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MeSH Disease

Human Phenotype

Transmission

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Seroprevalence
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    COVID-19: the key role of pulmonary capillary leakage. An observational cohort study

    Authors: Maddalena Alessandra Wu; Tommaso Fossali; Laura Pandolfi; Luca Carsana; Davide Ottolina; Vanessa Frangipane; Roberto Rech; Antonella Tosoni; Andrea Agarossi; Chiara Cogliati; Federica Meloni; Beatrice Marchini; Manuela Nebuloni; Emanuele Catena; Riccardo Colombo

    doi:10.1101/2020.05.17.20104877 Date: 2020-05-21 Source: medRxiv

    Background: COVID-19 induces progressive hypoxemic respiratory failure HP and acute respiratory distress HP syndrome MESHD, mostly due to a dysregulated inflammatory response. Since the first observations of COVID-19 patients, significant hypoalbuminemia MESHD hypoalbuminemia HP was detected. This study aimed to investigate the hypothesis that hypoalbuminemia MESHD hypoalbuminemia HP in COVID-19 patients is due to pulmonary capillary leakage and to test its correlation with indicators of respiratory function. Methods: 174 COVID-19 patients, 92 admitted to the Intermediate Medicine ward (IMW), and 82 to the Intensive Care Unit (ICU) at Luigi Sacco Hospital in Milan were included in this study. Findings: Serum SERO albumin concentration was decreased in the whole cohort, with ICU patients displaying lower values than IMW patients [20 (18-23) vs 28 (24-33) g/L, p<0.0001]. Lower albumin values were found in patients belonging to a more compromised group (lower PaO2 to FiO2 ratio and worst chest X-ray findings). In a subset of 26 patients, analysis of bronchoalveolar lavage fluid (BALF) highlighted high protein concentrations, which were correlated to Interleukin-8 and Interleukin-10 BALF concentration. The length of hospitalisation [20 (15-29) vs 8 (5-14) days, p<0.0001] and death MESHD rate (52.4% vs 21.7%, p<0.0001) were higher in ICU than in IMW patients, while a strict relation between hypoalbuminemia MESHD hypoalbuminemia HP and 30 day-survival was detected in the whole cohort. Electron microscopy examinations of eight out of ten autopsy lung tissues showed diffuse loosening of interendothelial junctional complex. Interpretation: The degree of hypoalbuminemia MESHD hypoalbuminemia HP can be considered as a useful severity marker in hospitalised COVID-19 patients. Pulmonary capillary leak syndrome MESHD capillary leak HP secondary to the hyperinflammatory state plays a key role in the pathogenesis of COVID-19 respiratory dysfunction and should be regarded as a therapeutic target.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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