Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 10 records in total 14
    records per page

    CT as a Tool to Depict Pulmonary Fibrosis MESHD Pulmonary Fibrosis HP in Patients With COVID-19: a Radiopathological Correlation 

    Authors: Anna Alguersuari; Miguel Angel Carrasco; Gemma Munné; Maria Eulalia Oliva; Cristina Simon; Maria Dolores Bosque; Melcior Martínez; Natalia Lugo; Xavier Herranz; Mariana Rovira

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    OBJECTIVESCT findings of COVID-19 infected patients has been well described, but it it’s roll in depicting signs of fibrosis MESHD in critically ill patients remains unclear. To our knowledge, there are no radiopathological correlations of the pulmonary pathology. Exudative and proliferative diffuse alveolar damage (DAD) are the most commonly reported injury. Few studies describe fibrosis MESHD, the last phase of DAD. Our study correlates post-mortem chest US and CT findings of COVID-19 infected patients with the histopathology from biopsies taken of the lung. It focuses on the role of CT to depict fibrosis MESHD. METHODSThis is a prospective observational study of six consecutive deceased patients infected with COVID-19. Post-mortem chest CTs and US were performed within 24 hours of death MESHD. CT and US were used to obtain biopsies of different radiological patterns. Pre-mortem CT examinations were also retrospectively evaluated. RESULTSOn CT, all patients presented with extensive areas of consolidation and ground-glass opacities affecting most segments of the lung. Pleural effusion MESHD Pleural effusion HP was present in all cases. Four of the patients showed signs of fibrosis MESHD. On US, subpleural consolidation, pleural thickening HP, and B-pattern were present.All patients showed different stages of DAD, mostly proliferative DAD. Four patients presented with fibrotic DAD, all of which had been admitted for over three weeks and correlated with the CT findings of fibrosis MESHD. CONCLUSIONIn our study, signs of fibrosis MESHD on CT show a histopathological correlation. CT may be useful to identify the group of COVID-infected patients that develop fibrosis MESHD as a marker of poor prognosis, in the late stage of the disease MESHD.

    Pulmonary CT signs in patients with COVID-19 infection MESHD

    Authors: Carmen Ali Zarad; Waleed Said Ahmed Abo Shanab

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: The aim of the study is to investigate the pulmonary CT signs in patients with confirmed COVID-19 infection MESHD. This study included 100 patients, 54 male TRANS and 46 female TRANS their ages TRANS ranged from 6 to 85 years. All Patients tested positive for COVID-19 infection MESHD by RT-PCR test included in this study. All the patients performed pulmonary CT scan and the CT findings were evaluated.Results: 90 patients (90%) had abnormal pulmonary CT. Two lungs affected in 79 patients (79%). Lesions involved 1 lobe (11%), 2-3 lobes (35%) and 4-5 lobes (44%). The most involved pulmonary lobes were right lower lobe (77 patients, 77%), followed by left lower lobe (71 patients, 71%), the most involved pulmonary segments were posterior segments (69 patients, 69%),peripheral sub-pleural lesions were the commonest lesions location (64 patients, 64%). The most common lesions pattern were ground glass pattern (44 patients, 44%), followed by mixed ground glass and consolidation patterns (33 patients, 33%). The commonest lesion shape was patchy opacities (40 patients, 40%). Reversed halo sign (28 patients, 28%), air bronchogram sign (39 patients, 39%), crazy paving pattern (77 patients, 77%), vascular thickening (66 patients, 66%), and pleural thickening HP (7 patients, 7%) CONCLUSION: The main pulmonary CT signs in patients with COVID-19 infection MESHD are bilateral, peripheral, multi-lobar patchy and nodular Ground glass opacification with or without consolidation. Other signs may also present include crazy paving pattern, reversed halo sign vascular thickening, and air bronchogram sign with no extra-pulmonary signs except for few pleural thickening HP.

    Lung Ultrasound Findings in Patients Hospitalized with Covid-19

    Authors: Andre D Kumar; Sukyung Chung; Youyou Duanmu; Sally Graglia; Farhan Lalani; Kavita Gandhi; Viveta Lobo; Trevor Jensen; Yingjie Weng; Jeffrey Nahn; John Kugler

    doi:10.1101/2020.06.25.20140392 Date: 2020-06-28 Source: medRxiv

    Introduction: Point-of-care ultrasound (POCUS) has the potential to transform healthcare delivery in the era of COVID-19 with its diagnostic and therapeutic expediency. It can be performed by clinicians already at the bedside, which permits an immediate and augmented assessment of a patient. Although lung ultrasound can be used to accurately diagnose a variety of disease MESHD states such as pneumothorax MESHD pneumothorax HP, pleural effusions MESHD pleural effusions HP, pneumonia MESHD pneumonia HP and interstitial lung disease2, there are limited reports on the sonographic manifestations of COVID-19. There is an urgent need to identify alternative diagnostic modalities that can be immediately employed at the bedside of COVID-19 patients. Methods: This study was conducted at two medical centers in the United States from 3/21/2020-6/01/2020. Any adult TRANS who was hospitalized with COVID-19 (based on symptomatology and a confirmatory RT-PCR for SARS-CoV-2) and received a pulmonary POCUS examination was included. Providers were instructed to use a 12-zone scanning protocol for pulmonary views and save 6 second clips of each lung zone. This study utilized several POCUS devices, including Butterfly IQ, Vave, Lumify, and Sonosite. The collected images were interpreted by the study researchers based on a consensus document developed by the study authors and previously accepted definitions of lung POCUS findings. Results: A total of 22 eligible patients who received 36 lung scans were included in our study. Eleven (50%) patients experienced clinical deterioration MESHD (defined as either ICU admission, invasive mechanical ventilation, or death MESHD within 28 days from the initial symptom onset TRANS). Among the 36 lung scans collected, only 3 (8%) were classified as normal. The remaining scans had the following abnormalities: presence of B-lines (n=32, 89%), consolidations (n=20, 56%), pleural thickening HP (n=17, 47%), and pleural effusion MESHD pleural effusion HP (n=4, 11%). Out of 20 scans with consolidations, 14 (70%) were subpleural and 5 (25%) were translobar. A-lines were present in 26 (72%) of patients, although they were only observed in the majority of the collected lung zones in 5 (14%) of patients. Ultrasound findings were stratified by time from symptom onset TRANS to the scan based on the following time periods: early (0-6 days), middle (7-13 days), and late (14-28 days). B-lines appeared early after symptom onset TRANS and persisted well into the late disease MESHD course. In contrast, pleural thickening HP increased in frequency over time (early: 25%, middle: 47%, late: 67%). Subpleural consolidations also appeared in higher frequency later in the disease MESHD course (early: 13%, middle 42%, late: 56%). Discussion: certain lung ultrasound findings may be common in Covid-19, while others may appear later in the disease MESHD course or only occur in patients who experience clinical deterioration MESHD. Future efforts should investigate the predictive utility of consolidations, pleural thickening HP and B-lines for clinical deterioration MESHD and compare them to traditional radiological studies such as X-rays or CTs.

    CT features of COVID-19 patients with two consecutive negative RT-PCR tests after treatment

    Authors: Zhao Fu; Ningning Tang; Yanqing Chen; Longbai Ma; Youyong Wei; Yumin Lu; Kun Ye; Hang Liu; Fen Tang; Guangyi Huang; Yingxia Yang; Fan Xu

    doi:10.21203/ Date: 2020-06-02 Source: ResearchSquare

    Purpose: The objective of this study is to expound the CT features of COVID-19 patients whose nucleic acid tests converted to negative after treatment.Materials and Methods: We retrospectively reviewed 46 COVID-19 patients with two consecutive negative RT-PCR tests after treatment. The cases were divided into moderate group and severe/critical group according to disease MESHD severity. Clinical and CT scanning data were collected. CT signs of pulmonary lesions and the score of long involvement were expounded.Results: 39 moderate cases and 7 severe/critical cases were included. All moderate patients showed peripheral lesions while severe/critical cases exhibited both central and peripheral lesions with all lobes involvement. Ground glass opacity (GGO) and mixed GGO were observed. Aberrant pulmonary interstitium manifested as reticular and thin linear pattern. Thickened blood SERO vessels and pleural thickening HP were found. Pulmonary fibrosis MESHD Pulmonary fibrosis HP, annular thickening of the bronchial wall, bronchiectasis MESHD bronchiectasis HP, air bronchogram and small amount of bilateral pleural effusion MESHD pleural effusion HP were observed in severe/critical patients. The severe/critical group showed higher CT score of involvement.Conclusions: Pulmonary lesions persisted even after twice consecutive nucleic acid tests converted to negative. We strongly recommended regular follow-up of CT scans after nucleic acid tests conversion. Evaluation of complete remission should base on chest CT.

    Lung ultrasound findings in patients with novel SARS-CoV2

    Authors: Mark Evert Haaksma; Micah L.A. Heldeweg; Jorge E. Lopez Matta; Jasper Martijn Smit; Jessica D. van Trigt; Jip Suzanne Nooitgedacht; Carlos V. Elzo Kraemer; Armand R.J. Girbes; Leo M.A. Heunks; David J. van Westerloo; Pieter R. Tuinman

    doi:10.1101/2020.05.18.20105775 Date: 2020-05-21 Source: medRxiv

    Background: Over 2 million people worldwide have been infected with Severe Acute Respiratory Distress HP Syndrome MESHD Corona Virus 2 (SARS CoV2). Lung ultrasound has been proposed to diagnose and it. However, little is known about ultrasound findings in these patients. Our aim is to present an overview of lung ultrasound characteristics in critically ill patients with SARS CoV2 pneumonia MESHD pneumonia HP overall and in relation to the duration of symptoms and clinical parameters. Methods: On the Intensive Care Unit of two academic hospitals, adult TRANS patients who tested positive for SARS-CoV2 were included. Images were analyzed for pleural line characteristics, number and appearance of B-lines, BLUE-profiles (Bedside Lung Ultrasound in Emergency MESHD), pathology in the PLAPS (Postero Lateral Alveolar and Pleural Syndrome MESHD) point and a LUS-score (lung ultrasound). The primary outcomes were frequencies, percentages and differences in lung ultrasound findings overall and between short ([≤]14 days) and long (>14 days) duration of symptoms and their correlation with clinical parameters. Results: In this pilot observational study, 61 patients were included with 75 examinations for analysis. The most prevalent ultrasound findings were decreased lung sliding (36%), thickening of the pleural HP line (42%) and a C-profile per view (37%). Patients with ''long'' duration of symptoms presented more frequently with a thickened and irregular pleural line (21% (32) vs 9% (11), p=.01), C-profile per patient (47% (18) vs. 25% (8),p=.01) and pleural effusion MESHD pleural effusion HP (19% (14) vs 5% (3),p=.02) compared to patients with short duration of symptoms. Lung ultrasound findings did not correlate with P/F ratio, fluid balance or dynamic compliance, with the exception of the LUS-score and dynamic compliance (R2=0.27, p=.02). Conclusion: SARS CoV2 results in significant ultrasound changes, with decreased lung sliding, thickening of the pleural HP line and a C-profile being the most observed. With time, a thickened and irregular pleural line, C-profile and pleural effusion MESHD pleural effusion HP become more common findings.

    Comparison of initial HRCT features of COVID-19 pneumonia MESHD pneumonia HP and other viral pneumonias MESHD pneumonias HP

    Authors: Yilong Huang; Yuanming Jiang; Li Wu; Wenfang Yi; Jiyao Ma; Peng Wang; Ying Xie; Zhipeng Li; Xiang Li; Minchang Hong; Jialong Zhou; Chuwei Duan; Yunhui Yang; Wei Zhao; Feng Yuan; Dan Han; Bo He

    doi:10.21203/ Date: 2020-05-17 Source: ResearchSquare

    Background: Multicenter retrospective comparison of the first high-resolution computed tomography (HRCT) findings of coronavirus disease MESHD 2019 (COVID-19) and other viral pneumonias MESHD pneumonias HP.Methods: We retrospectively collected clinical and imaging data from 254 cases of confirmed TRANS viral pneumonia MESHD pneumonia HP in 20 hospitals in Yunnan Province, China, from March 1, 2015, to March 15, 2020. According to the virus responsible for the pneumonia MESHD pneumonia HP, the pneumonias MESHD pneumonias HP were divided into non-COVID-19 (133 cases) and COVID-19 (121 cases). The non-COVID-19 pneumonias MESHD pneumonias HP included 3 types: cytomegalovirus (CMV) (31 cases), influenza A virus (82 cases), and influenza B virus (20 cases). The differences in the basic clinical characteristics, lesion distribution, location and imaging signs among the four viral pneumonias MESHD pneumonias HP were analyzed and compared.Results: Fever MESHD Fever HP and cough MESHD cough HP were the most common clinical symptoms of the four viral pneumonias MESHD pneumonias HP. Compared with the COVID-19 patients, the non-COVID-19 patients had higher proportions of fatigue MESHD fatigue HP, sore throat, expectorant and chest tightness HP (all p<0.000). In addition, in the CMV pneumonia MESHD pneumonia HP patients, the proportion of patients with combined acquired immunodeficiency syndrome MESHD immunodeficiency HP syndrome (AIDS) and leukopenia MESHD leukopenia HP were high (all p<0.000). Comparisons of the imaging findings of the four viral pneumonias MESHD pneumonias HP showed that pulmonary lesions of COVID-19 were more likely to occur in the peripheral and lower lobes of both lungs, while those of CMV pneumonia MESHD pneumonia HP were diffusely distributed. Compared with the non-COVID-19 pneumonias MESHD pneumonias HP, COVID-19 pneumonia MESHD pneumonia HP was more likely to present as ground-glass opacity (GGO), intralobular interstitial thickening HP, vascular thickening and halo sign (all p<0.05). In addition, in the early stage of COVID-19, extensive consolidation, fibrous stripes, subpleural lines, crazy-paving pattern, tree-in-bud HP, mediastinal lymphadenectasis, pleural thickening HP and pleural effusion MESHD pleural effusion HP were rare (all p<0.05).Conclusion: The HRCT findings of COVID-19 pneumonia MESHD pneumonia HP and other viral pneumonias MESHD pneumonias HP overlapped significantly, but many important differential imaging features could still be observed.

    Dynamic Changes of Chest CT Follow-up In Coronavirus Disease MESHD-19 (COVID-19) Pneumonia MESHD Pneumonia HP: Relationship To Clinical Typing

    Authors: Nian Liu; Guanghong He; Xiongxiong Yang; Jianxin Chen; Jie Wu; Min Ma; Wenying Lu; Qiang Li; Tao Cheng; Xiaohua Huang

    doi:10.21203/ Date: 2020-04-27 Source: ResearchSquare

    Background: To investigate the CT changes of different clinical types of COVID-19 pneumonia MESHD pneumonia HP. Methods: This retrospective study included 50 patients with COVID-19 from 16 January 2020 to 25 February 2020. We analyzed the clinical characteristics, CT characteristics and the pneumonia MESHD pneumonia HP involvement of the patients between the moderate group and the severe and critical group, and the dynamic changes of severity with the CT follow-up time. Results: There were differences in the CT severity score of the right lung in the initial CT, and total CT severity score in the initial and follow-up CT between the moderate group and the severe and critical group (all p <0.05). There was a quadratic relationship between total CT severity score and CT follow-up time in the severe and critical group (r2=0.137, p=0.008), the total CT severity score peaked at the second follow-up CT. There was no correlation between total CT severity score and CT follow-up time in the moderate group (p >0.05). There were no differences in the occurrence rate of CT characteristics in the initial CT between the two groups (all p >0.05). There were differences in the occurrence rate of ground-glass opacity and crazy-paving pattern in the second follow-up CT, and pleural thickening HP or adhesion in the third follow-up CT between the two groups (all p <0.05). Conclusions: The CT changes of COVID-19 pneumonia MESHD pneumonia HP with different severity were different, and the extent of pneumonia MESHD pneumonia HP involvement by CT can help to assess the severity of COVID-19 pneumonia MESHD pneumonia HP rather than the initial CT characteristics.

    Chest CT imaging characteristics of COVID-19 pneumonia MESHD pneumonia HP in preschool children TRANS: a retrospective study

    Authors: Yang Li; Jianghui Cao; Xiaolong Zhang; Guangzhi Liu; Xiaxia Wu; Baolin Wu

    doi:10.21203/ Date: 2020-04-07 Source: ResearchSquare

    Background: Recently, the World Health Organization has declared the coronavirus disease MESHD 2019 (COVID-19) outbreak a public health emergency MESHD of international concern. So far, however, limited data are available for children TRANS. Therefore, we aimed to investigate the clinical and chest CT imaging characteristics of COVID-19 in preschool children TRANS.Methods: From January 26, 2020 to February 20, 2020, the clinical and initial chest CT imaging data of eight preschool children TRANS with laboratory-confirmed COVID-19 from two hospitals were retrospectively collected. The chest CT imaging characteristics, including the distribution, shape, and density of lesions, and the pleural effusion MESHD pleural effusion HP, pleural changes, and enlarged lymph nodes were evaluated. Results: Two cases (25%) were classified as mild type, and they showed no obvious abnormal CT findings or minimal pleural thickening HP on the right side. Five cases (62.5%) were classified as moderate type. Among these patients, one case showed consolidation located in the subpleural region of the right upper lobe, with thickening in the adjacent pleura; one case showed multiple consolidation and ground-glass opacities with blurry margins; one case displayed bronchial pneumonia MESHD pneumonia HP-like changes in the left upper lobe; and two cases displayed asthmatic bronchitis MESHD bronchitis HP-like changes. One case (12.5%) was classified as critical type and showed bronchial pneumonia MESHD pneumonia HP-like changes in the bilateral lungs, presenting blurred and messy bilateral lung markings and multiple patchy shadows scattered along the lung markings with blurry margins.Conclusions: The chest CT findings of COVID-19 in preschool children TRANS are atypical and various. Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data. 

    Ultra-High-Resolution CT Follow-Up in Patients with Imported Early-Stage Coronavirus Disease MESHD 2019 (COVID-19) Related Pneumonia MESHD Pneumonia HP

    Authors: Yu Lin; Shaomao Lv; Jinan Wang; Jianghe Kang; Youbin Zhang; Zhipeng Feng

    doi:10.1101/2020.03.31.20048256 Date: 2020-04-06 Source: medRxiv

    Background: An ongoing outbreak of mystery pneumonia MESHD pneumonia HP in Wuhan was caused by coronavirus disease MESHD 2019 (COVID-19). The infectious disease MESHD disease has spread TRANS has spread globally and become a major threat to public health. Purpose: We aim to investigate the ultra-high-resolution CT (UHR-CT) findings of imported COVID-19 related pneumonia MESHD pneumonia HP from the initial diagnosis to early-phase follow-up. Methods: This retrospective study included confirmed cases TRANS with early-stage COVID-19 related pneumonia MESHD pneumonia HP imported from the epicenter. Initial and early-phase follow-up UHR-CT scans (within 5 days) were reviewed for characterizing the radiological findings. The normalized total volumes of ground-glass opacities (GGOs) and consolidations were calculated and compared during the radiological follow-up by artificial-intelligence-based methods. Results: Eleven patients (3 males TRANS and 8 females TRANS, aged TRANS 32-74 years) with confirmed COVID-19 were evaluated. Subpleural GGOs with inter/intralobular septal thickening were typical imaging findings. Other diagnostic CT features included distinct margins (8/11, 73%), pleural retraction or thickening (7/11, 64%), intralesional vasodilatation (6/11, 55%). Normalized volumes of pulmonary GGOs (p=0.003) and consolidations (p=0.003) significantly increased during the CT follow-up. Conclusions: The abnormalities of GGOs with peripleural distribution, consolidated areas, septal thickening, pleural HP involvement and intralesional vasodilatation on UHR-CT indicate the diagnosis of COVID-19. COVID-19 cases could manifest significantly progressed GGOs and consolidations with increased volume during the early-phase CT follow-up.

    Computed Tomography Findings and Short-term follow-up with Novel Coronavirus Pneumonia MESHD Pneumonia HP

    Authors: Shi Qi; Hui Guo; Hua Shao; Siqin Lan; Yuanlin He; Maijudan Tiheiran; Hongjun Li

    doi:10.1101/2020.04.02.20042614 Date: 2020-04-04 Source: medRxiv

    Objective: To assess the characteristics of computed tomography (CT) features and changes in CT monitoring in patients with novel coronavirus pneumonia MESHD pneumonia HP (NCP) . Methods: In this retrospective, two-center study, we reviewed the medical records of 57 patients with NCP in CT from January 21 to February 12, 2020. Cases were confirmed TRANS by the results of nucleic acid test positive, and were analyzed for demographic, clinical, and CT features. Results: Of the 57 patients, 31cases were male TRANS, and 45.6% were female TRANS. The average age TRANS was 46.5 years. Patients had fever MESHD fever HP (84.2%), cough MESHD cough HP (49.1%), weak (31.6%), muscle ache (17.5%), shortness of breath (12.3%). The distribution of abnormality was a subpleural lesions in 51 cases, with 96.5% ground-glass opacity (GGO) and 68.4% consolidation. Another observation reveals 45.6% fibrosis MESHD, 33.3% lymph node enlargement, 21.1% pleural thickening HP, 17.5% small nodule, 7.0% white lung, 5.3% emphysema MESHD emphysema HP, and 3.5% bronchiectasis MESHD bronchiectasis HP. Importantly, the group of men had more septal thickening and air trapping than the female TRANS group (p < 0.05); Compared with the younger, the elderly TRANS had higher of subpleural lesion, interlobular septal thickening and pleural HP thickening (p < 0.05). In the first monitoring, there were 37.3% improvement, 60.8% progress. In the second monitoring, there were 55% improvement, 35% progress. The improvement rate during the third follow-up visit was 100%. Conclusions: CT features and CT dynamic observation play a vital role in the diagnosis and treatment with NCP. It is conducive to early diagnosis, deepen the knowledge of NCP and accumulate experience.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.