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MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged TRANS People

    Authors: Sirio Fiorino; Claudio Gallo; Maddalena Zippi; Sergio Sabbatani; Roberto Manfredi; Renzo Moretti; Elisa Fogacci; Caterina Maggioli; Francesca Travasoni Loffredo; Enrico Giampieri; Ivan Corazza; Christoph Dickmans; Claudio Denitto; Michele Cammarosano; Michele Battilana; Paolo Emilio Orlandi; Francesco Del Forno; Francesco Miceli; Michela Visani; Giorgia Acquaviva; Paolo Leandri; Elio Jovine; Roberto Iovine; Dario de Biase

    id:202005.0304/v1 Date: 2020-05-18 Source: Preprints.org

    Objectives: In December 2019 a novel human-infecting coronavirus, SARS-CoV-2, has emerged. The WHO has stated the epidemic as a “public health emergency MESHD of international concern”. A dramatic situation has emerged with thousands of deaths MESHD, occurring mainly in the aged TRANS and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly TRANS individuals and these subjects often present a severe deficiency in nutrients as fatsoluble and hydrosoluble vitamins. Design: In this second part of the review about Cov2 in aged TRANS people, we searched for studies describing the possible efficacy of vitamins A, D, E and C in improving the immune system function and their possible activities against viruses. Results: Vitamins may shift the proinflammatory Th17 mediated immune-response arising in the autoimmune diseases MESHD towards a T-cell regulatory phenotype. These diseases MESHD may serve as a paradigm for the study of CRS emerging in the course of SARS CoV-2 infection MESHD. Conclusion: This review discusses about the possible activity of Vitamin A, D, E and C in restoring normal antiviral Immune System function or the potential therapeutic role of these micronutrients as a part of a multi-treatment strategy against SARS-CoV-2 infection MESHD.

    COVID-19 Perfect Storm (Part I): Cytokine Release Syndrome MESHD in Aged TRANS People

    Authors: Sirio Fiorino; Claudio Gallo; Maddalena Zippi; Sergio Sabbatani; Roberto Manfredi; Renzo Moretti; Elisa Fogacci; Caterina Maggioli; Francesca Travasoni Loffredo; Enrico Giampieri; Ivan Corazza; Christoph Dickmans; Claudio Denitto; Michele Cammarosano; Michele Battilana; Paolo Emilio Orlandi; Francesco Del Forno; Francesco Miceli; Michela Visani; Giorgia Acquaviva; Paolo Leandri; Elio Jovine; Roberto Jovine; Dario de Biase

    id:202005.0303/v1 Date: 2020-05-18 Source: Preprints.org

    Objectives: In December 2019 a novel human-infecting coronavirus, SARS-CoV-2, has emerged. The WHO has stated the epidemic as a “public health emergency MESHD of international concern”. A drammatic situation has emerged with thousands of deaths MESHD, occurring mainly in the aged TRANS and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly TRANS individuals and these subjects often present a severe deficiency in nutrients as fatsoluble and hydrosoluble vitamins. Design: In this first part of the review about Cov2 in aged TRANS people, we searched for reviews describing the characteristics of autoimmune diseases MESHD and the available therapeutic protocols for their treatment. We sed them as a paradigm with the purpose to retrieve pathogenetic mechanisms in common among these pathological conditions and SARS-CoV-2 infection MESHD, as well as the alteration induced in immune system function by this virus, or by its homologous SARS-CoV. Results: SARS-CoV-2 infection MESHD induces an important immune system dysfunction with the development of an exhuberant proinflammatory response in the host, and with the development of a life-threatening condition defined as Cytokine Release Syndrome MESHD (CRS). This leads to the Acute Respiratory Syndrome MESHD (ARDS), mainly in the aged TRANS people. High mortality and lethality rates have been observed in the elderly TRANS subjects with CoV-2-related infection MESHD. Conclusion: These diseases MESHD may serve as a paradigm for the study of CRS emerging in the course of SARS CoV-2 infection MESHD. This review discusses about the possible activity of Vitamin A, D, E and C in restoring normal antiviral Immune System function or the potential therapeutic role of these micronutrients as a part of a multi-treatment strategy against SARS- CoV-2 infection MESHD.

    A Novel RP-HPLC-DAD Method Development for Anti-Malarial and COVID-19 Hydroxy Chloroquine Sulfate Tablets and Profiling of In-Vitro Dissolution in Multimedia.

    Authors: THIRUPATHI DONGALA; Santhosh Kumar Ettaboina; Naresh Kumar Katari

    doi:10.21203/rs.3.pex-880/v2 Date: 2020-04-03 Source: ResearchSquare

    Hydroxychloroquine sulfate is one of a large series of 4-aminoquinolines with antimalarial activity. Moreover, it is used for the treatment of rheumatoid arthritis MESHD rheumatoid arthritis HP. Sometimes Hydroxychloroquine sulfate is very effective for the treatment of autoimmune diseases MESHD. Based on the recent clinical experiments it is exploiting for the treatment of COVID-19, corona virus across the globe. A Reverse phase RP-HPLC method have been developed and validated as per the current ICH guidelines for estimation of Hydroxychloroquine sulfate tablets. As part of method validation specificity, linearity, precision and recovery parameters were verified. The concentration and area relationships were linear (R2 > 0.999), over the concentration range of 25 to 300 µg mL-1 for HCQ. The relative standard deviations for precision and intermediate precision were less than 1.5%. The proposed RP-HPLC generic method was applied successfully for evaluation of invitro dissolution profile with different pH conditions like 0.1N HCl, pH 4.5 Acetate buffer and pH 6.8 Phosphate buffers of US marketed reference product.

    Repositioning Chloroquine as Ideal Antiviral Prophylactic against COVID-19 - Time is Now

    Authors: Raymond Chang; Wei-Zen Sun

    id:10.20944/preprints202003.0279.v1 Date: 2020-03-17 Source: Preprints.org

    The novel coronavirus 2019 (COVID-19) pandemic is rapidly advancing despite public health measures. Pharmaceutical prophylaxis is an established approach to potentially control infectious diseases MESHD and is one solution to the urgent public health challenge posed by COVID-19. Screening and development of new vaccines and antivirals is expensive and time consuming while the repositioning of available drugs should receive priority attention as well as international government and agency support. Here we propose an old drug chloroquine (CQ) to be urgently repositioned as an ideal antiviral prophylactic against COVID-19. CQ has ability to block viral attachment and entry to host cells. Its proven clinical efficacy against a variety of viruses including COVID-19 and its current deployment in COVID-19 therapeutic trials strengthens its potential candidacy as a prophylactic. Furthermore, CQ has a long safety record, is inexpensive and widely available. Here we reviewed CQ's antiviral mechanisms, its laboratory efficacy activity against COVID-19, as well as CQ's pharmacokinetics in its established use against malaria MESHD and autoimmune diseases MESHD to recommend safe and potentially efficacious dose regimens for protection against COVID-19: a pre-exposure prophylaxis of 250-500mg daily and post-exposure prophylaxis at 8mg/kg/day for 3 days. We recommend further urgent research on CQ for COVID-19 prevention and urge that the above regimens be investigated in parallel with mass deployment by relevant agencies in attempts to contain the pandemic without unnecessary regulatory delays as benefits far outweigh risks or costs.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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