Corpus overview


MeSH Disease

Human Phenotype

Fever (1)

Cough (1)

Dyspnea (1)

Fatigue (1)

Pneumonia (1)



There are no seroprevalence terms in the subcorpus

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    Effects of Coronavirus Disease MESHD 2019 (COVID-19) on Maternal, Perinatal and Neonatal Outcomes: a Systematic Review of 266 Pregnancies

    Authors: Juan Juan; Maria M Gil; Zhihui Rong; Yuanzhen Zhang; Huixia Yang; Liona Chiu Yee Poon

    doi:10.1101/2020.05.02.20088484 Date: 2020-05-06 Source: medRxiv

    Objective: To perform a systematic review of available published literature on pregnancies affected by COVID-19 to evaluate the effects of COVID-19 on maternal, perinatal and neonatal outcomes. Methods: We performed a systematic review to evaluate the effects of COVID-19 on pregnancy, perinatal and neonatal outcomes. We conducted a comprehensive literature search using PubMed, EMBASE, Cochrane library, China National Knowledge Infrastructure Database and Wan Fang Data until April 20, 2020 (studies were identified through PubMed alert after April 20, 2020). For the research strategy, combinations of the following keywords and MeSH terms were used: SARS-CoV-2, COVID-19, coronavirus disease MESHD 2019, pregnancy, gestation, maternal, mothers, vertical transmission TRANS, maternal-fetal transmission TRANS, intrauterine transmission TRANS, neonates, infant, delivery. Eligibility criteria included laboratory-confirmed and/or clinically diagnosed COVID-19, patient was pregnant on admission, availability of clinical characteristics, including maternal, perinatal or neonatal outcomes. Exclusion criteria were unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, and unreported maternal or perinatal outcomes. No language restrictions were applied. Results: We identified several case-reports and case-series but only 19 studies, including a total of 266 pregnant women with COVID-19, met eligibility criteria and were finally included in the review. In the combined data from seven case-series, the maternal age TRANS ranged from 20 to 41 years and the gestational age TRANS on admission ranged from 5 to 41 weeks. The most common symptoms at presentation were fever MESHD fever HP, cough MESHD cough HP, dyspnea MESHD dyspnea HP/shortness of breath and fatigue MESHD fatigue HP. The rate of severe pneumonia MESHD pneumonia HP was relatively low, with the majority of the cases requiring intensive care unit admission. Almost all cases from the case-series had positive computer tomography chest findings. There were six and 22 cases that had nucleic-acid testing in vaginal mucus and breast milk samples, respectively, which were negative for SARS-CoV-2. Only a few cases had spontaneous miscarriage or abortion. 177 cases had delivered, of which the majority by Cesarean section. The gestational age TRANS at delivery ranged from 28 to 41 weeks. Apgar scores at 1 and 5 minutes HP Apgar scores at 1 and 5 minutes HP ranged from 7 to 10 and 8 to 10, respectively. A few neonates had birthweight less than 2500 grams and over one-third of cases were transferred to neonatal intensive care unit. There was one case each of neonatal asphyxia HP asphyxia MESHD and neonatal death MESHD. There were 113 neonates that had nucleic-acid testing in throat swab, which was negative for SARS-CoV-2. From the case-reports, two maternal deaths MESHD among pregnant women with COVID-19 were reported. Conclusions: The clinical characteristics of pregnant women with COVID-19 are similar to those of nonpregnant adults TRANS with COVID-19. Currently, there is no evidence that pregnant women with COVID-19 are more prone to develop severe pneumonia MESHD pneumonia HP, in comparison to nonpregnant patients. The subject of vertical transmission TRANS of SARS-CoV-2 remains controversial and more data is needed to investigate this possibility. Most importantly, in order to collect meaningful pregnancy and perinatal outcome data, we urge researchers and investigators to reference previously published cases in their publications and to record such reporting when the data of a case is being entered into a registry or several registries.

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MeSH Disease
Human Phenotype

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