reached multiple continents currently.We aimed to reveal the infectious characteristics of COVID-19 that provide more information for the research of novel coronavirus. Methods: We performed a retrospective study on the clinical characteristics of 128 COVID-19 cases with laboratory-confirmed from Xiangyang No 1 Hospitalad during January 2020 to 16 February 2020. Results: Female TRANS patients account for 53.1%. The aged TRANS below 20 years that accounts for 1.6% of overall patients. The aged TRANS in 21~50, 51~65, over 66 years were accounts for 44.5%, 35.1%,18.8%, respectively. In the difference age TRANS spectrum, all severe groups compared with non-severe groups were difference significantly ( P < 0.01 ). Fever MESHD Fever HP ( 89.8% ) and Cough MESHD Cough HP ( 67.2% ) were common clinical symptoms. The rate of patients with sore throats (14.1%) was rare. The rate of chest computed tomography scan showing ground glass opacity in overall, non-severe, severe groups were 63.3%, 60.7%, 76.2%, respectively. White blood SERO cell counts in the normal range of overall patients, but severe group patients were increased significantly ( P < 0.01). Lymphocytes of overall patients were decreased. Alanine transaminase (ALT) and aspartate transaminase (AST) in the normal range of overall patients, but its were elevated in the severe group. Creatinine (CR) and blood SERO urea nitrogen (BUN) of overall patients in the normal range. C-reactive protein (CRP) level of all patients were increased markedly, but it in the severe group was significantly higher than that in the non-severe group ( P < 0.01 ). Conclusions: Our data provide more information that advanced age TRANS, lower lymphocytes levels at the diagnosed COVID-19 patients may be a risk factor for unfavourable prognosis. The white blood SERO cells and C-reactive protein level elevated HP in severe COVID-19 patients may be accompanying bacterial infection MESHD. 2019-nCov may be carries a risk factor of impaired liver and kidney function.

    The cross-sectional study of hospitalized coronavirus disease MESHD 2019 patients in Xiangyang, Hubei province

    Authors: Jinwei Ai; Junwen Chen; Yong Wang; Xiaoyun Liu; Wufeng Fan; Gaojing Qu; Meiling Zhang; Shengduo Polo Pei; Bowen Tang; Shuai Yuan; Yang Li; Lisha Wang; Guoxin Huang; Bin Pei

    doi:10.1101/2020.02.19.20025023 Date: 2020-02-23 Source: medRxiv

    Summary Objective To describe the epidemiological and clinical characteristics of the Coronavirus Disease MESHD 2019 (COVID-19) hospitalized patients and to offer suggestions to the urgent needs of COVID-19 prevention, diagnosis and treatment. Methods We included 102 confirmed COVID-19 cases hospitalized in Xiangyang No.1 peoples hospital, Hubei, China until Feb 9th, 2020. Demographic data, laboratory findings and chest computed tomographic (CT) images were obtained and analyzed. Findings All cases were confirmed TRANS by real-time RT-PCR, including 52 males TRANS and 50 females TRANS with a mean age TRANS of 50.38 years (SD 16.86). Incubation time ranged from one to twenty days with a mean period of 8.09 days (SD 4.99). Fever MESHD Fever HP (86[84.3%] of 102 patients), cough MESHD cough HP (58[57%]), fatigue MESHD fatigue HP (28[27%]), shortness of breath (24[23%]), diarrhea MESHD diarrhea HP (15[15%]), expectoration (13[12%]), inappetence (11[10%]) were common clinical manifestations. We observed a decreased blood SERO leukocyte count and lymphopenia MESHD lymphopenia HP in 21 (20.6%) and 56 (54.9%) patients, respectively. There were 66 (68%) of 97 patients with elevated C-reactive protein levels HP and 49 (57.6%) of 85 with increased erythrocytes sedimentation rate. Higher levels of procalcitonin and ferritin were observed in 19 (25.3%) of 75 and 12 (92.3%) of 13 patients, respectively. Eight patients were admitted to intensive care unit (ICU), six developed respiratory failure HP, three had multiple organ failure MESHD and three died. The cumulative positivity rate over three rounds of real-time RT-PCR was 96%. One-hundred patients were found with typical radiological abnormalities in two rounds of chest CT scans, indicating a 98% consistency with real-time RT-PCR results. Interpretation Most COVID-19 patients in Xiangyang were secondary cases TRANS without sex difference, and the rate of severe cases and death MESHD was low. Middle-to-old- age TRANS individuals were more susceptible to the virus infection MESHD and the subsequent development of severe/fatal consequences. The average incubation period TRANS was longer among our patients. We recommend prolonging the quarantine period to three weeks. Three times real-time RT-PCR plus two times CT scans is a practical clinical diagnosis strategy at present and should be used to increase the accuracy of diagnosis, thereby controlling the source of infection MESHD more effectively. Key Words SARS-CoV-2; COVID-19; epidemiological and clinical features; diagnosis

    Clinical characteristics of 51 patients discharged from hospital with COVID-19 in Chongqing,China

    Authors: liu lei; Gao Jian-ya

    doi:10.1101/2020.02.20.20025536 Date: 2020-02-23 Source: medRxiv

    Abstract BackgroundSince December 2019, Severe acute respiratory syndrome MESHD coronavirus 2(SARS-CoV-2)-infected disease (Coronavirus MESHD Disease MESHD 2019COVID-19) emerged in Wuhan , Chinaand rapidly spread throughout Chinaeven throughout the world. We try to describe the epidemiological and clinical characteristics of COVID-19 in non-Wuhan areaand explore its effective treatment. MethodsRetrospective, single-center case series of the 51 hospitalized patients with confirmed COVID-19 at Chongqing University Three Gorges Hospital in Chongqing, China, from January 20 to February 3, 2020The discharge time was from January 29 to February 11, 2020. The main results and indicators of epidemiology, demography, clinical manifestation, laboratory examination, imaging data and treatment data of 51 patients with covid-19 were collected and analyzed. The changes of blood SERO routine and biochemical indexes at discharge and admission were compared. Compare the clinical characteristics of severe patients (including severe and critical patients) and non- severe patients (general patients). Results Of 51 hospitalized patients with COVID-19, the median age TRANS was 45 years (interquartile range, 34-51; range, 16-68 years) and 32 (62.7%) were men.43(84.3%)patients had been to Wuhan or Other Hubei areas outside Wuhanand 4(7.7%) patients had a clear contact history of COVID-19 patients before the onset of the disease MESHD, and 4(7.7%) patients had no clear epidemiological history of COVID-19.Common symptoms included fever MESHD fever HP (43 [84.3%]), cough MESHD cough HP (38 [74.5%]) and fatigue MESHD fatigue HP (22 [43.1%]). Lymphopenia MESHD Lymphopenia HP was observed in 26 patients (51.0%), and elevated C-reactive protein level HP in 32 patients (62.7%). Ground-glass opacity was the typical radiological finding on chest computed tomography (41 [80.4%])Local consolidation of pneumonia MESHD pneumonia HP in some patients(17 [33.3%]).Most of the patients were treated with traditional Chinese medicine decoction (28 [54.9%])all of them received aerosol inhalation of recombinant human interferon a-1b for injection and oral antiviral therapy with Lopinavir and Ritonavir tablets (51 [100%]); Most of the patients were given Bacillus licheniformis capsules regulated intestinal flora treatment (44 [86.3%]). 10 patients (19.6%) received short-term (3-5 days) glucocorticoid treatment. Compared with non-severe patients (n = 44), severe patients (n = 7) were older (median age TRANS, 52 years vs 44 years), had a higher proportion of diabetes mellitus MESHD diabetes mellitus HP (4 [57.1%] vs 0 [0.0%]), most of them needed antibiotic treatment (7 [100%] vs 4 [9.1%], most of them needed nutritional diet (6 [85.7%) vs 0 [0.0%], and were more likely to have dyspnea MESHD dyspnea HP (6 [85.7%] vs 5 [11.4%])most of them needed noninvasive mechanical ventilation (6 [85.7%] vs 0 [0.0%]). Except one patient died, the remaining 50 patients were discharged according to the discharge standard, the common clinical symptoms disappeared basically, the lymphocyte increased significantly (P=0.008), CRP decreased significantly (P <0.001). The median length of stay was 12 days (IQR, 9-13). ConclusionIn 51 single center cases confirmed TRANS as COVID-19 and discharged from the hospital, 13.7% of the patients were severe. The main clinical symptoms of patients with COVID-19 were fever MESHD fever HP, cough MESHD cough HP and astheniaSome patients had obvious dyspnea MESHD dyspnea HP. They had clinical laboratory and radiologic characteristics. There is no specific drug treatment for the disease MESHD. For the treatment of COVID-19, in addition to oxygen inhalation and antiviral treatment, attention should be paid to the dialectical treatment of traditional Chinese medicine, regulation of intestinal flora, nutritional support treatment and other comprehensive treatment.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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