Corpus overview


MeSH Disease

Human Phenotype


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    Clinical Manifestation and Maternal Complications and Neonatal outcomes in Pregnant Women with COVID 19: An Update a Systematic Review and Meta-analysis

    Authors: Marzieh Soheili; Ghobad Moradi; Hamid Reza Baradaran; Maryam Soheili; Yousef Moradi

    doi:10.21203/ Date: 2020-05-07 Source: ResearchSquare

    Background Existing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with coronavirus infection MESHD. outbreaks suggest that pregnant women and their fetuses are particularly susceptible to poor outcomes. However, there is little known about pregnancy related complications and co-morbidity in this group of women. Therefore, this, systematic review and meta-analysis performed in order to find out whether COVID-19 may cause different manifestations and outcomes in antepartum and postpartum period or not.Methods We searched databases, including Medline (PubMed), Embase, Scopus, Web of sciences, Cochrane library, Ovid and CINHAL to retrieve all articles reporting the prevalence SERO of maternal and neonatal complications, in addition clinical manifestations, in pregnant women with COVID 19 that published with English language from January to April 2020. Results 11 studies with total 177 pregnant women included in this systematic review.Results show that the pooled prevalence SERO of neonatal mortality, lower birth weight MESHD, stillbirth MESHD, premature birth MESHD premature birth HP, and intrauterine fetal distress MESHD fetal distress HP in women with COVID 19 were 4% (95% Cl: 1 - 9%), 21% (95% Cl: 11 – 31%), 2% (95% Cl: 1 - 6%), 28% (95% Cl: 12 - 44%), and 15% (95% Cl: 4 - 26%); respectively. Also the pooled prevalence SERO of fever MESHD fever HP, cough MESHD cough HP, diarrhea MESHD diarrhea HP and dyspnea MESHD dyspnea HP were 56% (95% Cl: 30 - 83%), 30% (95% Cl: 21 - 39%), 9% (95% Cl: 2 - 16%), and 3% (95% Cl: 1 - 6%) in the pregnant women with COVID-19.Conclusion According to this systematic review and meta-analysis, the pregnant women with COVID-19 with or without pneumonia MESHD pneumonia HP, are at a higher risk of pre-eclampsia MESHD eclampsia HP, preterm birth, miscarriage and cesarean delivery. Furthermore, the risk of LBW and intrauterine fetal distress MESHD fetal distress HP seems increased in neonates.

    Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis

    Authors: Yi-jie Gao; Lei Ye; Jia-shuo Zhang; Yang-xue Yin; Min Liu; Hong-biao Yu; Rong Zhou

    doi:10.21203/ Date: 2020-05-05 Source: ResearchSquare

    Background: COVID-19 outbreak in Wuhan, China recently. It quickly spread throughout worldwide. In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19.Methods: PubMed、Web of Science、EMBASE、MEDLINE were searched from January 1, 2020 to April 16, 2020. Case review of pregnant women infected with COVID-19 were included. Two reviewers screened 366 literatures and 14 studies included, four reviewers independently extracted the features of the literatures. We used random-effects model to analyze incidence (P) and 95% confidence interval (95%CI). Heterogeneity was assessed using the I2 statistic.Results: The meta- analysis included 236 pregnant women with COVID-19. The results were as follows: positive CT findings (71%; 95%CI, 0.49~0.93), cesarean section (65%; 95%CI, 0.42~0.87), fever MESHD fever HP (51%; 95%CI, 0.35~0.67), lymphopenia MESHD lymphopenia HP (49%; 95%CI, 0.29~0.70), coexisting disorders (33%; 95%CI, 0.21~0.44), cough MESHD cough HP (31%; 95%CI, 0.23~0.39), fetal distress MESHD fetal distress HP (29%; 95%CI, 0.08~0.49), preterm labor (23%; 95%CI, 0.14~0.32), severe case or death MESHD (12%; 95%CI, 0.03~0.20). The subgroup analysis showed compared with nonpregnant patients, pregnant women with COVID-19 had significantly lower incidences of fever MESHD fever HP (pregnant women group, 51%; nonpregnant patients group, 91%; P<0.00001) and cough MESHD cough HP (pregnant women group, 31%; nonpregnant patients group, 67%; P<0.0001). Conclusions: The incidence of fever MESHD fever HP, cough MESHD cough HP and positive CT findings in pregnant women with COVID-19 is less than that in the general population, preterm labor is the opposite. There is no evidence that COVID-19 can propagate vertically for the time being. 

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MeSH Disease
Human Phenotype

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