Corpus overview


MeSH Disease

Hypercapnia (2)

Pneumonia (1)

Fistula (1)

Cough (1)

Dyspnea (1)

Human Phenotype


There are no transmission terms in the subcorpus

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    Risk and impact of using mask on COPD patients with acute exacerbation during the COVID-19 outbreak: a retrospective study

    Authors: You Mo; DunCan Wei; Qi Mai; Chongyue Chen; Hanguang Yu; Chaowen Jiang; Xuerui Tan

    doi:10.21203/ Date: 2020-07-01 Source: ResearchSquare

    Background:Chronic Obstructive Pulmonary Disease(COPD) is an inflammatory airway disease MESHD characterized by the presence of expiratory flow limitation. Exacerbations of COPD are common acute events. During epidemic of COVID-19, concerns have been raised with regard to mask- using because of increasing respiratory resistance. In this study, we aimed to evaluate the relationship between the vital signs , inflammation MESHD index, hypercapnia MESHD hypercapnia HP, hypoxia MESHD and mask-using in AECOPD patients.Methods:This retrospective study was performed at a tertiary hospital, and enrolled 23 patients with AECOPD who were hospitalized three or more times in the respiratory department. Patients in Group C were hospitalized and used masks during the epidemic period of COVID-19. Patient’s data of the previous two hospitalizations from the medical record system divided into group A and group B according to the time sequence. Vital signs, inflammation MESHD index, artery blood SERO gas from medical record system and questionnaires of three hospitalizations in the same patient were collected to perform paired test.Results: Surgical mask using increased the levels of PaCO2 (8.98mm Hg; p = 0.004), HCO3-act (4.1mmol/L; p =0.006), BE (3.01mmol/L; p =0.019) and systolic blood SERO pressure (11.39mm Hg; p = 0.01) in patients with AECOPD compared to last hospitalization. Surgical mask using for 30 to 120 minutes is associated with hypercapnia MESHD hypercapnia HP. There were no significant differences observed between group B and group A without using mask in vital signs, inflammation MESHD index, and artery blood SERO gas.Conclusions: In this study, we found that systolic blood SERO pressures and PaCO2, HCO3-act, BE were significantly elevated in AECOPD patients using masks compared to the other groups without masks. In addition,the changes in PaCO2,HCO3-act,BE is closely related to serum SERO chloride concentration. Therefore, it is need to increase awareness and understanding of the use of masks in patients with chronic cardiopulmonary diseases MESHD.

    Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19

    Authors: Yan Liu; Guoshi Luo; Xin Qian; Chenglin Wu; Yijun Tang; kun lu; Biyu Chen; Elaine Lai-Han Leung; Meifang Wang

    doi:10.21203/ Date: 2020-06-08 Source: ResearchSquare

    Object: To report the successful diagnosis and treatment of a patient with critical condition of novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) and to summarize its clinical features and airway management experience in successful treatment.Methods: Retrospectively analyzed the successful management of one case of COVID-19 with critical condition combined respiratory failure HP and discussed the clinical characteristics and airway management of the patient in conjunction with a review of the latest literature.Results: A patient with an anastomotic fistula MESHD after radical treatment of esophageal cancer and right-side encapsulated pyopneumothorax was admitted with cough MESHD cough HP and dyspnea MESHD dyspnea HP and was diagnosed with novel coronavirus pneumonia MESHD pneumonia HP and malnutrition MESHD malnutrition HP by pharyngeal swab nucleic acid test in combination with chest CT. The patient was treated with antibiotics, antiviral and antibacterial medications, respiratory support, expectorant nebulization, and nutritional support, expressed progressive deterioration. Endotracheal intubation and mechanical ventilation were performed since the onset of the type Ⅱ respiratory failure HP on the 13th day of admission. The patient had persistent refractory hypercapnia MESHD hypercapnia HP after mechanical ventilation. Based on the treatment mentioned above, combined with repeated bronchoalveolar lavage by using N-acetylcysteine ​​(NAC) inhalation solution, the patient's refractory hypercapnia MESHD hypercapnia HP was gradually improved. It was cured and discharged after being given the mechanical ventilation for 26 days as well as 46 days of hospitalization, currently is surviving well.Conclusion: Patients with severe conditions of novel coronavirus pneumonia MESHD pneumonia HP often encounter bacterial infection MESHD in their later illness-stages. They may suffer respiratory failure HP and refractory hypercapnia MESHD hypercapnia HP that is difficult to improve due to excessive mucus secretion leading to small airway obstruction MESHD. In addition to the use of reasonable antibiotics and symptomatic respiratory support and other treatment, timely artificial airway and repeated bronchoalveolar NAC inhalation solution lavage, expectorant and other airway management are essential for such patients.

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MeSH Disease
Human Phenotype

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