Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Clinical characteristics and factors associated with admission to intensive care units inhospitalized COVID-19 patients in Lyon University Hospitals, France

    Authors: Philippe Vanhems; Marie-Paule Gustin; Christelle ELIAS; Laetitia HENAFF; Cedric DANANCHE; Beatrice GRISI; Elodie MUNIER-MARION; Nagham KHANAFER; Delphine HILLIQUIN; Sophie GARDES; Solweig GERBIER-COLOMBAN; Selilah AMOUR; Elisabetta KUCZEWSKI; Vanessa ESCURET; Bruno LINA; Mitra SAADATIAN-ELAHI

    doi:10.1101/2020.06.09.20125286 Date: 2020-06-12 Source: medRxiv

    Introduction: A new respiratory virus, SARS-CoV-2, has emerged and spread worldwide since late 2019. This study aims at analyzing clinical presentation on admission and the determinants associated with direct admission or transfer to intensive care units (ICUs) in hospitalized COVID-19 patients. Patients and Methods: In this prospective hospital-based study, socio-demographic, clinical and biological characteristics, on admission, of adult TRANS COVID-19 hospitalized patients were prospectively collected and analyzed. The outcome was admission/transfer to intensive care units compared with total hospital stay in medical wards according to patient characteristics. Results: Of the 412 patients included, 325 were discharged and 87 died in hospital. Multivariable regression showed increasing odds of admission/transfer to ICUs with male TRANS gender TRANS (OR, 1.99 [95%CI, 1.07-3.73]), temperature (OR, 1.37 [95% CI, 1.01-1.88] per degree Celsius increase), abnormal lung auscultation on admission (OR, 2.62 [95% CI, 1.40-4.90]), elevated level of CRP (OR, 6.96 [95% CI, 1.45-33.35 for CRP>100mg/L vs CRP<10mg/L). Increased time was observed between symptom onset TRANS and hospital admission (OR, 4.82 [95% CI, 1.61-14.43] for time >10 days vs time <3 days) and monocytopenia HP (OR, 2.49 [95% CI, 1.29-4.82]). Monocytosis HP was associated with lower risk of admission/transfer to ICUs (OR, 0.25 [95% CI, 0.05-1.13]). Conclusions: Clinical and biological features on admission and time until admission were associated with admission to ICUs. Signs to predict worsening on admission could be partially associated with the time until admission. This finding reinforces the need for appropriate guidelines to manage COVID-19 patients in this time window.

    Monocyte class switch and hyperinflammation characterise severe COVID-19 in type 2 diabetes

    Authors: Fawaz ALZAID; Jean-Baptiste Julla; Marc Diedisheim; Charline Potier; Louis Potier; Gilberto Velho; Benedicte Gaborit; Philippe Manivet; Stephane Germain; Tiphaine Vidal-Trecan; Ronan Roussel; Jean-Pierre Riveline; Elise Dalmas; Nicolas Venteclef; Jean-Francois Gautier

    doi:10.1101/2020.06.02.20119909 Date: 2020-06-02 Source: medRxiv

    Background: Early in the COVID-19 pandemic type 2 diabetes (T2D) was marked as a risk factor of severe disease MESHD and mortality. Inflammation MESHD is central to the aetiology of both conditions where variations in immune responses have the potential to mitigate or aggravate disease MESHD course. Identifying at risk groups based on immuno-inflammatory signatures is valuable in directing personalised care and developing potential targets for precision therapy. Methods: This study characterised immunophenotypic variation associated with COVID-19 severity in type 2 diabetes. Broad-spectrum immunophenotyping quantified 15 leukocyte populations in peripheral circulation from a cohort of 45 hospitalised COVID-19 patients with and without type 2 diabetes. Results: Morphological anomalies in the monocyte pool, monocytopenia HP specific to quiescent monocytes, and a decreased frequency of cytotoxic lymphocytes were associated with severe COVID-19 in patients with type 2 diabetes requiring intensive care. An aggravated inflammatory gene expression profile, reminiscent of the type-1 interferon pathway, underlaid the immunophenotype associated with severe disease MESHD in T2D. Conclusion: Shifts in T-cell and monocyte dynamics underpin a maladaptive response to SARS-CoV-2. These alterations may impact type-1 interferon signalling which is the likely source of the hyperinflammation that increases voracity of COVID-19. These findings allow the identification of type 2 diabetic patients at risk of severe disease as well MESHD as providing evidence that the type-1 interferon pathway may be an actionable therapeutic target for future studies.

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MeSH Disease
Human Phenotype

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