Corpus overview


MeSH Disease

Human Phenotype


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    Association of BMI and Obesity MESHD Obesity HP with Composite poor outcome in COVID-19 adult TRANS patients: A Systematic Review and Meta-Analysis

    Authors: Arto Yuwono Soeroto; Nanny Natalia Soetedjo; Aga Purwiga; Prayudi Santoso; Iceu Dimas Kulsum; Hendarsyah Suryadinata; Ferdy Ferdian

    doi:10.1101/2020.06.28.20142240 Date: 2020-06-29 Source: medRxiv

    Aim: This study aimed to evaluate the association between obesity MESHD obesity HP and composite poor outcome in coronavirus disease MESHD 2019 (COVID-19) patients. Methods: We conducted a systematic literature search from PubMed and Embase database. We included all original research articles in COVID-19 adult TRANS patients and obesity MESHD obesity HP based on classification of Body Mass Index (BMI) and composite poor outcome which consist of mortality, morbidity, admission of Intensive Care Unit (ICU), mechanical ventilation, Acute Respiratory Distress HP Syndrome MESHD (ARDS), and severe COVID-19. Results: Nine studies were included in meta-analysis with 6 studies presented BMI as continuous outcome and 3 studies presented BMI as dichotomous outcome (obese and non-obese). Most studies were conducted in China (55.5%) with remaining studies from French, Germany, and United States (US). COVID-19 patients with composite poor outcome had higher BMI with mean difference 0.55 kg/m2 (95% CI 0.07-1.03, P=0.02). BMI [≥]30 (obese) was associated with composite poor outcome with odds ratio 1.89 (95% CI 1.06-3.34, P=0.03). Multivariate meta-regression analysis by including three moderators: age TRANS, hypertension MESHD hypertension HP, and Diabetes Mellitus type 2 MESHD Diabetes Mellitus type HP (DM type 2) showed the association between obesity MESHD obesity HP and composite poor outcome was affected by age TRANS with regression coefficient =-0.06 and P=0.02. Subgroup analysis was not performed due to the limited number of studies for several outcomes. Conclusion: Obesity MESHD Obesity HP is a risk factor of composite poor outcome of COVID-19. On the other hand, COVID-19 patients with composite poor outcome have higher BMI. BMI is an important routine procedure that should be assessed in the management of COVID-19 patients and special attention should be given to patients with obesity MESHD obesity HP. Keywords: Covid-19, Obesity MESHD Obesity HP, Body Mass Index

    Cellular exocytosis gene (EXOC6/6B): a potential molecular link for the susceptibility and mortality of COVID-19 in diabetic patients

    Authors: Jalal Taneera; Mahmood Yaseen Hachim; Ibrahim Yaseen Hachim; Saba Al Heialy; Nabil Sulaiman

    doi:10.1101/2020.06.25.170936 Date: 2020-06-25 Source: bioRxiv

    Diabetes is one of the most critical comorbidities linked to an increased risk of severe complications in the current coronavirus disease MESHD 2019 (COVID-19) pandemic. A better molecular understanding of COVID-19 in people with type diabetes mellitus HP diabetes mellitus MESHD (T2D) is mandatory, especially in countries with a high rate of T2D, such as the United Arab Emirates (UAE). Identification of the cellular and molecular mechanisms that make T2D patients prone to aggressive course of the disease MESHD can help in the discovery of novel biomarkers and therapeutic targets to improve our response to the disease MESHD pandemic. Herein, we employed a system genetics approach to explore potential genomic, transcriptomic alterations in genes specific to lung and pancreas tissues, affected by SARS-CoV-2 infection MESHD, and study their association with susceptibility to T2D in Emirati patients. Our results identified the Exocyst complex component, 6 (EXOC6/6B) gene (a component for docks insulin granules to the plasma SERO membrane) with documented INDEL in 3 of 4 whole genome sequenced Emirati diabetic patients. Publically available transcriptomic data showed that lung infected with SARS-CoV-2 showed significantly lower expression of EXOC6/6B compared to healthy lungs. In conclusion, our data suggest that EXOC6/6B might be an important molecular link between dysfunctional pancreatic islets and ciliated lung epithelium that makes diabetic patients more susceptible to severe SARS-COV-2 complication.

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MeSH Disease
Human Phenotype

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