Objectives: In December 2019 a novel human-infecting coronavirus, SARS-CoV-2, has emerged. The WHO has stated the epidemic as a “public health emergency MESHD of international concern”. A drammatic situation has emerged with thousands of deaths MESHD, occurring mainly in the aged TRANS and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly TRANS individuals and these subjects often present a severe deficiency in nutrients as fatsoluble and hydrosoluble vitamins. Design: In this first part of the review about Cov2 in aged TRANS people, we searched for reviews describing the characteristics of autoimmune diseases MESHD and the available therapeutic protocols for their treatment. We sed them as a paradigm with the purpose to retrieve pathogenetic mechanisms in common among these pathological conditions and SARS-CoV-2 infection MESHD, as well as the alteration induced in immune system function by this virus, or by its homologous SARS-CoV. Results: SARS-CoV-2 infection MESHD induces an important immune system dysfunction with the development of an exhuberant proinflammatory response in the host, and with the development of a life-threatening condition defined as Cytokine Release Syndrome MESHD (CRS). This leads to the Acute Respiratory Syndrome MESHD (ARDS), mainly in the aged TRANS people. High mortality and lethality rates have been observed in the elderly TRANS subjects with CoV-2-related infection MESHD. Conclusion: These diseases MESHD may serve as a paradigm for the study of CRS emerging in the course of SARS CoV-2 infection MESHD. This review discusses about the possible activity of Vitamin A, D, E and C in restoring normal antiviral Immune System function or the potential therapeutic role of these micronutrients as a part of a multi-treatment strategy against SARS- CoV-2 infection MESHD.