Corpus overview


Overview

MeSH Disease

Papilloma (2)

Nevus (1)

Conjunctivitis (1)

Cysts (1)

Polyps (1)


Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence

There are no seroprevalence terms in the subcorpus

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    COVID-19 receptor ACE2 is expressed in human conjunctival tissue, expecially in diseased conjunctival MESHD tissue

    Authors: shengjie li Sr.; danhui li; jianchen fang; qiang liu; xinghuai sun; gezhi xu; wenjun cao

    doi:10.1101/2020.05.21.20109652 Date: 2020-05-23 Source: medRxiv

    COVID-19 virus has currently caused major outbreaks worldwide. ACE2 is a major cellular-entry receptor for the COVID-19 virus. Although ACE2 is known to be expressed in many organs, whether it is expressed by the conjunctival tissue is largely unknown. Human conjunctival tissues from 68 subjects were obtained, which included 10 subjects with conjunctival nevi MESHD nevi HP, 20 subjects with conjunctivitis MESHD conjunctivitis HP, 9 subjects with conjunctival papilloma MESHD papilloma HP, 16 subjects with conjunctival cyst MESHD, 7 subjects with conjunctival polyps MESHD, and 6 ocular traumas as normal subjects. Expression of ACE2 was evaluated by immunohistochemistry, immunofluorescence, reverse transcriptase-quantitative polymerase chain reaction, and western blot assay. We observed the expression of ACE2 by conjunctival tissues, expecially in conjunctival epithelial cells. ACE2 was significantly (p<0.001) overexpressed in conjunctival cells obtained from subjects with conjunctivitis MESHD conjunctivitis HP, conjunctival nevi MESHD nevi HP, conjunctival papilloma MESHD papilloma HP, conjunctival cyst MESHD, and conjunctival polyps MESHD epithelial cells when compared to that in conjunctival epithelial cells obtained from control subjects. Collectively, clinical features of reported COVID-19 patients combined with our results indicate that COVID-19 is likely to be transmitted through the conjunctiva.

    Meta-analysis of transcriptomes of SARS-Cov2 infected human lung epithelial cells identifies transmembrane serine proteases co-expressed with ACE2 and biological processes related to viral entry, immunity, inflammation MESHD and cellular stress.

    Authors: Wasco Wruck; James Adjaye

    doi:10.1101/2020.05.12.091314 Date: 2020-05-13 Source: bioRxiv

    The COVID-19 pandemic resulting from the severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) which emerged in December 2019 in the Chinese city of Wuhan in the province Hubei has placed immense burden on national economies and global health. At present neither vaccination nor therapies are available although several antiviral agents such as remdesivir, originally an Ebola drug, nelfinavir, an HIV-1 protease inhibitor and other drugs such as lopinavir have been evaluated. Here, we performed a meta-analysis of RNA-sequencing data from three studies employing human lung epithelial cells. Of these one focused on lung epithelial cells infected with SARS-CoV-2. We aimed at identifying genes co-expressed with angiotensin I converting enzyme 2 (ACE2) the human cell entry receptor of SARS-CoV-2, and unveiled several genes correlated or inversely correlated with high significance, among the most significant of these was the transmembrane serine protease 4 (TMPRSS4). Serine proteases are known to be involved in the infection MESHD process by priming the virus spike protein. Pathway analysis revealed papilloma MESHD papilloma HP virus infection MESHD amongst the most significantly correlated pathways. Gene Ontologies revealed regulation of viral life cycle, immune responses, pro-inflammatory responses-several interleukins such as IL6, IL1, IL20 and IL33, IFI16 regulating the interferon response to a virus, chemo-attraction of macrophages, last and not least cellular stress resulting from activated Reactive Oxygen Species. We believe that this dataset will aid in a better understanding of the molecular mechanism(s) underlying COVID-19.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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