Corpus overview


MeSH Disease

Human Phenotype

Pneumonia (7)

Fever (6)

Cough (3)

Dyspnea (3)

Myalgia (2)


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    Etiology and Antimicrobial Resistance of Secondary Bacterial Infections MESHD in Patients Hospitalized With COVID-19 in Wuhan, China: A Retrospective Analysis

    Authors: Jie Li; Junwei Wang; Yi Yang; Peishan Cai; Jingchao Cao; Xuefeng Cai; Yu Zhang

    doi:10.21203/ Date: 2020-07-23 Source: ResearchSquare

    Background: A considerable proportion of patients hospitalized with corona virus disease MESHD 2019 (COVID-19) have acquired secondary bacterial infections MESHD (SBIs). We report the etiology and antimicrobial resistance of bacteria to provide theoretical basis for appropriate infection MESHD therapy.Methods: In the retrospective study, we reviewed electronic medical records of all the patients hospitalized with COVID-19 in the Wuhan Union hospital from January 27 to March 17, 2020. According to the inclusion and exclusion criteria, patients who acquired SBIs were enrolled. Demographic, clinical course, etiology and antimicrobial resistance data of the SBIs were collected. Outcomes were also compared between patients who were classified as severe on admission and those who were classified as critical.Results: 6.8% (102/1495) of the patients with COVID-19 had acquired SBIs and almost half of them (50, 49.0%) died during hospitalization. Compared with the severe patients, the critical patients had a higher chance of SBIs. 159 strains of bacteria were isolated, 85.5% of which were Gram-negative bacteria. The top three bacteria of SBIs were A. baumannii (35.8%), K. pneumoniae MESHD pneumoniae HP (30.8%) and Staphylococcus (8.8%). The isolation rate of carbapenem-resistant A. baumannii and K. pneumoniae MESHD pneumoniae HP were 91.2% and 75.5%, respectively. Meticillin resistance was in 100% of Staphylococcus, and vancomycin resistance was not found. Conclusions: SBIs may occur in patients hospitalized with COVID-19 and lead to high mortality. The incidence of SBIs was associated with the grade on admission. Gram-negative bacteria, especially A. baumannii and K. pneumoniae MESHD pneumoniae HP, were the main bacteria and the resistance rates of the major isolated bacteria were generally high.

    Molecular Basis of Kidney Defects in COVID-19 Patients

    Authors: Smartya Pulai; Madhurima Basu; Chinmay Saha; Nitai P. Bhattacharyya; Arpita Ray Chaudhury; Sujoy Ghosh

    id:10.20944/preprints202007.0452.v1 Date: 2020-07-20 Source:

    Background: Kidney damage is considered to be one of the risk factors for severity and mortality among COVID-19 patients. However, molecular nature of such observations remains unknown. Hypothesis: Altered gene expressions due to infection MESHD infection and in chronic HP and in chronic kidney disease MESHD could explain severity in COVID-19 with kidney defects. Methods: We collected gene expression data from publicly available resources Gene Expression Omnibus CKD, Enrichr for deregulated genes in SARS-CoV infected cells in vitro, DisGeNET and others and carried out enrichment analysis using Enrichr. Result: Number of common genes altered in chronic kidney disease HP kidney disease MESHD (CKD) and SARS-CoV infected cells was 2834. Enrichment analysis revealed that biological processes related viral life cycle and growth, cytokines, immunity, interferon, inflammation MESHD, apoptosis, autophagy, oxidative stress and others were significantly enriched with common deregulated genes. Similarly, significantly enriched pathways related to viral and bacterial infections MESHD, immunity and inflammation MESHD, cell cycle, ubiquitin mediated proteolysis, signaling pathways like Relaxin signaling pathway, mTOR signaling pathway, IL-17 signaling pathway, NF-kappa B signaling pathway were enriched with the common deregulated genes. These processes and pathways are known to be related to kidney damage. DisGeNET terms enriched include and related to Dengue MESHD fever MESHD fever HP, chronic Hepatitis MESHD chronic Hepatitis HP, measles MESHD, retroviridae infections MESHD, respiratory syncytial virus Infections MESHD and many others. Kidney dysfunction related terms ischemia MESHD of kidney, renal fibrosis HP fibrosis MESHD and diabetic nephropathy MESHD nephropathy HP. Conclusion: Common deregulated genes in SARS-CoV infected cells and chronic kidney disease HP kidney disease MESHD, as well as their enrichment with molecular processes and pathways relevant for viral pathogenesis and renal dysfunctions, could explain the severity of COVID-19 with kidney disease MESHD. This observation not only provides molecular relation of severity in COVID-19 with renal dysfunctions but might also help in the management and treatment targets for these cases.

    A severe coronavirus disease MESHD 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report

    Authors: Taojiang Chen; Qin Yang; Hongyu Duan

    doi:10.21203/ Date: 2020-07-17 Source: ResearchSquare

    Background: SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including  nausea, diarrhea MESHD diarrhea HP, and vomiting MESHD vomiting HP. Massive gastrointestinal bleeding, however, has rarely been reported. Case presentation: We herein describe a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male TRANS, hypertension MESHD hypertension HP, old age TRANS, mixed bacterial infection MESHD and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia HP was uncontrolled. The patient rapidly deteriorated, suffered cardiac arrest HP, and expired. Conclusions: Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection MESHD through faecal-oral transmission TRANS should be implemented in the process of patient care and infection MESHD control.

    Procalcitonin and COVID-19: A Reliable Clinical Tool

    Authors: Jessica Bass; Anshika Singh; Robin Williams; David H. Lindner

    doi:10.21203/ Date: 2020-07-15 Source: ResearchSquare

    BACKGROUND: A procalcitonin (PCT) level is commonly ordered to distinguish between bacterial and viral etiologies of lower respiratory tract infections MESHD respiratory tract infections HP as it is typically negative in the absence of inflammatory conditions and bacterial infections MESHD. With COVID-19 causing an influx of patients presenting with respiratory symptoms, clinicians are in need of useful tools to guide management of these patients. Given the inflammation MESHD that is caused by COVID-19, it is currently unknown whether PCT continues to be a reliable or useful test in suspected and confirmed cases TRANS of COVID-19 pneumonia MESHD pneumonia HP. OBJECTIVE: To determine whether PCT remains a clinically useful test in patients who present with lower respiratory tract symptoms in the era of COVID-19. DESIGN: Single-center retrospective cohort studyPARTICIPANTS: 243 adults TRANS with lower respiratory tract symptoms who presented to the hospital through the emergency MESHD department between April 11, 2020 and May 18, 2020 who received both a COVID-19 test as well as a PCT level. MAIN MEASURES: COVID-19 positivity/negative, PCT level KEY RESULTS: It was found that patients with COVID-19 consistently had negative procalcitonin levels (<0.25ng/mL). Based on the odds ratio, a patient with a positive PCT level was 3.4 times more likely to test negative for COVID than a patient with a PCT level <0.25ng/mL.  (1)=13.895, p<0.001.  CONCLUSIONS: There is a highly significant association between a negative procalcitonin and positive COVID-19 infection MESHD, thus supporting the continued use of PCT in the COVID-19 era.

    Haemophilus Influenza Coinfection MESHD is Common in COVID-19 Patients

    Authors: junping yan; liangshan Hu; Seyin Zou; guochen liu; donglin cao

    doi:10.21203/ Date: 2020-07-13 Source: ResearchSquare

    Background: The combined infection MESHD rate and bacterial spectrum has not been reported in COVID-19 patients. Methods: Constant temperature amplification reaction and real-time fluorescence analysis was performed for common bacterial respiratory pathogens on sputum samples (spontaneous or induced) from a prospective cohort study of infections MESHD. Forty-nine suspected COVID-19 cases from Guangdong Second Provincial General Hospital were included in the study, 49.0% were male TRANS. Results: Probable bacterial infection MESHD was detected in 33 participants. Haemophilus influenzae was the most common bacterial pathogens detected. Conclusions: Multiple coinfections MESHD were commonly detected. Sputum multiplex PCR could become a useful diagnostic tool for bacterial respiratory infections MESHD in COVID-19 infected inpatients.

    A false alarm of COVID-19 pneumonia MESHD pneumonia HP in lung cancer: a case report of anti-PD-1 related pneumonitis and literature review

    Authors: Ying Dai; Ying Dai; Sha Liu; Sha Liu; Zhiyan Zhao; Zhiyan Zhao; Xiaqiu Li; Xiaqiu Li; Yiruo Zhang; Yiruo Zhang; Pingping Liu; Pingping Liu; Yingying Du; Yingying Du

    doi:10.21203/ Date: 2020-07-11 Source: ResearchSquare

    Background: The fatal toxicity of anti-PD-1/PD-L1 agents is pneumonitis. The diagnosis consists of the history of immunotherapy, clinical symptoms and presentation of computed tomography (CT) imaging. The typical CT findings include ground-glass opacities. Based on the similar radiographic feature with 2019 Novel Coronavirus (COVID-19) pneumonia MESHD pneumonia HP, clinicians are cautious to evaluate diagnosis especially in COVID-19 epidemic areas. Case presentation: Herein we report a 67-year-old male TRANS patient with advanced non-small cell lung cancer developed pneumonitis post Sintilimab injection. The dyspnea MESHD dyspnea HP appeared at the 15th day of close contact TRANS with his son who returned from Wuhan, but not accompanied with fever MESHD fever HP. The chest CT indicated peripherally subpleural lattice opacities at the inferior right lung lobe and bilateral thoracic infusion. The real-time reverse-transcription polymerase-chain-reaction (RT-PCR) from double swab samples within 72 hours remained negative. The patient was thereafter treated with prednisolone and antibiotics for over two weeks. Thereafter the chest CT demonstrated the former lesion almost absorbed, in line with prominently falling HP CRP level. The anti-PD-1 related pneumonitis with bacterial infection MESHD was diagnosed finally based on the clinical evidence and good response to the prednisolone and antibiotics. Conclusion: Both ani-PD-1 related pneumonitis and COVID-19 pneumonia MESHD pneumonia HP harbor the common clinical symptom and the varied features of CT imaging. Differential diagnosis was based on the epidemiological and immunotherapy histories, RT-PCR tests. The response to glucocorticoid can indirectly help the diagnosis.

    Protocol for a retrospective cohort study for evaluating the early antibiotics use in non-severe COVID-19 patients

    Authors: Xiaoxv Yin; Li Liu; Xing Xu; Lei Huang; Ping Jing; Hui Li; Nan Jiang; Jing Wang; Zuxun Lu; Yanhong Gong; Nian Xiong; Changjun Li

    doi:10.21203/rs.3.pex-1020/v2 Date: 2020-07-02 Source: ResearchSquare

    The use of antibiotics is common in the treatment of COVID-19, but adequate evaluation is lacking. We aimed to evaluate the efficacy of antibiotic use in non-severe COVID-19 patients, particularly in patients admitted with low risk of bacterial infection MESHD. This is a multi-center retrospective cohort study. Patients are screened strictly according to the inclusion/exclusion criteria and are divided into two groups based on antibiotics exposure. The exposure is defined as the treatment of antibiotics prescribed within 48 hours after admission, with a course of treatment≥3 days; and patients in this group are classified as early antibiotic use group. Otherwise, patients are classified as the non early antibiotic use group. The primary end point of the study is progressing from non-severe type COVID-19 into severe type. This is the first protocol to put a focus on the transformation of the severity of the disease MESHD, based on a multi-center retrospective cohort design.

    Evaluation of early antibiotics use in non-severe COVID-19 patients admitted with low risk of bacterial infection MESHD

    Authors: Xiaoxv Yin; Li Liu; Xing Xu; Lei Huang; Ping Jing; Hui Li; Nan Jiang; Jing Wang; Zuxun Lu; Yanhong Gong; Nian Xiong; Changjun Li

    doi:10.21203/ Date: 2020-07-01 Source: ResearchSquare

    The use of antibiotics is common in the treatment of COVID-19, but adequate evaluation is lacking. This study aimed to evaluate the effect of early antibiotic use in non-severe COVID-19 patients admitted with low risk of bacterial infection MESHD. The multi-center retrospective cohort study included 1613 non-severe COVID-19 inpatients admitted with low risk of bacterial infection MESHD. During the follow-up of 30 days, the proportion of patients progressed into severe type COVID-19 in the early antibiotics use group was almost 1.5 times than that of the comparision group. In the mixed-effect model, the early use of antibiotics was associated with higher probability of developing severe type, staying in the hospital for over 15 days, and secondary infection MESHD. However, it was not significant association with mortality rate. Analysis with propensity score-matched cohort displayed similar results. It is suggested that antibiotic use should be avoided unless absolutely necessary in non-severe COVID-19 patients, particularly in the early stages.

    Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease MESHD

    Authors: Muhamed-Kheir Taha; Ala-Eddine Deghmane

    doi:10.21203/ Date: 2020-06-24 Source: ResearchSquare

    Objective: Few data are available on the association between SARS-CoV-2 and secondary bacterial infections MESHD. Such an association was described for flu and invasive meningococcal disease MESHD (IMD). We aimed exploring such a correlation between COVID-19and IMD.Results: We compared IMD cases received at the French National Reference Centre for meningococci and Haemophilus influenzae that are sent as part of the mandatory reporting of IMD. We compared these data during the period 01 January-15 May 2020 to those from the same period in 2019. IMD cases that were associated with respiratory presentations significantly increased in 2020, involved elderly TRANS and were due to unusual isolates. However, usual IMD cases due to highly transmissible isolates decreased during the lockdown. Enhancing IMD surveillance and anti-meningococcal vaccination in elderly TRANS should to be addressed.

    Clinical characteristics of hospitalized patients with COVID-19 in Yueyang, Hunan, China

    Authors: Chenglong Ge; Yuan Jiang; Qianyi Peng; Lei Wu; Kai Duan; Jing Yang

    doi:10.21203/ Date: 2020-06-23 Source: ResearchSquare

    The clinical characteristics of patients with novel coronavirus disease MESHD (COVID-19) in Hunan Province are less understood. We analyzed retrospectively the epidemiological, clinical characteristics, and risk factors associated with severity of 113 confirmed COVID-19 cases in Yueyang, Hunan Province, China, from January 20, 2020, to March 8, 2020, and followed until April 13, 2020. Of the 113 confirmed cases TRANS, 92 (81.4%) were from or infected by patients from Hubei province. More than half (63) of patients with COVID-19 had no fever MESHD fever HP in the early stages of disease MESHD. 23% patients had no symptoms at the onset TRANS. As of March 8, 2020, 113 (100%) of 113 patients had met the discharge criteria, 0 (0%) patients died. Compared with the non-severe cases, severe cases were associated with older age TRANS or patients with comorbidities, secondary bacterial infections MESHD, and higher levels of C-reactive protein. Longer duration of virus clearance was associated with a higher risk of progression to critical status. Older patients or patients with comorbidities such as diabetes were more likely to have severe condition. Prompt and effective treatment and sufficient medical resources may still significantly reduce hospital-related transmissions TRANS and mortality.

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MeSH Disease
Human Phenotype

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