Background: Fever MESHD Fever HP, dry cough MESHD cough HP and fatigue MESHD fatigue HP are the most common symptoms of the coronavirus disease MESHD-2019 (COVID-19). During the COVID-19 pandemic in China, we treated a patient with fever MESHD fever HP and finally diagnosed congenital heart disease MESHD.Case presentation: An 18-year-old lady came to the fever MESHD fever HP clinic with a complaint about the symptoms of fever MESHD fever HP, dry cough MESHD cough HP and dyspnea MESHD dyspnea HP for 15 days. She had a travel TRANS history of epidemic area two weeks ago. She had a low fever MESHD fever HP and dry cough MESHD cough HP accompanied with chest tightness HP and fatigue MESHD fatigue HP. Eventually she diagnosed ventricular septal defect HP complicated by infective endocarditis MESHD endocarditis HP. Two months after surgery, the patient returned to normal social life and physical activity.Conclusion: Early surgical treatment is an effective strategy for ventricular septal defect HP patients complicated with IE, which can improve the early survival rate of patients.