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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    The potential effect of the angiotensin-converting enzyme 2 (ACE2) receptor of 2019-nCoV on lung adenocarcinoma MESHD lung adenocarcinoma HP patients

    Authors: qin huo; zhenwei li; ling shao; siqi chen; jiaying li; ni xie

    doi:10.21203/rs.3.rs-49009/v1 Date: 2020-07-25 Source: ResearchSquare

    BackgroundThe 2019-nCoV epidemic is the public health emergency MESHD that has had the greatest impact on the world. Our study aimed to better understand the underlying mechanisms and function of angiotensin-converting enzyme 2 (ACE2) receptor of 2019-nCoV on lung adenocarcinoma MESHD lung adenocarcinoma HP patients (LUAD), and provide a theoretical basis for early diagnosis, prognosis and targeted therapy of 2019-nCoV. MethodsThis study focuses on the expression level, functions, mutation rate, and copy number variations (CNVs) of ACE2 in LUAD using an extensive bioinformatics data mining process. The interaction between ACE2 expression and clinical-pathological parameters of patients with LUAD was investigated using UALCAN. Also, the essential biological features, single nucleotide variations (SNVs), CNVs, and pathway activities of genes interacting with ACE2 in these cancers were further analyzed. ResultsWe found that ACE2 expression in LUAD patients increased with age TRANS, but it was not related to cancer status, patient’s race, patient’s gender TRANS, or patient’s smoking habits. Moreover, our results showed that compared to that in normal tissues, ACE2 was highly expressed in colon adenocarcinoma HP adenocarcinoma MESHD (COAD), kidney renal papillary cell carcinoma HP carcinoma MESHD (KIRP), pancreatic adenocarcinoma HP adenocarcinoma MESHD (PAAD), rectum adenocarcinoma MESHD (READ), and stomach adenocarcinoma MESHD (STAD). However, there is no significant difference in the expression of ACE2 in patients of different ages TRANS. ConclusionsThese findings demonstrate the importance of ACE2 in LUAD, and provide insights into the regulatory mechanisms and function of ACE2.

    Colon Cancer HP and SARS-CoV-2: Impact of ACE2 Expression in Susceptibility to COVID-19

    Authors: Mohsen Ahmadi; Negin Saffarzadeh; Mohammad Amin Habibi; Fatemeh Hajiesmaeili

    doi:10.1101/2020.06.11.146878 Date: 2020-06-13 Source: bioRxiv

    Novel coronavirus disease MESHD (COVID-19) pandemic has become a global health emergency MESHD. Severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) interacts with angiotensin-converting enzyme 2 (ACE2) to enter the cells and infects diverse human tissues. It has been reported that a few conditions, including cancer, predispose individuals to SARS-CoV-2 infection MESHD infection and severe HP and severe form of COVID-19. These findings led us to evaluate the susceptibility of colon adenocarcinoma HP adenocarcinoma MESHD (COAD) patients to SARS-CoV-2 infection MESHD by investigation of ACE2 expression in their tumor tissues. The expression analysis revealed that both mRNA and protein levels of ACE2 had increased in colon cancer HP samples than normal group. Next, the prognosis analysis has indicated that the upregulation of ACE2 was not correlated with patient survival outcomes. Further assessment displayed the hypomethylation of the ACE2 gene promoter in COAD patients. Surprisingly, this methylation status has a strong negative correlation with ACE2 gene expression. The functional enrichment analysis of the genes that had similar expression patterns with ACE2 in colon cancer HP tissues demonstrated that they mainly enriched in Vitamin digestion and absorption, Sulfur relay system, and Fat digestion and absorption pathways. Finally, we found that ACE2 gene expression had a significant association with the immune cell infiltration levels in COAD patients. In conclusion, it has plausible that COAD patients are more likely to be infected with SARS-CoV-2 and experience severe injuries. Moreover, COVID-19 would bring unfavorable survival outcomes of patients with colon cancer HP by the way of immune cell infiltration linked process. The present study highlights the importance of preventive actions for COAD patients during the COVID-19 pandemic.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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