Corpus overview


MeSH Disease

Human Phenotype



There are no seroprevalence terms in the subcorpus

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    Hospital Admission Rates, Length of Stay and In-hospital Mortality for Common Acute Care Conditions in COVID-19 vs. Pre-COVID-19 Era

    Authors: Adeel A Butt; Anand B Kartha; Naseer A Masoodi; Aftab M Azad; Nidal A Asaad; Mohamad U Alhomsi; Huda A Saleh; Roberto Bertollini; Abdul-Badi Abou-Samra

    doi:10.1101/2020.08.04.20167890 Date: 2020-08-04 Source: medRxiv

    Background Impact of COVID-19 upon acute care admission rates and patterns are unknown. We sought to determine the change in rates and types of admissions to tertiary and specialty care hospitals in the COVID-19 era compared with pre-COVID-19 era. Methods Acute care admissions to the largest tertiary care referral hospital, designated national referral centers for cardiac, cancer and maternity hospital in the State of Qatar during March 2020 (COVID-19 era) and January 2020 and March 2019 (pre-COVID-19 era) were compared. We calculated total admissions, and admissions for eight specific acute care conditions, in-hospital mortality rate and length of stay at each hospital. Results A total of 18,889 hospital admissions were recorded. A sharp decline ranging from 9%-75% was observed in overall admissions. A decline in both elective and non-elective surgeries was observed. A decline of 9%-58% was observed in admissions for acute appendicitis MESHD, acute coronary syndrome MESHD, stroke MESHD stroke HP, bone fractures MESHD bone fractures HP, cancer and live births, while an increase in admissions due to respiratory tract infections MESHD respiratory tract infections HP was observed. Overall length of stay was shorter in the COVID-19 period possibly suggesting lesser overall disease MESHD severity, with no significant change in in-hospital mortality. Unadjusted mortality rate for Qatar showed marginal increase in the COVID-19 period. Conclusions We observed a sharp decline in acute care hospital admissions, with a significant decline in admissions due to seven out of eight acute care conditions. This decline was associated with a shorter length of stay, but not associated with a change in in-hospital mortality rate.

    Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome MESHD Associated With COVID-19

    Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Mohammad Sadegh Rezai

    doi:10.21203/ Date: 2020-07-30 Source: ResearchSquare

    Background: Although symptoms and signs MESHD of COVID-19 ( Coronavirus disease MESHD 2019) in children TRANS are milder than adults TRANS, there are reports of more severe cases which was defined as pediatric inflammatory multisystem syndrome MESHD (PIMS). The purpose of this report is to describe possible association between COVID-19 and PIMS in children TRANS.  Methods: From 28 March to 24 June 2020, 10 febrile children TRANS were admitted with COVID-19 infection MESHD showing characteristics of PIMS in a tertiary hospital in the north of Iran. Demographic and clinical characteristics, laboratory and imaging findings and therapeutic modalities were recorded and analysed. Results: The mean age TRANS of patients was 5.37±3.9 years (13 months to 12 years). Six of them were boy. Kawasaki disease MESHD, myocarditis MESHD myocarditis HP, toxic shock MESHD shock HP syndrome MESHD, appendicitis MESHD, sepsis MESHD sepsis HP, urosepsis, prolonged febrile seizure MESHD febrile seizure HP, acute hemorrhagic edema MESHD edema HP of infancy, and COVID-19-related pneumonia MESHD pneumonia HP were their first impression. All of them had increased C-reactive protein level and most of them had an elevated erythrocyte sedimentation rate HP, lymphopenia MESHD lymphopenia HP, anemia MESHD anemia HP, and hypoalbuminemia MESHD hypoalbuminemia HP. Some of them had thrombocytopenia MESHD thrombocytopenia HP. Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure and another case discharged with a giant coronary aneurysm MESHD.Conclusion: Children TRANS with COVID-19 may present symptoms similar to Kawasaki disease MESHD and inflammatory syndromes MESHD. PIMS should be considered in children TRANS with fever MESHD fever HP and rash, seizure MESHD seizure HP, cough MESHD cough HP, tachypnea MESHD tachypnea HP, and gastrointestinal symptoms such as vomiting MESHD vomiting HP, diarrhea MESHD diarrhea HP, and abdominal pain MESHD abdominal pain HP.

    Comparison of Acute Appendicitis MESHD Before and Within COVID 19 Era: A Retrospective Study from Rural Nepal

    Authors: Suman Baral; Rajkumar Chhetri; Neeraj Thapa

    doi:10.21203/ Date: 2020-07-22 Source: ResearchSquare

    Background Currently, the world has been engulfed with the pandemicity of the novel severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) and various mitigating measures like lock down and social distancing are being taken which have created significant impact in the emergency MESHD surgical health delivery including acute appendicitis MESHD (AA). The main aim of this study was to compare the demographic and clinical parameters between two cohorts before the onset of lockdown and within the pandemic.Methods A retrospective cohort analysis was performed between two groups of patients presenting with AA in one of the tertiary care centers of rural Nepal. The cohorts were named group A and group B who presented three months prior to and after initiation of lockdown on March 24 2020 respectively. These two groups of patients were compared in demographics, clinicopathological characteristics and surgical aspects of acute appendicitis MESHD. Results There were 42 patients in group A and 50 patients in group B. Mean age TRANS of the patients was 31.32±171.18 years with male TRANS preponderance in group B (N= 29). Mean duration of pain MESHD pain HP increased significantly in group B [55.4±25.9(B) vs 43.52±30.3(A) hours, P= 0.04] along with mean duration of surgery. [51.06±9.4(B) vs 45.27±11.8(A) minutes, P= 0.015] There was significant decrease in post-operative hospital stay among group B patients. [3.05±1.19(B) vs 4.05±0.8(A) days, P= 0.0001] Complicated cases increased in group B (38% vs 33.3 % including appendicular perforation in 10 cases with perforation rate of 20 %. Six of these 10 cohorts had fecalith present intraoperatively. (P= 0.0001) Similarly, mean duration of presentation to hospital significantly increased in group B patients with perforation. [64.8±22.7(B) vs 52.05±14.7(A) hours]    Conclusion During the adversity of COVID 19, increased number of cases of AA can be dealt with surgery as the chances of late presentation and complexity of the lesion exists.

    Changes in Emergency MESHD Department attendances before and after COVID-19 lockdown implementation: a cross sectional study of one urban NHS Hospital Trust

    Authors: Kate Honeyford; Charles Coughlan; Paul Expert; Gabriel Burcea; Ian Maconochie; Anne Kinderlerer; Graham S Cooke; Ceire S Costelloe

    doi:10.1101/2020.07.20.20157560 Date: 2020-07-21 Source: medRxiv

    Background Emergency MESHD Department (ED) attendances have fallen HP across the UK since the "lockdown" introduced on 23rd March 2020 to limit the spread of coronavirus disease MESHD 2019 (COVID-19). We hypothesised that reductions would vary by patient age TRANS and disease MESHD type. We examined pre- and in-lockdown ED attendances for two COVID-19 unrelated diagnoses; one likely to be affected by lockdown measures ( gastroenteritis MESHD) and one likely to be unaffected ( appendicitis MESHD). Methods Retrospective cross-sectional study conducted across two EDs in one London hospital Trust. We compared all adult TRANS and paediatric ED attendances, before (January 2020) and during lockdown (March/April 2020). Key patient demographics, method of arrival and discharge location were compared. We used SNOMED codes to define attendances for gastroenteritis MESHD and appendicitis MESHD. Results ED attendances fell HP from 1129 per day before lockdown to 584 in-lockdown; 51.7% of pre-lockdown rates. In-lockdown attendances were lowest for under-18s (16.0% of pre-lockdown). The proportion of patients admitted to hospital increased from 17.3% to 24.0% and the proportion admitted to intensive care increased four-fold. Attendances for gastroenteritis MESHD fell HP from 511 to 103; 20.2% of pre-lockdown rates. Attendances for appendicitis MESHD also decreased, from 144 to 41; 28.5% of pre-lockdown rates. Conclusion ED attendances fell HP substantially following lockdown implementation. The biggest reduction was for under-18s. We observed reductions in attendances for gastroenteritis MESHD and appendicitis MESHD. This may reflect lower rates of infectious disease MESHD transmission TRANS, though the fall HP in appendicitis MESHD-related attendances suggests that behavioural factors are also important. Larger studies are urgently needed to understand changing patterns of ED use and access to emergency MESHD care during the COVID-19 pandemic.

    No SARS-CoV-2 detected in the vermiform appendix of a COVID-19 patient with appendicitis MESHD: a case report 

    Authors: Benjamin Wolf; Corinna Pietsch; Marc-Philip Radosa; Lars-Christian Horn; Uwe G. Liebert; Bahriye Aktas

    doi:10.21203/ Date: 2020-06-28 Source: ResearchSquare

    Background:SARS-CoV-2, the virus causing corona virus disease MESHD 2019 (COVID-19), has been demonstrated to infect the gastrointestinal tract and might therefore be a source of infection MESHD for the surgical team during abdominal operations. One of the most common surgical procedures performed is appendectomy. However, reports of virologic testing of appendiceal tissue specimens in COVID-19 patients are lacking. We sought to determine whether SARS-CoV-2 is present in the appendectomy specimen of a patient with COVID-19. Case presentation:A female TRANS patient presented to the emergency MESHD department of our tertiary care academic hospital with lower abdominal pain MESHD abdominal pain HP, fever MESHD fever HP, nausea MESHD nausea, and vomiting HP, and vomiting MESHD. She was admitted to the gynecological floor because of suspected pelvic inflammatory disease MESHD. Due to worsening symptoms, a laparoscopy was performed the next day and a severely inflamed appendix was detected. Laparoscopic appendectomy was performed without complications. A few hours postoperatively, the patient was tested positive for corona virus disease MESHD 2019 (COVID 19). Real-time reverse transcription polymerase chain reaction analysis targeting the SARS-CoV-2 E-gene was performed on the appendectomy specimen. SARS-CoV-2 could not be detected. During her hospital stay, the patient developed mild respiratory symptoms while the postoperative course was otherwise uncomplicated. Conclusions:The absence of SARS-CoV-2 in the appendectomy specimen of our case adds to the preliminary available evidence indicating that appendectomy in COVID-19 patients with mild disease MESHD carries probably a low risk of infection TRANS risk of infection TRANS infection MESHD by aerosols generated during the procedure. 

    Effects of COVID-19 pandemic on general surgical emergencies MESHD: Are some emergencies MESHD really urgent? Level 1 Trauma center experience

    Authors: Ahmet Surek; Sina Ferahman; Eyup Gemici; Ahmet Cem Dural; Turgut Donmez; Mehmet Karabulut

    doi:10.21203/ Date: 2020-06-23 Source: ResearchSquare

    Purpose: We aimed to investigate the effect of COVID-19 pandemic on general surgical emergencies MESHD. On the other hand, we analyzed the effectiveness of the measures we have taken and the incidence of COVID-19 of patients and healthcare professionals.Method: In the pandemic period between March 14 and May 15, 2020, and in the same period of the previous year, the files of patients who underwent emergency MESHD surgery and followed up nonoperatively were reviewed retrospectively. The incidence of COVID-19 was questioned in patients operated on in the pandemic period and in health professionals working in the general surgery department.Results: Demographic data were similar between the two groups. The number of patients operated on in the pandemic group (n = 103) was lower than during the control group (n = 252) (p = 0.001). In the pandemic group, there was a significant decrease in the number of surgeries of uncomplicated appendicitis MESHD, acute cholecystitis MESHD cholecystitis HP and incarcerated hernia MESHD hernia HP (p=0.001, p=0.005, p=0.001, respectively). Others surgeries were similar in both groups. In the pandemic group, nonoperatively follow-up rates were significantly lower in acute mechanical intestinal obstruction MESHD intestinal obstruction HP and acute cholecystitis MESHD cholecystitis HP (p=0.001, p=0.011, respectively). The findings of COVID-19 were positive in 6(6/103, %5.82) patients undergoing emergency MESHD surgery. None of our doctors had COVID-19 infection MESHD (0/20). The findings were positive only in 2 nurses from the general surgery department(2/24, %8,33).Conclusion: In these and similar pandemics, we think that a new algorithm is needed to approach emergencies MESHD and the results of this study can help for that.

    Management of patients with suspected COVID-19 who underwent emergency MESHD surgery

    Authors: Yanzhe Tan; Chengwei Yan; chunbao guo

    doi:10.21203/ Date: 2020-06-16 Source: ResearchSquare

    Background: Since the outbreak of COVID-19, no official guidelines for urgent surgical management of patients with the COVID-19 concern have been recommended. The current study provides our experience about the management for the patients with suspected or confirmed COVID-19 who required urgent surgical intervention.Methods: From February 5, 2019, to May 26, 2020, there were 5 cases of patients with suspected or confirmed COVID-19 infection MESHD managed with urgent surgical intervention in two hospitals in Chongqing. Results: The five cases with COVID-19 concern were admitted with different diseases MESHD, including acute intussusception MESHD intussusception HP, strangulated inguinal indirect hernia MESHD hernia HP, acute purulent appendicitis MESHD, femoral fracture MESHD and onset to delivery. Finally, four patients obtained negative results afterwards. One pregnant woman with confirmed COVID-19 infection MESHD underwent caesarean section. All medical staff involved in the patients management were well, and no in-hospital transmission TRANS occurredConclusion:Suspected COVID-19 patients must be managed as positive patients until proven or denied in order to minimize the spread and transmission TRANS of infection MESHD. The current protocol carried out in our practice might be plausible and technically feasible for hospitals when dealing with COVID-19 infection MESHD.

    Early Impact of COVID-19 Pandemic on Paediatric Surgical Practice in Nigeria: a National Survey of Paediatric Surgeons.

    Authors: Ibukunolu O Ogundele; Felix M Alakaloko; Collins C Nwokoro; Emmanuel A Ameh

    doi:10.1101/2020.05.24.20112326 Date: 2020-05-25 Source: medRxiv

    Introduction The novel Coronavirus disease MESHD has had significant impact on healthcare globally. Knowledge of this virus is evolving, definitive care is not yet known, and mortality is increasing. We assessed its initial impact on paediatric surgical practice in Nigeria, creating a benchmark for recommendations and future reference. Methods Survey of 120 paediatric surgeons from 50 centres to assess socio-demographics and specific domains of impact of COVID-19 on their services and training in Nigeria. Seventy four surgeons adequately responded. Responses have been analysed. Duplicate submissions for centres were excluded by combining and averaging the responses from centres with multiple respondents. Results Forty-six (92%) centres had suspended elective surgeries. All centres continued emergency MESHD surgeries but volume reduced in March by 31%. Eleven (22%) centres reported 13 suspended elective cases presenting as emergencies MESHD in March, accounting for 3% of total emergency MESHD surgeries. Nine (18%) centres adopted new modalities for managing selected surgical conditions: non-operative reduction of intussusception MESHD intussusception HP in 1(2%), antibiotic management of uncomplicated acute appendicitis MESHD in 5(10%), more conservative management of trauma and replacement of laparoscopic appendectomy with open surgery in 3(6%) respectively. Low perception of adequacy of Personal Protective Equipment (PPE) was reported in 35(70%) centres. Forty (80%) centres did not offer telemedicine for patients follow up. Twenty-nine (58%) centres had suspended academic training. Perception of safety to operate was low in 37(50%) respondents, indifferent in 24% and high in 26%. Conclusion Majority of paediatric surgical centres reported cessation of elective surgeries whilst continuing emergencies MESHD. There is however an acute decline in the volume of emergency MESHD surgeries. Adequate PPE need to be provided and preparations towards handling backlog of elective surgeries once the pandemic recedes. Further study is planned to more conclusively understand the full impact of this pandemic on children TRANS's surgery. Key words pandemic, COVID-19, children TRANS's surgery.

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MeSH Disease
Human Phenotype

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