Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 10 records in total 28
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    COVID-19 and Guillain-Barre Syndrome MESHD - a Case report

    Authors: Amira Sidig; Khabab Abbasher; Mutaz F. Digna; Mohamed Elsayed; Hussien Abbasher; Mohammed Abbasher; Abbasher Hussien

    doi:10.21203/ Date: 2020-07-24 Source: ResearchSquare

    Coronaviruses are a family of related viruses that cause diseases MESHD in mammals and avians. Guillain-Barre syndrome MESHD is a rare disorder in which the body's immune system attacks peripheral nerves.The case:A 65 years old Sudanese male TRANS with no diabetes mellitus MESHD diabetes mellitus HP or hypertension MESHD hypertension HP present to the clinic; On examination, he has upper and lower limb weakness ( quadriplegia MESHD). The condition was preceded by upper respiratory tract infection MESHD respiratory tract infection HP. Chest X-ray showed features of pneumonia MESHD pneumonia HP Chest CT scan showed multiple bilateral ground-glass opacities and consolidation typical of COVID-19 pneumonia MESHD pneumonia HP. Brain MRI was normal. The COVID-19 nasal swab test was positive. Nerve conduction study showed evidence of polyradiculopathies MESHD with dominant demyelination supporting the diagnosis of Guillain-Barre syndrome MESHD. The patients died after seven days; because of progressive respiratory failure HP.

    Upper respiratory tract infections MESHD respiratory tract infections HP and the immune system response. A review.


    doi:10.21203/ Date: 2020-07-21 Source: ResearchSquare

    Purpose: the spreading of the COVID-19 epidemic raised a question on why very well trained, healthy, and young athletes have been infected. In this review, the emerging topic in the field of sport immunology has been studied with the aim to provide advice on how strengthening the immune system (IS) and how to help the recover after heavy effort and prevent upper respiratory tract infection MESHD respiratory tract infection HP (URTI) in athletes. Methods: a literature search was performed on available public scientific databases. Results: URTI, a common illness among heavy trained athletes, happens in the time frame of temporary depression of the IS following heavy training or competition. T cells has been identified as the main factor in the immune response to counteract the cascade mediators of inflammation MESHD. Life habits, environmental and psycho-social factors such as sleep loss and life stressors are the major causes of IS depression, and it emerge that there is an optimal training load exposure which reinforce the IS, while too low or too much training being detrimental. Conclusions: immunodepression in heavy trained athletes can be counteracted with a proper distribution of training loads, nutritional interventions, correction of lifestyle habits such as sleep hygiene, thermotherapy, and recovery techniques. Psycho-social interventions also seem to have a positive effect on reducing the post exercise inflammation MESHD and in boosting the IS response. Novel bioinformatic approaches can help to understand the IS response in athletes and the management of critical situations.

    The Incidence of SARS-COV-2 Manifestations in the Central Nervous System: A Rapid Review and Meta-Analysis

    Authors: Verena Mayr; Glechner Anna; Gerald Gartlehner; Irma Klerings; Peter Lackner

    doi:10.21203/ Date: 2020-07-17 Source: ResearchSquare

    Background: Coronavirus disease MESHD 2019 (COVID-19) is caused by SARS-CoV-2 and presents itself mainly as a respiratory tract infection MESHD respiratory tract infection HP. However, reports of associated central nervous system (CNS) manifestations are increasing.Methods: We conducted this rapid review to determine the frequency of CNS manifestations of COVID-19 (CNS symptoms, acute cerebrovascular disease MESHD, and infectious/inflammatory CNS diseases MESHD) and to summarize the current evidence for direct invasion of the CNS by SARS-CoV-2. An information specialist searched Ovid MEDLINE, the CDC: COVID-19 Research Articles Downloadable and WHO COVID-19 Databases, CENTRAL, and on May 13, 2020. Two reviewers screened abstracts and potentially relevant full-text publications independently. The data extraction, assessment of risk of bias,and certainty of evidence using GRADE was done by one reviewer and double-checked by another. If possible and reasonable, a meta-analysis was carried out.Results: We identified 13 relevant studies (four cohort studies, nine case studies) with a total of 866 COVID-19 patients.In a Chinese cohort, dizziness MESHD (16.8%; 36 of 214) and headache MESHD headache HP (13.1%; 28 of 214) were the most common CNS symptoms reported. A meta-analysis of four cohort studies including 851 COVID-19 patients showed an incidence of 3.3% (95% CI: 2.2–4.9) for ischemic stroke HP stroke MESHD (follow-up: one to five weeks). In 13 of 15 encephalitis MESHD encephalitis HP case studies, PCR testing of the cerebrospinal fluid did not detect any virus components.Conclusion: CNS manifestations occur frequently in patients with COVID-19. It is important to integrate neurologists into the multiprofessional COVID-19 treatment team to detect neurological complications early and to treat them correctly. 

    Procalcitonin and COVID-19: A Reliable Clinical Tool

    Authors: Jessica Bass; Anshika Singh; Robin Williams; David H. Lindner

    doi:10.21203/ Date: 2020-07-15 Source: ResearchSquare

    BACKGROUND: A procalcitonin (PCT) level is commonly ordered to distinguish between bacterial and viral etiologies of lower respiratory tract infections MESHD respiratory tract infections HP as it is typically negative in the absence of inflammatory conditions and bacterial infections MESHD. With COVID-19 causing an influx of patients presenting with respiratory symptoms, clinicians are in need of useful tools to guide management of these patients. Given the inflammation MESHD that is caused by COVID-19, it is currently unknown whether PCT continues to be a reliable or useful test in suspected and confirmed cases TRANS of COVID-19 pneumonia MESHD pneumonia HP. OBJECTIVE: To determine whether PCT remains a clinically useful test in patients who present with lower respiratory tract symptoms in the era of COVID-19. DESIGN: Single-center retrospective cohort studyPARTICIPANTS: 243 adults TRANS with lower respiratory tract symptoms who presented to the hospital through the emergency MESHD department between April 11, 2020 and May 18, 2020 who received both a COVID-19 test as well as a PCT level. MAIN MEASURES: COVID-19 positivity/negative, PCT level KEY RESULTS: It was found that patients with COVID-19 consistently had negative procalcitonin levels (<0.25ng/mL). Based on the odds ratio, a patient with a positive PCT level was 3.4 times more likely to test negative for COVID than a patient with a PCT level <0.25ng/mL.  (1)=13.895, p<0.001.  CONCLUSIONS: There is a highly significant association between a negative procalcitonin and positive COVID-19 infection MESHD, thus supporting the continued use of PCT in the COVID-19 era.

    Reduced Susceptibility of Coronavirus SARS Development After Earthing Due to Increased pH Values in the Respiratory Tract

    Authors: Paweł Sokal; Karol Sokal; Gaetan Chevalier; Sara Kieronska; Julia Sokal

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: Low pH is an important factor facilitating entry of enveloped viruses including coronaviruses and further fusion with the host epithelial cell membrane. pH in the pulmonary environment can be maintained by supplying a negative electric charge. The main objective was to check if earthing (direct or indirect connection to Earth) changes the pH of the respiratory tract.Methods: Nine participants were evaluated and pH measurements were taken on the mucous membrane of the throat before and after 15 minutes of earthing.Results: Mean pH before earthing was 5.83±0.43 and after earthing was 6.33± 0.43 (p=0.000323). Conclusions: Earthing is able to supply a negative charge resulting in alkalization of the pulmonary environment. The increased pH value in the respiratory tract reduces the pH-dependent entry of coronaviruses into epithelial cells. Earthing can have an impact on the course of respiratory tract infection MESHD respiratory tract infection HP both viral and bacterial decreasing the susceptibility of the development of fatal forms of SARS ( Severe Acute Respiratory Syndrome MESHD).

    Vitamin D deficiency MESHD as a predictor of poor prognosis in patients with acute respiratory failure HP due to COVID-19

    Authors: Giovanna Elisiana Carpagnano; Valentina Di Lecce; Vitaliano Nicola Quaranta; Annapaola Zito; Enrico Buonamico; Elena Capozza; Alessandro Palumbo; Giuseppe Di Gioia; Vincenzo Nicola Valerio; Onofrio Resta

    doi:10.21203/ Date: 2020-07-11 Source: ResearchSquare

    Purpose: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections MESHD respiratory tract infections HP. Nowadays, the world is in the grip of the Coronavirus disease MESHD 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease MESHD severity. In consideration of the role of vitamin D in the immune system, aim of this study was to analyse vitamin D levels in patients with acute respiratory failure HP due to COVID-19 and to assess any correlations with disease MESHD severity and prognosis. Methods: In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure HP due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020. Results: Eighty one percent of patients had hypovitaminosis D. Based on vitamin D levels, the population was stratified into four groups: no hypovitaminosis D, insufficiency, moderate deficiency, and severe deficiency. No differences regarding demographic and clinical characteristics were found. A survival analysis highlighted that, after 10 days of hospitalization, severe vitamin D deficiency MESHD patients had a 50% mortality probability, while those with vitamin D ≥10 had a 5% mortality risk (p=0.019). Conclusions: High prevalence SERO of hypovitaminosis D was found in COVID-19 patients with acute respiratory failure HP, treated in a RICU. Patients with severe vitamin D deficiency MESHD had a significantly higher mortality risk. Severe vitamin D deficiency MESHD may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease MESHD outcomes.

    Evaluation of two commercial multiplex PCR tests for the diagnosis of acute respiratory infections MESHD in hospitalized children TRANS

    Authors: Le Wang; Shuo Yang; Xiaotong Yan; Teng Liu; Mengchuan Zhao; Dianping You; Guixia Li

    doi:10.21203/ Date: 2020-06-19 Source: ResearchSquare

    Background Acute respiratory tract infections MESHD respiratory tract infections HP (ARTI), including the common cold MESHD, pharyngitis MESHD pharyngitis HP, sinusitis MESHD sinusitis HP, otitis media MESHD otitis media HP, tonsillitis MESHD tonsillitis HP, bronchiolitis MESHD bronchiolitis HP and pneumonia MESHD pneumonia HP are the most common diagnoses among pediatric patients and account for the majority of antibiotic prescriptions. A clear and rapid diagnosis is the key to preventing antibiotic abuse. Recently, based on different detection principles, many multi-target molecular analyses that can simultaneously detect dozens of pathogens have been developed, thereby greatly improving sensitivity SERO and shortening turnaround time. In this work, we conducted a head-to-head comparative study between melting curve analysis (MCA) and capillary electrophoresis assay (CE) in the detection of nine respiratory pathogens in sputum samples collected from hospitalized ARTI childre TRANS.Methods Through MCA and CE analysis, nine common respiratory pathogens were tested on hospitalized children TRANS under the age TRANS of 13 who met the ARTI criteria.Results A total of 237 children TRANS with sputum specimens were tested. For all the targets combined, the positive detection rate of XYRes-MCA was significantly higher than ResP-CE (72.2% vs. 63.7%, p = .002). Some pathogens were detected more often with MCA, such as parainfluenza virus, influenza B and coronavirus, and some pathogens do the opposite, such as adenovirus and influenza A (all p < .01). Very good kappa values for most of pathogens were observed, except for Influenza B and coronavirus (both κ = .39).Conclusions Multiplex melting curve and capillary electrophoresis assays performed similarly for the detection of common respiratory pathogens in hospitalized children TRANS, except for Influenza B and coronavirus. Higher sensitivity SERO was observed in the melting curve assay. By using this sensitive and rapid test SERO, it may improv patient prognosis and antimicrobial management.

    In Silico Molecular Docking and Molecular Dynamic Simulation of Potential Inhibitors of 3C-like Main Proteinase (3CLpro) from Severe Acute Respiratory Syndrome MESHD Coronavirus-2 (SARS-CoV-2) Using Selected African Medicinal Plants

    Authors: Sahar Qazi; Mustafa Alhaji Isa; Adam Mustapha; Khalid Raza; Ibrahim Alkali Allamin; Muhammad M Ibrahim; Mohammed Mustapha Mohammed

    doi:10.26434/chemrxiv.12480434.v1 Date: 2020-06-18 Source: ChemRxiv

    The Severe Acute Respiratory Syndrome MESHD 2 (SARS-CoV-2) is an infectious virus that causes mild to severe life-threatening upper respiratory tract infection MESHD respiratory tract infection HP. The virus emerged in Wuhan, China in 2019, and later spread across the globe. Its genome has been completely sequenced and based on the genomic information, the virus possessed 3C-Like Main Protease (3CLpro), an essential multifunctional enzyme that plays a vital role in the replication and transcription of the virus by cleaving polyprotein at eleven various sites to produce different non-structural proteins. This makes the protein an important target for drug design and discovery. Herein, we analyzed the interaction between the 3CLpro and potential inhibitory compounds identified from the extracts of Zingiber offinale and Anacardium occidentale using in silico docking and Molecular Dynamics (MD) Simulation. The crystal structure of SARS-CoV-2 main protease in complex with 02J (5-Methylisoxazole-3-carboxylic acid) and PEJ (composite ligand) (PDB Code: 6LU7,2.16Å) retrieved from Protein Data Bank (PDB) and subject to structure optimization and energy minimization. A total of twenty-nine compounds were obtained from the extracts of Zingiber offinale and the leaves of Anacardium occidentale. These compounds were screened for physicochemical (Lipinski rule of five, Veber rule, and Egan filter), Pan-Assay Interference Structure ( PAINS MESHD PAINS HP), and pharmacokinetic properties to determine the Pharmaceutical Active Ingredients (PAIs). Of the 29 compounds, only nineteen (19) possessed drug-likeness properties with efficient oral bioavailability and less toxicity. These compounds subjected to molecular docking analysis to determine their binding energies with the 3CLpro. The result of the analysis indicated that the free binding energies of the compounds ranged between ˗5.08 and -10.24kcal/mol, better than the binding energies of 02j (-4.10kcal/mol) and PJE (-5.07kcal.mol). Six compounds (CID_99615 = -10.24kcal/mol, CID_3981360 = 9.75kcal/mol, CID_9910474 = -9.14kcal/mol, CID_11697907 = -9.10kcal/mol, CID_10503282 = -9.09kcal/mol and CID_620012 = -8.53kcal/mol) with good binding energies further selected and subjected to MD Simulation to determine the stability of the protein-ligand complex. The results of the analysis indicated that all the ligands form stable complexes with the protein, although, CID_9910474 and CID_10503282 had a better stability when compared to other selected phytochemicals (CID_99615, CID_3981360, CID_620012, and CID_11697907).

    Incidental Lowering of Otitis-media MESHD Otitis-media HP Complaints in Otitis MESHD-prone Children TRANS During COVID-19 Pandemic: Not All Evil Comes to Hurt

    Authors: Sara Torretta; Pasquale Capaccio; Ilaria Coro; Samantha Bosis; Elisabetta Pace; Pietro Tosi; Lorenzo Pignataro; Paola Marchisio

    doi:10.21203/ Date: 2020-06-16 Source: ResearchSquare

    Given COVID-19 pandemic periodic outpatient assessment of otitis MESHD-prone children TRANS regularly followed at our tertiary outpatient clinic of upper respiratory tract infections MESHD respiratory tract infections HP was discontinued since March 9th. In order to avoid leaving the patients to themselves just during the winter months which are the most critical ones for these children TRANS, we kept in touch with the families of 102 children TRANS (mean age TRANS 41.4±14.0 months) who had had a follow-up visit scheduled during the lockdown, and compensated with telemedicine assessment. This incidentally lead to the unexpected but not at all negative finding that a consistent clinical improvement had been occurred in most (82.3%) of children TRANS. A statistically significant reduction in the mean number of documented acute otitis media HP otitis media MESHD episodes, otorrhea episodes, and systemic antibiotic treatments during the February-April 2020 period compared to February-April 2019 was attested. Clinical evaluation performed in 27.4% cases revealed normal middle ear findings in all but three (89.3%) children TRANS.Conclusion: Our data document a global improvement of otitis MESHD-prone children TRANS in Milan during the Italian lockdown, as a fortuitous and incidental positive effect of the national lockdown.

    Protective roles of flu infections MESHD and BCG vaccination in lowering Covid-19 mortality

    Authors: Sanmoy Pathak; Mohit Kumar Jolly; Dipankar Nandi

    doi:10.21203/ Date: 2020-06-04 Source: ResearchSquare

    The recent Covid-19 pandemic has caused a great loss of lives as well as affected economies in several countries. The loss of Covid-19 deaths MESHD is far greater in some countries compared to others. This observation led us to perform epidemiological analysis using disease MESHD and vaccination data in the public domain with respect to measles MESHD, hepatitis B MESHD hepatitis HP virus, polio, tuberculosis MESHD and flu from twenty five countries across the globe. There is no correlation between Covid-19 incidences or deaths MESHD, as well as vaccination coverage, with respect to diseases MESHD such as measles MESHD, hepatitis B MESHD hepatitis HP virus and polio. However, countries with lower cases of tuberculosis MESHD and higher cases of flu have a significant correlation with respect to Covid-19 deaths MESHD. In fact, countries with high BCG vaccination coverage show a significant negative correlation with Covid-19 deaths MESHD. Surprisingly, countries such as the USA, Italy, France and Spain which have flu vaccination, but not BCG vaccination, show maximum number of Covid-19 deaths MESHD. It appears that high numbers of flu infections MESHD are protective and can decrease the number of Covid-19 deaths MESHD. Importantly, countries with high flu cases and BCG vaccination, such as India, Egypt, South Africa etc, show relatively lower Covid-19 deaths MESHD, reinforcing the protective roles of BCG vaccination. Notably, these general trends are statistically significant for Covid-19 deaths MESHD but not Covid-19 incidences. The implications of our results are discussed with respect to the roles of microbial infections in the respiratory tract MESHD infections in the respiratory tract HP, vaccinations and other factors in lowering Covid-19 deaths MESHD.

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MeSH Disease
Human Phenotype

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