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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Incidence, risk factors and mortality outcome in patients with acute kidney injury MESHD acute kidney injury HP in COVID-19: a single-center observational study

    Authors: Gaetano Alfano; Annachiara Ferrari; Francesco Fontana; Giacomo Mori; Riccardo Magistroni; Meschiari Marianna; Franceschini Erica; Marianna Menozzi; Gianluca Cuomo; Gabriella Orlando; Antonella Santoro; Margherita Di Gaetano; Cinzia Puzzolante; Federica Carli; Andrea Bedini; Jovana Milic; Paolo Raggi; Massimo Girardis; Cristina Mussini; Gianni Cappelli; Giovanni Guaraldi

    doi:10.1101/2020.06.24.20138230 Date: 2020-06-24 Source: medRxiv

    Background Acute kidney injury MESHD Acute kidney injury HP (AKI) is a recently recognized complication of coronavirus disease MESHD-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI in patients with documented COVID-19. Methods We reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy. Results AKI was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI patients had a mean age TRANS of 74.7 {+/-} 9.9 years and higher serum SERO levels of the main marker of inflammation MESHD and organ involvement (lung, liver, hearth and liver) than non-AKI patients. AKI events were more frequent in subjects with severe lung comprise. Two peaks of AKI events coincided with in-hospital admission and death MESHD of the patients. Kidney injury was associate with a higher rate of urinary abnormalities including proteinuria MESHD proteinuria HP (0.448{+/-} 0.85 vs 0.18 {+/-} 0.29; P=<0.0001) and hematuria MESHD hematuria HP (P=0.032) compared to non-AKI patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI. Risk factors for kidney injury were age TRANS, male TRANS sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI was independently associated with in-hospital death MESHD (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non-AKI patients. Groups of patients with AKI stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine HP serum SERO creatinine, likely due to muscle depletion occurred with prolonged bed rest. Conclusions AKI was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI and prevention of kidney injury by avoiding dehydration MESHD dehydration HP and nephrotoxic agents is imperative in this vulnerable cohort of patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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