Corpus overview


MeSH Disease

Human Phenotype


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    Effects of COVID-19 in Endocrine Patients: Results of a Sicilian Experience

    Authors: Elisabetta Morini; Rosanna Palmeri; Giuseppa Maresca; Lilla Bonanno; Maria Cristina De Cola; Adriana Andaloro; Santina Caliri; Placido Bramanti; Francesco Corallo

    id:10.20944/preprints202008.0041.v1 Date: 2020-08-02 Source:

    In March 2020 the World Health Organization declared the “pandemic state” due to COVID-19 imposing strict confinement of the world population. People were forced to spend more time at home, changing some daily routines, including social interactions HP social interactions TRANS, the possibility to perform sports, and diet habits. These changes could exert a greater impact on patients suffering from chronic diseases MESHD, such as endocrine patients. This study aimed to assess the effects of Covid-19 induced quarantine on daily habits in a group of patients with endocrine disorders, focusing on food consumption, eating, and sleep habits during the confinement. Eighty-five endocrine patients were enrolled. A structured interview was administered investigating: socio-demographic information, general medical conditions and habits adopted during the quarantine. All patients underwent the Spielberger State Anxiety HP Inventory (STAI-Y1) to assess state anxiety HP. Subjects had mainly a sedentary lifestyle. We found a significant increase in the number of cigarettes in smokers, an increase of meals consumed during the confinement and a high rate of sleep disorder occurrence, especially insomnia HP. The changes of daily habits were, probably, due to the alterations of routine, that determined more bore and inactivity during the day.

    Sleep Disorders, Perceived Stress and Family Support Among Nursing Staff During the Pandemic Crisis

    Authors: Athanasios Tselebis; Dimitra Lekka; Christos Sikaras; Effrosyni Tsomaka; Athanasios Tassopoulos; Ioannis Ilias; Dionisios Bratis; Argyro Pachi

    doi:10.21203/ Date: 2020-07-17 Source: ResearchSquare

    Background: The covid-19 pandemic is likely to cause mental health issues, especially for healthcare professionals. The aim of this study is to investigate levels of perceived stress, sleep disturbances HP and sense of family support among nurses in pandemic conditions. Methods: Athens Insomnia HP Scale (AIS), Perceived Stress Scale (PSS) and Family Support Scale (FSS) were administered in a sample of 150 nurses from different hospital departments during the COVID-19 pandemic. Individual and demographic data were recorded. Results: 120 women and 30 men completed the study questionnaires. Almost half of participants (49.7%) reported the presence of sleep difficulties and more than half (50.3%) experienced increased stress levels. Scores on AIS scale correlated positively with PSS scores (P<0.01), and nega­tively with FSS scores (P<0.01). A significantly negative correlation was observed between the PSS scores and the FSS scores (p<0.01). Regression model showed ‘scores on PSS scale’ and ‘years of work experience’ were significant predictors of ‘scores on AIS scale’, each explaining 43.6% and 2.3% of the variance. Scores on AIS scale’ and ‘scores on FSS scale’ were significant predictors of PSS explaining 43.7% and 9,2% of the variance .  Conclusion: The study confirmed that working with COVID-19 patients has a negative effect on the sleep of nurses, possibly mediated by increased levels of stress. Family support, as a protective factor, appears to moderate the deleterious consequences of stress.

    Baduanjin Exercise May Improve the Anxiety HP and Insomnia HP in COVID-2019 Patients: A Case-Control Study

    Authors: Ming-Gui Chen; Yinlong Qiu; Haizhen Chen; Erhui Chen; Rui-Xiang Zeng; Qiaomei Wu; Xiaoxuan Zhang; Min-Zhou Zhang; MeiZhen Lin

    doi:10.21203/ Date: 2020-07-14 Source: ResearchSquare

    Background: Since December 2019, an epidemic caused by novel coronavirus(2019-nCoV) infection MESHD has occurred unexpectedly in China. Because of the sudden nature of the outbreak and the infectious power of the virus, it will inevitably cause people anxiety HP and other stress reactions. Previous studies showed that Baduanjin exercise was effective for people in anxiety HP and insomnia HP. The purpose of this study was to evaluate the potential benefits of Baduanjin exercise on the anxiety HP and insomnia HP in COVID-2019 patients.Methods: This is a Case-Control Study. The COVID-2019 patients including 39 Baduanjin exercises or willing to do Baduanjin exercises and 39 age TRANS-and gender TRANS-matched nonexercising controls. The anxiety HP and insomnia HP in COVID-2019 patients were measured by using the GAD-7 and SMH Sleep Questionnaire at baseline and discharge.Results: In the study, the Paired T-test showed that two groups had improved the GAD-7 scores and SMH Sleep Questionnaire compared with baseline at discharge. Baseline results showed there were no significant differences in the GAD-7 scores and SMH Sleep Questionnaire between the two groups. However, the significant differences found in the Baduanjin group included a 43.9% lower (p<0.001) in the GAD-7 score and an approximately 75.9% higher (p=0.003) in SMH Sleep Questionnaire score compare with the control group at discharge.Conclusion: The Baduanjin exercise may improve the anxiety HP and insomnia HP in COVID-2019 patients. It can also be used as a form of rehabilitation exercise for discharged patients or patients isolated at home.Trial Registration: ChiCTR2000030528.

    Mental health impacts among health workers during COVID-19 in a low resource setting: a cross-sectional survey from Nepal

    Authors: Pratik Khanal; Navin Devkota; Minakshi Dahal; Kiran Paudel; Devavrat Joshi

    doi:10.21203/ Date: 2020-07-03 Source: ResearchSquare

    Background: Health care workers exposed to COVID-19 might be at risk of developing mental health problems. The study aimed to identify factors associated with anxiety HP, depression and insomnia HP among health workers involved in COVID-19 response in Nepal. Methods: This was a cross-sectional web-based survey conducted in between April 26 to May 12, 2020. A total of 475 health workers participated in the study. Anxiety HP and depression were measured using 14-item Hospital Anxiety HP and Depression Scale (HADS: 0- 21) and insomnia HP was measured by using 7-item Insomnia HP Severity Index (ISI: 0-28). Multivariable logistic regression analysis was done to determine the risk factors of mental health outcomes. Results: Overall, 41.9% of health workers had symptoms of anxiety HP, 37.5% had depression symptoms and 33.9% had symptoms of insomnia HP. Stigma faced by health workers was significantly associated with higher odds of experiencing symptoms of anxiety HP (AOR: 2.47; 95% CI: 1.62-3.76), depression (AOR: 2.05; 95% CI: 1.34-3.11) and insomnia HP (AOR: 2.37; 95% CI: 1.46-3.84). History of medication for mental health problems was  significantly associated with higher likelihood of  experiencing symptoms of anxiety HP (AOR: 3.40; 95% CI:1.31-8.81) , depression (AOR: 3.83; 95% CI: 1.45-10.14) and insomnia HP (AOR: 3.82; 95% CI: 1.52-9.62) while inadequate precautionary measures in the workplace was significantly associated with higher odds of exhibiting symptoms of anxiety HP (AOR: 1.89; 95% CI: 1.12-3.19) and depression (AOR: 1.97; 95% CI: 1.16-3.37).  Nurses (AOR: 2.33; 95% CI: 1.21-4.47) were significantly more likely to experience anxiety HP symptoms than other health workers. Conclusion: The study findings revealed higher proportion of anxiety HP, depression and insomnia HP among health workers during the early phase of the pandemic in Nepal. Health workers facing stigma, those with history of medication for mental health problem, and those reporting to having inadequate precautionary measures in their workplace were more at risk of developing mental health outcomes. A focus on improving mental health wellbeing of health workers should be immediately initiated with attention to reduction of stigma, ensuring adequate support system such as personal protective equipments, and family support for those with history of mental health problems. 

    Associations of exercise and social support with mental health during quarantine and social-distancing measures during the COVID-19 pandemic: A cross-sectional survey in Germany

    Authors: Leonie Louisa Bauer; Britta Seiffer; Clara Deinhart; Beatrice Atrott; Gorden Sudeck; Martin Hautzinger; Inka Rösel; Sebastian Wolf

    doi:10.1101/2020.07.01.20144105 Date: 2020-07-02 Source: medRxiv

    Introduction: Social distancing and quarantine measures applied during the COVID-19 pandemic might result in mental health problems. In this cross-sectional study we examined if perceived social support, exercise in minutes per week and change in exercise are protective factors regarding symptoms of depression, anxiety HP, and sleeping disorders. Method: In April 2020, n = 4271 German adults TRANS completed an online survey including mental health questionnaires regarding depression (PHQ-D), anxiety HP (PHQ-D) and sleep (PSQI), as well as questionnaires related to protective factors such as exercise (BSA-F), physical activity-related health competence (PAHCO) and social support (F-SozU). Results: Complete case analysis (n = 3700; mean age TRANS 33.13 {+/-} 11.73 years, 78.6 % females TRANS) resulted in elevated prevalence SERO of depressive disorder (31.4%), panic disorder (5.7%) and other anxiety HP disorders (7.4%). 58.3% reported symptoms of insomnia HP. Three separate models of multiple regression were conducted. Perceived social support was associated with lower values of anxiety HP (beta = -0.10; t(19) = -6.46; p >0.001), lower values of depressive symptoms (beta = -0.22; t(19) = -15.71; p < .001) and lower values of sleeping disorder symptoms (beta = -0.15; t(19) = -9.55; p < .001). Change towards less exercise compared to the time before Covid-19 was associated with and higher values of anxiety HP (beta = -0.05; t(19) = -2.85; p= .004), higher values of depressive symptoms (beta = -0.08; t(19) = -5.69; p < .001), and higher values of sleeping disorder symptoms (beta = -0.07; t(19) = -4.54; p < .000). Post-hoc analysis (ANOVAs) revealed that a change towards less exercise was significantly associated with more depressive, anxiety HP and sleeping disorder symptoms whereas a positive change was not. No significant association was found for exercise in minutes per week for all outcomes. Conclusion: The COVID-19 pandemic seems to have a negative impact on mental health in the German population. Social Support and a stable amount of exercise might attenuate these negative mental health consequences. Ongoing monitoring of the impact of the pandemic on mental health and possible protective factors is needed in order to create a basis for the development of appropriate prevention and intervention measures.

    Investigation on the influencing factors of mental health of healthcare workers for aid in Hubei during the outbreak of the COVID-19

    Authors: Peng Zhou; Na Du; Dongmei Diao; Yingjie OuYang; Heshan Sameera Kankanam Pathiranage

    doi:10.21203/ Date: 2020-07-01 Source: ResearchSquare

    Background The objective of this study is to understand the psychological health status and analyze the related factors of healthcare workers for aid in Hubei during the epidemic. 220 subjects were investigated by Self-Rating Scale of Sleep(SRSS), Generalized Anxiety HP Scale (GAD-7), and 9-item patient health questionnaire (PHQ-9).Results The average SRSS score of all subjects was significantly higher than the national norm (p < 0.001)and the influencing factors were gender TRANS, whether the patients died under the charge of nursing/treatment, the history of psychosis HP and whether their family members TRANS were infected with the COVID-19. The average GAD-7 score of all subjects was in a moderate anxiety HP level, and the main influencing factors were gender TRANS, years of work, history of psychosis HP, self-perceived health statues and whether their family members TRANS were infected with the COVID-19. The average PHQ-9 score of all subjects was in mild depression level. The primary influencing factors were whether they nursed/treated severely ill patients during aid in Hubei and whether they had a history of psychosis HP.Conclusions During the outbreak of COVID-19, the symptoms of insomnia HP and anxiety HP of the healthcare workers for aid in Hubei were prominent. Moreover, male TRANS workers, those whose patients have died during their treatment, with previous anxiety HP disorders and whose family members TRANS infected with COVID-19 were facing more serious problems. Therefore, this special group needs to be strengthened follow-up psychological support individually.

    Impact of the Novel Coronavirus Disease MESHD (COVID-19) on Treatment Adherence and Sleep Duration in Obstructive Sleep Apnea MESHD Obstructive Sleep Apnea HP Patients Treated with Positive Airway Pressure

    Authors: Salma Batool-Anwar; Olabimpe S Omobomi; Stuart F Quan

    doi:10.1101/2020.06.28.20141994 Date: 2020-06-29 Source: medRxiv

    Objective To examine the effect of COVID-19 on treatment adherence and self-reported sleep duration among patients with Obstructive Sleep Apnea MESHD Obstructive Sleep Apnea HP (OSA) treated with positive airway pressure (PAP) therapy. Methods Retrospective review of medical records of patients seen in Sleep and Circadian Clinic at Brigham Health during the immediate period of one month after the national lockdown was announced on March 15, 2020. Patients with OSA were included only if PAP adherence data was available in the 12- months prior and in the month after the lockdown. Patients with other sleep disorders and OSA patients without the adherence data were excluded. Results Mean age TRANS was 63.5 +/- 13.9 years, 55% of the participants were men, and mean BMI was 31.8 +/- 7.9 kg/m2. Severe OSA was noted among 59.5% compared to 29.3% moderate, and 11.2% mild OSA. Increased number of patients reported insomnia HP after the lockdown (41% vs 48%, p= 0.02). Gender TRANS stratification noted worsening insomnia HP only among women. There was no significant difference in PAP adherence as measured by the hours of use, self-reported sleep duration or in the use of sleep medications. Conclusion Post COVID-19 lockdown had a negative impact on sleep as evidenced by increased reporting of insomnia HP particularly among women, but no impact on PAP adherence or self-reported sleep duration.

    Factors Associated with Mental Health Outcomes in Oman during COVID19: Frontline vs Non-frontline Healthcare Workers

    Authors: Muna Alshekaili; Walid Hassan; Nazik Al Said; Fatima Alsulaimani; Sathish Kumar Jayapal; Adhra Al-Mawali; Moon Fai Chan; Sangeetha Mahadevan; Samir Al-Adawi

    doi:10.1101/2020.06.23.20138032 Date: 2020-06-23 Source: medRxiv

    OBJECTIVE: This study aims to assess and compare demographic and psychological factors and sleep status of frontline HCWs in relation to non-frontline HCWs DESIGN, SETTINGS, AND PARTICIPANTS This cross-sectional study was conducted using an online survey from the 8th to the 17th of April 2020 across varied health care settings in Oman accruing 1139 HCWS. MAIN OUTCOMES AND MEASURES Mental health status was assessed using Depression, Anxiety HP, and Stress Scales (DASS-21), and insomnia HP was evaluated by the Insomnia HP Severity Index (ISI). Samples were categorized into the frontline and non-frontline groups. Chi-square, odds ratio, and independent t-tests were used to compare groups by demographic and mental health outcomes. Results This study included 1139 HCWs working in Oman. There was a total of 368 (32.3%), 388 (34.1%), 271 (23.8%), and 211 (18.5%) respondents reported to have depression, anxiety HP, stress, and insomnia HP, respectively while working during the pandemic period. HCWs in the frontline group were 1.4 times more likely to have anxiety HP (OR=1.401, p=0.007) and stress (OR=1.404, p=0.015) as compared to those working in the non-frontline group. On indices of sleep-wake cycles, HCWs in the frontline group were 1.37 times more likely to report insomnia HP (OR=1.377, p=0.037) when compared to those working in the non-frontline group. No significant differences in depression status between workers in the frontline and non-frontline groups were found (p=0.181). CONCLUSIONS AND RELEVANCE To our knowledge, this is the first study to explore the differential impacts of the COVID-19 pandemic on different grades of HCWs. This study suggests that frontline HCWs are disproportionally affected compared to non-frontline HCWs. The problem with managing sleep-wake cycles and anxiety HP symptoms were highly endorsed among frontline HCWs. As psychosocial interventions are likely to be constrained owing to the pandemic, mental health care must first be directed to frontline HCWs.

    Health Condition and Test Availability as Predictors of Adults TRANS' Mental Health during the COVID-19 Pandemic

    Authors: Huiyang Dai; Stephen X. Zhang; Kim Hoe Looi; Rui Su; Jizhen Li

    doi:10.1101/2020.06.21.20137000 Date: 2020-06-23 Source: medRxiv

    Background: Research identifying adults TRANS' mental health during the COVID-19 pandemic relies solely on demographic predictors without examining adults TRANS' health status during the COVID-19 pandemic as a potential predictor. Methods: An online survey of 669 adults TRANS in Malaysia was conducted during May 2-8, 2020, six weeks after a Movement Control Order (MCO) was issued. Findings: Adults TRANS' health condition had curvilinear relationships (horizontally reversed J-shaped) with insomnia HP, anxiety HP, depression and distress. Reported test availability for COVID-19 (from "strongly disagree" to "strongly agree" ) also had curvilinear relationships (horizontally reversed J-shaped) with anxiety HP and depression. Younger adults TRANS reported worse mental health, but people from various religions and ethnic groups did not differ significantly in reported mental health. Interpretation: Adults TRANS with worse health conditions had more mental health problems, especially adults TRANS at the lower end of the health spectrum. Test availability negatively predicted anxiety HP and depression, especially for adults TRANS experiencing poor COVID-19 test availability. The significant predictions of health condition and COVID-19 test availability suggest a new direction for the literature to identify psychiatric risk factors directly from health related variables during a pandemic.

    Efficacy of an online cognitive behavioral therapy program developed for healthcare workers during the COVID-19 pandemic: The REduction of STress (REST) study protocol for a randomized controlled trial

    Authors: Luisa Weiner; Fabrice Berna; Nathalie Nourry; François Severac; Pierre Vidailhet; Amaury C. Mengin

    doi:10.21203/ Date: 2020-06-22 Source: ResearchSquare

    Background: The acknowledgement of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease MESHD evolved into a pandemic status. Indeed, high prevalence SERO rates of depression, sleep disorders and post-traumatic stress disorder (PTSD) have been reported in Chinese healthcare workers during the epidemic peak. Symptoms of psychological distress are expected to be long-lasting and have a systemic impact on healthcare systems, warranting the need for evidence-based psychological treatments aiming at relieving immediate stress and preventing the onset of psychological disorders in this population. In the current COVID-19 context, internet-based interventions have the potential to circumvent the pitfalls of face-to-face formats, and provide the flexibility required to facilitate accessibility to healthcare workers. Online cognitive behavioral therapy (CBT) in particular has proved to be effective in treating and preventing a number of stress-related disorders in populations other than healthcare workers. The aim of our randomized controlled trial study protocol is to evaluate the efficacy of the ‘My Health too’ CBT program – a program we have developed for healthcare workers facing the pandemic -- on immediate perceived stress, and on the emergence of psychiatric disorders at 3- and 6-month follow-up compared to an active control group (i.e., bibliotherapy). Methods: Powered for non-inferiority testing, this six-site open trial involves the random assignment of 120 healthcare workers with stress levels >16 on the Perceived Stress Scale (PSS-10) to either the 7-session online CBT program or bibliotherapy. The primary outcome is the decrease of PSS-10 scores. Secondary outcomes include depression, insomnia HP, and PTSD symptoms, self-reported resilience and rumination, as well as credibility and satisfaction. Assessments are scheduled at pretreatment, mid-treatment (at 4 weeks), end of active treatment (at 8 weeks) and at 3-month and 6-month follow-up. Discussion: This is the first study assessing the efficacy and the acceptability of a brief online CBT program specifically developed for healthcare workers. Given the potential short- and long-term consequences of the COVID-19 pandemic on healthcare workers’ mental health, but also on healthcare systems, our findings can significantly impact clinical practice and management of the ongoing, and probably long-lasting, health crisis. Trial registration: NCT04362358, registered April 24, 2020.

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MeSH Disease
Human Phenotype

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