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Human Phenotype

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    Early Diagnosis and Clinical Significance of Acute Cardiac Injury - Under the Iceberg: A Retrospective Cohort Study of 619 Non-critically Ill Hospitalized COVID-19 Pneumonia MESHD Pneumonia HP Patients

    Authors: Yang Xie; Sichun Chen; Xueli Wang; Baige Li; Tianlu Zhang; Xingwei He; NingLing Sun; Luyan Wang; Hesong Zeng; Yin Shen

    doi:10.1101/2020.07.06.20147256 Date: 2020-07-07 Source: medRxiv

    Rationale: Coronavirus disease MESHD 2019 (COVID-19) can cause a viral pneumonia MESHD pneumonia HP together with other extrapulmonary complications. Acute cardiac related injury MESHD (ACRI) is common in hospitalized COVID-19 patients. Objective: To explain the pathological mechanism of ACRI and improve the treatment strategy by retrospectively observing the factors associated with ACRI and factors affecting the prognosis of ACRI with COVID-19 at an early stage. Methods: 619 COVID-19 patients were from Tongji Hospital, Wuhan. T test was used for continuous variables while Chi-square test for categorical factors. Univariable and multivariable logistic regression models were applied to estimate odds ratio (OR) with 95% confidence interval (CI). Results: Among the 619 OOS Level-I hospitalized COVID-19 patients, 102 (16.5%) were defined as ACRI (stage-1: 59 cases, stage-2: 43 cases). 50% of ACRI patients developed into severe cases and 25 patients died (CFR=24.5%), 42 times that of non-ACRI patients. Elderly TRANS (OR=2.83, P<0.001) , HTN (OR=2.09, P=0.005), {gamma}-globulin (OR=2.08, P=0.004), TCM (OR=0.55, P=0.017), PLT (OR=2.94, P<0.001) and NLR (OR=2.20, P=0.004) were independently correlated with ACRI. SBP[≥]140, dyspnea MESHD dyspnea HP, DM, smoking history were correlated with ACRI-stage2 only. In the prognostic subgroup analysis of ACRI patients,{gamma}-globulin treatment could prolong LOS. TCM (OR=0.26, P=0.006), SBP[≥]160 (OR= 22.70, P=0.005), male TRANS (OR=2.66, P=0.044) were associated with severe illness while corticosteroids treatment (OR=3.34, P=0.033) and male TRANS (OR=4.303, P=0.008) with death MESHD. Surprisingly, we found the mortality of non- elderly TRANS patients is higher than elderly TRANS (32.4% VS 20.0%, P=0.164), and both IKF and RASI treatment were not correlated with any prognostic indicators including severe, death MESHD and LOS. Conclusion: This study observed that several non-traditional issues were associated with early cardiac injury in COVID-19 while many traditional cardiovascular risk factors were not. Besides elderly TRANS and male TRANS, hypertension MESHD hypertension HP was confirmed to be the most important risk factor.

    The Impact of Coronavirus Disease MESHD 2019 (COVID-19) on Liver Injury in China: A Systematic Review and Meta-analysis

    Authors: Xin Zhao; Zehua Lei

    doi:10.1101/2020.05.03.20089557 Date: 2020-05-08 Source: medRxiv

    Abstract Background: The evidence for the incidence and severity of liver injury in Chinese patients with COVID-19 is still controversial. Aims: The purpose of this study was to summarize the incidence of liver injury and the differences between liver injury markers among different patients with COVID-19 in China. Methods: Computer searches of PubMed, Embase, CNKI and medRxiv were used to obtain reports on the incidence and markers of liver injury in Chinese patients with COVID-19, from January 1, 2020 to April 10, 2020. (No. CRD42020181350) Results: A total of 57 reports from China were included, including 9889 confirmed cases TRANS of COVID-19 infection MESHD. The results of the meta-analysis showed that among the patients with early COVID-19 infection MESHD in China, the incidence of liver injury events was 24.7% (95% CI, 23.4%-26.4%). Liver injury in severe patients was more common than that in non-severe patients, with a risk ratio of 2.07 (95% CI, 1.77 to 2.43). Quantitative analysis showed that the severe the coronavirus infection MESHD, the higher the level of AST, ALT, TB, ALP, GGT and the lower the level of ALB. The changing trend of the appeal index was similar in ICU patients and dead patients. Conclusion: There is a certain risk of liver injury in Chinese patients with COVID-19, and the risk and degree of liver injury are related MESHD to the severity of COVID-19.

    Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia MESHD pneumonia HP

    Authors: Hui Hui; Yingqian Zhang; Xin Yang; Xi Wang; Bingxi He; Li Li; Hongjun Li; Jie Tian; Yundai Chen

    doi:10.1101/2020.02.24.20027052 Date: 2020-02-27 Source: medRxiv

    Objective: To investigate the correlation between clinical characteristics and cardiac injury of COVID-2019 pneumonia MESHD pneumonia HP. Methods: In this retrospective, single-center study, 41 consecutive corona virus disease MESHD 2019 (COVID-2019) patients (including 2 deaths MESHD) of COVID-2019 in Beijing Youan Hospital, China Jan 21 to Feb 03, 2020, were involved in this study. The high risk factors of cardiac injury in different COVID-2019 patients were analyzed. Computed tomographic (CT) imaging of epicardial adipose tissue (EAT) has been used to demonstrate the cardiac inflammation MESHD of COVID-2019. ResultsOf the 41 COVID-2019 patients, 2 (4.88%), 32 (78.05%), 4 (9.75%) and 3 (7.32%) patients were clinically diagnosed as light, mild, severe and critical cases, according to the 6th guidance issued by the National Health Commission of China. 10 (24.4%) patients had underlying complications, such as hypertension MESHD hypertension HP, CAD, type 2 diabetes mellites and tumor. The peak value of TnI in critical patients is 40-fold more than normal value. 2 patients in the critical group had the onset of atrial fibrillation MESHD atrial fibrillation HP, and the peak heart rates reached up to 160 bpm. CT scan showed low EAT density in severe and critical patients. Conclusion: Our results indicated that cardiac injury of COVID-2019 was rare in light and mild patients, while common in severe and critical patients. Therefore, the monitoring of the heart functions of COVID-2019 patients and applying potential interventions for those with abnormal cardiac injury related MESHD characteristics, is vital to prevent the fatality.

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MeSH Disease
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