Background. At present, the Americas region contributes to the largest number of cases of COVID-19 worldwide. In this area, Mexico is in third place respecting deaths MESHD (20,781 total deaths MESHD), rate that may be explained by the high proportion of the population over 50 years and the rate of chronic diseases MESHD. The aim of the present work was estimate the risk factors associated with the death MESHD rate, considering the time between symptoms onset TRANS and the death MESHD occurrence, in the Mexican population. Methods. Information of all the confirmed cases TRANS for COVID-19 reported on the public dataset released by the Epidemiological Surveillance System for Viral Respiratory Diseases MESHD of the Mexican Ministry of Health was analyzed. Kapplan-Meier curves were plotted, and a Cox proportional hazard model was constructed. Results. The analysis included 16,752 registries of confirmed cases TRANS of COVID-19 with mean age TRANS 46.55±15.55 years; 58.02% (n=9719) men and 9.37% (n=1,569) died. Men (H.R. 1.21, p<0.01, 95% C.I. 1.09-1.35), older age TRANS (H.R. 8.24, p<0.01, 95% C.I. 4.22-16.10), CKD (H.R. 1.85, p<0.01, 95% C.I. 1.51-2.25), pneumonia MESHD pneumonia HP (H.R. 2.07, p<0.01, 95% C.I. 1.81-2.38), hospitalization and ICU admissions (H.R. 5.86, p<0.01, 95% C.I. 4.81-7.14, and H.R. 1.32, p<0.01, 95% C.I. 1.12-1.55, respectively), intubation (H.R. 2.93, p<0.01, 95% C.I. 2.50-3.45) and health care in public health services (more than twice the risk, p<0.01), were independent factors increasing the risk of death MESHD due to COVID-19. Conclusions. The risk of dying at any time during follow-up was especially higher in men, individuals at the older age groups TRANS, with chronic kidney disease HP kidney disease MESHD and people hospitalized in the public health services.