Corpus overview


Overview

MeSH Disease

Death (1)

Disease (1)


Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Patient trajectories and risk factors for severe outcomes among persons hospitalized for COVID-19 in the Maryland/DC region

    Authors: Brian T Garibaldi; Jacob Fiksel; John Muschelli; Matthew L Robinson; Masoud Rouhizadeh; Paul Nagy; Josh H Gray; Harsha Malapati; Mariam Ghobadi-Krueger; Timothy M Niessen; Bo Soo Kim; Peter M Hill; M. Shafeeq Ahmed; Eric D Dobkin; Renee Blanding; Jennifer Abele; Bonnie Woods; Kenneth Harkness; David R Thiemann; Mary Grace Bowring; Aalok B. Shah; Mei Cheng Wang; Karen Bandeen-Roche; Antony Rosen; Scott L Zeger; Amita Gupta

    doi:10.1101/2020.05.24.20111864 Date: 2020-05-26 Source: medRxiv

    Background: Risk factors for poor outcomes from COVID-19 are emerging among US cohorts, but patient trajectories during hospitalization ranging from mild-moderate, severe, and death MESHD and the factors associated with these outcomes have been underexplored. Methods: We performed a cohort analysis of consecutive COVID-19 hospital admissions at 5 Johns Hopkins hospitals in the Baltimore/DC area between March 4 and April 24, 2020. Disease MESHD severity and outcomes were classified using the WHO COVID-19 disease MESHD severity ordinal scale. Cox proportional-hazards regressions were performed to assess relationships between demographics, clinical features and progression to severe disease MESHD or death MESHD. Results: 832 COVID-19 patients were hospitalized; 633 (76.1%) were discharged, 113 (13.6%) died, and 85 (10.2%) remained hospitalized. Among those discharged, 518 (82%) had mild/moderate and 116 (18%) had severe illness. Mortality was statistically significantly associated with increasing age TRANS per 10 years (adjusted hazard ratio (aHR) 1.54; 95%CI 1.28-1.84), nursing home residence (aHR 2.13, 95%CI 1.41-3.23), Charlson comorbidity index (1.13; 95% CI 1.02-1.26), respiratory rate (aHR 1.13; 95%CI 1.09-1.17), D-dimer greater than 1mg/dL (aHR 2.79; 95% 1.53-5.09), and detectable troponin (aHR 2.79; 95%CI 1.53-5.09). In patients under 60, only male TRANS sex (aHR 1.7;95%CI 1.11-2.58), increasing body mass index HP (BMI) (aHR1.25 1.14-1.37), Charlson score (aHR 1.27; 1.1-1.46) and respiratory rate (aHR 1.16; 95%CI 1.13-1.2) were associated with severe illness or death MESHD. Conclusions: A combination of demographic and clinical features on admission is strongly associated with progression to severe disease MESHD or death MESHD in a US cohort of COVID-19 patients. Younger patients have distinct risk factors for poor outcomes.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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