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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    An Analysis on the Clinical Features of MHD MESHD Patients with Coronavirus Disease MESHD 2019: A Single Center Study

    Authors: cheng li; Min Yonglong; Tu Can; Mao Dongdong; Wan Sheng; Liu Haifeng; Xiong Fei

    doi:10.21203/rs.3.rs-18043/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: In this study, we aimed to find out the features of the maintenance hemodialysis ( MHD MESHD) patients infected with Coronavirus Disease MESHD 2019 (COVID-19) in the Blood SERO Purification Center of Wuhan No.1 Hospital, Hubei Province, China, and provide evidences for clinical treatment.Methods: We collected the data of all the MHD MESHD patients in this hemodialysis center by February 20, 2020, including those infected with COVID-19. These patients were divided into three groups: the control group (537 cases), confirmed TRANS group (66 cases) and suspected group (24 cases). We compared the relevant data of the three groups and analyzed the factors that may affect the possibility of catching COVID-19.Results: 1. By February 20, 2020, there were 627 MHD MESHD patients in the Hemodialysis Center of Wuhan No.1 Hospital. The prevalence SERO rate of the COVID-19 was 14.35% (90/627, including 66 confirmed cases TRANS and 24 suspected cases); the fatality rate 13.33% (12/90, including 12 death MESHD cases); the mortality rate 1.91% (12/627).2. The comparison between the three groups revealed the following results: weekly hemodialysis duration ( WHD MESHD), ultrafiltration volume (UFV) and ultrafiltration rate (UFR) of the confirmed group were obviously lower than those of the control and suspected groups (P<0.05); the neutrophil ratio (N%), neutrophil (N#), monocyte (M#) and total carbon dioxide (TCO2) were significantly higher than those of the control group while the lymphocyte ratio (L%) was much lower (P<0.05).3. The lung CT scans found three common features: bilateral abnormalities (81.54%), multiple abnormalities MESHD (84.62%) and patchy opacity (61.54%).4. The binary logstic regression analysis showed that diabetes MESHD (OR=5.404,95% CI 1.950~14.976, P=0.001) and hypertension HP hypertension MESHD (OR=3.099,95% CI 1.380~6.963, P=0.006) are independent risk factors for MHD MESHD patients to be infected with COVID-19; WHD (OR=0.846,95% CI 0.737~0.970, P=0.017), UFR (OR=0.012,95% CI 0.002~0.058, P<0.001) and serum SERO ferritin (SF, OR=0.823,95% CI 0.748~0.906, P<0.001) are independent protective factors.Conclusion: MHD MESHD patients with diabetes MESHD or hypertension HP hypertension MESHD are more likely to be infected with COVID-19. In clinical treatment, hemodialysis duration, UFR and SF levels should be controlled appropriately to reduce the risk of infection TRANS risk of infection TRANS infection MESHD.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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